GENTAUR Molecular Products.

 TSN32_MOUSE             Reviewed;         256 AA.
 Q9JHH2; Q923G9; Q9ESH0; Q9JHQ9; Q9JHR0; Q9JHR1; Q9JHR2; Q9JHS8;
 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
 27-MAR-2002, sequence version 2.
 12-SEP-2018, entry version 117.
 RecName: Full=Tetraspanin-32;
          Short=Tspan-32;
 AltName: Full=AML1-regulated transmembrane protein 1;
 AltName: Full=Protein Phemx;
 Name=Tspan32; Synonyms=Art1, Phemx, Tssc6;
 Mus musculus (Mouse).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
 Muroidea; Muridae; Murinae; Mus; Mus.
 NCBI_TaxID=10090;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
 DEVELOPMENTAL STAGE.
 STRAIN=C57BL/6J;
 PubMed=10950922; DOI=10.1006/geno.2000.6277;
 Nicholson R.H., Pantano S., Eliason J.F., Galy A., Weiler S.,
 Kaplan J., Hughes M.R., Ko M.S.H.;
 "Phemx, a novel mouse gene expressed in hematopoietic cells maps to
 the imprinted cluster on distal chromosome 7.";
 Genomics 68:13-21(2000).
 [2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4 AND 5).
 STRAIN=129/Sv, and C57BL/6J;
 PubMed=10915772; DOI=10.1093/hmg/9.12.1829;
 Paulsen M., El-Maarri O., Engemann S., Stroedicke M., Franck O.,
 Davies K., Reinhardt R., Reik W., Walter J.;
 "Sequence conservation and variability of imprinting in the Beckwith-
 Wiedemann syndrome gene cluster in human and mouse.";
 Hum. Mol. Genet. 9:1829-1841(2000).
 [3]
 NUCLEOTIDE SEQUENCE (ISOFORM 6).
 PubMed=11718897; DOI=10.1016/S0167-4781(01)00306-2;
 Robb L., Tarrant J., Groom J., Ibrahim M., Li R., Borobakas B.,
 Wright M.D.;
 "Molecular characterisation of mouse and human TSSC6: evidence that
 TSSC6 is a genuine member of the tetraspanin superfamily and is
 expressed specifically in haematopoietic organs.";
 Biochim. Biophys. Acta 1522:31-41(2001).
 [4]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
 STRAIN=C57BL/6J; TISSUE=Spleen;
 PubMed=11396961; DOI=10.1006/bbrc.2001.5005;
 Harada Y., Harada H., Downing J.R., Kimura A.;
 "A hematopoietic-specific transmembrane protein, Art-1, is possibly
 regulated by aml1.";
 Biochem. Biophys. Res. Commun. 284:714-722(2001).
 -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
     protein {ECO:0000305}.
 -!- ALTERNATIVE PRODUCTS:
     Event=Alternative splicing; Named isoforms=6;
       Comment=Additional isoforms seem to exist.;
     Name=6;
       IsoId=Q9JHH2-1; Sequence=Displayed;
     Name=1;
       IsoId=Q9JHH2-2; Sequence=VSP_003939;
     Name=2;
       IsoId=Q9JHH2-3; Sequence=VSP_003939, VSP_003941;
     Name=3;
       IsoId=Q9JHH2-4; Sequence=VSP_003939, VSP_003942, VSP_003943;
     Name=4;
       IsoId=Q9JHH2-5; Sequence=VSP_003939, VSP_003940, VSP_003941;
     Name=5;
       IsoId=Q9JHH2-6; Sequence=VSP_003939, VSP_003940, VSP_003942;
 -!- TISSUE SPECIFICITY: Expressed exclusively in hematopoietic
     tissues. Expression detected in spleen, thymus, bone marrow and
     peripheral blood leukocytes but not in heart, brain, lung, liver,
     kidney or testis. {ECO:0000269|PubMed:10950922}.
 -!- DEVELOPMENTAL STAGE: Expressed from early embryogenesis through to
     adulthood. {ECO:0000269|PubMed:10950922}.
 -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
     {ECO:0000305}.
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 EMBL; AF175771; AAG27268.1; -; mRNA.
 EMBL; AJ251788; CAB94716.1; -; Genomic_DNA.
 EMBL; AJ251835; CAB94777.1; -; Genomic_DNA.
 EMBL; AJ279791; CAB94719.1; -; mRNA.
 EMBL; AJ279792; CAB94720.1; -; mRNA.
 EMBL; AJ279793; CAB94721.1; -; mRNA.
 EMBL; AJ279794; CAB94722.1; -; mRNA.
 EMBL; AJ279795; CAB94723.1; -; mRNA.
 EMBL; AY039000; AAK84430.1; -; mRNA.
 EMBL; AF291425; AAK83110.1; -; mRNA.
 CCDS; CCDS52459.1; -. [Q9JHH2-1]
 RefSeq; NP_001121552.1; NM_001128080.2. [Q9JHH2-1]
 RefSeq; NP_001121553.1; NM_001128081.1.
 RefSeq; NP_001121554.1; NM_001128082.1.
 RefSeq; NP_064682.1; NM_020286.3.
 UniGene; Mm.28172; -.
 ProteinModelPortal; Q9JHH2; -.
 STRING; 10090.ENSMUSP00000009396; -.
 PhosphoSitePlus; Q9JHH2; -.
 PaxDb; Q9JHH2; -.
 PRIDE; Q9JHH2; -.
 Ensembl; ENSMUST00000009396; ENSMUSP00000009396; ENSMUSG00000000244. [Q9JHH2-1]
 GeneID; 27027; -.
 KEGG; mmu:27027; -.
 UCSC; uc009kom.2; mouse. [Q9JHH2-1]
 CTD; 10077; -.
 MGI; MGI:1350360; Tspan32.
 eggNOG; ENOG410IY3A; Eukaryota.
 eggNOG; ENOG410YXBH; LUCA.
 GeneTree; ENSGT00390000003287; -.
 HOVERGEN; HBG053580; -.
 InParanoid; Q9JHH2; -.
 KO; K17359; -.
 OMA; LTYFGAH; -.
 OrthoDB; EOG091G0JTB; -.
 PhylomeDB; Q9JHH2; -.
 TreeFam; TF336277; -.
 PRO; PR:Q9JHH2; -.
 Proteomes; UP000000589; Chromosome 7.
 Bgee; ENSMUSG00000000244; Expressed in 132 organ(s), highest expression level in spleen.
 CleanEx; MM_ART1; -.
 CleanEx; MM_TSPAN32; -.
 ExpressionAtlas; Q9JHH2; baseline and differential.
 Genevisible; Q9JHH2; MM.
 GO; GO:0009986; C:cell surface; IDA:MGI.
 GO; GO:0070442; C:integrin alphaIIb-beta3 complex; IDA:MGI.
 GO; GO:0005622; C:intracellular; IDA:MGI.
 GO; GO:0007596; P:blood coagulation; IMP:MGI.
 GO; GO:0007010; P:cytoskeleton organization; IMP:MGI.
 GO; GO:0042832; P:defense response to protozoan; IGI:MGI.
 GO; GO:0007599; P:hemostasis; IMP:MGI.
 GO; GO:0007229; P:integrin-mediated signaling pathway; IMP:MGI.
 GO; GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.
 GO; GO:0030886; P:negative regulation of myeloid dendritic cell activation; IGI:MGI.
 GO; GO:0070527; P:platelet aggregation; IMP:MGI.
 GO; GO:0050688; P:regulation of defense response to virus; IGI:MGI.
 InterPro; IPR000301; Tetraspanin.
 InterPro; IPR008952; Tetraspanin_EC2_sf.
 PIRSF; PIRSF002419; Tetraspanin; 1.
 SUPFAM; SSF48652; SSF48652; 1.
 2: Evidence at transcript level;
 Alternative splicing; Complete proteome; Membrane; Reference proteome;
 Transmembrane; Transmembrane helix.
 CHAIN         1    256       Tetraspanin-32.
                              /FTId=PRO_0000219279.
 TRANSMEM     15     35       Helical. {ECO:0000255}.
 TRANSMEM     61     81       Helical. {ECO:0000255}.
 TRANSMEM     90    110       Helical. {ECO:0000255}.
 TRANSMEM    203    223       Helical. {ECO:0000255}.
 VAR_SEQ       1     30       Missing (in isoform 1, isoform 2, isoform
                              3, isoform 4 and isoform 5).
                              {ECO:0000303|PubMed:10915772,
                              ECO:0000303|PubMed:10950922,
                              ECO:0000303|PubMed:11396961}.
                              /FTId=VSP_003939.
 VAR_SEQ     119    152       Missing (in isoform 4 and isoform 5).
                              {ECO:0000303|PubMed:10915772}.
                              /FTId=VSP_003940.
 VAR_SEQ     182    209       Missing (in isoform 2 and isoform 4).
                              {ECO:0000303|PubMed:10915772}.
                              /FTId=VSP_003941.
 VAR_SEQ     182    206       DCLQSIRNVLWTHYSIASILTCTSL -> IPWFPDPGTQPL
                              QMDLGWAGASMPC (in isoform 3 and isoform
                              5). {ECO:0000303|PubMed:10915772}.
                              /FTId=VSP_003942.
 VAR_SEQ     207    236       Missing (in isoform 3).
                              {ECO:0000303|PubMed:10915772}.
                              /FTId=VSP_003943.
 CONFLICT    174    174       Q -> L (in Ref. 1; AAG27268).
                              {ECO:0000305}.
 CONFLICT    235    235       Y -> F (in Ref. 1; AAG27268).
                              {ECO:0000305}.
 SEQUENCE   256 AA;  28906 MW;  A20EF0F6248FF67A CRC64;
 MGHWNRIKIA KCQILITNFL VLLLGLSMAT MVVVIHFGDH FTVIGHASLE RNPYETLRYW
 AFYVGISLAG LLSLGAALST IATVREAHGL MAAGFLCFAL SFCILVQVAF WRFYNPTQVE
 DAVLDTYDFV YDQAMKSPSS NWWQELAVIQ DTFLCCGKKS PFGLLVSTGA IMCQGREAMR
 EDCLQSIRNV LWTHYSIASI LTCTSLALTV YAMMLCAFLW FAIHSYHGLD RKGRYSLTPP
 RSHGFQTQEP SLFRWT

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