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Taste receptor type 2 member 43 (T2R43)

 T2R43_PANTR             Reviewed;         309 AA.
Q646B4;
23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
25-OCT-2004, sequence version 1.
05-JUL-2017, entry version 59.
RecName: Full=Taste receptor type 2 member 43;
Short=T2R43;
Name=TAS2R43;
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=15496549; DOI=10.1093/molbev/msi027;
Fischer A., Gilad Y., Man O., Paeaebo S.;
"Evolution of bitter taste receptors in humans and apes.";
Mol. Biol. Evol. 22:432-436(2005).
-!- FUNCTION: Gustducin-coupled receptor immplicated in the perception
of bitter compounds in the oral cavity and the gastrointestinal
tract. Signals through PLCB2 and the calcium-regulated cation
channel TRPM5. Activated by the sulfonyl amide sweeteners
saccharin and acesulfame K. In airway epithelial cells, binding of
bitter compounds increases the intracellular calcium ion
concentration and stimulates ciliary beat frequency. May act as
chemosensory receptors in airway epithelial cells to detect and
eliminate potential noxious agents from the airways (By
similarity). {ECO:0007001}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell
projection, cilium membrane {ECO:0007001}. Note=In airway
epithelial cells, localizes to motile cilia. {ECO:0007001}.
-!- MISCELLANEOUS: Most taste cells may be activated by a limited
number of bitter compounds; individual taste cells can
discriminate among bitter stimuli.
-!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
{ECO:0000320}.
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EMBL; AY724889; AAU21105.1; -; Genomic_DNA.
ProteinModelPortal; Q646B4; -.
STRING; 9598.ENSPTRP00000054709; -.
PaxDb; Q646B4; -.
eggNOG; ENOG410J9F7; Eukaryota.
eggNOG; ENOG4111BEG; LUCA.
HOGENOM; HOG000234595; -.
HOVERGEN; HBG060698; -.
InParanoid; Q646B4; -.
Proteomes; UP000002277; Unplaced.
GO; GO:0060170; C:ciliary membrane; RCA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; ISS:GO_Central.
GO; GO:0031514; C:motile cilium; HMP:UniProtKB.
GO; GO:0033038; F:bitter taste receptor activity; ISS:GO_Central.
GO; GO:0004930; F:G-protein coupled receptor activity; RCA:UniProtKB-KW.
GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISS:GO_Central.
InterPro; IPR007960; T2R.
PANTHER; PTHR11394; PTHR11394; 1.
Pfam; PF05296; TAS2R; 1.
3: Inferred from homology;
Cell membrane; Cell projection; Cilium; Complete proteome;
G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
Reference proteome; Sensory transduction; Taste; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 309 Taste receptor type 2 member 43.
/FTId=PRO_0000082305.
TOPO_DOM 1 1 Extracellular. {ECO:0000270}.
TRANSMEM 2 22 Helical; Name=1. {ECO:0000270}.
TOPO_DOM 23 46 Cytoplasmic. {ECO:0000270}.
TRANSMEM 47 67 Helical; Name=2. {ECO:0000270}.
TOPO_DOM 68 86 Extracellular. {ECO:0000270}.
TRANSMEM 87 107 Helical; Name=3. {ECO:0000270}.
TOPO_DOM 108 126 Cytoplasmic. {ECO:0000270}.
TRANSMEM 127 147 Helical; Name=4. {ECO:0000270}.
TOPO_DOM 148 178 Extracellular. {ECO:0000270}.
TRANSMEM 179 199 Helical; Name=5. {ECO:0000270}.
TOPO_DOM 200 229 Cytoplasmic. {ECO:0000270}.
TRANSMEM 230 250 Helical; Name=6. {ECO:0000270}.
TOPO_DOM 251 259 Extracellular. {ECO:0000270}.
TRANSMEM 260 280 Helical; Name=7. {ECO:0000270}.
TOPO_DOM 281 309 Cytoplasmic. {ECO:0000270}.
CARBOHYD 161 161 N-linked (GlcNAc...) asparagine.
{ECO:0000270}.
CARBOHYD 176 176 N-linked (GlcNAc...) asparagine.
{ECO:0000270}.
SEQUENCE 309 AA; 35612 MW; 504332C099242D52 CRC64;
MITFLPIIFS SLVVVTFVIG NFANGFIALV NSIEWFKRQK ISFADQILTA LAVSRVGLLW
VLLLNWYSTV LNPAFNSVEV RTTAYNIWAV INHFSNWLAT SLSIFYLLKI ANFSNFIFLH
LKRRVKSVIL VMLLGPLLFL ACHLFVINMN EIVRTKEFEG NMTWKIKLKS AMYFSNMTVT
MVANLVPFTL TLLSFLLLIC SLCKHLKKMQ LHGKGSQDPS TKVHIKVLQT VISFLLLCAI
YFLSIMISVW SFGSLKNKPV FMFCKAMRFS YPSIHPFILI WGNKKLKQTF LSVFWQMRYW
VKGEKTSSP


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