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Thrombin-like enzyme LMR-47 (SVTLE LM-47) (SVTLE LMR-47) (EC 3.4.21.74) (Fibrinogen-clotting enzyme) (Gyroxin analog) (Snake venom serine protease) (SVSP) (Venombin A) (Fragment)

 VSPF_LACMR              Reviewed;          30 AA.
Q9PRP4;
10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
05-DEC-2018, entry version 59.
RecName: Full=Thrombin-like enzyme LMR-47;
Short=SVTLE LM-47;
Short=SVTLE LMR-47;
EC=3.4.21.74;
AltName: Full=Fibrinogen-clotting enzyme;
AltName: Full=Gyroxin analog;
AltName: Full=Snake venom serine protease;
Short=SVSP;
AltName: Full=Venombin A;
Flags: Fragment;
Lachesis muta rhombeata (Bushmaster).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Lachesis.
NCBI_TaxID=60219;
[1]
PROTEIN SEQUENCE, BIOPHYSICOCHEMICAL PROPERTIES, AND GLYCOSYLATION.
TISSUE=Venom;
PubMed=8783450; DOI=10.1016/0041-0101(95)00159-X;
Aguiar A.S., Alves C.R., Melgarejo A., Giovanni-de-Simone S.;
"Purification and partial characterization of a thrombin-like/gyroxin
enzyme from bushmaster (Lachesis muta rhombeata) venom.";
Toxicon 34:555-565(1996).
[2]
PROTEIN SEQUENCE OF 1-25.
TISSUE=Venom;
PubMed=15994137; DOI=10.1016/j.jchromb.2005.04.018;
De-Simone S.G., Correa-Netto C., Antunes O.A., De-Alencastro R.B.,
Silva F.P. Jr.;
"Biochemical and molecular modeling analysis of the ability of two p-
aminobenzamidine-based sorbents to selectively purify serine proteases
(fibrinogenases) from snake venoms.";
J. Chromatogr. B 822:1-9(2005).
-!- FUNCTION: Thrombin-like snake venom serine protease that
specifically hydrolyzes the Aalpha chain of fibrinogen (FGA).
Exhibits strong N-p-tosyl-L-arginine methyl esterase activity, and
hydrolyzes tripeptide nitroanilide derivatives weakly or not at
all.
-!- CATALYTIC ACTIVITY:
Reaction=Selective cleavage of Arg-|-Xaa bond in fibrinogen, to
form fibrin, and release fibrinopeptide A. The specificity of
further degradation of fibrinogen varies with species origin of
the enzyme.; EC=3.4.21.74;
-!- ACTIVITY REGULATION: Inactivated by antipain, PMSF, TPCK,
leupeptin, pepstatin, EDTA, and E-64 (trans-
epoxysuccinylleucylamido(4-guanidino)butane).
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=12 uM for N-p-tosyl-L-arginine methyl ester (TAME)
{ECO:0000269|PubMed:8783450};
KM=589 uM for NBz-Pro-Phe-Arg-pNA {ECO:0000269|PubMed:8783450};
KM=1320 uM for NBz-Val-Gly-Arg-pNA {ECO:0000269|PubMed:8783450};
KM=857 uM for NBz-DL-Arg-pNA {ECO:0000269|PubMed:8783450};
Vmax=877.0 nmol/sec/mg enzyme for N-p-tosyl-L-arginine methyl
ester (TAME) {ECO:0000269|PubMed:8783450};
Vmax=51.0 nmol/sec/mg enzyme for NBz-Pro-Phe-Arg-pNA
{ECO:0000269|PubMed:8783450};
Vmax=75.0 nmol/sec/mg enzyme for NBz-Val-Gly-Arg-pNA
{ECO:0000269|PubMed:8783450};
Vmax=39.3 nmol/sec/mg enzyme for NBz-DL-Arg-pNA
{ECO:0000269|PubMed:8783450};
-!- SUBUNIT: Monomer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- PTM: Glycosylated. {ECO:0000269|PubMed:8783450}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
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SMR; Q9PRP4; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
1: Evidence at protein level;
Blood coagulation cascade activating toxin; Direct protein sequencing;
Fibrinogenolytic toxin; Glycoprotein; Hemostasis impairing toxin;
Hydrolase; Protease; Secreted; Serine protease; Toxin.
CHAIN 1 >30 Thrombin-like enzyme LMR-47.
/FTId=PRO_0000295178.
DOMAIN 1 >30 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
NON_TER 30 30
SEQUENCE 30 AA; 3171 MW; FA1B2609921853DB CRC64;
VIGGDECNIN EHRFLVALYD GLSGTFLCGG


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