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Thrombin-like enzyme Cdc SI (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)

 VSP1_CRODM              Reviewed;          10 AA.
P0DKX2;
06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
06-FEB-2013, sequence version 1.
22-NOV-2017, entry version 11.
RecName: Full=Thrombin-like enzyme Cdc SI;
Short=SVTLE;
EC=3.4.21.-;
AltName: Full=Fibrinogen-clotting enzyme;
AltName: Full=Snake venom serine protease;
Short=SVSP;
Flags: Fragment;
Crotalus durissus cumanensis (South American rattlesnake).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
NCBI_TaxID=184542;
[1]
PROTEIN SEQUENCE, FUNCTION, ENZYME REGULATION, BIOPHYSICOCHEMICAL
PROPERTIES, MASS SPECTROMETRY, AND IDENTIFICATION BY MASS
SPECTROMETRY.
TISSUE=Venom;
PubMed=23178323; DOI=10.1016/j.toxicon.2012.11.010;
Patino A.C., Pereanez J.A., Gutierrez J.M., Rucavado A.;
"Biochemical and biological characterization of a two serine
proteinases from Colombian Crotalus durissus cumanensis snake venom.";
Toxicon 63:32-43(2013).
-!- FUNCTION: Thrombin-like snake venom serine protease that
coagulates human plasma and bovine fibrinogen by hydrolysis of the
alpha chains (FGA) (minimum coagulation dose is 120 ug on
fibrinogen). Has fibrinogenolytic activities, and degrades
preferentially the Aalpha chain (FGA). Shows amidolytic activity
toward N-benzoyl-L-Arg-p-nitroanilide, has a lower activity than
Cdc SII. In vivo, intravenous injection induces
defibrin(ogen)ation and a loss of the righting reflex and
opisthotoxins, together with a typical gyroxin-like effect (18-20
minutes). Subcutaneous injection into the footpads induces
moderate edema. Potentiates local hemorrhagic activity induced by
metalloproteinases (BaP1). {ECO:0000269|PubMed:23178323}.
-!- ENZYME REGULATION: Strongly inhibited by PMSF. Not inhibited by
EDTA, aprotinin, pepstatin, leupeptin, and bestatin.
{ECO:0000269|PubMed:23178323}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=0.034 mM for N-benzoyl-L-Arg-p-nitroanilide
{ECO:0000269|PubMed:23178323};
Vmax=0.038 nmol/min/mg enzyme {ECO:0000269|PubMed:23178323};
-!- SUBUNIT: Monomer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- MASS SPECTROMETRY: Mass=28561.4; Method=MALDI; Range=1-?;
Evidence={ECO:0000269|PubMed:23178323};
-!- MISCELLANEOUS: Does not induce myotoxicity or hemorrhage, when
injected intramuscularly. Is not lethal when administered either
intravenously or intraperitoneally into mice (maximum dose tested
is 20 ug) (PubMed:23178323). {ECO:0000305|PubMed:23178323}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
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GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
1: Evidence at protein level;
Blood coagulation cascade activating toxin; Direct protein sequencing;
Disulfide bond; Fibrinogenolytic toxin; Hemostasis impairing toxin;
Hydrolase; Protease; Secreted; Serine protease; Toxin.
CHAIN 1 >10 Thrombin-like enzyme Cdc SI.
/FTId=PRO_0000421249.
DOMAIN 1 ? Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
DISULFID 7 ? {ECO:0000255|PROSITE-ProRule:PRU00274}.
UNSURE 7 7 Assigned by comparison with orthologs.
NON_TER 10 10
SEQUENCE 10 AA; 1033 MW; 252FDA4EBB1AA878 CRC64;
VIGGDECNIN


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