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Testis cDNA clone: QtsA-12227, similar to human transforming growth factor, beta 2 (TGFB2)

 Q4R461_MACFA            Unreviewed;       278 AA.
Q4R461;
19-JUL-2005, integrated into UniProtKB/TrEMBL.
19-JUL-2005, sequence version 1.
23-MAY-2018, entry version 68.
SubName: Full=Testis cDNA clone: QtsA-12227, similar to human transforming growth factor, beta 2 (TGFB2) {ECO:0000313|EMBL:BAE02105.1};
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541 {ECO:0000313|EMBL:BAE02105.1};
[1] {ECO:0000313|EMBL:BAE02105.1}
NUCLEOTIDE SEQUENCE.
PubMed=15944441; DOI=10.1093/molbev/msi187;
Osada N., Hirata M., Tanuma R., Kusuda J., Hida M., Suzuki Y.,
Sugano S., Gojobori T., Shen C.K., Wu C.I., Hashimoto K.;
"Substitution rate and structural divergence of 5'UTR evolution:
comparative analysis between human and cynomolgus monkey cDNAs.";
Mol. Biol. Evol. 22:1976-1982(2005).
[2] {ECO:0000313|EMBL:BAE02105.1}
NUCLEOTIDE SEQUENCE.
International consortium for macaque cDNA sequencing and analysis;
"DNA sequences of macaque genes expressed in brain or testis and its
evolutionary implications.";
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00581915}.
-!- SIMILARITY: Belongs to the TGF-beta family.
{ECO:0000256|RuleBase:RU000354, ECO:0000256|SAAS:SAAS00581927}.
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EMBL; AB179054; BAE02105.1; -; mRNA.
UniGene; Mfa.4010; -.
ProteinModelPortal; Q4R461; -.
HOVERGEN; HBG074115; -.
GO; GO:0031012; C:extracellular matrix; ISS:AgBase.
GO; GO:0005576; C:extracellular region; ISS:AgBase.
GO; GO:0005615; C:extracellular space; ISS:AgBase.
GO; GO:0001540; F:amyloid-beta binding; ISS:AgBase.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0042803; F:protein homodimerization activity; ISS:AgBase.
GO; GO:0005102; F:signaling receptor binding; ISS:AgBase.
GO; GO:0005160; F:transforming growth factor beta receptor binding; ISS:AgBase.
GO; GO:0005114; F:type II transforming growth factor beta receptor binding; ISS:AgBase.
GO; GO:0034714; F:type III transforming growth factor beta receptor binding; ISS:AgBase.
GO; GO:0032147; P:activation of protein kinase activity; ISS:AgBase.
GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; ISS:AgBase.
GO; GO:0060038; P:cardiac muscle cell proliferation; ISS:AgBase.
GO; GO:0010002; P:cardioblast differentiation; ISS:AgBase.
GO; GO:0007050; P:cell cycle arrest; ISS:AgBase.
GO; GO:0008219; P:cell death; ISS:AgBase.
GO; GO:0016477; P:cell migration; ISS:AgBase.
GO; GO:0000902; P:cell morphogenesis; ISS:AgBase.
GO; GO:0045216; P:cell-cell junction organization; ISS:AgBase.
GO; GO:0030199; P:collagen fibril organization; ISS:AgBase.
GO; GO:0048566; P:embryonic digestive tract development; ISS:AgBase.
GO; GO:0001837; P:epithelial to mesenchymal transition; ISS:AgBase.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISS:AgBase.
GO; GO:0001654; P:eye development; ISS:AgBase.
GO; GO:0008347; P:glial cell migration; ISS:AgBase.
GO; GO:0001942; P:hair follicle development; ISS:AgBase.
GO; GO:0007507; P:heart development; ISS:AgBase.
GO; GO:0003007; P:heart morphogenesis; ISS:AgBase.
GO; GO:0010693; P:negative regulation of alkaline phosphatase activity; ISS:AgBase.
GO; GO:0030308; P:negative regulation of cell growth; ISS:AgBase.
GO; GO:0008285; P:negative regulation of cell proliferation; ISS:AgBase.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISS:AgBase.
GO; GO:0010936; P:negative regulation of macrophage cytokine production; ISS:AgBase.
GO; GO:0060389; P:pathway-restricted SMAD protein phosphorylation; ISS:AgBase.
GO; GO:0051891; P:positive regulation of cardioblast differentiation; ISS:AgBase.
GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; ISS:AgBase.
GO; GO:0030307; P:positive regulation of cell growth; ISS:AgBase.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:AgBase.
GO; GO:0010634; P:positive regulation of epithelial cell migration; ISS:AgBase.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISS:AgBase.
GO; GO:0045823; P:positive regulation of heart contraction; ISS:AgBase.
GO; GO:0045726; P:positive regulation of integrin biosynthetic process; ISS:AgBase.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISS:AgBase.
GO; GO:0045778; P:positive regulation of ossification; ISS:AgBase.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:AgBase.
GO; GO:0050714; P:positive regulation of protein secretion; ISS:AgBase.
GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:AgBase.
GO; GO:0051795; P:positive regulation of timing of catagen; ISS:AgBase.
GO; GO:0006468; P:protein phosphorylation; ISS:AgBase.
GO; GO:0032909; P:regulation of transforming growth factor beta2 production; ISS:AgBase.
GO; GO:0042493; P:response to drug; ISS:AgBase.
GO; GO:0032570; P:response to progesterone; ISS:AgBase.
GO; GO:0009611; P:response to wounding; ISS:AgBase.
GO; GO:0007435; P:salivary gland morphogenesis; ISS:AgBase.
GO; GO:0023014; P:signal transduction by protein phosphorylation; ISS:AgBase.
GO; GO:0060395; P:SMAD protein signal transduction; ISS:BHF-UCL.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:AgBase.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR016319; TGF-beta.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR003940; TGFb2.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
PANTHER; PTHR11848:SF141; PTHR11848:SF141; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
PRINTS; PR01423; TGFBETA.
PRINTS; PR01425; TGFBETA2.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Disulfide bond {ECO:0000256|SAAS:SAAS00516088};
Growth factor {ECO:0000256|RuleBase:RU000354,
ECO:0000256|SAAS:SAAS00516085};
Secreted {ECO:0000256|SAAS:SAAS00516087}.
DOMAIN 163 278 TGF_BETA_2.
{ECO:0000259|PROSITE:PS51362}.
SEQUENCE 278 AA; 31966 MW; E3C3CD9058F49364 CRC64;
MEKNASNLVK AEFRVFRLQN PKARVPEQRI ELYQILKSKD LTSPTQRYID SKVVKTRAEG
EWLSFDVTDA VHEWLHHKDR NLGFKISLHC PCCTFVPSNN YIIPNKSEEL EARFAGIDGT
STYTSGDQKT IKSTRKKNSG KTPHLLLMLL PSYRLESQQT NRRKKRALDA AYCFRNVQDN
CCLRPLYIDF KRDLGWKWIH EPKGYNANFC AGACPYLWSS DTQHSRVLSL YNTINPEASA
SPCCVSQDLE PLTILYYIGK TPKIEQLSNM IVKSCKCS


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