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Tegument protein UL47 homolog

 TEG5_VZVD               Reviewed;         819 AA.
P09263;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
23-MAY-2018, entry version 66.
RecName: Full=Tegument protein UL47 homolog;
ORFNames=ORF11;
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Alphaherpesvirinae; Varicellovirus.
NCBI_TaxID=10338;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=3018124;
Davison A.J., Scott J.E.;
"The complete DNA sequence of varicella-zoster virus.";
J. Gen. Virol. 67:1759-1816(1986).
[2]
SUBCELLULAR LOCATION.
PubMed=17005680; DOI=10.1128/JVI.01322-06;
Verhagen J., Donnelly M., Elliott G.;
"Characterization of a novel transferable CRM-1-independent nuclear
export signal in a herpesvirus tegument protein that shuttles between
the nucleus and cytoplasm.";
J. Virol. 80:10021-10035(2006).
[3]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=21276599; DOI=10.1016/j.virol.2010.12.055;
Che X., Oliver S.L., Sommer M.H., Rajamani J., Reichelt M.,
Arvin A.M.;
"Identification and functional characterization of the Varicella
zoster virus ORF11 gene product.";
Virology 412:156-166(2011).
[4]
INTERACTION WITH ORF9.
PubMed=23427162; DOI=10.1128/JVI.00102-13;
Che X., Oliver S.L., Reichelt M., Sommer M.H., Haas J., Rovis T.L.,
Arvin A.M.;
"ORF11 protein interacts with the ORF9 essential tegument protein in
varicella-zoster virus infection.";
J. Virol. 87:5106-5117(2013).
-!- FUNCTION: Tegument protein that can bind to various RNA
transcripts. Plays a role in the attenuation of selective viral
and cellular mRNA degradation by modulating the activity of host
shutoff RNase ORF17/VHS. Plays also a role in the primary
envelopement of virions in the perinuclear space, probably by
interacting with two nuclear egress proteins ORF24 and ORF27.
{ECO:0000250|UniProtKB:P10231, ECO:0000269|PubMed:21276599}.
-!- SUBUNIT: Interacts with US3 kinase. Interacts with ORF24 and
ORF27; these interactions seem important for efficient virion
nuclear egress. Interacts with ORF17/VHS. Interacts with ORF9.
{ECO:0000250|UniProtKB:P10231, ECO:0000269|PubMed:23427162}.
-!- SUBCELLULAR LOCATION: Virion tegument
{ECO:0000269|PubMed:21276599}. Host nucleus
{ECO:0000269|PubMed:21276599}. Host cytoplasm
{ECO:0000269|PubMed:21276599}. Note=Major tegument protein of the
virion. Undergoes nucleocytoplasmic shuttling during infection.
Localizes to the major sites of transcription in the infected cell
nucleus. {ECO:0000250|UniProtKB:P10231}.
-!- DOMAIN: The nuclear export signal is CRM1-dependent.
{ECO:0000250|UniProtKB:P10231}.
-!- PTM: Phosphorylated by US3. This phosphorylation is required for
proper nuclear localization. {ECO:0000250|UniProtKB:P10231}.
-!- MISCELLANEOUS: Expressed in late in the infection. {ECO:0000250}.
-!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL47 family.
{ECO:0000305}.
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EMBL; X04370; CAA27894.1; -; Genomic_DNA.
PIR; B27342; TNBE11.
PRIDE; P09263; -.
OrthoDB; VOG0900002D; -.
Proteomes; UP000002602; Genome.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR005029; Herpes_UL47.
Pfam; PF03362; Herpes_UL47; 1.
1: Evidence at protein level;
Complete proteome; Host cytoplasm; Host nucleus; Late protein;
Reference proteome; Repeat; RNA-binding; Transcription;
Transcription regulation; Virion; Virion tegument.
CHAIN 1 819 Tegument protein UL47 homolog.
/FTId=PRO_0000116080.
REPEAT 117 132 1-1.
REPEAT 133 148 1-2.
REPEAT 149 164 1-3.
REPEAT 165 190 1-4.
REPEAT 191 206 1-5.
REPEAT 207 218 1-6; truncated.
REGION 117 218 6 X 16 AA approximate tandem repeats.
MOTIF 11 31 Nuclear localization signal.
{ECO:0000255}.
MOTIF 785 807 Nuclear export signal. {ECO:0000250}.
COMPBIAS 105 217 Glu-rich.
COMPBIAS 690 695 Poly-Leu.
SEQUENCE 819 AA; 91830 MW; 1814DA0D5493B8C8 CRC64;
MQSGHYNRRQ SRRQRISSNT TDSPRHTHGT RYRSTNWYTH PPQILSNSET LVAVQELLNS
EMDQDSSSDA SDDFPGYALH HSTYNGSEQN TSTSRHENRI FKLTEREANE EININTDAID
DEGEAEEGEA EEDAIDDEGE AEEGEAEEDA IDDEGEAEEG EAEEDAIDDE GEAEEGEAEE
GEAEEGEAEE DAIDDEGEAE EDAAEEDAID DEGEAEEDYF SVSQVCSRDA DEVYFTLDPE
ISYSTDLRIA KVMEPAVSKE LNVSKRCVEP VTLTGSMLAH NGFDESWFAM RECTRREYIT
VQGLYDPIHL RYQFDTSRMT PPQILRTIPA LPNMTLGELL LIFPIEFMAQ PISIERILVE
DVFLDRRASS KTHKYGPRWN SVYALPYNAG KMYVQHIPGF YDVSLRAVGQ GTAIWHHMIL
STAACAISNR ISHGDGLGFL LDAAIRISAN CIFLGRNDNF GVGDPCWLED HLAGLPREAV
PDVLQVTQLV LPNRGPTVAI MRGFFGALAY WPELRIAISE PSTSLVRYAT GHMELAEWFL
FSRTHSLKPQ FTPTEREMLA SFFTLYVTLG GGMLNWICRA TAMYLAAPYH SRSAYIAVCE
SLPYYYIPVN SDLLCDLEVL LLGEVDLPTV CESYATIAHE LTGYEAVRTA ATNFMIEFAD
CYKESETDLM VSAYLGAVLL LQRVLGHANL LLLLLSGAAL YGGCSIYIPR GILDAYNTLM
LAASPLYAHQ TLTSFWKDRD DAMQTLGIRP TTDVLPKEQD RIVQASPIEM NFRFVGLETI
YPREQPIPSV DLAENLMQYR NEILGLDWKS VAMHLLRKY


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