GENTAUR Molecular Products.

 KTHY_DICDI              Reviewed;         222 AA.
 Q54GN2;
 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
 24-MAY-2005, sequence version 1.
 05-DEC-2018, entry version 81.
 RecName: Full=Thymidylate kinase;
          EC=2.7.4.9;
 AltName: Full=dTMP kinase;
 Name=dtymk; Synonyms=tmkA; ORFNames=DDB_G0290033;
 Dictyostelium discoideum (Slime mold).
 Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales;
 Dictyosteliaceae; Dictyostelium.
 NCBI_TaxID=44689;
 [1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=AX4;
 PubMed=15875012; DOI=10.1038/nature03481;
 Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
 Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
 Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
 Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
 Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
 Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
 Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
 Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
 Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
 Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
 Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
 Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
 Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
 Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
 Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
 Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
 Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
 Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
 Kuspa A.;
 "The genome of the social amoeba Dictyostelium discoideum.";
 Nature 435:43-57(2005).
 -!- FUNCTION: Catalyzes the conversion of dTMP to dTDP.
 -!- CATALYTIC ACTIVITY:
     Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
       ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
       ChEBI:CHEBI:456216; EC=2.7.4.9;
 -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
 -!- SIMILARITY: Belongs to the thymidylate kinase family.
     {ECO:0000305}.
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 EMBL; AAFI02000151; EAL62422.1; -; Genomic_DNA.
 RefSeq; XP_635930.1; XM_630838.1.
 ProteinModelPortal; Q54GN2; -.
 SMR; Q54GN2; -.
 STRING; 44689.DDB0230101; -.
 PaxDb; Q54GN2; -.
 EnsemblProtists; EAL62422; EAL62422; DDB_G0290033.
 GeneID; 8627451; -.
 KEGG; ddi:DDB_G0290033; -.
 dictyBase; DDB_G0290033; dtymk.
 eggNOG; KOG3327; Eukaryota.
 eggNOG; COG0125; LUCA.
 InParanoid; Q54GN2; -.
 KO; K00943; -.
 OMA; FEGVDRC; -.
 PhylomeDB; Q54GN2; -.
 Reactome; R-DDI-499943; Interconversion of nucleotide di- and triphosphates.
 UniPathway; UPA00575; -.
 PRO; PR:Q54GN2; -.
 Proteomes; UP000002195; Chromosome 5.
 Proteomes; UP000002195; Unassembled WGS sequence.
 GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
 GO; GO:0005829; C:cytosol; IBA:GO_Central.
 GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
 GO; GO:0005634; C:nucleus; IBA:GO_Central.
 GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO; GO:0004550; F:nucleoside diphosphate kinase activity; IBA:GO_Central.
 GO; GO:0004798; F:thymidylate kinase activity; ISS:dictyBase.
 GO; GO:0009041; F:uridylate kinase activity; ISS:dictyBase.
 GO; GO:0006233; P:dTDP biosynthetic process; ISS:dictyBase.
 GO; GO:0006235; P:dTTP biosynthetic process; ISS:dictyBase.
 GO; GO:0006227; P:dUDP biosynthetic process; ISS:dictyBase.
 HAMAP; MF_00165; Thymidylate_kinase; 1.
 InterPro; IPR027417; P-loop_NTPase.
 InterPro; IPR018095; Thymidylate_kin_CS.
 InterPro; IPR039430; Thymidylate_kin_like_dom.
 InterPro; IPR018094; Thymidylate_kinase.
 Pfam; PF02223; Thymidylate_kin; 1.
 SUPFAM; SSF52540; SSF52540; 1.
 TIGRFAMs; TIGR00041; DTMP_kinase; 1.
 PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
 3: Inferred from homology;
 ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
 Nucleotide-binding; Reference proteome; Transferase.
 CHAIN         1    222       Thymidylate kinase.
                              /FTId=PRO_0000328101.
 NP_BIND      26     33       ATP. {ECO:0000255}.
 SEQUENCE   222 AA;  25582 MW;  AFB7D8A5C0858C9D CRC64;
 MINTKKEEGE EEKTMIKRGL FILFEGVDRV GKSTQVQSLT NHISNVQKLP TKSLRFPDRT
 TPIGQIINQY LQNATNMDDR ALHLLFSSNR WEARDSILEL LNNGTNIVVD RYSYSGVAYS
 AAKGIDFDWC YACEKGLPKP DLIFYLSMSS EDATKRGEYG GERYEKLEFQ KKIKQIYEEK
 LVDDQWKIIN ANRSIDEISN EISSIFDSEF KKIQLTSIAK LE

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