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Taste receptor type 2 member 40 (T2R40) (mT2R33)

 T2R40_MOUSE             Reviewed;         319 AA.
Q7TQB8;
16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2003, sequence version 1.
30-AUG-2017, entry version 103.
RecName: Full=Taste receptor type 2 member 40;
Short=T2R40;
Short=mT2R33;
Name=Tas2r40; Synonyms=T2r33, Tas2r144, Tas2r44;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000312|EMBL:AAN63043.1};
[1] {ECO:0000312|EMBL:AAN63043.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=C57BL/6J {ECO:0000312|EMBL:AAN63043.1};
PubMed=12734386; DOI=10.1152/physiolgenomics.00060.2003;
Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
"Evolutionary relationships of the Tas2r receptor gene families in
mouse and human.";
Physiol. Genomics 14:73-82(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3] {ECO:0000305}
IDENTIFICATION.
PubMed=12679530; DOI=10.1093/molbev/msg083;
Shi P., Zhang J., Yang H., Zhang Y.-P.;
"Adaptive diversification of bitter taste receptor genes in mammalian
evolution.";
Mol. Biol. Evol. 20:805-814(2003).
-!- FUNCTION: Gustducin-coupled receptor implicated in the perception
of bitter compounds in the oral cavity and the gastrointestinal
tract. Signals through PLCB2 and the calcium-regulated cation
channel TRPM5 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- MISCELLANEOUS: Several bitter taste receptors are expressed in a
single taste receptor cell.
-!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AY145468; AAN63043.1; -; Genomic_DNA.
EMBL; AC155654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BK001095; DAA01234.1; -; Genomic_DNA.
CCDS; CCDS20062.1; -.
RefSeq; NP_001001453.1; NM_001001453.1.
UniGene; Mm.377922; -.
ProteinModelPortal; Q7TQB8; -.
STRING; 10090.ENSMUSP00000067734; -.
PhosphoSitePlus; Q7TQB8; -.
PaxDb; Q7TQB8; -.
PRIDE; Q7TQB8; -.
DNASU; 387515; -.
Ensembl; ENSMUST00000063489; ENSMUSP00000067734; ENSMUSG00000051917.
GeneID; 387515; -.
KEGG; mmu:387515; -.
UCSC; uc009bqn.1; mouse.
CTD; 387515; -.
MGI; MGI:2681312; Tas2r144.
eggNOG; ENOG410IP9I; Eukaryota.
eggNOG; ENOG410YMY3; LUCA.
GeneTree; ENSGT00760000119096; -.
HOGENOM; HOG000234595; -.
HOVERGEN; HBG060698; -.
InParanoid; Q7TQB8; -.
KO; K08474; -.
OMA; QIWMMLE; -.
OrthoDB; EOG091G0FKI; -.
PhylomeDB; Q7TQB8; -.
TreeFam; TF335891; -.
Reactome; R-MMU-418594; G alpha (i) signalling events.
Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
PRO; PR:Q7TQB8; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000051917; -.
CleanEx; MM_TAS2R144; -.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
InterPro; IPR007960; T2R.
PANTHER; PTHR11394; PTHR11394; 1.
Pfam; PF05296; TAS2R; 1.
3: Inferred from homology;
Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
Receptor; Reference proteome; Sensory transduction; Taste; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 319 Taste receptor type 2 member 40.
/FTId=PRO_0000082314.
TOPO_DOM 1 17 Extracellular. {ECO:0000255}.
TRANSMEM 18 38 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 39 66 Cytoplasmic. {ECO:0000255}.
TRANSMEM 67 87 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 88 97 Extracellular. {ECO:0000255}.
TRANSMEM 98 118 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 119 136 Cytoplasmic. {ECO:0000255}.
TRANSMEM 137 157 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 158 189 Extracellular. {ECO:0000255}.
TRANSMEM 190 210 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 211 251 Cytoplasmic. {ECO:0000255}.
TRANSMEM 252 272 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 273 281 Extracellular. {ECO:0000255}.
TRANSMEM 282 302 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 303 319 Cytoplasmic. {ECO:0000255}.
CARBOHYD 169 169 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 178 178 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 319 AA; 36559 MW; 9508F899390BE4AD CRC64;
MAIITTNSDY FAHRYEVIIP FVVSTICSIV GIIGNGFITV IYGTEWVRSK RLPTGENLML
MLSFSRLLLQ IWMMVEITYS LLFPIIYNHN AMYKLFKAIS VFLNYCNLWF AAWLNVFYCL
KIVNLAHPLF LLMKQKIIGL MPRLLSLSVL VSFSLSSFFS KDILNVYVNT SVPIPSSNST
KMKYIFMINV LSLAFLYYMG IFLPLFMFIM AATLLITSLK RHTLHMENST TGSRDSSMEA
HVGAIKSTSH SLILYIINAL ALFISMSNIL GAYSVWNSLC NIIMTAYPAG QSVHLILRNP
GLRRAWRRFQ HHVHLYLKR


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