Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Taste receptor type 2 member 45 (T2R45) (G-protein coupled receptor 59)

 T2R45_HUMAN             Reviewed;         299 AA.
P59539;
11-APR-2003, integrated into UniProtKB/Swiss-Prot.
11-APR-2003, sequence version 1.
10-MAY-2017, entry version 92.
RecName: Full=Taste receptor type 2 member 45;
Short=T2R45;
AltName: Full=G-protein coupled receptor 59;
Name=TAS2R45; Synonyms=GPR59;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=12379855; DOI=10.1038/ng1014;
Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.;
"The human TAS2R16 receptor mediates bitter taste in response to beta-
glucopyranosides.";
Nat. Genet. 32:397-401(2002).
[2]
REVIEW.
PubMed=12139982; DOI=10.1016/S0959-4388(02)00345-8;
Montmayeur J.-P., Matsunami H.;
"Receptors for bitter and sweet taste.";
Curr. Opin. Neurobiol. 12:366-371(2002).
[3]
REVIEW.
PubMed=11696554; DOI=10.1074/jbc.R100054200;
Margolskee R.F.;
"Molecular mechanisms of bitter and sweet taste transduction.";
J. Biol. Chem. 277:1-4(2002).
[4]
REVIEW.
PubMed=12581520; DOI=10.1016/S0092-8674(03)00071-0;
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
Zuker C.S., Ryba N.J.;
"Coding of sweet, bitter, and umami tastes: different receptor cells
sharing similar signaling pathways.";
Cell 112:293-301(2003).
-!- FUNCTION: Receptor that may play a role in the perception of
bitterness and is gustducin-linked. May play a role in sensing the
chemical composition of the gastrointestinal content. The activity
of this receptor may stimulate alpha gustducin, mediate PLC-beta-2
activation and lead to the gating of TRPM5 (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells
of the tongue and exclusively in gustducin-positive cells.
-!- MISCELLANEOUS: Most taste cells may be activated by a limited
number of bitter compounds; individual taste cells can
discriminate among bitter stimuli.
-!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF494226; AAM19317.1; -; Genomic_DNA.
UniGene; Hs.287378; -.
ProteinModelPortal; P59539; -.
iPTMnet; P59539; -.
PhosphoSitePlus; P59539; -.
DMDM; 29839477; -.
PRIDE; P59539; -.
GeneCards; TAS2R45; -.
HGNC; HGNC:18876; TAS2R45.
MIM; 613967; gene.
neXtProt; NX_P59539; -.
PharmGKB; PA38730; -.
HOVERGEN; HBG060698; -.
InParanoid; P59539; -.
PhylomeDB; P59539; -.
Reactome; R-HSA-418594; G alpha (i) signalling events.
Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
PRO; PR:P59539; -.
Proteomes; UP000005640; Unplaced.
CleanEx; HS_TAS2R45; -.
GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
InterPro; IPR007960; T2R.
PANTHER; PTHR11394; PTHR11394; 1.
Pfam; PF05296; TAS2R; 1.
2: Evidence at transcript level;
Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
Receptor; Reference proteome; Sensory transduction; Taste; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 299 Taste receptor type 2 member 45.
/FTId=PRO_0000082315.
TOPO_DOM 1 1 Extracellular. {ECO:0000255}.
TRANSMEM 2 22 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 23 55 Cytoplasmic. {ECO:0000255}.
TRANSMEM 56 76 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 77 98 Extracellular. {ECO:0000255}.
TRANSMEM 99 119 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 120 126 Cytoplasmic. {ECO:0000255}.
TRANSMEM 127 147 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 148 178 Extracellular. {ECO:0000255}.
TRANSMEM 179 199 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 200 229 Cytoplasmic. {ECO:0000255}.
TRANSMEM 230 250 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 251 259 Extracellular. {ECO:0000255}.
TRANSMEM 260 280 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 281 299 Cytoplasmic. {ECO:0000255}.
CARBOHYD 161 161 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 299 AA; 34278 MW; 50E181C3C5FCFC6B CRC64;
MITFLPIIFS ILVVVTFVIG NFANGFIALV NSTEWVKRQK ISFADQIVTA LAVSRVGLLW
VLLLNWYSTV LNPAFCSVEL RTTAYNIWAV TGHFSNWPAT SLSIFYLLKI ANFSNLIFLR
LKRRVKSVIL VVLLGPLLFL ACHLFVVNMN QIVWTKEYEG NMTWKIKLRR AMYLSDTTVT
MLANLVPFTV TLISFLLLVC SLCKHLKKMQ LHGKGSQDPS TKVHIKVLQT VISFFLLRAI
YFVSVIISVW SFKNLENKPV FMFCQAIGFS CSSAHPFILI WGNKKLKQTY LSVLWQMRY


Related products :

Catalog number Product name Quantity
EIAAB41135 GPR59,G-protein coupled receptor 59,Homo sapiens,Human,T2R45,TAS2R45,Taste receptor type 2 member 45
EIAAB41127 GPR60,G-protein coupled receptor 60,Homo sapiens,Human,T2R40,T2R58,TAS2R40,Taste receptor type 2 member 40,Taste receptor type 2 member 58
18-461-10709 Taste receptor type 1 member 2 - G-protein coupled receptor 71; Sweet taste receptor T1R2 Polyclonal 0.05 ml
EIAAB44170 GPR71,G-protein coupled receptor 71,Homo sapiens,Human,Sweet taste receptor T1R2,T1R2,TAS1R2,Taste receptor type 1 member 2,TR2
EIAAB44171 Gpr71,G-protein coupled receptor 71,Mouse,Mus musculus,Sweet taste receptor T1R2,T1r2,Tas1r2,Taste receptor type 1 member 2,Tr2
EIAAB44172 Gpr71,G-protein coupled receptor 71,Rat,Rattus norvegicus,Sweet taste receptor T1R2,T1r2,Tas1r2,Taste receptor type 1 member 2,Tr2
EIAAB43677 Mouse,mT2R45,Mus musculus,T2R104,T2r45,Tas2r104,Taste receptor type 2 member 104
EIAAB43709 Rat,Rattus norvegicus,T2R123,T2R2,T2R23,Tas2r123,Tas2r14,Tas2r2,Tas2r23,Taste receptor type 2 member 123,Taste receptor type 2 member 2,Taste receptor type 2 member 23
EIAAB43704 Rat,Rattus norvegicus,T2R1,T2R119,T2R19,Tas2r1,Tas2r119,Tas2r19,Taste receptor type 2 member 1,Taste receptor type 2 member 119,Taste receptor type 2 member 19
EIAAB41120 Homo sapiens,Human,T2R31,T2R44,T2R53,TAS2R31,TAS2R44,Taste receptor type 2 member 31,Taste receptor type 2 member 44,Taste receptor type 2 member 53
EIAAB43678 Mouse,Mus musculus,T2R105,T2R5,T2R9,Tas2r105,Tas2r5,Tas2r9,Taste receptor type 2 member 105,Taste receptor type 2 member 5,Taste receptor type 2 member 9
EIAAB43674 Mouse,Mus musculus,T2R10,T2R103,Tas2r10,Tas2r103,Taste receptor family B member 2,Taste receptor type 2 member 10,Taste receptor type 2 member 103,TRB2
EIAAB43724 Mouse,mT2r64,mTRB3,mTRB5,Mus musculus,T2R13,T2R140,T2R40,T2r64,T2R8,Tas2r13,Tas2r137,Tas2r140,Tas2r40,Tas2r8,Taste receptor family B member 3,Taste receptor type 2 member 140,Taste receptor type 2 mem
EIAAB41117 Homo sapiens,Human,T2R48,TAS2R19,TAS2R23,TAS2R48,Taste receptor type 2 member 19,Taste receptor type 2 member 23,Taste receptor type 2 member 48
EIAAB41118 Homo sapiens,Human,T2R49,T2R56,TAS2R20,TAS2R49,Taste receptor type 2 member 20,Taste receptor type 2 member 49,Taste receptor type 2 member 56
EIAAB41122 Homo sapiens,Human,PTC,PTC bitter taste receptor,T2R38,T2R61,TAS2R38,Taste receptor type 2 member 38,Taste receptor type 2 member 61
EIAAB44168 Gpr70,G-protein coupled receptor 70,Mouse,Mus musculus,T1r1,Tas1r1,Taste receptor type 1 member 1,Tr1
EIAAB44169 Gpr70,G-protein coupled receptor 70,Rat,Rattus norvegicus,T1r1,Tas1r1,Taste receptor type 1 member 1,Tr1
EIAAB44167 GM148,GPR70,G-protein coupled receptor 70,Homo sapiens,Human,T1R1,TAS1R1,Taste receptor type 1 member 1,TR1
EIAAB43708 Mouse,mT2R55,Mus musculus,STC9-2,T2R123,T2R23,T2r55,Tas2r123,Tas2r23,Taste receptor type 2 member 123,Taste receptor type 2 member 23
EIAAB43718 Mouse,mT2r38,Mus musculus,T2R135,T2R35,T2r38,Tas2r135,Tas2r35,Taste receptor type 2 member 135,Taste receptor type 2 member 35
EIAAB43721 Mouse,mT2r52,Mus musculus,T2R136,T2R36,T2r52,Tas2r136,Tas2r36,Taste receptor type 2 member 136,Taste receptor type 2 member 36
EIAAB43727 Mouse,mT2R36,Mus musculus,T2R143,T2r36,T2R43,Tas2r143,Tas2r43,Taste receptor type 2 member 143,Taste receptor type 2 member 43
EIAAB43716 Rat,Rattus norvegicus,T2R134,T2R23,T2R34,Tas2r134,Tas2r23,Tas2r34,Taste receptor type 2 member 134,Taste receptor type 2 member 23
EIAAB43683 Rat,Rattus norvegicus,T2R107,T2R4,Tas2r10,Tas2r107,Tas2r4,Taste receptor type 2 member 107,Taste receptor type 2 member 4


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur