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Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)

 TSN5_HUMAN              Reviewed;         268 AA.
P62079; B2RDY2; O60628; O60746; Q6FHE5; Q9JLY1;
21-JUN-2004, integrated into UniProtKB/Swiss-Prot.
21-JUN-2004, sequence version 1.
07-NOV-2018, entry version 114.
RecName: Full=Tetraspanin-5;
Short=Tspan-5;
AltName: Full=Tetraspan NET-4;
AltName: Full=Transmembrane 4 superfamily member 9;
Name=TSPAN5; Synonyms=TM4SF9;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9714763; DOI=10.1016/S0167-4781(98)00087-6;
Todd S.C., Doctor V.S., Levy S.;
"Sequences and expression of six new members of the tetraspanin/TM4SF
family.";
Biochim. Biophys. Acta 1399:101-104(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Rubinstein E., Serru V., Boucheix C.;
"New tetraspans identified in the EST database.";
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
Korn B., Zuo D., Hu Y., LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
FUNCTION, INTERACTION WITH ADAM10, AND SUBCELLULAR LOCATION.
PubMed=26686862; DOI=10.1007/s00018-015-2111-z;
Jouannet S., Saint-Pol J., Fernandez L., Nguyen V., Charrin S.,
Boucheix C., Brou C., Milhiet P.E., Rubinstein E.;
"TspanC8 tetraspanins differentially regulate the cleavage of ADAM10
substrates, Notch activation and ADAM10 membrane
compartmentalization.";
Cell. Mol. Life Sci. 73:1895-1915(2016).
-!- FUNCTION: Regulates ADAM10 maturation and trafficking to the cell
surface. Promotes ADAM10-mediated cleavage of CD44.
{ECO:0000269|PubMed:26686862}.
-!- SUBUNIT: Interacts with ADAM10. {ECO:0000269|PubMed:26686862}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26686862};
Multi-pass membrane protein {ECO:0000305}.
-!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
{ECO:0000305}.
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EMBL; AF053455; AAC69712.1; -; Genomic_DNA.
EMBL; AF065389; AAC17120.1; -; mRNA.
EMBL; CR541809; CAG46608.1; -; mRNA.
EMBL; AK315723; BAG38079.1; -; mRNA.
EMBL; CH471057; EAX06074.1; -; Genomic_DNA.
EMBL; BC009704; AAH09704.1; -; mRNA.
CCDS; CCDS3646.1; -.
PIR; A59261; A59261.
RefSeq; NP_005714.2; NM_005723.3.
UniGene; Hs.118118; -.
ProteinModelPortal; P62079; -.
BioGrid; 115405; 63.
STRING; 9606.ENSP00000307701; -.
iPTMnet; P62079; -.
PhosphoSitePlus; P62079; -.
SwissPalm; P62079; -.
BioMuta; TSPAN5; -.
DMDM; 49065848; -.
MaxQB; P62079; -.
PaxDb; P62079; -.
PeptideAtlas; P62079; -.
PRIDE; P62079; -.
ProteomicsDB; 57363; -.
DNASU; 10098; -.
Ensembl; ENST00000305798; ENSP00000307701; ENSG00000168785.
GeneID; 10098; -.
KEGG; hsa:10098; -.
UCSC; uc003hub.4; human.
CTD; 10098; -.
DisGeNET; 10098; -.
EuPathDB; HostDB:ENSG00000168785.7; -.
GeneCards; TSPAN5; -.
HGNC; HGNC:17753; TSPAN5.
MIM; 613136; gene.
neXtProt; NX_P62079; -.
OpenTargets; ENSG00000168785; -.
PharmGKB; PA134864098; -.
eggNOG; KOG3882; Eukaryota.
eggNOG; ENOG4111IRY; LUCA.
GeneTree; ENSGT00880000137851; -.
HOGENOM; HOG000230652; -.
HOVERGEN; HBG108605; -.
InParanoid; P62079; -.
KO; K17345; -.
OMA; IYIKGCV; -.
OrthoDB; EOG091G0CHZ; -.
PhylomeDB; P62079; -.
TreeFam; TF313002; -.
ChiTaRS; TSPAN5; human.
GenomeRNAi; 10098; -.
PRO; PR:P62079; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000168785; Expressed in 220 organ(s), highest expression level in secondary oocyte.
CleanEx; HS_TSPAN5; -.
ExpressionAtlas; P62079; baseline and differential.
Genevisible; P62079; HS.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; IMP:UniProtKB.
GO; GO:0072659; P:protein localization to plasma membrane; IMP:UniProtKB.
GO; GO:0051604; P:protein maturation; IMP:UniProtKB.
Gene3D; 1.10.1450.10; -; 1.
InterPro; IPR000301; Tetraspanin.
InterPro; IPR018499; Tetraspanin/Peripherin.
InterPro; IPR018503; Tetraspanin_CS.
InterPro; IPR008952; Tetraspanin_EC2_sf.
Pfam; PF00335; Tetraspannin; 1.
PIRSF; PIRSF002419; Tetraspanin; 1.
PRINTS; PR00259; TMFOUR.
SUPFAM; SSF48652; SSF48652; 1.
PROSITE; PS00421; TM4_1; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Glycoprotein; Membrane;
Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 268 Tetraspanin-5.
/FTId=PRO_0000219243.
TOPO_DOM 1 17 Cytoplasmic. {ECO:0000255}.
TRANSMEM 18 38 Helical. {ECO:0000255}.
TOPO_DOM 39 61 Extracellular. {ECO:0000255}.
TRANSMEM 62 82 Helical. {ECO:0000255}.
TOPO_DOM 83 92 Cytoplasmic. {ECO:0000255}.
TRANSMEM 93 113 Helical. {ECO:0000255}.
TOPO_DOM 114 232 Extracellular. {ECO:0000255}.
TRANSMEM 233 253 Helical. {ECO:0000255}.
TOPO_DOM 254 268 Cytoplasmic. {ECO:0000255}.
CARBOHYD 49 49 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 169 169 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 174 174 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 232 232 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 91 94 Missing (in Ref. 1; AAC69712).
{ECO:0000305}.
SEQUENCE 268 AA; 30337 MW; 7F4480BD0FA6192D CRC64;
MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG ITFLGIGLWA WNEKGVLSNI SSITDLGGFD
PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI IFFLELTAGV LAFVFKDWIK
DQLYFFINNN IRAYRDDIDL QNLIDFTQEY WQCCGAFGAD DWNLNIYFNC TDSNASRERC
GVPFSCCTKD PAEDVINTQC GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF
IGIALLQIFG ICLAQNLVSD IEAVRASW


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