GENTAUR Molecular Products.

 TOLL7_DROME             Reviewed;        1446 AA.
 Q7KIN0; E1NZA7; Q2XXU8;
 06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
 03-OCT-2006, sequence version 1.
 05-DEC-2018, entry version 128.
 RecName: Full=Toll-like receptor 7 {ECO:0000305};
 Flags: Precursor;
 Name=Toll-7 {ECO:0000312|FlyBase:FBgn0034476};
 ORFNames=CG8595 {ECO:0000312|FlyBase:FBgn0034476};
 Drosophila melanogaster (Fruit fly).
 Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
 Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
 Ephydroidea; Drosophilidae; Drosophila; Sophophora.
 NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
 [1] {ECO:0000312|EMBL:AAF86225.1}
 NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
 PubMed=10973475; DOI=10.1073/pnas.180130797;
 Tauszig S., Jouanguy E., Hoffmann J.A., Imler J.L.;
 "Toll-related receptors and the control of antimicrobial peptide
 expression in Drosophila.";
 Proc. Natl. Acad. Sci. U.S.A. 97:10520-10525(2000).
 [2] {ECO:0000312|Proteomes:UP000000803}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
 PubMed=10731132; DOI=10.1126/science.287.5461.2185;
 Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
 Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
 George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
 Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
 Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
 Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
 Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
 Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
 Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
 Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
 Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
 Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
 de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
 Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
 Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
 Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
 Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
 Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
 Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
 Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
 Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
 Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
 Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
 Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
 Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
 Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
 Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
 Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
 Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
 Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
 Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
 Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
 Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
 Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
 Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
 Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
 "The genome sequence of Drosophila melanogaster.";
 Science 287:2185-2195(2000).
 [3] {ECO:0000312|Proteomes:UP000000803}
 GENOME REANNOTATION.
 STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
 PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
 Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
 Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
 Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
 Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
 Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
 Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
 Lewis S.E.;
 "Annotation of the Drosophila melanogaster euchromatic genome: a
 systematic review.";
 Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
 [4] {ECO:0000312|EMBL:ABA86520.1}
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-1435.
 STRAIN=Ral1 {ECO:0000312|EMBL:ABA86520.1};
 PubMed=16120803; DOI=10.1093/molbev/msi246;
 Comeron J.M., Guthrie T.B.;
 "Intragenic Hill-Robertson interference influences selection intensity
 on synonymous mutations in Drosophila.";
 Mol. Biol. Evol. 22:2519-2530(2005).
 [5] {ECO:0000312|EMBL:ADN32842.1}
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-1031.
 Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
 Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
 [6] {ECO:0000305}
 DEVELOPMENTAL STAGE.
 PubMed=12617819; DOI=10.1016/S1567-133X(02)00020-0;
 Kambris Z., Hoffmann J.A., Imler J.L., Capovilla M.;
 "Tissue and stage-specific expression of the Tolls in Drosophila
 embryos.";
 Gene Expr. Patterns 2:311-317(2002).
 [7] {ECO:0000305}
 DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
 PubMed=21158756; DOI=10.1111/j.1440-169X.2010.01213.x;
 Yagi Y., Nishida Y., Ip Y.T.;
 "Functional analysis of Toll-related genes in Drosophila.";
 Dev. Growth Differ. 52:771-783(2010).
 [8] {ECO:0000305}
 FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY VIRAL INFECTION, AND
 DISRUPTION PHENOTYPE.
 PubMed=22464169; DOI=10.1016/j.immuni.2012.03.003;
 Nakamoto M., Moy R.H., Xu J., Bambina S., Yasunaga A., Shelly S.S.,
 Gold B., Cherry S.;
 "Virus recognition by Toll-7 activates antiviral autophagy in
 Drosophila.";
 Immunity 36:658-667(2012).
 [9] {ECO:0000305}
 FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
 PubMed=23892553; DOI=10.1038/nn.3474;
 McIlroy G., Foldi I., Aurikko J., Wentzell J.S., Lim M.A.,
 Fenton J.C., Gay N.J., Hidalgo A.;
 "Toll-6 and Toll-7 function as neurotrophin receptors in the
 Drosophila melanogaster CNS.";
 Nat. Neurosci. 16:1248-1256(2013).
 [10] {ECO:0000305}
 FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
 PubMed=25741726; DOI=10.1016/j.neuron.2015.02.003;
 Ward A., Hong W., Favaloro V., Luo L.;
 "Toll receptors instruct axon and dendrite targeting and participate
 in synaptic partner matching in a Drosophila olfactory circuit.";
 Neuron 85:1013-1028(2015).
 -!- FUNCTION: Toll-related receptor which binds to the neurotrophins
     NT1 and spz5 (PubMed:10973475, PubMed:23892553). Essential for
     antiviral autophagy, it detects and binds to the vesicular
     stomatitis virus (vsv) following infection (PubMed:22464169). This
     role is likely to be independent of the canonical Toll, immune
     deficiency, and JAK-STAT signaling pathways (PubMed:22464169).
     Functions in olfactory circuit assembly by promoting synaptic
     partner matching between olfactory receptor neurons (ORN) axons
     and projection neurons (PN) dendrites partners in the antennal
     lobe (PubMed:25741726). Function in the Va1d ORNs is necessary and
     sufficient for correct targeting to their partner PN dendrites
     (PubMed:25741726). Also involved in the targeting of other classes
     of ORN axons (PubMed:25741726). Functions with Toll-6 to regulate
     motor axon targeting and neuronal survival in the central nervous
     system (CNS) (PubMed:23892553). May be an upstream component of
     the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).
     {ECO:0000269|PubMed:10973475, ECO:0000269|PubMed:22464169,
     ECO:0000269|PubMed:23892553, ECO:0000269|PubMed:25741726}.
 -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22464169};
     Single-pass type I membrane protein {ECO:0000305}.
 -!- TISSUE SPECIFICITY: Expressed in the fan-shaped body and the
     ellipsoid body, which are components of the locomotion center in
     the CNS (at protein level) (PubMed:23892553).
     {ECO:0000269|PubMed:23892553}.
 -!- DEVELOPMENTAL STAGE: In embryos, expressed in the ventral neurons,
     motor neurons and in the longitudinal interneuron axons (at
     protein level) (PubMed:23892553). May also be expressed in the
     motor neuron dendrites or possibly the glia (at protein level)
     (PubMed:23892553). Expressed 48 hours after puparium formation in
     the lateral glomeruli of the anterior and central regions of the
     antennal lobe, including the DA1, VA1d and VA1v glomeruli (at
     protein level) (PubMed:25741726). Expressed zygotically
     (PubMed:12617819). High levels of expression in embryos and pupae,
     and relatively low levels of expression in larvae and adults
     (PubMed:10973475). At germ band extension, expressed as 14 stripes
     in the embryo (PubMed:12617819). At germ band retraction,
     expressed in a subset of neurons in the CNS, the precursors of the
     leg imaginal disks and in the ventral epithelium of the large
     intestine (PubMed:12617819). Expressed in the posterior and
     anterior spiracles (PubMed:12617819). In stage 16 embryos,
     expression decreases and is mainly localized to the CNS
     (PubMed:12617819). Expressed in the proximal region of the wing
     imaginal disks, around the wing pouch and hinge regions
     (PubMed:21158756). Also expressed in the distal segments of the
     leg imaginal disks, with high levels of expression around the A-P
     border of the tarsal to tibia segments (PubMed:21158756). In
     larvae, detected in the fat body (PubMed:12617819).
     {ECO:0000269|PubMed:10973475, ECO:0000269|PubMed:12617819,
     ECO:0000269|PubMed:21158756, ECO:0000269|PubMed:23892553,
     ECO:0000269|PubMed:25741726}.
 -!- INDUCTION: Up-regulated during vesicular stomatitis virus (VSV)
     infection. {ECO:0000269|PubMed:22464169}.
 -!- DISRUPTION PHENOTYPE: Mistargeting of VA1d ORN axons to a medial
     position (PubMed:25741726). No effect on the immune response to
     septic injury using a mixture of Gram-positive and Gram-negative
     bacteria; adults are able induce expression of antibacterial
     peptide genes (Drs, AttA, DptA and Mtk) and mount a proper innate
     immune response (PubMed:21158756). RNAi-mediated knockdown results
     in adults that are acutely sensitive to the vesicular stomatitis
     virus (vsv) (PubMed:22464169). Following infection with vsv adult
     survival is decreased, and adults show a dramatic increase in
     viral RNA production 6 days post vsv infection and viral
     replication 9 days post infection (PubMed:22464169). Reduced
     autophagy in adult fat body cells following vsv infection
     (PubMed:22464169). Starvation-induced autophagy is not affected
     (PubMed:22464169). {ECO:0000269|PubMed:21158756,
     ECO:0000269|PubMed:22464169, ECO:0000269|PubMed:25741726}.
 -!- SIMILARITY: Belongs to the Toll-like receptor family.
     {ECO:0000305}.
 -----------------------------------------------------------------------
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 EMBL; AF247765; AAF86225.1; -; mRNA.
 EMBL; DQ138914; ABA86520.1; -; Genomic_DNA.
 EMBL; AE013599; AAF57514.1; -; Genomic_DNA.
 EMBL; BT125656; ADN32842.1; -; mRNA.
 RefSeq; NP_523797.1; NM_079073.3.
 UniGene; Dm.2660; -.
 ProteinModelPortal; Q7KIN0; -.
 STRING; 7227.FBpp0085638; -.
 PaxDb; Q7KIN0; -.
 PRIDE; Q7KIN0; -.
 EnsemblMetazoa; FBtr0086336; FBpp0085638; FBgn0034476.
 GeneID; 37272; -.
 KEGG; dme:Dmel_CG8595; -.
 UCSC; CG8595-RA; d. melanogaster.
 CTD; 37272; -.
 FlyBase; FBgn0034476; Toll-7.
 eggNOG; KOG4641; Eukaryota.
 eggNOG; COG4886; LUCA.
 GeneTree; ENSGT00940000159318; -.
 InParanoid; Q7KIN0; -.
 OMA; NHAFIGR; -.
 OrthoDB; EOG091G0137; -.
 PhylomeDB; Q7KIN0; -.
 GenomeRNAi; 37272; -.
 PRO; PR:Q7KIN0; -.
 Proteomes; UP000000803; Chromosome 2R.
 Bgee; FBgn0034476; Expressed in 24 organ(s), highest expression level in embryo.
 ExpressionAtlas; Q7KIN0; baseline and differential.
 GO; GO:0009897; C:external side of plasma membrane; IDA:FlyBase.
 GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
 GO; GO:0005615; C:extracellular space; IBA:GO_Central.
 GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
 GO; GO:0005030; F:neurotrophin receptor activity; IMP:FlyBase.
 GO; GO:0008329; F:signaling pattern recognition receptor activity; IC:FlyBase.
 GO; GO:0046790; F:virion binding; IDA:FlyBase.
 GO; GO:0007411; P:axon guidance; IMP:FlyBase.
 GO; GO:0002752; P:cell surface pattern recognition receptor signaling pathway; IC:FlyBase.
 GO; GO:0051607; P:defense response to virus; IMP:FlyBase.
 GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO; GO:0010508; P:positive regulation of autophagy; IMP:FlyBase.
 GO; GO:0050688; P:regulation of defense response to virus; IMP:FlyBase.
 Gene3D; 3.40.50.10140; -; 1.
 Gene3D; 3.80.10.10; -; 5.
 InterPro; IPR000483; Cys-rich_flank_reg_C.
 InterPro; IPR001611; Leu-rich_rpt.
 InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
 InterPro; IPR032675; LRR_dom_sf.
 InterPro; IPR000157; TIR_dom.
 InterPro; IPR035897; Toll_tir_struct_dom_sf.
 Pfam; PF00560; LRR_1; 1.
 Pfam; PF13855; LRR_8; 5.
 Pfam; PF13676; TIR_2; 1.
 SMART; SM00369; LRR_TYP; 20.
 SMART; SM00082; LRRCT; 1.
 SMART; SM00255; TIR; 1.
 SUPFAM; SSF52200; SSF52200; 1.
 PROSITE; PS51450; LRR; 23.
 PROSITE; PS50104; TIR; 1.
 1: Evidence at protein level;
 Cell membrane; Complete proteome; Developmental protein;
 Disulfide bond; Immunity; Innate immunity; Leucine-rich repeat;
 Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
 Transmembrane helix.
 SIGNAL        1     16       {ECO:0000255}.
 CHAIN        17   1446       Toll-like receptor 7.
                              /FTId=PRO_5006489795.
 TOPO_DOM     17   1049       Extracellular. {ECO:0000305}.
 TRANSMEM   1050   1070       Helical. {ECO:0000255}.
 TOPO_DOM   1071   1446       Cytoplasmic. {ECO:0000305}.
 REPEAT      133    156       LRR 1. {ECO:0000255}.
 REPEAT      158    180       LRR 2. {ECO:0000255}.
 REPEAT      188    211       LRR 3. {ECO:0000255}.
 REPEAT      213    235       LRR 4. {ECO:0000255}.
 REPEAT      246    270       LRR 5. {ECO:0000255}.
 REPEAT      271    294       LRR 6. {ECO:0000255}.
 REPEAT      295    318       LRR 7. {ECO:0000255}.
 REPEAT      320    342       LRR 8. {ECO:0000255}.
 REPEAT      344    368       LRR 9. {ECO:0000255}.
 REPEAT      369    392       LRR 10. {ECO:0000255}.
 REPEAT      393    416       LRR 11. {ECO:0000255}.
 REPEAT      417    440       LRR 12. {ECO:0000255}.
 REPEAT      442    464       LRR 13. {ECO:0000255}.
 REPEAT      465    488       LRR 14. {ECO:0000255}.
 REPEAT      489    511       LRR 15. {ECO:0000255}.
 REPEAT      513    535       LRR 16. {ECO:0000255}.
 REPEAT      536    559       LRR 17. {ECO:0000255}.
 REPEAT      561    582       LRR 18. {ECO:0000255}.
 REPEAT      584    605       LRR 19. {ECO:0000255}.
 REPEAT      606    629       LRR 20. {ECO:0000255}.
 REPEAT      631    652       LRR 21. {ECO:0000255}.
 REPEAT      653    675       LRR 22. {ECO:0000255}.
 REPEAT      677    699       LRR 23. {ECO:0000255}.
 DOMAIN      716    773       LRRCT. {ECO:0000255}.
 REPEAT      828    851       LRR 24. {ECO:0000255}.
 REPEAT      852    875       LRR 25. {ECO:0000255}.
 REPEAT      876    899       LRR 26. {ECO:0000255}.
 REPEAT      900    923       LRR 27. {ECO:0000255}.
 REPEAT      925    947       LRR 28. {ECO:0000255}.
 REPEAT      951    979       LRR 29. {ECO:0000255}.
 DOMAIN     1096   1236       TIR. {ECO:0000255|PROSITE-
                              ProRule:PRU00204}.
 DISULFID    722    772       {ECO:0000250|UniProtKB:P08953}.
 DISULFID    796    802       {ECO:0000250|UniProtKB:P08953}.
 DISULFID    800    815       {ECO:0000250|UniProtKB:P08953}.
 DISULFID    966    993       {ECO:0000250|UniProtKB:P08953}.
 CONFLICT     58     58       P -> L (in Ref. 4; ABA86520).
                              {ECO:0000305}.
 CONFLICT    124    124       T -> K (in Ref. 4; ABA86520).
                              {ECO:0000305}.
 CONFLICT   1426   1426       Missing (in Ref. 4; ABA86520).
                              {ECO:0000305}.
 SEQUENCE   1446 AA;  160950 MW;  80D281BDA9500ABC CRC64;
 MAAILLLLLG FSWSLAVESA LAPKESESSA SAMLGAGTGA AATVSLSGDY SSLLSNVPAA
 SPVPANPSQP SGPANQCSWS YNGTSSVHCA LRLIERQPGL DLQGADGSSQ LTIQCSELYL
 FESTLPVAVF ARLQTLEALR LDSCKLLQLP NNAFEGLATL KSLRLSTHNS EWGPTRTLEL
 FPDSLGGLKQ LTDLDLGDNN LRQLPSGFLC PVGNLQVLNL TRNRIRTAEQ MGFADMNCGA
 GSGSAGSELQ VLDASHNELR SISESWGISR LRRLQHLNLA YNNLSELSGE ALAGLASLRI
 VNLSNNHLET LPEGLFAGSK ELREIHLQQN ELYELPKGLF HRLEQLLVVD LSGNQLTSNH
 VDNTTFAGLI RLIVLNLAHN ALTRIDYRTF KELYFLQILN LRNNSIGHIE DNAFLPLYNL
 HTLNLAENRL HTLDDKLFNG LYVLSKLTLN NNLISVVEPA VFKNCSDLKE LDLSSNQLNE
 VPRALQDLAM LRTLDLGENQ IRTFDNQSFK NLHQLTGLRL IDNQIGNITV GMFQDLPRLS
 VLNLAKNRIQ SIERGSFDKN FELEAIRLDR NFLADINGVF ATLVSLLWLN LSENHLVWFD
 YAFIPSNLKW LDIHGNYIEA LGNYYKLQEE IRVKTLDASH NRITEIGPMS IPNTIELLFI
 NNNLIGNVQP NAFVDKANLA RVDLYANQLS KLQLQQLRVA PVVAPKPLPE FYLGGNPFEC
 DCTMDWLQRI NNLTTRQHPR VMDMANIECV MPHARGAAVR PLSGLRPQDF LCRYESHCFA
 LCHCCDFDAC DCEMTCPSNC TCYHDQIWST NVVDCGGQQT TELPRRVPMD SSVVYLDGNN
 FPVLKNHAFI GRKNLRALYV NGSQVAAIQN RTFASLASLQ LLHLADNKLR TLHGYEFEQL
 SALRELYLQN NQLTTIENAT LAPLAALELI RIDGNRLVTL PIWQMHATHF GTRLKSISLG
 RNQWSCRCQF LQALTSYVAD NALIVQDAQD IYCMAASSGT GSAALEDSSS NSGSLEKREL
 DFNATGAACT DYYSGGSMLQ HGIPESYIPL LAAALALLFL LVVIAMVFAF RESLRIWLFA
 HYGVRVFGPR CEESEKLYDA VLLHSAKDSE FVCQHLAAQL ETGRPPLRVC LQHRDLAHDA
 THYQLLEATR VSRRVVILLT RNFLQTEWAR CELRRSVHDA LRGRPQKLVI IEEPEVAFEA
 ESDIELLPYL KTSAVHRIRR SDRHFWEKLR YALPVDYPTF RGNNYTLELD HHNHERVKQP
 ASPGLLYRQA PPPAYCGPAD AVGIGAVPQV VPVNASVPAE QNYSTATTAT PSPRPQRRGE
 QPGSGSGGNH HLHAQYYQHH GMRPPSEHIY SSIDSDYSTL DNEQHMLMMP GAPGGLAMEA
 AQRAQTWRPK REQLHLQQAQ AGTLGSKASQ AAHQQQQQQQ QQQQQQPNPT AVSGQQQGPH
 VQAYLV

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