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Telomere-binding protein cav (Anonymous fast evolving 1G5) (HP1/ORC-associated protein) (HOAP p55) (Protein caravaggio)

 CAV_DROME               Reviewed;         345 AA.
Q95RV2; B6UW60; B6UW70; B6UW72; B6UW76; B6UW79; B6UW88; O16046;
O18360; O18361; O18362; O18667; O18675; Q7KLS0; Q7KQE4; Q7KQE8;
Q86BN7; Q9TVU4; Q9U4P0; Q9VCB3;
07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
25-OCT-2017, entry version 110.
RecName: Full=Telomere-binding protein cav {ECO:0000303|PubMed:12510197};
AltName: Full=Anonymous fast evolving 1G5 {ECO:0000303|PubMed:12510197};
AltName: Full=HP1/ORC-associated protein {ECO:0000303|PubMed:11408576};
Short=HOAP p55 {ECO:0000303|PubMed:11408576};
AltName: Full=Protein caravaggio {ECO:0000303|PubMed:12510197};
Name=cav {ECO:0000303|PubMed:12510197};
Synonyms=anon fe 1G5 {ECO:0000303|PubMed:12510197},
anon1G5 {ECO:0000303|PubMed:10581279},
Hoap {ECO:0000303|PubMed:11408576}, IG5 {ECO:0000303|PubMed:9275195};
ORFNames=CG6219;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1] {ECO:0000305, ECO:0000312|EMBL:AAB81482.1}
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), NUCLEOTIDE SEQUENCE [GENOMIC
DNA] OF 28-293, AND VARIANTS THR-144; CYS-149; THR-154; ILE-198;
TYR-236 AND PHE-273.
STRAIN=Australia 2 {ECO:0000312|EMBL:AAB62252.1},
Australia 4 {ECO:0000312|EMBL:AAB62253.1},
Australia 5 {ECO:0000312|EMBL:AAB62254.1},
Canada {ECO:0000312|EMBL:AAB62255.1},
Canton-S {ECO:0000312|EMBL:AAB81482.1},
Cyprus {ECO:0000312|EMBL:AAB62256.1},
Irak {ECO:0000312|EMBL:AAB62257.1},
Italy {ECO:0000312|EMBL:AAB62258.1},
Japan {ECO:0000312|EMBL:AAB62259.1},
Peru {ECO:0000312|EMBL:AAB62260.1},
USA 1 {ECO:0000312|EMBL:AAB62265.1},
USA 2 {ECO:0000312|EMBL:AAB62266.1},
USA 3 {ECO:0000312|EMBL:AAB62267.1}, and
USSR 1 {ECO:0000312|EMBL:AAB62268.1};
PubMed=9275195; DOI=10.1073/pnas.94.18.9746;
Schmid K.J., Tautz D.;
"A screen for fast evolving genes from Drosophila.";
Proc. Natl. Acad. Sci. U.S.A. 94:9746-9750(1997).
[2] {ECO:0000312|EMBL:AAN13988.2}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3] {ECO:0000305, ECO:0000312|EMBL:AAN13988.2}
GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4] {ECO:0000305, ECO:0000312|EMBL:AAL28662.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
STRAIN=Berkeley {ECO:0000312|EMBL:AAL28662.1};
TISSUE=Embryo {ECO:0000269|PubMed:12537569};
PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
[5] {ECO:0000305, ECO:0000312|EMBL:ACI96383.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-149, AND VARIANT ASN-27.
STRAIN=MW11 {ECO:0000312|EMBL:ACI96383.1},
MW38 {ECO:0000312|EMBL:ACI96402.1},
MW56 {ECO:0000312|EMBL:ACI96406.1}, MW6 {ECO:0000312|EMBL:ACI96407.1},
MW63 {ECO:0000312|EMBL:ACI96408.1}, MW9 {ECO:0000312|EMBL:ACI96411.1},
NC301 {ECO:0000312|EMBL:ACI96388.1},
NC303 {ECO:0000312|EMBL:ACI96389.1},
NC304 {ECO:0000312|EMBL:ACI96390.1},
NC306 {ECO:0000312|EMBL:ACI96391.1},
NC319 {ECO:0000312|EMBL:ACI96392.1},
NC322 {ECO:0000312|EMBL:ACI96393.1},
NC336 {ECO:0000312|EMBL:ACI96394.1},
NC350 {ECO:0000312|EMBL:ACI96395.1},
NC357 {ECO:0000312|EMBL:ACI96396.1},
NC358 {ECO:0000312|EMBL:ACI96397.1},
NC359 {ECO:0000312|EMBL:ACI96398.1},
NC361 {ECO:0000312|EMBL:ACI96399.1},
NC362 {ECO:0000312|EMBL:ACI96400.1},
NC375 {ECO:0000312|EMBL:ACI96401.1},
NC390 {ECO:0000312|EMBL:ACI96403.1},
NC397 {ECO:0000312|EMBL:ACI96404.1},
NC399 {ECO:0000312|EMBL:ACI96405.1},
NC732 {ECO:0000312|EMBL:ACI96409.1}, and
NC774 {ECO:0000312|EMBL:ACI96410.1};
PubMed=18984573; DOI=10.1534/genetics.108.093807;
Anderson J.A., Gilliland W.D., Langley C.H.;
"Molecular population genetics and evolution of Drosophila meiosis
genes.";
Genetics 181:177-185(2009).
[6] {ECO:0000305, ECO:0000312|EMBL:AAD45790.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-293, AND VARIANT THR-154.
STRAIN=Kenya 38 {ECO:0000312|EMBL:AAD45788.1},
Kenya 43 {ECO:0000312|EMBL:AAD45789.1}, and
Oregon-R {ECO:0000312|EMBL:AAD45790.1};
PubMed=10581279;
Schmid K.J., Nigro L., Aquadro C.F., Tautz D.;
"Large number of replacement polymorphisms in rapidly evolving genes
of Drosophila. Implications for genome-wide surveys of DNA
polymorphism.";
Genetics 153:1717-1729(1999).
[7] {ECO:0000305}
FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
PubMed=11408576; DOI=10.1091/mbc.12.6.1671;
Shareef M.M., King C., Damaj M., Badagu R., Huang D.W., Kellum R.;
"Drosophila heterochromatin protein 1 (HP1)/origin recognition complex
(ORC) protein is associated with HP1 and ORC and functions in
heterochromatin-induced silencing.";
Mol. Biol. Cell 12:1671-1685(2001).
[8] {ECO:0000305}
FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SU(VAR)205,
SU(VAR)205-BINDING MOTIF, AND MUTAGENESIS OF PRO-298.
PubMed=12826664; DOI=10.1074/jbc.M305262200;
Badugu R., Shareef M.M., Kellum R.;
"Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition
complex-associated protein (HOAP) repeat motif in HP1/HOAP
interactions and chromocenter associations.";
J. Biol. Chem. 278:34491-34498(2003).
[9] {ECO:0000305}
FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
PubMed=12510197; DOI=10.1038/ncb902;
Cenci G., Siriaco G., Raffa G.D., Kellum R., Gatti M.;
"The Drosophila HOAP protein is required for telomere capping.";
Nat. Cell Biol. 5:82-84(2003).
[10] {ECO:0000305}
FUNCTION, AND INTERACTION WITH HP6.
PubMed=19190990; DOI=10.1007/s10577-008-9002-1;
Joppich C., Scholz S., Korge G., Schwendemann A.;
"Umbrea, a chromo shadow domain protein in Drosophila melanogaster
heterochromatin, interacts with Hip, HP1 and HOAP.";
Chromosome Res. 17:19-36(2009).
[11] {ECO:0000305}
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH MOI.
PubMed=19181850; DOI=10.1073/pnas.0812702106;
Raffa G.D., Siriaco G., Cugusi S., Ciapponi L., Cenci G., Wojcik E.,
Gatti M.;
"The Drosophila modigliani (moi) gene encodes a HOAP-interacting
protein required for telomere protection.";
Proc. Natl. Acad. Sci. U.S.A. 106:2271-2276(2009).
-!- FUNCTION: Binds to chromosome ends in a sequence-dependent manner
and is required for telomere capping.
{ECO:0000269|PubMed:11408576, ECO:0000269|PubMed:12510197,
ECO:0000269|PubMed:12826664, ECO:0000269|PubMed:19181850,
ECO:0000269|PubMed:19190990}.
-!- SUBUNIT: Interacts (via C-terminus) with Su(var)205 dimer (via
hinge and chromoshadow domain) and with moi to form the terminin
telomere-capping complex. Interacts with HP6, which is also part
of the terminin complex. {ECO:0000269|PubMed:12826664,
ECO:0000269|PubMed:19181850, ECO:0000269|PubMed:19190990}.
-!- INTERACTION:
Q7JWP6:HipHop; NbExp=7; IntAct=EBI-104820, EBI-103483;
B7Z0L8:moi; NbExp=2; IntAct=EBI-104820, EBI-15755079;
P05205:Su(var)205; NbExp=5; IntAct=EBI-104820, EBI-155532;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11408576,
ECO:0000269|PubMed:12510197, ECO:0000269|PubMed:12826664,
ECO:0000269|PubMed:19181850}. Chromosome, telomere
{ECO:0000269|PubMed:11408576, ECO:0000269|PubMed:12510197,
ECO:0000269|PubMed:12826664, ECO:0000269|PubMed:19181850}.
Note=Enriched at interphase, polytene and mitotic chromosome
telomeres. Localized predominantly at telomeres and diffusely
throughout regions of pericentric heterochromatin.
{ECO:0000269|PubMed:11408576, ECO:0000269|PubMed:12510197,
ECO:0000269|PubMed:12826664, ECO:0000269|PubMed:19181850}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=A {ECO:0000269|PubMed:10731132};
IsoId=Q95RV2-1; Sequence=Displayed;
Note=No experimental confirmation available. {ECO:0000305};
Name=B {ECO:0000269|PubMed:9275195}; Synonyms=D
{ECO:0000269|PubMed:10731132};
IsoId=Q95RV2-2; Sequence=VSP_053126;
Name=E {ECO:0000269|PubMed:10731132};
IsoId=Q95RV2-3; Sequence=VSP_053127;
Note=No experimental confirmation available. {ECO:0000305};
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
{ECO:0000269|PubMed:11408576}.
-!- DISRUPTION PHENOTYPE: Death at the larval/pupal boundary due to
extensive telomere-telomere fusions in larval brain cells.
{ECO:0000269|PubMed:12510197}.
-!- MISCELLANEOUS: Multiple telomeric associations (TAs) in the same
metaphase spread often result in multicentric linear chromosomes
that resemble little 'trains' of chromosomes, hence the name
'caravaggio', an Italian train. {ECO:0000269|PubMed:12510197}.
-!- SEQUENCE CAUTION:
Sequence=AAB62252.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAB62253.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAB62254.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAB62255.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAB62256.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAB62257.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAB62258.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAB62259.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAB62260.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAB62265.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAB62266.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAB62267.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAB62268.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AF005851; AAB81482.1; -; mRNA.
EMBL; AF005865; AAB62252.1; ALT_INIT; Genomic_DNA.
EMBL; AF005866; AAB62253.1; ALT_INIT; Genomic_DNA.
EMBL; AF005867; AAB62254.1; ALT_INIT; Genomic_DNA.
EMBL; AF005868; AAB62255.1; ALT_INIT; Genomic_DNA.
EMBL; AF005869; AAB62256.1; ALT_INIT; Genomic_DNA.
EMBL; AF005870; AAB62257.1; ALT_INIT; Genomic_DNA.
EMBL; AF005871; AAB62258.1; ALT_INIT; Genomic_DNA.
EMBL; AF005872; AAB62259.1; ALT_INIT; Genomic_DNA.
EMBL; AF005873; AAB62260.1; ALT_INIT; Genomic_DNA.
EMBL; AF005878; AAB62265.1; ALT_INIT; Genomic_DNA.
EMBL; AF005879; AAB62266.1; ALT_INIT; Genomic_DNA.
EMBL; AF005880; AAB62267.1; ALT_INIT; Genomic_DNA.
EMBL; AF005881; AAB62268.1; ALT_INIT; Genomic_DNA.
EMBL; AE014297; AAF56260.1; -; Genomic_DNA.
EMBL; AE014297; AAN13988.2; -; Genomic_DNA.
EMBL; AE014297; AAN13989.1; -; Genomic_DNA.
EMBL; AE014297; AAN13990.2; -; Genomic_DNA.
EMBL; AY061114; AAL28662.1; -; mRNA.
EMBL; FJ218758; ACI96383.1; -; Genomic_DNA.
EMBL; FJ218763; ACI96388.1; -; Genomic_DNA.
EMBL; FJ218764; ACI96389.1; -; Genomic_DNA.
EMBL; FJ218765; ACI96390.1; -; Genomic_DNA.
EMBL; FJ218766; ACI96391.1; -; Genomic_DNA.
EMBL; FJ218767; ACI96392.1; -; Genomic_DNA.
EMBL; FJ218768; ACI96393.1; -; Genomic_DNA.
EMBL; FJ218769; ACI96394.1; -; Genomic_DNA.
EMBL; FJ218770; ACI96395.1; -; Genomic_DNA.
EMBL; FJ218771; ACI96396.1; -; Genomic_DNA.
EMBL; FJ218772; ACI96397.1; -; Genomic_DNA.
EMBL; FJ218773; ACI96398.1; -; Genomic_DNA.
EMBL; FJ218774; ACI96399.1; -; Genomic_DNA.
EMBL; FJ218775; ACI96400.1; -; Genomic_DNA.
EMBL; FJ218776; ACI96401.1; -; Genomic_DNA.
EMBL; FJ218777; ACI96402.1; -; Genomic_DNA.
EMBL; FJ218778; ACI96403.1; -; Genomic_DNA.
EMBL; FJ218779; ACI96404.1; -; Genomic_DNA.
EMBL; FJ218780; ACI96405.1; -; Genomic_DNA.
EMBL; FJ218781; ACI96406.1; -; Genomic_DNA.
EMBL; FJ218782; ACI96407.1; -; Genomic_DNA.
EMBL; FJ218783; ACI96408.1; -; Genomic_DNA.
EMBL; FJ218784; ACI96409.1; -; Genomic_DNA.
EMBL; FJ218785; ACI96410.1; -; Genomic_DNA.
EMBL; FJ218786; ACI96411.1; -; Genomic_DNA.
EMBL; AF161784; AAD45788.1; -; Genomic_DNA.
EMBL; AF161785; AAD45789.1; -; Genomic_DNA.
EMBL; AF161786; AAD45790.1; -; Genomic_DNA.
RefSeq; NP_524477.3; NM_079753.4. [Q95RV2-1]
RefSeq; NP_732969.1; NM_170133.2. [Q95RV2-2]
RefSeq; NP_732970.1; NM_170134.2. [Q95RV2-2]
RefSeq; NP_732971.2; NM_170135.2. [Q95RV2-3]
UniGene; Dm.20244; -.
BioGrid; 67812; 16.
DIP; DIP-48712N; -.
IntAct; Q95RV2; 5.
MINT; MINT-749059; -.
STRING; 7227.FBpp0083943; -.
PaxDb; Q95RV2; -.
PRIDE; Q95RV2; -.
EnsemblMetazoa; FBtr0084556; FBpp0083941; FBgn0026257. [Q95RV2-3]
EnsemblMetazoa; FBtr0084557; FBpp0083942; FBgn0026257. [Q95RV2-2]
EnsemblMetazoa; FBtr0084558; FBpp0083943; FBgn0026257. [Q95RV2-1]
EnsemblMetazoa; FBtr0084559; FBpp0083944; FBgn0026257. [Q95RV2-2]
GeneID; 42881; -.
KEGG; dme:Dmel_CG6219; -.
UCSC; CG6219-RA; d. melanogaster. [Q95RV2-1]
UCSC; CG6219-RB; d. melanogaster.
UCSC; CG6219-RE; d. melanogaster.
CTD; 42881; -.
FlyBase; FBgn0026257; cav.
eggNOG; ENOG410KBH0; Eukaryota.
eggNOG; ENOG4110N9A; LUCA.
InParanoid; Q95RV2; -.
OMA; RCDQINS; -.
OrthoDB; EOG091G0A95; -.
PhylomeDB; Q95RV2; -.
GenomeRNAi; 42881; -.
PRO; PR:Q95RV2; -.
Proteomes; UP000000803; Chromosome 3R.
Bgee; FBgn0026257; -.
ExpressionAtlas; Q95RV2; differential.
Genevisible; Q95RV2; DM.
GO; GO:0000775; C:chromosome, centromeric region; IDA:FlyBase.
GO; GO:0000781; C:chromosome, telomeric region; IDA:FlyBase.
GO; GO:0000784; C:nuclear chromosome, telomeric region; IDA:FlyBase.
GO; GO:0005634; C:nucleus; IDA:FlyBase.
GO; GO:0000782; C:telomere cap complex; IDA:UniProtKB.
GO; GO:0042162; F:telomeric DNA binding; IMP:UniProtKB.
GO; GO:0016233; P:telomere capping; IMP:UniProtKB.
GO; GO:0000723; P:telomere maintenance; IMP:FlyBase.
1: Evidence at protein level;
Alternative splicing; Chromosome; Complete proteome; DNA-binding;
Nucleus; Polymorphism; Reference proteome; Repeat; Telomere.
CHAIN 1 345 Telomere-binding protein cav.
/FTId=PRO_0000379489.
REGION 115 337 Required for binding to Su(var)205.
{ECO:0000269|PubMed:12826664}.
MOTIF 231 237 Su(var)205-binding Pro-containing repeat
1. {ECO:0000255,
ECO:0000269|PubMed:12826664}.
MOTIF 298 304 Su(var)205-binding Pro-containing repeat
2. {ECO:0000255,
ECO:0000269|PubMed:12826664}.
VAR_SEQ 1 8 Missing (in isoform B).
{ECO:0000303|PubMed:9275195}.
/FTId=VSP_053126.
VAR_SEQ 2 6 LLLLC -> VKE (in isoform E).
{ECO:0000303|PubMed:10731132}.
/FTId=VSP_053127.
VARIANT 27 27 K -> N (in strain: NC350 and NC358).
{ECO:0000269|PubMed:18984573}.
VARIANT 144 144 S -> T (in strain: Canton-S).
{ECO:0000269|PubMed:9275195}.
VARIANT 149 149 W -> C (in strain: Canton-S).
{ECO:0000269|PubMed:9275195}.
VARIANT 154 154 S -> T (in strain: Australia 2, Kenya 38,
Kenya 43, Peru and USA 3).
{ECO:0000269|PubMed:10581279,
ECO:0000269|PubMed:9275195}.
VARIANT 198 198 M -> I (in strain: Australia 5).
{ECO:0000269|PubMed:9275195}.
VARIANT 236 236 N -> Y (in strain: Japan).
{ECO:0000269|PubMed:9275195}.
VARIANT 273 273 Y -> F (in strain: Australia 5 and USA
1). {ECO:0000269|PubMed:9275195}.
MUTAGEN 298 298 P->E: Prevents binding to HP1 hinge
domain but no effect on binding to HP1
chromoshadow domain.
{ECO:0000269|PubMed:12826664}.
SEQUENCE 345 AA; 39408 MW; FB325B88570FCF0E CRC64;
MLLLLCVNMS GTQMSAFLRK YLADEDKKIR AQFKESDPNN KLILWMHEKT RITEEDLARP
YTEDEVKELC LRTKVKVDMT AWNCLWEAKK RFEAKGRFVN KSERFINRMY MKAVRRKMVQ
PYPEEFVAQR REIVAAETKK QNISRLDRWQ KKKSQNLSAP ESSPDAHASS NDAVQSHEDQ
ANTNLSSLSQ MNFQVEAMAP PGVSSSDLSG IGDDEDEQQQ SGFQDENINR PETEINENSV
RCDPINLGRM RTGCINSQAN NSFRNTESDP DYYMFGTQLS TLVRPTSTQE PDDQVNCPET
EMNESWVRCD QINSESLSIG PSIDSEGTIT FQNTESEPID VTSIA


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