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Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)
KTHY_DICDI Reviewed; 222 AA.
Q54GN2;
08-APR-2008, integrated into UniProtKB/Swiss-Prot.
24-MAY-2005, sequence version 1.
28-FEB-2018, entry version 78.
RecName: Full=Thymidylate kinase;
EC=2.7.4.9;
AltName: Full=dTMP kinase;
Name=dtymk; Synonyms=tmkA; ORFNames=DDB_G0290033;
Dictyostelium discoideum (Slime mold).
Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales;
Dictyosteliaceae; Dictyostelium.
NCBI_TaxID=44689;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
PubMed=15875012; DOI=10.1038/nature03481;
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
-!- FUNCTION: Catalyzes the conversion of dTMP to dTDP.
-!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
-!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
-!- SIMILARITY: Belongs to the thymidylate kinase family.
{ECO:0000305}.
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EMBL; AAFI02000151; EAL62422.1; -; Genomic_DNA.
RefSeq; XP_635930.1; XM_630838.1.
ProteinModelPortal; Q54GN2; -.
SMR; Q54GN2; -.
STRING; 44689.DDB0230101; -.
PaxDb; Q54GN2; -.
EnsemblProtists; EAL62422; EAL62422; DDB_G0290033.
GeneID; 8627451; -.
KEGG; ddi:DDB_G0290033; -.
dictyBase; DDB_G0290033; dtymk.
eggNOG; KOG3327; Eukaryota.
eggNOG; COG0125; LUCA.
InParanoid; Q54GN2; -.
KO; K00943; -.
OMA; TPIGQMI; -.
PhylomeDB; Q54GN2; -.
Reactome; R-DDI-499943; Interconversion of nucleotide di- and triphosphates.
UniPathway; UPA00575; -.
PRO; PR:Q54GN2; -.
Proteomes; UP000002195; Chromosome 5.
Proteomes; UP000002195; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004798; F:thymidylate kinase activity; ISS:dictyBase.
GO; GO:0009041; F:uridylate kinase activity; ISS:dictyBase.
GO; GO:0006233; P:dTDP biosynthetic process; ISS:dictyBase.
GO; GO:0006235; P:dTTP biosynthetic process; ISS:dictyBase.
GO; GO:0006227; P:dUDP biosynthetic process; ISS:dictyBase.
HAMAP; MF_00165; Thymidylate_kinase; 1.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR018095; Thymidylate_kin_CS.
InterPro; IPR018094; Thymidylate_kinase.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00041; DTMP_kinase; 1.
PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
3: Inferred from homology;
ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
Nucleotide-binding; Reference proteome; Transferase.
CHAIN 1 222 Thymidylate kinase.
/FTId=PRO_0000328101.
NP_BIND 26 33 ATP. {ECO:0000255}.
SEQUENCE 222 AA; 25582 MW; AFB7D8A5C0858C9D CRC64;
MINTKKEEGE EEKTMIKRGL FILFEGVDRV GKSTQVQSLT NHISNVQKLP TKSLRFPDRT
TPIGQIINQY LQNATNMDDR ALHLLFSSNR WEARDSILEL LNNGTNIVVD RYSYSGVAYS
AAKGIDFDWC YACEKGLPKP DLIFYLSMSS EDATKRGEYG GERYEKLEFQ KKIKQIYEEK
LVDDQWKIIN ANRSIDEISN EISSIFDSEF KKIQLTSIAK LE
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Pathways :
WP1493: Carbon assimilation C4 pathway
WP1567: Glycolysis and Gluconeogenesis
WP1619: Amino sugar and nucleotide sugar metabolism
WP1653: Galactose metabolism
WP1681: Pantothenate and CoA biosynthesis
WP1701: Starch and sucrose metabolism
WP1703: Streptomycin biosynthesis
WP1844: MAP kinase cascade
WP1946: Cori Cycle
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP253: Glycolysis
WP32: Translation Factors
Related Genes :
[thyX Rv2754c MTV002.19c] Flavin-dependent thymidylate synthase (FDTS) (EC 2.1.1.148) (FAD-dependent thymidylate synthase) (Thymidylate synthase ThyX) (TS) (TSase)
[thyX thy1 TM_0449] Flavin-dependent thymidylate synthase (FDTS) (EC 2.1.1.148) (FAD-dependent thymidylate synthase) (Thymidylate synthase ThyX) (TS) (TSase)
[thyX HP_1533] Flavin-dependent thymidylate synthase (FDTS) (EC 2.1.1.148) (FAD-dependent thymidylate synthase) (Thymidylate synthase ThyX) (TS) (TSase)
[] Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
[] Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
[TYMS TS OK/SW-cl.29] Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
[thyA b2827 JW2795] Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
[CDC21 CRT9 TMP1 YOR074C YOR29-25] Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) (Cell division cycle protein 21) (Constitutive RNR3 transcription protein 9)
[tmk Rv3247c] Thymidylate kinase (EC 2.7.4.9) (Thymidine monophosphate kinase) (dTMP kinase) (TMPK)
[THY-1 At2g16370 F16F14.13] Bifunctional dihydrofolate reductase-thymidylate synthase 1 (DHFR-TS 1) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
[Tyms] Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
[Tyms] Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
[tmk ycfG b1098 JW1084] Thymidylate kinase (EC 2.7.4.9) (Thymidine monophosphate kinase) (dTMP kinase) (TMPK)
[CDC8 YJR057W J1715] Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)
[thyA Rv2764c MTV002.29c] Thymidylate synthase ThyA (TS) (TSase) (EC 2.1.1.45)
[DTYMK CDC8 TMPK TYMK] Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)
[] Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
[ZEU1 At5g59440] Thymidylate kinase (AtTMPK) (EC 2.7.4.9) (Protein ZEUS1)
[ENOSF1 RTS TYMSAS] Mitochondrial enolase superfamily member 1 (EC 4.2.1.68) (Antisense RNA to thymidylate synthase) (rTS) (L-fuconate dehydratase)
[Dtymk Tmk] Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)
[THY-2 At4g34570 T4L20.150] Bifunctional dihydrofolate reductase-thymidylate synthase 2 (DHFR-TS 2) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
[thyA thy1 DDB_G0280045] Flavin-dependent thymidylate synthase (FDTS) (EC 2.1.1.148) (FAD-dependent thymidylate synthase) (Thymidylate synthase thy1) (TS) (TSase)
[thyA2 thyB BSU21820] Thymidylate synthase 2 (TS 2) (TSase 2) (EC 2.1.1.45) (Thymidylate synthase A) (TS A) (TSase A)
[] Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
[SPAC15E1.04] Probable thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
[] Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
[thyX thy1 PF0540] Flavin-dependent thymidylate synthase (FDTS) (EC 2.1.1.148) (FAD-dependent thymidylate synthase) (Thymidylate synthase ThyX) (TS) (TSase)
[] Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]
[thyX aq_640] Flavin-dependent thymidylate synthase (FDTS) (EC 2.1.1.148) (FAD-dependent thymidylate synthase) (Thymidylate synthase ThyX) (TS) (TSase)
[thyA1 BSU17680] Thymidylate synthase 1 (TS 1) (TSase 1) (EC 2.1.1.45) (Thymidylate synthase A) (TS A) (TSase A)
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