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Tau-theraphotoxin-Pc1c (Tau-TRTX-Pc1c) (Vanillotoxin-3) (VaTx3)

 TX3_PSACA               Reviewed;          34 AA.
P0C246;
28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
28-NOV-2006, sequence version 1.
22-NOV-2017, entry version 43.
RecName: Full=Tau-theraphotoxin-Pc1c;
Short=Tau-TRTX-Pc1c;
AltName: Full=Vanillotoxin-3 {ECO:0000303|PubMed:17093448};
Short=VaTx3 {ECO:0000303|PubMed:17093448};
Psalmopoeus cambridgei (Trinidad chevron tarantula).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
Araneae; Mygalomorphae; Theraphosidae; Psalmopoeus.
NCBI_TaxID=179874;
[1]
PROTEIN SEQUENCE, SYNTHESIS, FUNCTION, TOXIN TARGET, MASS
SPECTROMETRY, SUBCELLULAR LOCATION, AND AMIDATION AT PHE-34.
TISSUE=Venom;
PubMed=17093448; DOI=10.1038/nature05285;
Siemens J., Zhou S., Piskorowski R., Nikai T., Lumpkin E.A.,
Basbaum A.I., King D., Julius D.;
"Spider toxins activate the capsaicin receptor to produce inflammatory
pain.";
Nature 444:208-212(2006).
-!- FUNCTION: Selectively activates mammalian TRPV1, or capsaicin
receptor, a non-selective cation channel expressed by sensory
neurons of the pain pathway. Is more potent than VaTx1 and VaTx2.
Interacts with distinct regions of the channel than capsaicin,
since it only acts on the extracellular face of the channel, and
capsaicin binds to the cytosolic side. Also activates avian TRPV1,
which is insensitive to capsaicin. In mice, elicits pain-related
behaviors, such as licking and flinching of the affected limb. The
paw of toxin-injected mice shows substantial edema.
{ECO:0000269|PubMed:17093448}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17093448}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
{ECO:0000305|PubMed:17093448}.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin.
{ECO:0000250|UniProtKB:P60992}.
-!- MASS SPECTROMETRY: Mass=4179.0; Method=Unknown; Range=1-34;
Evidence={ECO:0000269|PubMed:17093448};
-!- MISCELLANEOUS: This toxin does not affect TRPV2, TRPV3, TRPV4,
TRPA1, TRPM8, Kv1.2/KCNA2, Kv2.1/KCNB1 and Kv4.2/KCND2 potassium
channels. {ECO:0000269|PubMed:17093448}.
-!- SIMILARITY: Belongs to the huwentoxin-1 family. Vatx subfamily.
{ECO:0000305}.
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ProteinModelPortal; P0C246; -.
SMR; P0C246; -.
TCDB; 8.B.5.3.2; the na(+)/k(+)/ca(2+) channel targeting tarantula huwentoxin (tht) family.
ArachnoServer; AS000276; tau-theraphotoxin-Pc1c.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
InterPro; IPR011696; Huwentoxin-1.
InterPro; IPR013140; Huwentoxin_CS1.
Pfam; PF07740; Toxin_12; 1.
PROSITE; PS60021; HWTX_1; 1.
1: Evidence at protein level;
Amidation; Direct protein sequencing; Disulfide bond;
Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Toxin.
CHAIN 1 34 Tau-theraphotoxin-Pc1c.
{ECO:0000269|PubMed:17093448}.
/FTId=PRO_0000262453.
MOD_RES 34 34 Phenylalanine amide.
{ECO:0000269|PubMed:17093448}.
DISULFID 2 16 {ECO:0000250|UniProtKB:P60992}.
DISULFID 9 21 {ECO:0000250|UniProtKB:P60992}.
DISULFID 15 28 {ECO:0000250|UniProtKB:P60992}.
SEQUENCE 34 AA; 4190 MW; D1220D7C1D716912 CRC64;
ECRWYLGGCK EDSECCEHLQ CHSYWEWCLW DGSF


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