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Tetratricopeptide repeat protein 41 (TPR repeat protein 41) (Grp94-neighboring nucleotidase)

 TTC41_MOUSE             Reviewed;        1318 AA.
Q692V3; Q3TLE1; Q692V4; Q692V5; Q8K0V5;
01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
13-SEP-2004, sequence version 1.
20-JUN-2018, entry version 99.
RecName: Full=Tetratricopeptide repeat protein 41 {ECO:0000312|MGI:MGI:2387653};
Short=TPR repeat protein 41 {ECO:0000305};
AltName: Full=Grp94-neighboring nucleotidase {ECO:0000303|PubMed:15827139};
Name=Ttc41 {ECO:0000312|MGI:MGI:2387653};
Synonyms=GNN {ECO:0000312|MGI:MGI:2387653};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 4), SUBCELLULAR
LOCATION, AND TISSUE SPECIFICITY.
STRAIN=NIH Swiss;
PubMed=15827139; DOI=10.1128/JVI.79.9.5249-5258.2005;
van den Akker E., Vankan-Berkhoudt Y., Valk P.J.M., Loewenberg B.,
Delwel R.;
"The common viral insertion site Evi12 is located in the 5'-noncoding
region of Gnn, a novel gene with enhanced expression in two subclasses
of human acute myeloid leukemia.";
J. Virol. 79:5249-5258(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1297 (ISOFORM 3).
STRAIN=C57BL/6J;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15827139}.
-!- SUBCELLULAR LOCATION: Isoform 2: Cytoplasm.
-!- SUBCELLULAR LOCATION: Isoform 4: Cytoplasm.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1; Synonyms=Gnn3;
IsoId=Q692V3-1; Sequence=Displayed;
Name=2; Synonyms=Gnn2;
IsoId=Q692V3-2; Sequence=VSP_034500, VSP_034501;
Note=No experimental confirmation available.;
Name=3;
IsoId=Q692V3-3; Sequence=VSP_034497;
Note=No experimental confirmation available.;
Name=4; Synonyms=Gnn1;
IsoId=Q692V3-4; Sequence=VSP_034498, VSP_034499;
-!- TISSUE SPECIFICITY: Highly expressed in lung and myeloid leukemia
cell line (at protein level). Isoform 4: expressed in heart (at
protein level). {ECO:0000269|PubMed:15827139}.
-----------------------------------------------------------------------
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EMBL; AY651019; AAT81231.1; -; mRNA.
EMBL; AY651020; AAT81232.1; -; mRNA.
EMBL; AY651021; AAT81233.1; -; mRNA.
EMBL; AK166553; BAE38851.1; -; mRNA.
EMBL; BC030307; AAH30307.1; -; mRNA.
CCDS; CCDS24098.1; -. [Q692V3-1]
CCDS; CCDS24099.1; -. [Q692V3-4]
RefSeq; NP_001003910.2; NM_001003910.2.
RefSeq; NP_001003939.2; NM_001003939.2.
UniGene; Mm.440762; -.
ProteinModelPortal; Q692V3; -.
iPTMnet; Q692V3; -.
PhosphoSitePlus; Q692V3; -.
PaxDb; Q692V3; -.
PRIDE; Q692V3; -.
DNASU; 103220; -.
GeneID; 103220; -.
KEGG; mmu:103220; -.
UCSC; uc007gqj.1; mouse. [Q692V3-4]
UCSC; uc007gql.1; mouse. [Q692V3-2]
UCSC; uc011xkv.1; mouse. [Q692V3-3]
CTD; 103220; -.
MGI; MGI:2387653; Ttc41.
eggNOG; ENOG410IGT3; Eukaryota.
eggNOG; ENOG410XRF5; LUCA.
HOGENOM; HOG000172545; -.
HOVERGEN; HBG107956; -.
InParanoid; Q692V3; -.
PhylomeDB; Q692V3; -.
PRO; PR:Q692V3; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
InterPro; IPR007111; NACHT_NTPase.
InterPro; IPR027417; P-loop_NTPase.
Pfam; PF05729; NACHT; 1.
SUPFAM; SSF52540; SSF52540; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Cytoplasm;
Reference proteome; Repeat; TPR repeat.
CHAIN 1 1318 Tetratricopeptide repeat protein 41.
/FTId=PRO_0000342550.
REPEAT 401 434 TPR 1.
REPEAT 653 686 TPR 2.
REPEAT 819 852 TPR 3.
REPEAT 860 893 TPR 4.
REPEAT 993 1029 TPR 5.
REPEAT 1047 1084 TPR 6.
VAR_SEQ 1 831 Missing (in isoform 3).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_034497.
VAR_SEQ 401 409 PRLEMDFLN -> NRASLMGRK (in isoform 4).
{ECO:0000303|PubMed:15489334,
ECO:0000303|PubMed:15827139}.
/FTId=VSP_034498.
VAR_SEQ 410 1318 Missing (in isoform 4).
{ECO:0000303|PubMed:15489334,
ECO:0000303|PubMed:15827139}.
/FTId=VSP_034499.
VAR_SEQ 600 600 P -> V (in isoform 2).
{ECO:0000303|PubMed:15827139}.
/FTId=VSP_034500.
VAR_SEQ 601 1318 Missing (in isoform 2).
{ECO:0000303|PubMed:15827139}.
/FTId=VSP_034501.
CONFLICT 139 140 KK -> EQ (in Ref. 3; AAH30307).
{ECO:0000305}.
CONFLICT 355 355 N -> D (in Ref. 1; AAT81232).
{ECO:0000305}.
CONFLICT 917 917 E -> K (in Ref. 2; BAE38851).
{ECO:0000305}.
CONFLICT 1263 1263 R -> L (in Ref. 2; BAE38851).
{ECO:0000305}.
SEQUENCE 1318 AA; 150823 MW; DED7377763676059 CRC64;
MSDEASETGQ RYNGQPILKR QKPILPYICS TLDFQEERDF LAKSIFPRLN DICSSRGTYF
KAVDLRWSAV KAHKSFTSNQ FRQYSCLQSQ HLKLSLDYVN RCFPFFIGLL GQTYGDFLPD
YTPFLLSQVK DFESLSKGKK NLYIAAKNGY PWVLKTPNCS LTEFEIIQAV FRKKSQFQFF
YFRTSNSLLR TFNEEEEEEE EKLSSAYLLN EQGKMKVGKL KAKIIGKGLP VRFYRDLEEL
GDMVWKDWSA VVEKLYPFTT IMGNIDYKHS FENLYHEEFV ENCKQVFVTS KESNRTFEIL
ERFAIKDLDL DLDTDSTIAG SGLDSILRIN SLPTCKSILL LSGERGCGKS TLIANWVSNF
QSKHPGVLMI PYFVGSTCES CDIMSVIHYF VMELQHRANG PRLEMDFLNE DSNVLVFSLL
VEVFIAAISL KPCILVLDGI EELIGIYGIS GQKAKDFSWL PRSLPPHCKF ILSSVSSSLS
CKSLCARPDV KIVELNSIGD EDTKFNIFRQ HLSPADQERF GQSKPILRKK PNLSPLKLAI
IASELQECKI YRNEFQCLRE YLEVASVQEL WELILKRWVE DYSWTLKPKD TTLDTVIPGP
SGWVVDVLCL LCISHCGLAE DELLQLLDTM GYRDHHKVTA VHWAAFRQAT KTWIQEKPNG
LLYFQHQSLR SAVEHKLLGV STPVRESNPN VAQNSVNHKK AHFHQVLMRF FQRQTIFWRV
YQELPWHMKM SGYWEGLCNF ITNPSITDFI SKIQNPSLWT RLHLVHYWDV LLEAGNDVSE
AFLLSVAKIE GEQFQKLKKR TTLSVLECSL SEITAADKGR IILFIGSFLK LMGKINEAEK
LFLSAEDLLL QSPSMTEMLL RAQNAIGELY LEIGMTPKGL TYFQKAWSNL LRFTLSDLKI
SQELMKQKVK VMNNLAESAP GEFLKENHVL EYATEISKYV TGNPRDHATM KYTEGVLMLA
SGNAALAKLK FQECLTIRRW LFGNKNILVG EIMEFLADLL FFLLGENEKS QKKQAIEYYK
QVIKIKEKAD TVATCKLVRK HLSISLSDTL CKLAGQLLSG DFCHHATMEA VSYLYRSLDL
RAAHLGPTHA SIEGILHLLR EIQRSRGRRS WPQSMNHLFP NGSRNGFSLW ENVPKLNFHS
AQSSDTVNTA MCMNIRRFQR VKSTQPSLVS DKPKYVPGKG KKTLAPILCK SAEEKFQRQA
SDSQIWNSPR RQPARKKAAC PLKTVSLIDK NGLVRLSRQS VSSAELDSRK GLITSICRQP
LQRPHNVDNP WKSISELVSE KWLFHTPQYC FTPQKPGFPR RSQIESKLLK TSDDPNKE


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