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Tetraspanin-21

 TSP21_CAEEL             Reviewed;         301 AA.
Q5WRN1;
30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
10-JUN-2008, sequence version 2.
12-SEP-2018, entry version 99.
RecName: Full=Tetraspanin-21 {ECO:0000305};
Name=tsp-21 {ECO:0000312|WormBase:C17G1.8};
ORFNames=C17G1.8 {ECO:0000312|WormBase:C17G1.8};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
[1] {ECO:0000312|Proteomes:UP000001940}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[2] {ECO:0000305}
FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, DISRUPTION
PHENOTYPE, AND MUTAGENESIS OF GLY-109.
PubMed=25978409; DOI=10.1371/journal.pgen.1005221;
Liu Z., Shi H., Szymczak L.C., Aydin T., Yun S., Constas K.,
Schaeffer A., Ranjan S., Kubba S., Alam E., McMahon D.E., He J.,
Shwartz N., Tian C., Plavskin Y., Lindy A., Dad N.A., Sheth S.,
Amin N.M., Zimmerman S., Liu D., Schwarz E.M., Smith H., Krause M.W.,
Liu J.;
"Promotion of bone morphogenetic protein signaling by tetraspanins and
glycosphingolipids.";
PLoS Genet. 11:E1005221-E1005221(2015).
-!- FUNCTION: Regulates cell fate specification in the postembryonic
mesodermal M lineage and body size, probably by positively
modulating BMP-like Sma/Mab signaling at the ligand-receptor
level. Promotes ventral fate specification in the M lineage,
probably by positively modulating lin-12/Notch signaling.
{ECO:0000269|PubMed:25978409}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000255|RuleBase:RU361218, ECO:0000269|PubMed:25978409};
Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}.
Basolateral cell membrane {ECO:0000269|PubMed:25978409}; Multi-
pass membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane
{ECO:0000269|PubMed:25978409}; Multi-pass membrane protein
{ECO:0000305}. Note=Specifically localizes to the basolateral side
of intestinal cells. Localizes to cytoplasmic vesicles in the M
mesoblast. {ECO:0000269|PubMed:25978409}.
-!- DEVELOPMENTAL STAGE: Expressed at 100-cell embryonic stage, in the
pharynx, intestine, hypodermis and M lineage (M-1 to M-16 stages)
at the L1 larval stage and in somatic gonad, vulva and rectal
epithelium at the L4 larval stage. {ECO:0000269|PubMed:25978409}.
-!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown in a sma-9 (cc604)
mutant background restores the production of the 2 M lineage-
derived coelomocytes. {ECO:0000269|PubMed:25978409}.
-!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
{ECO:0000255|RuleBase:RU361218, ECO:0000255|SAAS:SAAS00545671}.
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EMBL; BX284606; CAH60758.2; -; Genomic_DNA.
RefSeq; NP_001024415.2; NM_001029244.4.
UniGene; Cel.25081; -.
ProteinModelPortal; Q5WRN1; -.
STRING; 6239.C17G1.8; -.
EPD; Q5WRN1; -.
PaxDb; Q5WRN1; -.
PeptideAtlas; Q5WRN1; -.
EnsemblMetazoa; C17G1.8.1; C17G1.8.1; WBGene00023491.
EnsemblMetazoa; C17G1.8.2; C17G1.8.2; WBGene00023491.
GeneID; 259720; -.
KEGG; cel:CELE_C17G1.8; -.
UCSC; C17G1.8; c. elegans.
CTD; 259720; -.
WormBase; C17G1.8; CE42559; WBGene00023491; tsp-21.
eggNOG; KOG3882; Eukaryota.
eggNOG; ENOG4111IRY; LUCA.
GeneTree; ENSGT00510000047764; -.
HOGENOM; HOG000016557; -.
InParanoid; Q5WRN1; -.
OMA; DWLYHHI; -.
OrthoDB; EOG091G0K4P; -.
PhylomeDB; Q5WRN1; -.
PRO; PR:Q5WRN1; -.
Proteomes; UP000001940; Chromosome X.
Bgee; WBGene00023491; Expressed in 3 organ(s), highest expression level in multi-cellular organism.
GO; GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:UniProtKB.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; IMP:UniProtKB.
GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IMP:UniProtKB.
GO; GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
GO; GO:0042661; P:regulation of mesodermal cell fate specification; IGI:UniProtKB.
GO; GO:1901048; P:transforming growth factor beta receptor signaling pathway involved in regulation of multicellular organism growth; IGI:UniProtKB.
Gene3D; 1.10.1450.10; -; 1.
InterPro; IPR000301; Tetraspanin.
InterPro; IPR018499; Tetraspanin/Peripherin.
InterPro; IPR008952; Tetraspanin_EC2_sf.
Pfam; PF00335; Tetraspannin; 1.
PIRSF; PIRSF002419; Tetraspanin; 1.
PRINTS; PR00259; TMFOUR.
SUPFAM; SSF48652; SSF48652; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Cytoplasmic vesicle; Glycoprotein;
Membrane; Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 301 Tetraspanin-21.
/FTId=PRO_0000441402.
TOPO_DOM 1 16 Cytoplasmic. {ECO:0000305}.
TRANSMEM 17 37 Helical. {ECO:0000255}.
TOPO_DOM 38 59 Extracellular. {ECO:0000305}.
TRANSMEM 60 80 Helical. {ECO:0000255}.
TOPO_DOM 81 86 Cytoplasmic. {ECO:0000305}.
TRANSMEM 87 107 Helical. {ECO:0000255}.
TOPO_DOM 108 222 Extracellular. {ECO:0000305}.
TRANSMEM 223 243 Helical. {ECO:0000255}.
TOPO_DOM 244 301 Cytoplasmic. {ECO:0000305}.
CARBOHYD 129 129 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 161 161 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 191 191 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
MUTAGEN 109 109 G->E: In jj60; in a sma-9 (cc604) mutant
background, restores the production of
the 2 M lineage-derived coelomocytes.
{ECO:0000269|PubMed:25978409}.
SEQUENCE 301 AA; 34408 MW; 3A725BA37C22AFAE CRC64;
MIDLKSIWND KRKITYFFLA NVCFLISGLS SLIVGVWLYS SKNNFIELTP TSYSALSAAG
LCVFTGVTIF IIVAVGYLGV SWSNKSLLYS YIGFVILLIL VHGIARITGS LHKEEAKENL
RKSMLHNINT TAVVTKIGRE IKLSLTWDHL QRELQCCGVD NYTDWHYSVH WPNNLYTPDS
CCDPQHFDAE NGTENCGKLP DEQSLLYQKG CFPKFSDWLY HHIILVNWVT SILFVVEILL
LILSLVVLRV LKNSRHKTRR SHRERDPETT SENMRLNSMD RIADARLETD TVEDGMSINS
R


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