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Taste receptor type 2 member 39 (T2R39) (Taste receptor type 2 member 32) (T2R32)

 T2R39_RAT               Reviewed;         319 AA.
Q67ER9;
25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
11-OCT-2004, sequence version 1.
30-AUG-2017, entry version 80.
RecName: Full=Taste receptor type 2 member 39;
Short=T2R39;
AltName: Full=Taste receptor type 2 member 32;
Short=T2R32;
Name=Tas2r39 {ECO:0000250|UniProtKB:Q7TQA5}; Synonyms=Tas2r32;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1] {ECO:0000312|EMBL:AAR13360.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13360.1};
Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
"Identification of new putative rat taste receptors belonging to the
T2R family.";
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Putative taste receptor which may play a role in the
perception of bitterness. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}.
-!- MISCELLANEOUS: Several bitter taste receptors are expressed in a
single taste receptor cell. {ECO:0000305}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
{ECO:0000255}.
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EMBL; AY362751; AAR13360.1; -; Genomic_DNA.
RefSeq; NP_001074374.1; NM_001080905.1.
UniGene; Rn.202938; -.
ProteinModelPortal; Q67ER9; -.
STRING; 10116.ENSRNOP00000035471; -.
PhosphoSitePlus; Q67ER9; -.
PaxDb; Q67ER9; -.
PRIDE; Q67ER9; -.
Ensembl; ENSRNOT00000037220; ENSRNOP00000035471; ENSRNOG00000028135.
GeneID; 680188; -.
KEGG; rno:680188; -.
UCSC; RGD:1595436; rat.
CTD; 353148; -.
RGD; 1595436; Tas2r39.
eggNOG; ENOG410IVEI; Eukaryota.
eggNOG; ENOG410YMY3; LUCA.
GeneTree; ENSGT00760000119096; -.
HOGENOM; HOG000234595; -.
HOVERGEN; HBG060698; -.
InParanoid; Q67ER9; -.
KO; K08474; -.
OMA; WRISELM; -.
OrthoDB; EOG091G0FKI; -.
PhylomeDB; Q67ER9; -.
TreeFam; TF335891; -.
Reactome; R-RNO-418594; G alpha (i) signalling events.
Reactome; R-RNO-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
PRO; PR:Q67ER9; -.
Proteomes; UP000002494; Chromosome 4.
Bgee; ENSRNOG00000028135; -.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR007960; T2R.
PANTHER; PTHR11394; PTHR11394; 1.
Pfam; PF05296; TAS2R; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
Receptor; Reference proteome; Sensory transduction; Taste; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 319 Taste receptor type 2 member 39.
/FTId=PRO_0000247658.
TOPO_DOM 1 16 Extracellular. {ECO:0000255}.
TRANSMEM 17 37 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 38 56 Cytoplasmic. {ECO:0000255}.
TRANSMEM 57 77 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 78 97 Extracellular. {ECO:0000255}.
TRANSMEM 98 118 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 119 137 Cytoplasmic. {ECO:0000255}.
TRANSMEM 138 158 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 159 187 Extracellular. {ECO:0000255}.
TRANSMEM 188 208 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 209 247 Cytoplasmic. {ECO:0000255}.
TRANSMEM 248 268 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 269 273 Extracellular. {ECO:0000255}.
TRANSMEM 274 294 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 295 319 Cytoplasmic. {ECO:0000255}.
CARBOHYD 82 82 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 167 167 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 176 176 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 319 AA; 36420 MW; F6A2952B95EBA269 CRC64;
MAQPSNYWKQ DLLPLSILIL TLVATECTIG IIASGIITVV NAVSWVQKRA VSITTRILLL
LSVSRIGLQS IILIEMTSSI FNFSSYNSVL YRVSRVSFVF LNYCSLWFAA LLSFFHFVKI
ANFSYPLFFK LKWRISELMP WLLWLSVFIS FSSSMFFCNH KYTVYNNISL SSNICNFTME
LYVAEANVVN VAFLFSFGIL PPLTMFIATA TLLIFSLRRH TLHMRNGDAD SRNPRVEAHK
QAIKETSCFL FLYILYAAVL FLSTSNIADA SLFWSSVLRI SLPVYPAGHS VLLIQSNPGL
KRTWKQLLSQ IHLHLQSRY


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