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Taste receptor type 2 member 42 (T2R42) (T2R55)

 T2R42_MACMU             Reviewed;         314 AA.
Q645T9;
23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
25-OCT-2004, sequence version 1.
05-JUL-2017, entry version 53.
RecName: Full=Taste receptor type 2 member 42;
Short=T2R42;
AltName: Full=T2R55;
Name=TAS2R42; Synonyms=TAS2R55;
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=15496549; DOI=10.1093/molbev/msi027;
Fischer A., Gilad Y., Man O., Paeaebo S.;
"Evolution of bitter taste receptors in humans and apes.";
Mol. Biol. Evol. 22:432-436(2005).
-!- FUNCTION: Receptor that may play a role in the perception of
bitterness and is gustducin-linked. May play a role in sensing the
chemical composition of the gastrointestinal content. The activity
of this receptor may stimulate alpha gustducin, mediate PLC-beta-2
activation and lead to the gating of TRPM5 (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- MISCELLANEOUS: Most taste cells may be activated by a limited
number of bitter compounds; individual taste cells can
discriminate among bitter stimuli.
-!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
{ECO:0000305}.
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EMBL; AY724998; AAU21180.1; -; Genomic_DNA.
STRING; 9544.ENSMMUP00000011680; -.
eggNOG; ENOG410JAUJ; Eukaryota.
eggNOG; ENOG41117W6; LUCA.
HOGENOM; HOG000234595; -.
HOVERGEN; HBG060698; -.
InParanoid; Q645T9; -.
Proteomes; UP000006718; Unplaced.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
InterPro; IPR007960; T2R.
PANTHER; PTHR11394; PTHR11394; 1.
Pfam; PF05296; TAS2R; 1.
3: Inferred from homology;
Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
Receptor; Reference proteome; Sensory transduction; Taste; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 314 Taste receptor type 2 member 42.
/FTId=PRO_0000082345.
TOPO_DOM 1 7 Extracellular. {ECO:0000255}.
TRANSMEM 8 28 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 29 50 Cytoplasmic. {ECO:0000255}.
TRANSMEM 51 71 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 72 101 Extracellular. {ECO:0000255}.
TRANSMEM 102 122 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 123 127 Cytoplasmic. {ECO:0000255}.
TRANSMEM 128 148 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 149 187 Extracellular. {ECO:0000255}.
TRANSMEM 188 208 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 209 238 Cytoplasmic. {ECO:0000255}.
TRANSMEM 239 259 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 260 265 Extracellular. {ECO:0000255}.
TRANSMEM 266 286 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 287 314 Cytoplasmic. {ECO:0000255}.
CARBOHYD 163 163 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 314 AA; 36165 MW; E9B3526B445DD51E CRC64;
MATEMDKIFL TLATVEFIIG MLGNVFIGLV NCSEGIKNQK VFSVDFILTC LAISTIGHLL
VILFDSCVVG LAPHLYATDR VRRPVTMLWH MXNHLTTWLA TCLSIFYFFK IAHFPHSLFL
WLRWRMNRVI AILLTLSLFL LIFDCLVLEM FIDXSLNIID KSNLTLYLDE SKTPYDKLSL
LKILLSLNSF IPFSLCLTSL LFLFLSLVRH TRNLKLSSLG SRDSSTEAHR RAMKMVMSLL
FLFIVHFFSL QVANWTFCIL GNNKYTQFVT LALHAFPSCH SFILILGNSK LRQTAVRLLW
HLRNYTKRPN PLPL


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EIAAB43704 Rat,Rattus norvegicus,T2R1,T2R119,T2R19,Tas2r1,Tas2r119,Tas2r19,Taste receptor type 2 member 1,Taste receptor type 2 member 119,Taste receptor type 2 member 19
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EIAAB41118 Homo sapiens,Human,T2R49,T2R56,TAS2R20,TAS2R49,Taste receptor type 2 member 20,Taste receptor type 2 member 49,Taste receptor type 2 member 56
EIAAB41117 Homo sapiens,Human,T2R48,TAS2R19,TAS2R23,TAS2R48,Taste receptor type 2 member 19,Taste receptor type 2 member 23,Taste receptor type 2 member 48
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EIAAB41122 Homo sapiens,Human,PTC,PTC bitter taste receptor,T2R38,T2R61,TAS2R38,Taste receptor type 2 member 38,Taste receptor type 2 member 61
EIAAB41127 GPR60,G-protein coupled receptor 60,Homo sapiens,Human,T2R40,T2R58,TAS2R40,Taste receptor type 2 member 40,Taste receptor type 2 member 58
EIAAB43727 Mouse,mT2R36,Mus musculus,T2R143,T2r36,T2R43,Tas2r143,Tas2r43,Taste receptor type 2 member 143,Taste receptor type 2 member 43
EIAAB43716 Rat,Rattus norvegicus,T2R134,T2R23,T2R34,Tas2r134,Tas2r23,Tas2r34,Taste receptor type 2 member 134,Taste receptor type 2 member 23
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EIAAB41119 Homo sapiens,Human,T2R30,T2R47,TAS2R30,TAS2R47,Taste receptor type 2 member 30,Taste receptor type 2 member 47
EIAAB43683 Rat,Rattus norvegicus,T2R107,T2R4,Tas2r10,Tas2r107,Tas2r4,Taste receptor type 2 member 107,Taste receptor type 2 member 4
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EIAAB41181 Mouse,Mus musculus,T2R4,T2R8,Tas2r108,Tas2r4,Tas2r8,Taste receptor type 2 member 4,Taste receptor type 2 member 8
EIAAB43719 Rat,Rattus norvegicus,T2R135,T2R28,T2R35,Tas2r135,Tas2r28,Taste receptor type 2 member 135,Taste receptor type 2 member 28
EIAAB41185 Rat,Rattus norvegicus,T2R6,T2R7,Tas2r6,Tas2r7,Taste receptor type 2 member 6,Taste receptor type 2 member 7
EIAAB41110 Rat,Rattus norvegicus,T2R13,T2R7,Tas2r13,Tas2r7,Taste receptor type 2 member 13,Taste receptor type 2 member 7
EIAAB43685 Rat,Rattus norvegicus,T2R109,T2R38,Tas2r109,Tas2r38,Taste receptor type 2 member 109,Taste receptor type 2 member 38
EIAAB43692 Rat,Rattus norvegicus,T2R10,T2R110,Tas2r10,Tas2r110,Taste receptor type 2 member 10,Taste receptor type 2 member 110


 

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