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Thrombin-like enzyme BpSP-1 (SVTLE BpSP-1) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Thrombin-like enzyme BpSP-I) (SVTLE BpSP-I) (Fragment)

 VSP1_BOTPA              Reviewed;          15 AA.
P0DJF1;
21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
21-MAR-2012, sequence version 1.
22-NOV-2017, entry version 16.
RecName: Full=Thrombin-like enzyme BpSP-1;
Short=SVTLE BpSP-1;
EC=3.4.21.-;
AltName: Full=Fibrinogen-clotting enzyme;
AltName: Full=Snake venom serine protease;
Short=SVSP;
AltName: Full=Thrombin-like enzyme BpSP-I;
Short=SVTLE BpSP-I;
Flags: Fragment;
Bothrops pauloensis (Neuwied's lancehead) (Bothrops neuwiedi
pauloensis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
NCBI_TaxID=1042543;
[1]
PROTEIN SEQUENCE, ENZYME REGULATION, GLYCOSYLATION, AND SIALIC ACID.
TISSUE=Venom;
PubMed=19539638; DOI=10.1016/j.toxicon.2009.05.040;
Costa F.L., Rodrigues R.S., Izidoro L.F., Menaldo D.L., Hamaguchi A.,
Homsi-Brandeburgo M.I., Fuly A.L., Soares S.G.,
Selistre-de-Araujo H.S., Barraviera B., Soares A.M., Rodrigues V.M.;
"Biochemical and functional properties of a thrombin-like enzyme
isolated from Bothrops pauloensis snake venom.";
Toxicon 54:725-735(2009).
-!- FUNCTION: Thrombin-like enzyme that has high clotting activity
upon bovine and human plasma. Has also fibrinogenoltic activity by
rapidly hydrolyzing Aalpha chain of fibrinogen (FGA), and
partially consumes Bbeta chain (FGB). Has high catalytic activity
upon substrates such as TAME, and specific substrates for thrombin
S-2238 and S-2288. Also hydrolyzes specific substrates for
kallikrein (S-2266 and S-2302), however, no release of kinin upon
plasma has been determined. When administered intraperitoneally in
mice, causes defibrinogenation, making the plasma incoagulable.
-!- ENZYME REGULATION: Inhibited PMSF, benzamidine, leupeptin, and
Cu(2+). {ECO:0000269|PubMed:19539638}.
-!- SUBUNIT: Monomer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- PTM: N-glycosylated. Contains sialic acid residues.
{ECO:0000269|PubMed:19539638}.
-!- MISCELLANEOUS: Does not act on the gamma chain of fibrinogen. Does
not act upon factor Xa (F10) and plasmin substrates. Does not
induce hemorrhage, myotoxicity or edema (PubMed:19539638).
{ECO:0000305|PubMed:19539638}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
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GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
1: Evidence at protein level;
Blood coagulation cascade activating toxin; Direct protein sequencing;
Disulfide bond; Glycoprotein; Hemostasis impairing toxin; Hydrolase;
Protease; Secreted; Serine protease; Sialic acid; Toxin.
CHAIN 1 >15 Thrombin-like enzyme BpSP-1.
/FTId=PRO_0000416021.
DOMAIN 1 >15 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
DISULFID 7 ? {ECO:0000255|PROSITE-ProRule:PRU00274}.
NON_TER 15 15
SEQUENCE 15 AA; 1658 MW; 81F3926227D52FD4 CRC64;
VIGGDECDIN EHPFL


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