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Thrombin-like enzyme saxthrombin (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Thrombin-like enzyme defibrase)

 VSPSX_GLOSA             Reviewed;         258 AA.
Q7SZE1;
24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
01-OCT-2003, sequence version 1.
10-MAY-2017, entry version 56.
RecName: Full=Thrombin-like enzyme saxthrombin;
Short=SVTLE;
EC=3.4.21.-;
AltName: Full=Fibrinogen-clotting enzyme;
AltName: Full=Snake venom serine protease;
Short=SVSP;
AltName: Full=Thrombin-like enzyme defibrase;
Flags: Precursor;
Gloydius saxatilis (Rock mamushi) (Gloydius intermedius saxatilis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Gloydius.
NCBI_TaxID=92067;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND SUBUNIT.
TISSUE=Venom, and Venom gland;
Sun D.J., Yang C.W., Yang T.S., Yan W.Q., Wang W.;
"Purification, cDNA cloning and sequence analysis of thrombin-like
enzyme from Gloydius saxatilis.";
Dong Wu Xue Bao 49:878-882(2003).
[2]
FUNCTION, AND CRYSTALLIZATION.
TISSUE=Venom;
PubMed=17671373; DOI=10.1107/S1744309107031429;
Wei W., Zhao W., Wang X., Teng M., Niu L.;
"Purification, crystallization and preliminary X-ray diffraction
analysis of saxthrombin, a thrombin-like enzyme from Gloydius
saxatilis venom.";
Acta Crystallogr. F 63:704-707(2007).
[3]
X-RAY CRYSTALLOGRAPHY (1.43 ANGSTROMS), AND ACTIVE SITES.
TISSUE=Venom;
PubMed=21821882; DOI=10.1107/S1744309111022548;
Huang K., Zhao W., Gao Y., Wei W., Teng M., Niu L.;
"Structure of saxthrombin, a thrombin-like enzyme from Gloydius
saxatilis.";
Acta Crystallogr. F 67:862-865(2011).
-!- FUNCTION: Thrombin-like snake venom serine protease that shows
strong blood coagulation activity in vitro.
{ECO:0000269|PubMed:17671373}.
-!- SUBUNIT: Monomer. {ECO:0000269|Ref.1}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
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EMBL; AY204243; AAP20638.1; -; mRNA.
PDB; 3S69; X-ray; 1.43 A; A=25-258.
PDBsum; 3S69; -.
ProteinModelPortal; Q7SZE1; -.
SMR; Q7SZE1; -.
MEROPS; S01.347; -.
HOVERGEN; HBG013304; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
1: Evidence at protein level;
3D-structure; Blood coagulation cascade activating toxin;
Disulfide bond; Glycoprotein; Hemostasis impairing toxin; Hydrolase;
Protease; Secreted; Serine protease; Signal; Toxin; Zymogen.
SIGNAL 1 18 {ECO:0000255}.
PROPEP 19 24 {ECO:0000250}.
/FTId=PRO_0000296366.
CHAIN 25 258 Thrombin-like enzyme saxthrombin.
/FTId=PRO_0000296367.
DOMAIN 25 249 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
ACT_SITE 65 65 Charge relay system.
{ECO:0000269|PubMed:21821882}.
ACT_SITE 110 110 Charge relay system.
{ECO:0000269|PubMed:21821882}.
ACT_SITE 204 204 Charge relay system.
{ECO:0000269|PubMed:21821882}.
CARBOHYD 44 44 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 251 251 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 31 163 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 50 66 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 98 256 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 142 210 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 174 189 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 200 225 {ECO:0000255|PROSITE-ProRule:PRU00274}.
STRAND 39 43 {ECO:0000244|PDB:3S69}.
STRAND 48 56 {ECO:0000244|PDB:3S69}.
STRAND 59 62 {ECO:0000244|PDB:3S69}.
HELIX 64 66 {ECO:0000244|PDB:3S69}.
STRAND 72 76 {ECO:0000244|PDB:3S69}.
STRAND 80 82 {ECO:0000244|PDB:3S69}.
STRAND 88 90 {ECO:0000244|PDB:3S69}.
STRAND 92 97 {ECO:0000244|PDB:3S69}.
STRAND 112 118 {ECO:0000244|PDB:3S69}.
STRAND 141 148 {ECO:0000244|PDB:3S69}.
STRAND 150 154 {ECO:0000244|PDB:3S69}.
STRAND 162 169 {ECO:0000244|PDB:3S69}.
HELIX 171 177 {ECO:0000244|PDB:3S69}.
STRAND 187 191 {ECO:0000244|PDB:3S69}.
STRAND 207 210 {ECO:0000244|PDB:3S69}.
STRAND 213 220 {ECO:0000244|PDB:3S69}.
STRAND 232 236 {ECO:0000244|PDB:3S69}.
HELIX 237 240 {ECO:0000244|PDB:3S69}.
HELIX 241 249 {ECO:0000244|PDB:3S69}.
SEQUENCE 258 AA; 28172 MW; 401F9260EC46CBF2 CRC64;
MVLIRVLANL LILQLSYAQK SSELVIGGDE CNINEHRSLV AFFNSTGFFC SGTLINEEWV
LTAAHCDNTN FQMKLGVHSK KVLNEDEQTR NPKEKFICPN KKNDEVLDKD IMLIKLDSRV
SNSEHIVPLS LPSSPPSVGS VCHIMGWGSI TPIKVTYPDV PYCAYINLLD DAVCQAGYPE
LLTEYRTLCA GILEGGKDTC GGDSGGPLIC NGQFQGIVSF GAHPCGQGLK PGVYTKVFDY
NHWIQSIIAG NTTVTCPQ


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