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Toll like receptor 8

 G3WLZ9_SARHA            Unreviewed;      1039 AA.
G3WLZ9;
16-NOV-2011, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 1.
05-DEC-2018, entry version 53.
SubName: Full=Toll like receptor 8 {ECO:0000313|Ensembl:ENSSHAP00000016454};
Name=TLR8 {ECO:0000313|Ensembl:ENSSHAP00000016454};
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000016454, ECO:0000313|Proteomes:UP000007648};
[1] {ECO:0000313|Ensembl:ENSSHAP00000016454}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=21709235; DOI=10.1073/pnas.1102838108;
Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
"Genetic diversity and population structure of the endangered
marsupial Sarcophilus harrisii (Tasmanian devil).";
Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
[2] {ECO:0000313|Ensembl:ENSSHAP00000016454}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the Toll-like receptor family.
{ECO:0000256|SAAS:SAAS00596625}.
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EMBL; AEFK01126332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
ProteinModelPortal; G3WLZ9; -.
STRING; 9305.ENSSHAP00000016454; -.
Ensembl; ENSSHAT00000016591; ENSSHAP00000016454; ENSSHAG00000013998.
eggNOG; KOG4641; Eukaryota.
eggNOG; COG4886; LUCA.
GeneTree; ENSGT00940000160879; -.
InParanoid; G3WLZ9; -.
OMA; FDCTCDI; -.
OrthoDB; EOG091G014D; -.
TreeFam; TF351113; -.
Proteomes; UP000007648; Unassembled WGS sequence.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0003677; F:DNA binding; IEA:Ensembl.
GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:InterPro.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl.
GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl.
GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl.
GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl.
GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl.
Gene3D; 3.40.50.10140; -; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR000483; Cys-rich_flank_reg_C.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR026906; LRR_5.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000157; TIR_dom.
InterPro; IPR027175; TLR8.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1.
Pfam; PF13306; LRR_5; 1.
Pfam; PF13855; LRR_8; 5.
Pfam; PF01582; TIR; 1.
SMART; SM00369; LRR_TYP; 16.
SMART; SM00082; LRRCT; 1.
SMART; SM00255; TIR; 1.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS51450; LRR; 20.
PROSITE; PS50104; TIR; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000007648};
Immunity {ECO:0000256|SAAS:SAAS00472892};
Innate immunity {ECO:0000256|SAAS:SAAS00472892};
Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|SAAS:SAAS00473103};
Reference proteome {ECO:0000313|Proteomes:UP000007648};
Repeat {ECO:0000256|SAAS:SAAS00597472};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 1039 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003459088.
TRANSMEM 826 848 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 878 1025 TIR. {ECO:0000259|PROSITE:PS50104}.
SEQUENCE 1039 AA; 119941 MW; F18DE26850B68794 CRC64;
QVTMILQSLN FICLCFLVIC SPELLDQKVN LRDYPCSIKR QNSSVIANCL ACRLHSVPKS
LDHNVTEIDL SFNFIKNITS ESFVGLNNLT KINLNSNTNS QVEDRNFMKI SDGAFFNLTN
LKELLLEDNH LQKIPIHLPP SLTTISLVLN NIYHITKNCT SGLIQLKSLY LGWNCFYGNE
CKKNVLIDDG AFEDLANLTV LSLSFNNLSH VPTKLPPSLN ELYLSNNKIK NISQDDFKNL
GNLRVLDLSG NCPRCFNNPY PCTPCENSAS IQIHPDAFQN LGQLTHLNLS STSLKSLPAS
WFSNMTNLEV LLLEFNYLVK EIATGDFFTK LPKLEILDFS YNYLKNSYPQ YIVISGNFSK
LVSLKTLHLK GYVFQELRKE DFQPLTKLQN LQSINLGINF INHIDFTLFE EFNNLSLIYL
SENRISPQVT NSLGEKSNSL SFTNHVIHQR SIDSDNEPLG HYEIDPHRNF YHHTYPLMKP
ECTSYGKALD LSLNSIFFVN HNLFEGLHDI VCLNLSSNGN AQVLNGSEFS SINRTKYLDL
SHNRLDFDDD GAFQELRELE VLDLSNNEHY FRIAGVTHRL GFIQNLPQLK VLNLSQNGIF
TLTENQLISK SLKELVFKGN RLDILWKKED KRYLAIFKEL SNLTLLDLSI NRLHRIPNEA
FLNLPHSLEE LRLNNNHLSI FNWTSLQYFH SLRVLDLQSN SLSTINFDLS NSSLKILLLG
KNRISHLPDD LLSKAKGLYQ LDLSYNHIKM INKSTFQMKA SNHLKILELR GNPFDCTCEI
RDFRKWMDEN LNVTIPKLVE VTCSTPGDQM GKSIMELELN TCISDVIAAI FFFFSFIITV
SSMVIATFHH LFYWDIWYIY HLCSAKIKGY KSVSTSKTFY DAFIAYDTKD TCVTDWVINE
LRFQLEENEE KKVLLCLEER DWDPGIAIID NLMQSINQSK KTIFVLTKKY AKNWNFKTAF
YLALQRLMDD NMDVIIFILL EPVLQHSQYL RLRRRICKSS VLKWPDNPKA EELFWQSLKN
VVLTDNDTRY NNLYVKFIK


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