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Tetraspanin

 H0VGI8_CAVPO            Unreviewed;       219 AA.
H0VGI8;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
22-NOV-2017, entry version 38.
RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
Name=CD53 {ECO:0000313|Ensembl:ENSCPOP00000009230};
Cavia porcellus (Guinea pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Hystricomorpha; Caviidae; Cavia.
NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000009230};
[1] {ECO:0000313|Ensembl:ENSCPOP00000009230}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000009230};
PubMed=21993624; DOI=10.1038/nature10530;
Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
Pedersen J.S., Lander E.S., Kellis M.;
"A high-resolution map of human evolutionary constraint using 29
mammals.";
Nature 478:476-482(2011).
[2] {ECO:0000313|Ensembl:ENSCPOP00000009230}
IDENTIFICATION.
STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000009230};
Ensembl;
Submitted (JAN-2012) to UniProtKB.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361218};
Multi-pass membrane protein {ECO:0000256|RuleBase:RU361218}.
-!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
{ECO:0000256|RuleBase:RU361218, ECO:0000256|SAAS:SAAS00545671}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000009230}.
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EMBL; AAKN02004557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAKN02004558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_003479272.1; XM_003479224.3.
STRING; 10141.ENSCPOP00000009230; -.
Ensembl; ENSCPOT00000010374; ENSCPOP00000009230; ENSCPOG00000010280.
GeneID; 100735881; -.
CTD; 963; -.
eggNOG; KOG3882; Eukaryota.
eggNOG; ENOG4111IRY; LUCA.
GeneTree; ENSGT00880000137858; -.
InParanoid; H0VGI8; -.
OMA; VCVIQVL; -.
OrthoDB; EOG091G0CQO; -.
TreeFam; TF352892; -.
Proteomes; UP000005447; Unassembled WGS sequence.
Bgee; ENSCPOG00000010280; -.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0001772; C:immunological synapse; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
GO; GO:1901741; P:positive regulation of myoblast fusion; IEA:Ensembl.
Gene3D; 1.10.1450.10; -; 1.
InterPro; IPR000301; Tetraspanin.
InterPro; IPR018499; Tetraspanin/Peripherin.
InterPro; IPR018503; Tetraspanin_CS.
InterPro; IPR008952; Tetraspanin_EC2_sf.
Pfam; PF00335; Tetraspannin; 1.
PIRSF; PIRSF002419; Tetraspanin; 1.
PRINTS; PR00259; TMFOUR.
SUPFAM; SSF48652; SSF48652; 1.
PROSITE; PS00421; TM4_1; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000005447};
Membrane {ECO:0000256|RuleBase:RU361218,
ECO:0000256|SAAS:SAAS00028005};
Reference proteome {ECO:0000313|Proteomes:UP000005447};
Transmembrane {ECO:0000256|RuleBase:RU361218,
ECO:0000256|SAAS:SAAS00028005};
Transmembrane helix {ECO:0000256|RuleBase:RU361218,
ECO:0000256|SAAS:SAAS00028005}.
TRANSMEM 12 35 Helical. {ECO:0000256|RuleBase:RU361218}.
TRANSMEM 47 69 Helical. {ECO:0000256|RuleBase:RU361218}.
TRANSMEM 81 105 Helical. {ECO:0000256|RuleBase:RU361218}.
TRANSMEM 182 206 Helical. {ECO:0000256|RuleBase:RU361218}.
SEQUENCE 219 AA; 24522 MW; 329CD505551CA6BD CRC64;
MGMSSLKLLK YVLFFFNLLF WLCGCCILGF GIYFLVHNDF GVLFHKLPFL TLGNILVIVG
SIIMVVAFLG CMGSIKENKC LLMSFFVLLL IILLAEVTLA ILLFVHEQKL NSYVAEGLTE
SIHRYYLDNS TKAAWDSIQS FLHCCGVNQT SDWSGHPPAS CPSEQGVKGC YMKTQEWFHS
NFLYIGIIII CICMIQVLGM SFALTLNCQI DKTSQAIGL


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