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Taste receptor type 2 member 38 (T2R38) (Taste receptor type 2 member 26) (T2R26)

 T2R38_RAT               Reviewed;         331 AA.
Q4VHE7; Q67ES4;
25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
05-JUL-2005, sequence version 1.
22-NOV-2017, entry version 76.
RecName: Full=Taste receptor type 2 member 38;
Short=T2R38;
AltName: Full=Taste receptor type 2 member 26;
Short=T2R26;
Name=T2r38 {ECO:0000312|RGD:1560649}; Synonyms=Tas2r26;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1] {ECO:0000305, ECO:0000312|EMBL:AAX99135.1}
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=Sprague-Dawley {ECO:0000269|PubMed:15886333};
PubMed=15886333; DOI=10.1152/physiolgenomics.00030.2005;
Wu S.V., Chen M.C., Rozengurt E.;
"Genomic organization, expression, and function of bitter taste
receptors (T2R) in mouse and rat.";
Physiol. Genomics 22:139-149(2005).
[2] {ECO:0000312|EMBL:AAR13355.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13355.1};
Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
"Identification of new putative rat taste receptors belonging to the
T2R family.";
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Putative taste receptor which may play a role in the
perception of bitterness. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}.
-!- TISSUE SPECIFICITY: Expressed in tongue, stomach and duodenum.
{ECO:0000269|PubMed:15886333}.
-!- MISCELLANEOUS: Several bitter taste receptors are expressed in a
single taste receptor cell. {ECO:0000305}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
{ECO:0000255}.
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EMBL; AY916512; AAX99135.1; -; mRNA.
EMBL; AY362746; AAR13355.1; -; Genomic_DNA.
RefSeq; NP_001019856.1; NM_001024685.1.
UniGene; Rn.156466; -.
ProteinModelPortal; Q4VHE7; -.
STRING; 10116.ENSRNOP00000028969; -.
PhosphoSitePlus; Q4VHE7; -.
PaxDb; Q4VHE7; -.
GeneID; 500091; -.
KEGG; rno:500091; -.
UCSC; RGD:1560649; rat.
CTD; 387513; -.
RGD; 1560649; T2R38.
eggNOG; ENOG410IH9N; Eukaryota.
eggNOG; ENOG410Z3YE; LUCA.
HOGENOM; HOG000041379; -.
HOVERGEN; HBG098741; -.
InParanoid; Q4VHE7; -.
KO; K08474; -.
PhylomeDB; Q4VHE7; -.
TreeFam; TF335891; -.
PRO; PR:Q4VHE7; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; ISO:RGD.
GO; GO:0033038; F:bitter taste receptor activity; ISO:RGD.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:RGD.
CDD; cd15025; 7tm_TAS2R38; 1.
InterPro; IPR007960; T2R.
InterPro; IPR030050; TAS2R38.
PANTHER; PTHR11394; PTHR11394; 1.
PANTHER; PTHR11394:SF52; PTHR11394:SF52; 1.
Pfam; PF05296; TAS2R; 1.
2: Evidence at transcript level;
Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
Receptor; Reference proteome; Sensory transduction; Taste; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 331 Taste receptor type 2 member 38.
/FTId=PRO_0000247657.
TOPO_DOM 1 17 Extracellular. {ECO:0000255}.
TRANSMEM 18 38 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 39 54 Cytoplasmic. {ECO:0000255}.
TRANSMEM 55 75 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 76 94 Extracellular. {ECO:0000255}.
TRANSMEM 95 115 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 116 142 Cytoplasmic. {ECO:0000255}.
TRANSMEM 143 163 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 164 198 Extracellular. {ECO:0000255}.
TRANSMEM 199 219 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 220 243 Cytoplasmic. {ECO:0000255}.
TRANSMEM 244 264 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 265 276 Extracellular. {ECO:0000255}.
TRANSMEM 277 297 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 298 331 Cytoplasmic. {ECO:0000255}.
CARBOHYD 177 177 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 101 101 S -> I (in Ref. 2; AAR13355).
{ECO:0000305}.
SEQUENCE 331 AA; 37233 MW; E435EDCB9AC664B5 CRC64;
MLTLTPVLTV SYEAKISFLF LSVVEFAVGI MANAFIVLVN FWDMVKKQPL NNCDIALLCL
SITRLFLQGL LLLDAIQLAC FQQMKDPLSH NYQAILTLWM SANQVSLWLA ACLSLLYCAK
IVRFSHTFPL HLASWVSRRF LQMLLVALLF SGVCTALCLW DFFSRSHTVV TSMLHMNNTE
FNLQIEKLNF FYSFVFCNVG SVPPSLVFLI SSGVLVISLG NHMRTMKSQT RGSRDPSLEA
HVRAIIFLVS FLCFYVVSFC AALISIPLLV LWHNKGGVMV CIGMMAACPS GHAAILISGN
AKLKKVIVTI LFWFQSRQKV RRVHKVLPRI L


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