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Thrombin-like enzyme acutin (SVTLE acutin) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Thrombin-like defibrase 1) (DFA1) (Fragment)

 VSPA_DEIAC              Reviewed;         234 AA.
Q9YGS1;
21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
10-MAY-2017, entry version 72.
RecName: Full=Thrombin-like enzyme acutin;
Short=SVTLE acutin;
EC=3.4.21.-;
AltName: Full=Fibrinogen-clotting enzyme;
AltName: Full=Snake venom serine protease;
Short=SVSP;
AltName: Full=Thrombin-like defibrase 1;
Short=DFA1;
Flags: Precursor; Fragment;
Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae;
Deinagkistrodon.
NCBI_TaxID=36307;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-16, AND FUNCTION.
TISSUE=Venom, and Venom gland;
PubMed=10049722; DOI=10.1006/bbrc.1999.0203;
Pan H., Du X., Yang G., Zhou Y., Wu X.;
"cDNA cloning and expression of acutin, a thrombin-like enzyme from
Agkistrodon acutus.";
Biochem. Biophys. Res. Commun. 255:412-415(1999).
-!- FUNCTION: Thrombin-like snake venom serine protease. Has arginyl
esterase and fibrinogen clotting activities.
{ECO:0000269|PubMed:10049722}.
-!- SUBUNIT: Monomer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- MISCELLANEOUS: Does not have phospholipase, fibrinolytic and
hemorrhagic activities. {ECO:0000305|PubMed:10049722}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
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EMBL; AF089847; AAD19350.1; -; mRNA.
PIR; JG0169; JG0169.
ProteinModelPortal; Q9YGS1; -.
SMR; Q9YGS1; -.
HOVERGEN; HBG013304; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
1: Evidence at protein level;
Blood coagulation cascade activating toxin; Direct protein sequencing;
Disulfide bond; Glycoprotein; Hemostasis impairing toxin; Hydrolase;
Protease; Secreted; Serine protease; Toxin; Zymogen.
PROPEP <1 1
/FTId=PRO_0000416383.
CHAIN 2 234 Thrombin-like enzyme acutin.
/FTId=PRO_0000416384.
DOMAIN 2 225 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
ACT_SITE 42 42 Charge relay system. {ECO:0000250}.
ACT_SITE 87 87 Charge relay system. {ECO:0000250}.
ACT_SITE 180 180 Charge relay system. {ECO:0000250}.
CARBOHYD 21 21 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 8 140 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 27 43 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 75 232 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 119 186 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 151 165 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 176 201 {ECO:0000255|PROSITE-ProRule:PRU00274}.
CONFLICT 6 6 D -> V (in Ref. 1; AA sequence).
{ECO:0000305}.
NON_TER 1 1
SEQUENCE 234 AA; 25408 MW; 3F1C3653E00BCA39 CRC64;
MVIGGDECDI NEHRFLVAFF NTTGFFCGGT LINPEWVVTA AHCDSTNFQM QLGVHSKKVL
NEDEQTRNPK EKFICPNKNN NEVLDKDIML IKLDKPISNS KHIAPLSLPS SPPSVGSVCR
IMGWGSITPV KETFPDVPYC ANINLLDHAV CQTGYPSCWR NTTLCAGFLE GGKDTCGGDS
GGPLICNGQF QGIVSYGAHS CGQGPKPGIY TNVFDYTDWI QRNIAGNTDA TCPP


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