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Tetraspanin-32 (Tspan-32) (AML1-regulated transmembrane protein 1) (Protein Phemx)
TSN32_MOUSE Reviewed; 256 AA.
Q9JHH2; Q923G9; Q9ESH0; Q9JHQ9; Q9JHR0; Q9JHR1; Q9JHR2; Q9JHS8;
27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
27-MAR-2002, sequence version 2.
28-FEB-2018, entry version 116.
RecName: Full=Tetraspanin-32;
Short=Tspan-32;
AltName: Full=AML1-regulated transmembrane protein 1;
AltName: Full=Protein Phemx;
Name=Tspan32; Synonyms=Art1, Phemx, Tssc6;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
STRAIN=C57BL/6J;
PubMed=10950922; DOI=10.1006/geno.2000.6277;
Nicholson R.H., Pantano S., Eliason J.F., Galy A., Weiler S.,
Kaplan J., Hughes M.R., Ko M.S.H.;
"Phemx, a novel mouse gene expressed in hematopoietic cells maps to
the imprinted cluster on distal chromosome 7.";
Genomics 68:13-21(2000).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4 AND 5).
STRAIN=129/Sv, and C57BL/6J;
PubMed=10915772; DOI=10.1093/hmg/9.12.1829;
Paulsen M., El-Maarri O., Engemann S., Stroedicke M., Franck O.,
Davies K., Reinhardt R., Reik W., Walter J.;
"Sequence conservation and variability of imprinting in the Beckwith-
Wiedemann syndrome gene cluster in human and mouse.";
Hum. Mol. Genet. 9:1829-1841(2000).
[3]
NUCLEOTIDE SEQUENCE (ISOFORM 6).
PubMed=11718897; DOI=10.1016/S0167-4781(01)00306-2;
Robb L., Tarrant J., Groom J., Ibrahim M., Li R., Borobakas B.,
Wright M.D.;
"Molecular characterisation of mouse and human TSSC6: evidence that
TSSC6 is a genuine member of the tetraspanin superfamily and is
expressed specifically in haematopoietic organs.";
Biochim. Biophys. Acta 1522:31-41(2001).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Spleen;
PubMed=11396961; DOI=10.1006/bbrc.2001.5005;
Harada Y., Harada H., Downing J.R., Kimura A.;
"A hematopoietic-specific transmembrane protein, Art-1, is possibly
regulated by aml1.";
Biochem. Biophys. Res. Commun. 284:714-722(2001).
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=6;
Comment=Additional isoforms seem to exist.;
Name=6;
IsoId=Q9JHH2-1; Sequence=Displayed;
Name=1;
IsoId=Q9JHH2-2; Sequence=VSP_003939;
Name=2;
IsoId=Q9JHH2-3; Sequence=VSP_003939, VSP_003941;
Name=3;
IsoId=Q9JHH2-4; Sequence=VSP_003939, VSP_003942, VSP_003943;
Name=4;
IsoId=Q9JHH2-5; Sequence=VSP_003939, VSP_003940, VSP_003941;
Name=5;
IsoId=Q9JHH2-6; Sequence=VSP_003939, VSP_003940, VSP_003942;
-!- TISSUE SPECIFICITY: Expressed exclusively in hematopoietic
tissues. Expression detected in spleen, thymus, bone marrow and
peripheral blood leukocytes but not in heart, brain, lung, liver,
kidney or testis. {ECO:0000269|PubMed:10950922}.
-!- DEVELOPMENTAL STAGE: Expressed from early embryogenesis through to
adulthood. {ECO:0000269|PubMed:10950922}.
-!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
{ECO:0000305}.
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EMBL; AF175771; AAG27268.1; -; mRNA.
EMBL; AJ251788; CAB94716.1; -; Genomic_DNA.
EMBL; AJ251835; CAB94777.1; -; Genomic_DNA.
EMBL; AJ279791; CAB94719.1; -; mRNA.
EMBL; AJ279792; CAB94720.1; -; mRNA.
EMBL; AJ279793; CAB94721.1; -; mRNA.
EMBL; AJ279794; CAB94722.1; -; mRNA.
EMBL; AJ279795; CAB94723.1; -; mRNA.
EMBL; AY039000; AAK84430.1; -; mRNA.
EMBL; AF291425; AAK83110.1; -; mRNA.
CCDS; CCDS52459.1; -. [Q9JHH2-1]
RefSeq; NP_001121552.1; NM_001128080.2. [Q9JHH2-1]
RefSeq; NP_001121553.1; NM_001128081.1.
RefSeq; NP_001121554.1; NM_001128082.1.
RefSeq; NP_064682.1; NM_020286.3.
UniGene; Mm.28172; -.
ProteinModelPortal; Q9JHH2; -.
STRING; 10090.ENSMUSP00000009396; -.
PhosphoSitePlus; Q9JHH2; -.
PaxDb; Q9JHH2; -.
PRIDE; Q9JHH2; -.
Ensembl; ENSMUST00000009396; ENSMUSP00000009396; ENSMUSG00000000244. [Q9JHH2-1]
GeneID; 27027; -.
KEGG; mmu:27027; -.
UCSC; uc009kom.2; mouse. [Q9JHH2-1]
CTD; 10077; -.
MGI; MGI:1350360; Tspan32.
eggNOG; ENOG410IY3A; Eukaryota.
eggNOG; ENOG410YXBH; LUCA.
GeneTree; ENSGT00390000003287; -.
HOVERGEN; HBG053580; -.
InParanoid; Q9JHH2; -.
KO; K17359; -.
OMA; LTYFGAH; -.
OrthoDB; EOG091G0JTB; -.
PhylomeDB; Q9JHH2; -.
TreeFam; TF336277; -.
PRO; PR:Q9JHH2; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000000244; -.
CleanEx; MM_ART1; -.
CleanEx; MM_TSPAN32; -.
ExpressionAtlas; Q9JHH2; baseline and differential.
Genevisible; Q9JHH2; MM.
GO; GO:0009986; C:cell surface; IDA:MGI.
GO; GO:0070442; C:integrin alphaIIb-beta3 complex; IDA:MGI.
GO; GO:0005622; C:intracellular; IDA:MGI.
GO; GO:0007596; P:blood coagulation; IMP:MGI.
GO; GO:0007010; P:cytoskeleton organization; IMP:MGI.
GO; GO:0042832; P:defense response to protozoan; IGI:MGI.
GO; GO:0007599; P:hemostasis; IMP:MGI.
GO; GO:0007229; P:integrin-mediated signaling pathway; IMP:MGI.
GO; GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.
GO; GO:0030886; P:negative regulation of myeloid dendritic cell activation; IGI:MGI.
GO; GO:0070527; P:platelet aggregation; IMP:MGI.
GO; GO:0050688; P:regulation of defense response to virus; IGI:MGI.
InterPro; IPR000301; Tetraspanin.
InterPro; IPR008952; Tetraspanin_EC2_sf.
PIRSF; PIRSF002419; Tetraspanin; 1.
SUPFAM; SSF48652; SSF48652; 1.
2: Evidence at transcript level;
Alternative splicing; Complete proteome; Membrane; Reference proteome;
Transmembrane; Transmembrane helix.
CHAIN 1 256 Tetraspanin-32.
/FTId=PRO_0000219279.
TRANSMEM 15 35 Helical. {ECO:0000255}.
TRANSMEM 61 81 Helical. {ECO:0000255}.
TRANSMEM 90 110 Helical. {ECO:0000255}.
TRANSMEM 203 223 Helical. {ECO:0000255}.
VAR_SEQ 1 30 Missing (in isoform 1, isoform 2, isoform
3, isoform 4 and isoform 5).
{ECO:0000303|PubMed:10915772,
ECO:0000303|PubMed:10950922,
ECO:0000303|PubMed:11396961}.
/FTId=VSP_003939.
VAR_SEQ 119 152 Missing (in isoform 4 and isoform 5).
{ECO:0000303|PubMed:10915772}.
/FTId=VSP_003940.
VAR_SEQ 182 209 Missing (in isoform 2 and isoform 4).
{ECO:0000303|PubMed:10915772}.
/FTId=VSP_003941.
VAR_SEQ 182 206 DCLQSIRNVLWTHYSIASILTCTSL -> IPWFPDPGTQPL
QMDLGWAGASMPC (in isoform 3 and isoform
5). {ECO:0000303|PubMed:10915772}.
/FTId=VSP_003942.
VAR_SEQ 207 236 Missing (in isoform 3).
{ECO:0000303|PubMed:10915772}.
/FTId=VSP_003943.
CONFLICT 174 174 Q -> L (in Ref. 1; AAG27268).
{ECO:0000305}.
CONFLICT 235 235 Y -> F (in Ref. 1; AAG27268).
{ECO:0000305}.
SEQUENCE 256 AA; 28906 MW; A20EF0F6248FF67A CRC64;
MGHWNRIKIA KCQILITNFL VLLLGLSMAT MVVVIHFGDH FTVIGHASLE RNPYETLRYW
AFYVGISLAG LLSLGAALST IATVREAHGL MAAGFLCFAL SFCILVQVAF WRFYNPTQVE
DAVLDTYDFV YDQAMKSPSS NWWQELAVIQ DTFLCCGKKS PFGLLVSTGA IMCQGREAMR
EDCLQSIRNV LWTHYSIASI LTCTSLALTV YAMMLCAFLW FAIHSYHGLD RKGRYSLTPP
RSHGFQTQEP SLFRWT
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Pathways :
WP1616: ABC transporters
WP1665: Limonene and pinene degradation
WP1675: Nitrogen metabolism
WP1685: Peptidoglycan biosynthesis
WP1714: Tyrosine metabolism
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation
Related Genes :
[Tspan32 Art1 Phemx Tssc6] Tetraspanin-32 (Tspan-32) (AML1-regulated transmembrane protein 1) (Protein Phemx)
[TSPAN32 PHEMX TSSC6] Tetraspanin-32 (Tspan-32) (Protein Phemx)
[TSPAN1] Tetraspanin-1 (Tspan-1) (Tetraspan NET-1) (Tetraspanin TM4-C)
[CD63 MLA1 TSPAN30] CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63)
[CD82 KAI1 SAR2 ST6 TSPAN27] CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82)
[CD53 MOX44 TSPAN25] Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)
[CD9 MIC3 TSPAN29 GIG2] CD9 antigen (5H9 antigen) (Cell growth-inhibiting gene 2 protein) (Leukocyte antigen MIC3) (Motility-related protein) (MRP-1) (Tetraspanin-29) (Tspan-29) (p24) (CD antigen CD9)
[CD151 TSPAN24] CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151)
[CD81 TAPA1 TSPAN28] CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
[TSPAN12 NET2 TM4SF12 UNQ774/PRO1568] Tetraspanin-12 (Tspan-12) (Tetraspan NET-2) (Transmembrane 4 superfamily member 12)
[TSPAN14 TM4SF14] Tetraspanin-14 (Tspan-14) (DC-TM4F2) (Transmembrane 4 superfamily member 14)
[TSPAN4 NAG2 TM4SF7] Tetraspanin-4 (Tspan-4) (Novel antigen 2) (NAG-2) (Transmembrane 4 superfamily member 7)
[tsp-12 T14G10.6] Tetraspanin-12
[tsp-21 C17G1.8] Tetraspanin-21
[TSPAN7 A15 DXS1692E MXS1 TM4SF2] Tetraspanin-7 (Tspan-7) (Cell surface glycoprotein A15) (Membrane component chromosome X surface marker 1) (T-cell acute lymphoblastic leukemia-associated antigen 1) (TALLA-1) (Transmembrane 4 superfamily member 2) (CD antigen CD231)
[PRPH2 PRPH RDS TSPAN22] Peripherin-2 (Retinal degeneration slow protein) (Tetraspanin-22) (Tspan-22)
[TSPAN15 NET7 TM4SF15 UNQ677/PRO1311] Tetraspanin-15 (Tspan-15) (Tetraspan NET-7) (Transmembrane 4 superfamily member 15)
[HTN3 HIS2] Histatin-3 (Basic histidine-rich protein) (Hst) (Histidine-rich protein 3) (PB) [Cleaved into: Histatin-3; His3-(20-44)-peptide (His3 20/44) (His3-(1-25)-peptide) (His3 1/25) (Histatin-3 1/25) (Histatin-6); His3-(20-43)-peptide (His3 20/43) (His3-(1-24)-peptide) (His3 1/24) (Histatin-3 1/24) (Histatin-5); His3-(20-32)-peptide (His3 20/32) (His3-(1-13)-peptide) (His3 1/13) (Histatin-3 1/13); His3-(20-31)-peptide (His3 20/31) (His3-(1-12)-peptide) (His3 1/12) (Histatin-3 1/12); His3-(20-30)-peptide (His3 20/30) (His3-(1-11)-peptide) (His3 1/11) (Histatin-3 1/11); His3-(24-32)-peptide (His3 24/32) (His3-(5-13)-peptide) (His3 5/13) (Histatin-3 5/13); His3-(24-31)-peptide (His3 24/31) (His3-(5-12)-peptide) (His3 5/12) (Histatin-11) (Histatin-3 5/12); His3-(24-30)-peptide (His3 24/30) (His3-(5-11)-peptide) (His3 5/11) (Histatin-12) (Histatin-3 5/11); His3-(25-32)-peptide (His3 25/32) (His3-(6-13)-peptide) (His3 6/13) (Histatin-3 6/13); His3-(25-30)-peptide (His3 25/30) (His3-(6-11)-peptide) (His3 6/11) (Histatin-3 6/11); His3-(26-32)-peptide (His3 26/32) (His3-(7-13)-peptide) (His3 7/13) (Histatin-3 7/13); His3-(26-31)-peptide (His3 26/31) (His3-(7-12)-peptide) (His3 7/12) (Histatin-3 7/12); His3-(26-30)-peptide (His3 26/30) (His3-(7-11)-peptide) (His3 7/11) (Histatin-3 7/11); His3-(31-51)-peptide (His3 31/51) (His3-(12-32)-peptide) (His3 12/32) (Histatin-3 12/32) (Histatin-4); His3-(31-44)-peptide (His3 31/44) (His3-(12-25)-peptide) (His3 12/25) (Histatin-3 12/25) (Histatin-9); His3-(31-43)-peptide (His3 31/43) (His3-(12-24)-peptide) (His3 12/24) (Histatin-3 12/24) (Histatin-7); His3-(32-44)-peptide (His3 32/44) (His3-(13-25)-peptide) (His3 13/25) (Histatin-10) (Histatin-3 13/25); His3-(32-43)-peptide (His3 32-43) (His3-(13-24)-peptide) (His3 13/24) (Histatin-3 13/24) (Histatin-8); His3-(33-44)-peptide (His3 33/44) (His3-(14-25)-peptide) (His3 14/25) (Histatin-3 14/25); His3-(33-43)-peptide (His3 33/43) (His3-(14-24)-peptide) (His3 14/24) (Histatin-3 14/24); His3-(34-44)-peptide (His3 34/44) (His3-(15-25)-peptide) (His3 15/25) (Histatin-3 15/25); His3-(34-43)-peptide (His3 34/43) (His3-(15-24)-peptide) (His3 15/24) (Histatin-3 15/24); His3-(45-51)-peptide (His3 45/51) (His3-(26-32)-peptide) (His3 26/32) (Histatin-3 26/32); His3-(47-51)-peptide (His3 47/51) (His3-(28-32)-peptide) (His3 28/32) (Histatin-3 28/32); His3-(48-51)-peptide (His3 48/51) (His3-(29-32)-peptide) (His3 29/32) (Histatin-3 29/32)]
[TRN2 TET1 At5g46700 MZA15.11] Protein TORNADO 2 (Protein EKEKO) (TETRASPANIN-1)
[tsp-14 F39C12.3] Tetraspanin-14
[Tspan33 Pen] Tetraspanin-33 (Tspan-33) (Penumbra) (mPen) (Proerythroblast new membrane)
[Tspan12 Tm4sf12] Tetraspanin-12 (Tspan-12) (Transmembrane 4 superfamily member 12)
[UPK1A TSPAN21] Uroplakin-1a (UP1a) (Tetraspanin-21) (Tspan-21) (Uroplakin Ia) (UPIa) (UPKa)
[ROM1 TSPAN23] Rod outer segment membrane protein 1 (ROSP1) (Tetraspanin-23) (Tspan-23)
[Tspan15] Tetraspanin-15 (Tspan-15) (Transmembrane 4 superfamily member 15)
[TSPAN33 PEN] Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41); Surface protein gp120 (SU) (Glycoprotein 120) (gp120)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41); Surface protein gp120 (SU) (Glycoprotein 120) (gp120)]
[NPPB] Natriuretic peptides B (Gamma-brain natriuretic peptide) [Cleaved into: Brain natriuretic peptide 32 (BNP(1-32)) (BNP-32); BNP(1-30); BNP(1-29); BNP(1-28); BNP(2-31); BNP(3-32); BNP(3-30); BNP(3-29); BNP(4-32); BNP(4-31); BNP(4-30); BNP(4-29); BNP(4-27); BNP(5-32); BNP(5-31); BNP(5-29)]
[tspan36 tspan3c] Tetraspanin-36 (Tetraspanin-3c)
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