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Toll like receptor 3

 F6TNZ8_MONDO            Unreviewed;       905 AA.
F6TNZ8;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
12-SEP-2018, entry version 58.
SubName: Full=Toll like receptor 3 {ECO:0000313|Ensembl:ENSMODP00000005984};
Name=TLR3 {ECO:0000313|Ensembl:ENSMODP00000005984};
Monodelphis domestica (Gray short-tailed opossum).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000005984, ECO:0000313|Proteomes:UP000002280};
[1] {ECO:0000313|Ensembl:ENSMODP00000005984, ECO:0000313|Proteomes:UP000002280}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=17495919; DOI=10.1038/nature05805;
Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
Samollow P.B., Lander E.S., Lindblad-Toh K.;
"Genome of the marsupial Monodelphis domestica reveals innovation in
non-coding sequences.";
Nature 447:167-177(2007).
[2] {ECO:0000313|Ensembl:ENSMODP00000005984}
IDENTIFICATION.
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the Toll-like receptor family.
{ECO:0000256|SAAS:SAAS00598595}.
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RefSeq; XP_001368540.1; XM_001368503.2.
RefSeq; XP_007496096.1; XM_007496034.2.
RefSeq; XP_007496097.1; XM_007496035.1.
ProteinModelPortal; F6TNZ8; -.
STRING; 13616.ENSMODP00000005984; -.
Ensembl; ENSMODT00000006110; ENSMODP00000005984; ENSMODG00000004861.
GeneID; 100014223; -.
KEGG; mdo:100014223; -.
CTD; 7098; -.
eggNOG; KOG4641; Eukaryota.
eggNOG; COG4886; LUCA.
GeneTree; ENSGT00760000119006; -.
InParanoid; F6TNZ8; -.
KO; K05401; -.
OMA; HLLKDPL; -.
OrthoDB; EOG091G02Q2; -.
TreeFam; TF325595; -.
Proteomes; UP000002280; Chromosome 5.
Bgee; ENSMODG00000004861; Expressed in 6 organ(s), highest expression level in adult mammalian kidney.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0007252; P:I-kappaB phosphorylation; IEA:Ensembl.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; IEA:InterPro.
GO; GO:0097527; P:necroptotic signaling pathway; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro.
GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl.
GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl.
GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0034123; P:positive regulation of toll-like receptor signaling pathway; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0034346; P:positive regulation of type III interferon production; IEA:Ensembl.
GO; GO:0002730; P:regulation of dendritic cell cytokine production; IEA:Ensembl.
GO; GO:0043331; P:response to dsRNA; IBA:GO_Central.
GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl.
GO; GO:0034138; P:toll-like receptor 3 signaling pathway; IEA:InterPro.
GO; GO:0002224; P:toll-like receptor signaling pathway; IBA:GO_Central.
Gene3D; 3.40.50.10140; -; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR000483; Cys-rich_flank_reg_C.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000157; TIR_dom.
InterPro; IPR027173; TLR3.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
PANTHER; PTHR44599; PTHR44599; 1.
Pfam; PF13855; LRR_8; 6.
Pfam; PF01582; TIR; 1.
SMART; SM00369; LRR_TYP; 15.
SMART; SM00082; LRRCT; 1.
SMART; SM00255; TIR; 1.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS51450; LRR; 18.
PROSITE; PS50104; TIR; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000002280};
Immunity {ECO:0000256|SAAS:SAAS00472892};
Innate immunity {ECO:0000256|SAAS:SAAS00472892};
Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|SAAS:SAAS00473103};
Reference proteome {ECO:0000313|Proteomes:UP000002280};
Repeat {ECO:0000256|SAAS:SAAS00597472};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 25 {ECO:0000256|SAM:SignalP}.
CHAIN 26 905 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003343499.
TRANSMEM 705 726 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 755 901 TIR. {ECO:0000259|PROSITE:PS50104}.
SEQUENCE 905 AA; 103923 MW; E5FA9EFABC8F03DC CRC64;
MERCLIHWSY FFLRILPFCM VCTQSVKNCV VRNEVADCSH QKLTQIPPDL PANITTLNLT
HNQLKRLPPA NLTRYGQLVI LDGGFNSISK LEPELCQSLP LLKVLNLQHN ELSQLSDKTF
AFCLSLTELH LKSNPIQKIS DNPLKNLKNL HLLDLSHIGL SSAKLGTQVQ LENLQELLLT
NNKIRMLKRE DFDYLGNSSL RKLDLSSNHL IEFSPDCFRS IGKLYDLSLN NVQLGPELTE
KLCLELSSTS VQSLNLSAIQ LTKISNMTFR GLNQTNLTVL NLSHNGLTSI ANDSFAWLSH
LEWLVLENNN IDHLFSRSFY GLSNVKYLNL KRSFFKPKNS KISFPKIDDF SFQWLKCLEY
LSMEDNSFSG ITTNMFTGLT NLKSINLSSS FANLQILTNT TFSSLAYSPL LILNLTRNKI
SQIESGAFSW LGHLEVLDLG VNEISQELTG QEWKGLENIM EIYLSYNRYL ILNSNSFASV
PILKRLMLRR VDCKQLDVSP SPFHPLRNLT ILDLSNNNIA NINAEMLEGL DKLEILDLQH
NNLARLWKHA NPGGPVHFLK GLSHLRVLNL ESNGFDEIPS DVFKGLFQLR AIYLGLNNLN
LLPASLFDHQ TSLKSLSLQK NLITSVEKGV FGPAFQNLTL LDMSFNPFDC TCESIAWFVS
WLNKTHTHIE DLPSHYLCNT PPQYHGTPVM LFDISPCKDS APFKMFFIIN ASFLCTLIFV
VLLVHFQGWR ISFYWNVTIH RALGFKEIER QQEQFDYAAY IIHAQEDSRW IWKYFSPMEE
KDHSLRFCLE ERDFEAGRPE LEAIVHSIKR SRKIIFVVTQ NLLKDPLCKR FKVHHAVQQA
IEQNLDSIIL IFLEDIPDYK LNHALCLRRG MFKSHCILHW PAQKERVHAF YQKLQVALGM
RNRAH


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