GENTAUR Molecular Products.

 KTHY_DESAG              Reviewed;         212 AA.
 Q30YW1;
 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
 06-DEC-2005, sequence version 1.
 28-FEB-2018, entry version 74.
 RecName: Full=Thymidylate kinase {ECO:0000255|HAMAP-Rule:MF_00165};
          EC=2.7.4.9 {ECO:0000255|HAMAP-Rule:MF_00165};
 AltName: Full=dTMP kinase {ECO:0000255|HAMAP-Rule:MF_00165};
 Name=tmk {ECO:0000255|HAMAP-Rule:MF_00165};
 OrderedLocusNames=Dde_2338;
 Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans
 (strain G20)).
 Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
 Desulfovibrionaceae; Desulfovibrio.
 NCBI_TaxID=207559;
 [1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=G20;
 PubMed=21685289; DOI=10.1128/JB.05400-11;
 Hauser L.J., Land M.L., Brown S.D., Larimer F., Keller K.L.,
 Rapp-Giles B.J., Price M.N., Lin M., Bruce D.C., Detter J.C.,
 Tapia R., Han C.S., Goodwin L.A., Cheng J.F., Pitluck S., Copeland A.,
 Lucas S., Nolan M., Lapidus A.L., Palumbo A.V., Wall J.D.;
 "Complete genome sequence and updated annotation of Desulfovibrio
 alaskensis G20.";
 J. Bacteriol. 193:4268-4269(2011).
 -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
     salvage pathways of dTTP synthesis. {ECO:0000255|HAMAP-
     Rule:MF_00165}.
 -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP. {ECO:0000255|HAMAP-
     Rule:MF_00165}.
 -!- SIMILARITY: Belongs to the thymidylate kinase family.
     {ECO:0000255|HAMAP-Rule:MF_00165}.
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 EMBL; CP000112; ABB39135.1; -; Genomic_DNA.
 RefSeq; WP_011368212.1; NC_007519.1.
 ProteinModelPortal; Q30YW1; -.
 SMR; Q30YW1; -.
 STRING; 207559.Dde_2338; -.
 EnsemblBacteria; ABB39135; ABB39135; Dde_2338.
 KEGG; dde:Dde_2338; -.
 eggNOG; ENOG4108ZMD; Bacteria.
 eggNOG; COG0125; LUCA.
 HOGENOM; HOG000229077; -.
 KO; K00943; -.
 OMA; FLYTADH; -.
 OrthoDB; POG091H02B9; -.
 BioCyc; DALA207559:G1G52-2190-MONOMER; -.
 Proteomes; UP000002710; Chromosome.
 GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
 GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
 HAMAP; MF_00165; Thymidylate_kinase; 1.
 InterPro; IPR027417; P-loop_NTPase.
 InterPro; IPR018095; Thymidylate_kin_CS.
 InterPro; IPR018094; Thymidylate_kinase.
 SUPFAM; SSF52540; SSF52540; 1.
 TIGRFAMs; TIGR00041; DTMP_kinase; 1.
 PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
 3: Inferred from homology;
 ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
 Nucleotide-binding; Reference proteome; Transferase.
 CHAIN         1    212       Thymidylate kinase.
                              /FTId=PRO_1000023184.
 NP_BIND       7     14       ATP. {ECO:0000255|HAMAP-Rule:MF_00165}.
 SEQUENCE   212 AA;  23361 MW;  3BD3D69604A1BE00 CRC64;
 MFITFEGIEG SGKSTALARL KDWLQEHGHG ATLTREPGGS RLGGILRSIL LDIGNDDLTG
 ETELFLYLAD RSQHVHQVIR PALAEGVAVI SDRYADSTVV YQGYGRGLDP ALLHRLNDVA
 VRGLWPDLTL LFDLEPEIGL KRATTRNLRE GTGATEGRFE AESLAFHTRV REGYLTWAAL
 NKERFRIIDA AASPDEVFEQ VRSAVADVFT IG

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