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Thrombin-like enzyme BJ-48 (SVTLE BJ-48) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)

 VSP48_BOTJR             Reviewed;          22 AA.
P0DJF0;
21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
21-MAR-2012, sequence version 1.
22-NOV-2017, entry version 15.
RecName: Full=Thrombin-like enzyme BJ-48;
Short=SVTLE BJ-48;
EC=3.4.21.-;
AltName: Full=Fibrinogen-clotting enzyme;
AltName: Full=Snake venom serine protease;
Short=SVSP;
Flags: Fragment;
Bothrops jararacussu (Jararacussu).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
NCBI_TaxID=8726;
[1]
PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION,
BIOPHYSICOCHEMICAL PROPERTIES, GLYCOSYLATION, SIALIC ACID CONTENT, AND
MASS SPECTROMETRY.
TISSUE=Venom;
PubMed=17433397; DOI=10.1016/j.toxicon.2007.02.018;
Silva-Junior F.P., Guedes H.L., Garvey L.C., Aguiar A.S.,
Bourguignon S.C., Di Cera E., Giovanni-De-Simone S.;
"BJ-48, a novel thrombin-like enzyme from the Bothrops jararacussu
venom with high selectivity for Arg over Lys in P1: Role of N-
glycosylation in thermostability and active site accessibility.";
Toxicon 50:18-31(2007).
[2]
PROTEIN SEQUENCE OF 1-15.
TISSUE=Venom;
PubMed=15994137; DOI=10.1016/j.jchromb.2005.04.018;
De-Simone S.G., Correa-Netto C., Antunes O.A., De-Alencastro R.B.,
Silva F.P. Jr.;
"Biochemical and molecular modeling analysis of the ability of two p-
aminobenzamidine-based sorbents to selectively purify serine proteases
(fibrinogenases) from snake venoms.";
J. Chromatogr. B 822:1-9(2005).
[3]
CIRCULAR DICHROISM, AND SUBUNIT.
TISSUE=Venom;
PubMed=18069115; DOI=10.1016/j.bpc.2007.11.002;
Guedes H.L., Silva F.P. Jr., Netto C.C., de Salles C.M., Alexandre G.,
Oliveira C.L., Torriani I., De Simone S.G.;
"Structural characterization and low-resolution model of BJ-48, a
thrombin-like enzyme from Bothrops jararacussu venom.";
Biophys. Chem. 132:159-164(2008).
-!- FUNCTION: Thrombin-like serine protease which cleaves specifically
the Aalpha chain of human fibrinogen (FGA) to release
fibrinopeptide A. Also cleaves rapidly the Bbeta chain of human
fibrinogen (FGB). Is selective for Arg over Lys at position 1 of
the tripeptide substrates. {ECO:0000269|PubMed:17433397}.
-!- ENZYME REGULATION: Inhibited by aprotinin and dithiothreitol.
{ECO:0000269|PubMed:17433397}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=0.83 mM for BApNA {ECO:0000269|PubMed:17433397};
KM=0.4 mM for BAME {ECO:0000269|PubMed:17433397};
KM=0.6 mM for TAME {ECO:0000269|PubMed:17433397};
KM=0.3 mM for Nalpha-Tos-Gly-Pro-ME
{ECO:0000269|PubMed:17433397};
KM=0.36 mM for Nalpha-Tos-Gly-Pro-Arg-pNA
{ECO:0000269|PubMed:17433397};
pH dependence:
Optimum pH is 7.5. {ECO:0000269|PubMed:17433397};
Temperature dependence:
Optimum temperature is 50 degrees Celsius.
{ECO:0000269|PubMed:17433397};
-!- SUBUNIT: Monomer. {ECO:0000269|PubMed:18069115}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- PTM: Glycosylated; required for activity. Highly glycosylated with
42% of N-linked carbohydrates composed of
Fuc(1):GalN(4):GlcN(5):Gal(1):Man(2) and a high content of sialic
acid residues (8-12%). {ECO:0000269|PubMed:17433397}.
-!- MASS SPECTROMETRY: Mass=48036; Method=Electrospray; Range=1-?;
Evidence={ECO:0000269|PubMed:17433397};
-!- MISCELLANEOUS: Is inactive toward protein C, protease-activated
receptor-1 or inhibitors such as hirudin and antithrombin.
{ECO:0000305|PubMed:17433397}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
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GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
1: Evidence at protein level;
Blood coagulation cascade activating toxin; Direct protein sequencing;
Disulfide bond; Glycoprotein; Hemostasis impairing toxin; Hydrolase;
Protease; Secreted; Serine protease; Sialic acid; Toxin.
CHAIN 1 >22 Thrombin-like enzyme BJ-48.
/FTId=PRO_0000416020.
DOMAIN 1 >22 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
DISULFID 6 ? {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 22 ? {ECO:0000255|PROSITE-ProRule:PRU00274}.
UNSURE 6 6 Assigned by comparison with orthologs.
UNSURE 22 22 Assigned by comparison with orthologs.
NON_TER 22 22
SEQUENCE 22 AA; 2468 MW; 98D2A3AFB4EED743 CRC64;
VVGGDCIPQV PFLAFLYSEY FC


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