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Toll like receptor 3

 E2RIV9_CANLF            Unreviewed;       905 AA.
E2RIV9;
30-NOV-2010, integrated into UniProtKB/TrEMBL.
31-OCT-2012, sequence version 2.
12-SEP-2018, entry version 69.
SubName: Full=Toll like receptor 3 {ECO:0000313|Ensembl:ENSCAFP00000011004};
Name=TLR3 {ECO:0000313|Ensembl:ENSCAFP00000011004,
ECO:0000313|VGNC:VGNC:51831};
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000011004, ECO:0000313|Proteomes:UP000002254};
[1] {ECO:0000313|Ensembl:ENSCAFP00000011004, ECO:0000313|Proteomes:UP000002254}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000011004,
ECO:0000313|Proteomes:UP000002254};
PubMed=16341006; DOI=10.1038/nature04338;
Broad Sequencing Platform;
Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
"Genome sequence, comparative analysis and haplotype structure of the
domestic dog.";
Nature 438:803-819(2005).
[2] {ECO:0000313|Ensembl:ENSCAFP00000011004}
IDENTIFICATION.
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000011004};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the Toll-like receptor family.
{ECO:0000256|SAAS:SAAS00598595}.
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EMBL; AAEX03010493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_005630024.1; XM_005629967.1.
RefSeq; XP_005630025.1; XM_005629968.2.
RefSeq; XP_013975660.1; XM_014120185.1.
RefSeq; XP_540020.4; XM_540020.4.
UniGene; Cfa.48411; -.
ProteinModelPortal; E2RIV9; -.
STRING; 9615.ENSCAFP00000011004; -.
PaxDb; E2RIV9; -.
Ensembl; ENSCAFT00000011868; ENSCAFP00000011004; ENSCAFG00000007406.
GeneID; 482905; -.
KEGG; cfa:482905; -.
CTD; 7098; -.
VGNC; VGNC:51831; TLR3.
eggNOG; KOG4641; Eukaryota.
eggNOG; COG4886; LUCA.
GeneTree; ENSGT00760000119006; -.
InParanoid; E2RIV9; -.
KO; K05401; -.
OMA; HLLKDPL; -.
OrthoDB; EOG091G02Q2; -.
TreeFam; TF325595; -.
Reactome; R-CFA-1679131; Trafficking and processing of endosomal TLR.
Proteomes; UP000002254; Chromosome 16.
Bgee; ENSCAFG00000007406; Expressed in 3 organ(s), highest expression level in liver.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; IEA:InterPro.
GO; GO:0097527; P:necroptotic signaling pathway; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro.
GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl.
GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl.
GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0034123; P:positive regulation of toll-like receptor signaling pathway; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0034346; P:positive regulation of type III interferon production; IEA:Ensembl.
GO; GO:0002730; P:regulation of dendritic cell cytokine production; IEA:Ensembl.
GO; GO:0043331; P:response to dsRNA; IBA:GO_Central.
GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl.
GO; GO:0034138; P:toll-like receptor 3 signaling pathway; IEA:InterPro.
GO; GO:0002224; P:toll-like receptor signaling pathway; IBA:GO_Central.
Gene3D; 3.40.50.10140; -; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR000483; Cys-rich_flank_reg_C.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000157; TIR_dom.
InterPro; IPR027173; TLR3.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
PANTHER; PTHR44599; PTHR44599; 1.
Pfam; PF00560; LRR_1; 1.
Pfam; PF13855; LRR_8; 6.
Pfam; PF01582; TIR; 1.
SMART; SM00369; LRR_TYP; 18.
SMART; SM00082; LRRCT; 1.
SMART; SM00255; TIR; 1.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS51450; LRR; 20.
PROSITE; PS50104; TIR; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000002254};
Immunity {ECO:0000256|SAAS:SAAS00472892};
Innate immunity {ECO:0000256|SAAS:SAAS00472892};
Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|SAAS:SAAS00473103};
Reference proteome {ECO:0000313|Proteomes:UP000002254};
Repeat {ECO:0000256|SAAS:SAAS00597472};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 24 {ECO:0000256|SAM:SignalP}.
CHAIN 25 905 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003163595.
TRANSMEM 705 726 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 755 859 TIR. {ECO:0000259|PROSITE:PS50104}.
SEQUENCE 905 AA; 103971 MW; 8A1895486D406DB5 CRC64;
MSQSLLYHIY SFLGLLPFWI LCTSSTNKCV VRHEVADCSH LKLTQVPDDL PANITVLNLT
HNQLRRLPPA NFTRYSQLTI LDGGFNSISK LEPELCQKLP LLEILNLQHN ELSHLSDQTF
VFCVNLTELH LMSNSIKIIQ NNPFRSLKNL VKLDLSHNGL SSTKLGSQLQ LENLQELLLS
NNKINVLRRE ELDFLGNSSL EKLELSSNPI KEFSPGCFHA IGKLFGLSLN NVQLNPSLTE
NLCLELSNTS IQNLSLSNTQ LHRTSNMTFL GLKHTNLTML DLSHNNLNVI ENNSFVWLPH
LEYFLLEYNN IEHLFSHSFY GLLNVRYLDL KRSFAKQSTS LASHPRIDDF SFQWLKCLQY
LNMEDNYFAG IKSNMFTGLI KLKHLSLSNS FTSLQTLTNE TFLSLAQSPL ITLNLTKNKI
SKIESGAFSW LGHLQVLDLG LNEIGQELTG QEWRGLENIV EIYLSYNKYL QLTSSSFALI
PSLRRLMLRR TALRNVDSSP SPFHPLRNLN ILDLSNNNIA NINDELLEGL EKLEILDMQH
NNLARLWKHA NPGGPVHFLK GLSHLHILNL ESNGFDEIPA EVFKGLSELK SIDLGLNNLN
IFPSSLFNDQ VSLKSLNLQK NLITSVEKNV FGPAFRNLSN LDMSFNPFDC TCESIAWFVN
WINSTHTNIS ELSSHYLCNT PPQYHGFPVM LFDISPCKDS APFEIFFIIN TSVLLTFIFI
VLLIHFEGWR ISFYWNVSVH RILGFKEIDK QPEQFEYAAY IIHAYKDRDW VWEHFSPMEE
KDETLKFCLE ERDFEAGVLE LESIINSIKK SRKTIFVITQ HLLKDPLCKR FKVHQAVQQA
IEQNLESIIL IFLEEIPDYK LNHALCLRRG MFKSHCILNW PVQKERVNAF HHKLQVALGS
RNSIH


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