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Testis cDNA, clone: QtsA-18492, similar to human CD36 antigen (collagen type I receptor, thrombospondinreceptor) (CD36)

 Q4R6B4_MACFA            Unreviewed;       472 AA.
Q4R6B4;
19-JUL-2005, integrated into UniProtKB/TrEMBL.
19-JUL-2005, sequence version 1.
28-MAR-2018, entry version 42.
SubName: Full=CD36 molecule {ECO:0000313|Ensembl:ENSMFAP00000025488};
SubName: Full=Testis cDNA, clone: QtsA-18492, similar to human CD36 antigen (collagen type I receptor, thrombospondinreceptor) (CD36) {ECO:0000313|EMBL:BAE01361.1};
Name=CD36 {ECO:0000313|Ensembl:ENSMFAP00000025488};
ORFNames=EGM_12817 {ECO:0000313|EMBL:EHH52385.1};
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541 {ECO:0000313|EMBL:BAE01361.1};
[1] {ECO:0000313|EMBL:BAE01361.1}
NUCLEOTIDE SEQUENCE.
PubMed=15944441; DOI=10.1093/molbev/msi187;
Osada N., Hirata M., Tanuma R., Kusuda J., Hida M., Suzuki Y.,
Sugano S., Gojobori T., Shen C.K., Wu C.I., Hashimoto K.;
"Substitution rate and structural divergence of 5'UTR evolution:
comparative analysis between human and cynomolgus monkey cDNAs.";
Mol. Biol. Evol. 22:1976-1982(2005).
[2] {ECO:0000313|EMBL:BAE01361.1}
NUCLEOTIDE SEQUENCE.
International consortium for macaque cDNA sequencing and analysis;
"DNA sequences of macaque genes expressed in brain or testis and its
evolutionary implications.";
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:EHH52385.1, ECO:0000313|Proteomes:UP000009130}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CE-4 {ECO:0000313|EMBL:EHH52385.1};
PubMed=22002653; DOI=10.1038/nbt.1992;
Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
Wang X., Wang J.;
"Genome sequencing and comparison of two nonhuman primate animal
models, the cynomolgus and Chinese rhesus macaques.";
Nat. Biotechnol. 29:1019-1023(2011).
[4] {ECO:0000313|Ensembl:ENSMFAP00000025488}
NUCLEOTIDE SEQUENCE.
Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|Ensembl:ENSMFAP00000025488}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2018) to UniProtKB.
-!- SIMILARITY: Belongs to the CD36 family.
{ECO:0000256|SAAS:SAAS00579224}.
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EMBL; AQIA01047502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AQIA01047503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AB169273; BAE01361.1; -; mRNA.
EMBL; CM001278; EHH52385.1; -; Genomic_DNA.
RefSeq; XP_005550429.1; XM_005550372.2.
RefSeq; XP_005550430.1; XM_005550373.2.
RefSeq; XP_005550431.1; XM_005550374.2.
RefSeq; XP_005550433.1; XM_005550376.2.
RefSeq; XP_005550434.1; XM_005550377.2.
RefSeq; XP_005550435.1; XM_005550378.2.
RefSeq; XP_015303331.1; XM_015447845.1.
RefSeq; XP_015303333.1; XM_015447847.1.
RefSeq; XP_015303334.1; XM_015447848.1.
UniGene; Mfa.8195; -.
Ensembl; ENSMFAT00000033638; ENSMFAP00000025488; ENSMFAG00000044200.
GeneID; 101926577; -.
KEGG; mcf:101926577; -.
CTD; 948; -.
GeneTree; ENSGT00530000062927; -.
HOVERGEN; HBG002754; -.
KO; K06259; -.
Proteomes; UP000009130; Chromosome 3.
GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0043235; C:receptor complex; IEA:Ensembl.
GO; GO:0008035; F:high-density lipoprotein particle binding; IEA:Ensembl.
GO; GO:0008289; F:lipid binding; IEA:Ensembl.
GO; GO:0070892; F:lipoteichoic acid receptor activity; IEA:Ensembl.
GO; GO:0030169; F:low-density lipoprotein particle binding; IEA:Ensembl.
GO; GO:0005041; F:low-density lipoprotein receptor activity; IEA:Ensembl.
GO; GO:0035325; F:Toll-like receptor binding; IEA:Ensembl.
GO; GO:1990000; P:amyloid fibril formation; IEA:Ensembl.
GO; GO:0043277; P:apoptotic cell clearance; IEA:Ensembl.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl.
GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl.
GO; GO:0071726; P:cellular response to diacyl bacterial lipopeptide; IEA:Ensembl.
GO; GO:0071447; P:cellular response to hydroperoxide; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0071223; P:cellular response to lipoteichoic acid; IEA:Ensembl.
GO; GO:0140052; P:cellular response to oxidised low-density lipoprotein particle stimulus; IEA:Ensembl.
GO; GO:0019934; P:cGMP-mediated signaling; IEA:Ensembl.
GO; GO:0070508; P:cholesterol import; IEA:Ensembl.
GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0050702; P:interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:0030299; P:intestinal cholesterol absorption; IEA:Ensembl.
GO; GO:0019915; P:lipid storage; IEA:Ensembl.
GO; GO:0042953; P:lipoprotein transport; IEA:Ensembl.
GO; GO:0044539; P:long-chain fatty acid import; IEA:Ensembl.
GO; GO:0034383; P:low-density lipoprotein particle clearance; IEA:Ensembl.
GO; GO:0055096; P:low-density lipoprotein particle mediated signaling; IEA:Ensembl.
GO; GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0042992; P:negative regulation of transcription factor import into nucleus; IEA:Ensembl.
GO; GO:0007263; P:nitric oxide mediated signal transduction; IEA:Ensembl.
GO; GO:0006910; P:phagocytosis, recognition; IEA:Ensembl.
GO; GO:0030194; P:positive regulation of blood coagulation; IEA:Ensembl.
GO; GO:2000334; P:positive regulation of blood microparticle formation; IEA:Ensembl.
GO; GO:0010942; P:positive regulation of cell death; IEA:Ensembl.
GO; GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Ensembl.
GO; GO:0010886; P:positive regulation of cholesterol storage; IEA:Ensembl.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:1900227; P:positive regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0060100; P:positive regulation of phagocytosis, engulfment; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:2000505; P:regulation of energy homeostasis; IEA:Ensembl.
GO; GO:0043497; P:regulation of protein heterodimerization activity; IEA:Ensembl.
GO; GO:2000121; P:regulation of removal of superoxide radicals; IEA:Ensembl.
GO; GO:0034121; P:regulation of toll-like receptor signaling pathway; IEA:Ensembl.
GO; GO:0070543; P:response to linoleic acid; IEA:Ensembl.
GO; GO:0035634; P:response to stilbenoid; IEA:Ensembl.
GO; GO:0050909; P:sensory perception of taste; IEA:Ensembl.
GO; GO:0034197; P:triglyceride transport; IEA:Ensembl.
InterPro; IPR005428; CD36/SCARB1/SNMP1.
InterPro; IPR033076; CD36_chordates.
InterPro; IPR002159; CD36_fam.
PANTHER; PTHR11923; PTHR11923; 1.
PANTHER; PTHR11923:SF12; PTHR11923:SF12; 1.
Pfam; PF01130; CD36; 1.
PRINTS; PR01610; CD36ANTIGEN.
PRINTS; PR01609; CD36FAMILY.
2: Evidence at transcript level;
Collagen {ECO:0000313|EMBL:BAE01361.1};
Complete proteome {ECO:0000313|Proteomes:UP000009130};
Membrane {ECO:0000256|SAAS:SAAS00106193, ECO:0000256|SAM:Phobius};
Receptor {ECO:0000313|EMBL:BAE01361.1};
Reference proteome {ECO:0000313|Proteomes:UP000009130};
Transmembrane {ECO:0000256|SAAS:SAAS00106193,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00106193,
ECO:0000256|SAM:Phobius}.
TRANSMEM 7 29 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 440 466 Helical. {ECO:0000256|SAM:Phobius}.
SEQUENCE 472 AA; 53041 MW; E26EEF2671CA2581 CRC64;
MGCDRNCGLI TGAVIGAVLA VFGGILMPVG DMLIQKTIKK EVVLEEGTIA FKNWVKTGTE
IYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK ENITQDPKDN TVSFLQPNGA
IFEPSLSVGT EADNFTVLNL AVAAASHIYP NPFVQVVLNS LINKSKSSMF QVRTLRELLW
GYTDPFLSLV PYPVSTRVGM FYPYNNTADG VYKVFNGKDS ISKVAIIDTY KGKRNLSYWE
SYCDMINGTD AASFPPFVEK SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF
ASPVQNPDNH CFCTEKIISK NCTSYGVLDI SKCKEGKPVY ISLPHFLYAS PDVSETIDGL
NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSNKIQ VLKRLKRNYI VPILWLNETG
TIGDEKAKMF RSQVTGKINL LGLIEMILLS VGVVMFVAFM ISYCACRSKT IK


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