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Thrombin-like enzyme gyroxin B1.4 (SVTLE gyroxin B1.4) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)

 VSP14_CRODU             Reviewed;         262 AA.
B0FXM2;
21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
26-FEB-2008, sequence version 1.
22-NOV-2017, entry version 43.
RecName: Full=Thrombin-like enzyme gyroxin B1.4;
Short=SVTLE gyroxin B1.4;
EC=3.4.21.-;
AltName: Full=Fibrinogen-clotting enzyme;
AltName: Full=Snake venom serine protease;
Short=SVSP;
Flags: Precursor;
Crotalus durissus terrificus (South American rattlesnake).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
NCBI_TaxID=8732;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Venom gland;
PubMed=19341755; DOI=10.1016/j.toxicon.2009.03.022;
Yonamine C.M., Prieto-da-Silva A.R., Magalhaes G.S.,
Radis-Baptista G., Morganti L., Ambiel F.C., Chura-Chambi R.M.,
Yamane T., Camillo M.A.;
"Cloning of serine protease cDNAs from Crotalus durissus terrificus
venom gland and expression of a functional Gyroxin homologue in COS-7
cells.";
Toxicon 54:110-120(2009).
[2]
FUNCTION.
PubMed=11137545; DOI=10.1016/S0041-0101(00)00222-1;
Camillo M.A., Arruda Paes P.C., Troncone L.R., Rogero J.R.;
"Gyroxin fails to modify in vitro release of labelled dopamine and
acetylcholine from rat and mouse striatal tissue.";
Toxicon 39:843-853(2001).
[3]
FUNCTION.
PubMed=20637222; DOI=10.1016/j.toxicon.2010.06.027;
Alves da Silva J.A., Oliveira K.C., Camillo M.A.;
"Gyroxin increases blood-brain barrier permeability to Evans blue dye
in mice.";
Toxicon 57:162-167(2011).
-!- FUNCTION: Thrombin-like snake venom serine protease. Displays a
specificity similar to trypsin. Releases only fibrinopeptide A in
the conversion of fibrinogen to fibrin. Shows coagulant, esterase
and amidase activities (By similarity). Reversibly increases the
permeability of the blood brain barrier (BBB) in mice. Induces the
barrel rotation syndrome in mice, which is manifested by gyroxin-
like, rapid rolling motions. This syndrome may be due to its
effect on BBB permeability, and certainly also to other actions
affecting endogenous substrates present in the endothelium,
nervous tissues or blood. {ECO:0000250,
ECO:0000269|PubMed:11137545, ECO:0000269|PubMed:20637222}.
-!- SUBUNIT: Monomer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- MISCELLANEOUS: Does not have phospholipase activity, does not
aggregate platelet, and does not affect the release of the
neurotransmitters dopamine and acetylcholine in the nervous
system. {ECO:0000305|PubMed:11137545}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
-!- CAUTION: Information taken from PubMed:20637222 and
PubMed:11137545 are not linked to a specific sequence. Hence, it
is not sure whether the function corresponds to this protein or to
a paralog. {ECO:0000305}.
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EMBL; EU360952; ABY65930.1; -; mRNA.
ProteinModelPortal; B0FXM2; -.
SMR; B0FXM2; -.
HOVERGEN; HBG013304; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
2: Evidence at transcript level;
Blood coagulation cascade activating toxin; Disulfide bond;
Glycoprotein; Hemostasis impairing toxin; Hydrolase; Protease;
Secreted; Serine protease; Signal; Toxin.
SIGNAL 1 18 {ECO:0000255}.
PROPEP 19 262 {ECO:0000250}.
/FTId=PRO_5000301406.
CHAIN 25 262 Thrombin-like enzyme gyroxin B1.4.
/FTId=PRO_5000301407.
DOMAIN 25 253 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
ACT_SITE 67 67 Charge relay system. {ECO:0000250}.
ACT_SITE 112 112 Charge relay system. {ECO:0000250}.
ACT_SITE 208 208 Charge relay system. {ECO:0000250}.
CARBOHYD 105 105 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 31 165 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 52 68 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 102 260 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 144 214 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 176 193 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 204 229 {ECO:0000255|PROSITE-ProRule:PRU00274}.
SEQUENCE 262 AA; 29262 MW; 1AD0EF3DD3A8E590 CRC64;
MVLIRVLANL LILQLSYAQK SSELVIGGDE CNINEHNFLV ALYEYWSQSF LCGGTLINGE
WVLTAAHCDR THFLIYVGVH DRSVQFDKEQ RRFPKEKYFF NCGNNFTKWD KDIMLIRLNK
PVRNNEHIAP LSLPSSPPSV GSVCRVMGWG QTTSPQNTLP DVPHCANINL LDYEVCRTAL
PQLRLPATSR ILCAGVLEGG IDTCNRDSGG PLICNGEFQG IVFWGPDPCA QPDKPALYSK
VFDHLDWIQS IIAGNTIVNC PP


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