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Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)

 KTHY_JANMA              Reviewed;         204 AA.
A6SZH9;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
21-AUG-2007, sequence version 1.
20-JUN-2018, entry version 62.
RecName: Full=Thymidylate kinase {ECO:0000255|HAMAP-Rule:MF_00165};
EC=2.7.4.9 {ECO:0000255|HAMAP-Rule:MF_00165};
AltName: Full=dTMP kinase {ECO:0000255|HAMAP-Rule:MF_00165};
Name=tmk {ECO:0000255|HAMAP-Rule:MF_00165};
OrderedLocusNames=mma_1986;
Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis).
Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
Oxalobacteraceae; Janthinobacterium.
NCBI_TaxID=375286;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Marseille;
PubMed=17722982; DOI=10.1371/journal.pgen.0030138;
Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M.,
Raoult D., Drancourt M.;
"Genome analysis of Minibacterium massiliensis highlights the
convergent evolution of water-living bacteria.";
PLoS Genet. 3:1454-1463(2007).
-!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
salvage pathways of dTTP synthesis. {ECO:0000255|HAMAP-
Rule:MF_00165}.
-!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP. {ECO:0000255|HAMAP-
Rule:MF_00165}.
-!- SIMILARITY: Belongs to the thymidylate kinase family.
{ECO:0000255|HAMAP-Rule:MF_00165}.
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EMBL; CP000269; ABR88747.1; -; Genomic_DNA.
RefSeq; WP_012079839.1; NC_009659.1.
ProteinModelPortal; A6SZH9; -.
SMR; A6SZH9; -.
STRING; 375286.mma_1986; -.
PRIDE; A6SZH9; -.
EnsemblBacteria; ABR88747; ABR88747; mma_1986.
KEGG; mms:mma_1986; -.
eggNOG; ENOG4108ZMD; Bacteria.
eggNOG; COG0125; LUCA.
HOGENOM; HOG000229078; -.
KO; K00943; -.
OMA; FLYTADH; -.
OrthoDB; POG091H02B9; -.
BioCyc; JSP375286:MMA_RS10280-MONOMER; -.
Proteomes; UP000006388; Chromosome.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
HAMAP; MF_00165; Thymidylate_kinase; 1.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR018094; Thymidylate_kinase.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00041; DTMP_kinase; 1.
3: Inferred from homology;
ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
Nucleotide-binding; Reference proteome; Transferase.
CHAIN 1 204 Thymidylate kinase.
/FTId=PRO_1000023203.
NP_BIND 11 18 ATP. {ECO:0000255|HAMAP-Rule:MF_00165}.
SEQUENCE 204 AA; 23008 MW; 36AF29433BFD0856 CRC64;
MTTGKFITFE GIDGAGKSTH LSFVAELLCE RKKTVVVTRE PGGTSLGEEL REILLHEKMH
LETEALLMFA ARREHIAQVI APALERGDWV ISDRFTDATF AYQGGGRKLD RAKLNALEQW
VHPHLQPHLT LLFDVPLDVA RARLDATRTL DKFEQEKAEF FAATRAEYLR RAAEFPQRFH
VIDSTRSIAA IQEQLRAIVA GIDS


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