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Testis-expressed protein 101 (Lipid raft-associated glycoprotein TEC-21)

 TX101_RAT               Reviewed;         250 AA.
Q924B5;
25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
23-MAY-2018, entry version 78.
RecName: Full=Testis-expressed protein 101 {ECO:0000250|UniProtKB:Q9BY14};
AltName: Full=Lipid raft-associated glycoprotein TEC-21;
Flags: Precursor;
Name=Tex101 {ECO:0000312|RGD:621373};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-44, FUNCTION,
GLYCOSYLATION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
STRAIN=Wistar; TISSUE=Leukemia;
PubMed=11809740; DOI=10.1093/intimm/14.2.213;
Halova I., Draberova L., Draber P.;
"A novel lipid raft-associated glycoprotein, TEC-21, activates rat
basophilic leukemia cells independently of the type 1 Fc epsilon
receptor.";
Int. Immunol. 14:213-223(2002).
-!- FUNCTION: Plays a role in fertilization by controlling binding of
sperm to zona pellucida and migration of spermatozoa into the
oviduct (By similarity). May play a role in signal transduction
and promote protein tyrosine phosphorylation (PubMed:11809740).
{ECO:0000250|UniProtKB:Q9JMI7, ECO:0000269|PubMed:11809740}.
-!- SUBUNIT: Interacts with VAMP3. Interacts with LY6K. Interacts with
DPEP3; co-localized on the cell surface of spermatocytes,
spermatids, and testicular spermatozoa, co-localized only in
cytoplasmic droplets of caput and corpus epididymal sperm.
Interacts with ADAM5. {ECO:0000250|UniProtKB:Q9JMI7}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11809740};
Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11809740}. Membrane
raft {ECO:0000269|PubMed:11809740}. Cytoplasmic vesicle, secretory
vesicle, acrosome {ECO:0000250|UniProtKB:Q9JMI7}. Secreted
{ECO:0000250|UniProtKB:Q9JMI7}. Cytoplasmic vesicle
{ECO:0000250|UniProtKB:Q9JMI7}. Note=Located on plasma membrane of
spermatocytes, round and elongated spermatids, and testicular
spermatozoa. {ECO:0000250|UniProtKB:Q9JMI7}.
-!- TISSUE SPECIFICITY: Detected in testis.
{ECO:0000269|PubMed:11809740}.
-!- PTM: N-glycosylated; by high mannose and/or biantennary complex
and/or certain types of hybrid oligosaccharides; possesses
different oligosaccharides chains according to its subcellular
localization in the testis. {ECO:0000269|PubMed:11809740}.
-!- PTM: Sheds from membrane raft by ACE and released from the cell
surface of epididymal sperm while it passes through the caput
epididymis leading to disappearance of TEX101 on spermatozoa; is
essential to produce fertile spermatozoa.
{ECO:0000250|UniProtKB:Q9JMI7}.
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EMBL; AF347056; AAK58911.1; -; mRNA.
RefSeq; NP_620606.1; NM_139037.1.
UniGene; Rn.27161; -.
STRING; 10116.ENSRNOP00000027202; -.
PaxDb; Q924B5; -.
PRIDE; Q924B5; -.
GeneID; 207113; -.
KEGG; rno:207113; -.
UCSC; RGD:621373; rat.
CTD; 83639; -.
RGD; 621373; Tex101.
eggNOG; ENOG410J0X3; Eukaryota.
eggNOG; ENOG41118MD; LUCA.
HOGENOM; HOG000294143; -.
HOVERGEN; HBG094100; -.
InParanoid; Q924B5; -.
PhylomeDB; Q924B5; -.
PRO; PR:Q924B5; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0001669; C:acrosomal vesicle; ISS:UniProtKB.
GO; GO:0031225; C:anchored component of membrane; IDA:RGD.
GO; GO:0046658; C:anchored component of plasma membrane; ISS:UniProtKB.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0045121; C:membrane raft; IDA:RGD.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0007339; P:binding of sperm to zona pellucida; ISS:UniProtKB.
GO; GO:0009566; P:fertilization; ISS:UniProtKB.
GO; GO:0002696; P:positive regulation of leukocyte activation; IDA:RGD.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:RGD.
GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:RGD.
GO; GO:1901317; P:regulation of flagellated sperm motility; ISS:UniProtKB.
GO; GO:0097722; P:sperm motility; ISS:UniProtKB.
InterPro; IPR016054; LY6_UPA_recep-like.
Pfam; PF00021; UPAR_LY6; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Cytoplasmic vesicle;
Direct protein sequencing; Glycoprotein; GPI-anchor; Lipoprotein;
Membrane; Reference proteome; Secreted; Signal.
SIGNAL 1 25 {ECO:0000269|PubMed:11809740}.
CHAIN 26 224 Testis-expressed protein 101.
/FTId=PRO_0000247625.
PROPEP 225 250 Removed in mature form. {ECO:0000255}.
/FTId=PRO_0000247626.
DOMAIN 141 215 UPAR/Ly6.
LIPID 224 224 GPI-anchor amidated glycine.
{ECO:0000255}.
CARBOHYD 45 45 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 110 110 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 134 134 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 160 160 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 250 AA; 27004 MW; CFF31D13C980AC4C CRC64;
MGACRIQYIL LVFLLIASHW TLVQNIYCEV SRTLSLEDNP SGTFNWTSKA EKCNPGEFCQ
ETVLLIKAEG TKTAILASKS CVPQGAETMT FVQYTAPPGL VAISYSNYCN DSLCNNRNNL
ASILQAPEPT ATSNMSGARH CPTCLALEPC SSAPSMPCAN GTTQCYHGKI ELSGGGMDSV
VHVKGCTTAI GCRLMAKMES VGPMTVKETC SYQSFLHPRM AEIGASWMPT SLWVLELLLP
ALSLPLIYFP


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