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Toll-like receptor 8

 B2BE52_FELCA            Unreviewed;      1039 AA.
B2BE52; M3WT64;
20-MAY-2008, integrated into UniProtKB/TrEMBL.
20-MAY-2008, sequence version 1.
05-DEC-2018, entry version 77.
SubName: Full=Toll-like receptor 8 {ECO:0000313|EMBL:ABS28967.1, ECO:0000313|Ensembl:ENSFCAP00000017550};
Name=TLR8 {ECO:0000313|EMBL:ABS28967.1,
ECO:0000313|Ensembl:ENSFCAP00000017550};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|EMBL:ABS28967.1};
[1] {ECO:0000313|Ensembl:ENSFCAP00000017550, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017550,
ECO:0000313|Proteomes:UP000011712};
PubMed=17975172; DOI=10.1101/gr.6380007;
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
"Initial sequence and comparative analysis of the cat genome.";
Genome Res. 17:1675-1689(2007).
[2] {ECO:0000313|EMBL:ABS28967.1}
NUCLEOTIDE SEQUENCE.
PubMed=19568743; DOI=10.1007/s00251-009-0381-z;
Astakhova N.M., Perelygin A.A., Zharkikh A.A., Lear T.L.,
Coleman S.J., Macleod J.N., Brinton M.A.;
"Characterization of equine and other vertebrate TLR3, TLR7, and TLR8
genes.";
Immunogenetics 61:529-539(2009).
[3] {ECO:0000313|Ensembl:ENSFCAP00000017550}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017550};
Hillier L.W., Warren W., Obrien S., Wilson R.K.;
"Sequence assembly of the Felis catus genome version 6.2.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|Ensembl:ENSFCAP00000017550}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017550};
Ensembl;
Submitted (MAR-2013) to UniProtKB.
-!- SIMILARITY: Belongs to the Toll-like receptor family.
{ECO:0000256|SAAS:SAAS00596625}.
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EMBL; AANG04001271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; EF484949; ABS28967.1; -; Genomic_DNA.
RefSeq; XP_019679113.1; XM_019823554.1.
RefSeq; XP_019679114.1; XM_019823555.1.
RefSeq; XP_019679115.1; XM_019823556.1.
ProteinModelPortal; B2BE52; -.
STRING; 9685.ENSFCAP00000017550; -.
Ensembl; ENSFCAT00000022218; ENSFCAP00000017550; ENSFCAG00000027513.
GeneID; 101091762; -.
KEGG; fca:101091762; -.
eggNOG; KOG4641; Eukaryota.
eggNOG; COG4886; LUCA.
GeneTree; ENSGT00940000160879; -.
HOVERGEN; HBG018601; -.
KO; K10170; -.
OrthoDB; EOG091G014D; -.
Proteomes; UP000011712; Chromosome X.
Bgee; ENSFCAG00000027513; Expressed in 3 organ(s), highest expression level in liver.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0003677; F:DNA binding; IEA:Ensembl.
GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:InterPro.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl.
GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl.
GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl.
GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl.
GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl.
Gene3D; 3.40.50.10140; -; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR000483; Cys-rich_flank_reg_C.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000157; TIR_dom.
InterPro; IPR027175; TLR8.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1.
Pfam; PF13855; LRR_8; 5.
Pfam; PF01582; TIR; 1.
SMART; SM00369; LRR_TYP; 18.
SMART; SM00082; LRRCT; 1.
SMART; SM00255; TIR; 1.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS51450; LRR; 20.
PROSITE; PS50104; TIR; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000011712};
Immunity {ECO:0000256|SAAS:SAAS00472892};
Innate immunity {ECO:0000256|SAAS:SAAS00472892};
Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:ABS28967.1};
Reference proteome {ECO:0000313|Proteomes:UP000011712};
Repeat {ECO:0000256|SAAS:SAAS00597472};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 18 {ECO:0000256|SAM:SignalP}.
CHAIN 19 1039 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5014084809.
TRANSMEM 825 845 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 876 1023 TIR. {ECO:0000259|PROSITE:PS50104}.
SEQUENCE 1039 AA; 119530 MW; 20A5D0A2979498A2 CRC64;
MTLQSLLLTC LFLLISDSRE FFTEANYSRS YPCDEKRQNG SIIAQCNDRR LREVPQTVSK
YVTALDLSYN FITHITNESF QGLQNLTRIN LNHNANQQHL NENPDINRSG MNITDGAFLN
LQNLNQLLLE DNQLDQIPAG LPGSLRELSL IQNNIIWVAK KNTSGLTNLQ RLYLSWNCYF
GNNCNNKTFD IEDGTFESLT NLQVLSLSFN KLVHVPPKLP NSLTELYLSN AKIKVISQED
FKGLTNLRVL DLSGNCPRCF NAPFPCTPCE GGSSIQIHPL AFQTLTELRY LNLSSTSLQK
IPAMWFQSMH NLKVLHLEFN YLVDEIASGE FLTKLPSLEI LDLSYNYVKA KYPRYINISQ
NFSHLKLLQT LHLRGYVFQE LRAEDFQPLM NLSNLKTINL GINFIKQINF TLFQNFSNLS
IIYLSENRIS PLVNDIKQND MSGSSFQSHI RRLRSADTEF DPHSNFYHNT NPLIKPQCTV
YGKALDLSLN SIFFIGREQF KAFHDIACLN LSSNGNGQVL HGTEFSAVPH IKYLDLTNNR
LDFDDDNALS DLPELEVLDL SYNAHYFRIA GVTHRLGFIQ NLTQLKVLNL SHNSIYTLTE
QDLRSMSLKE LVFSGNRLDI LWNAEGDKYW KIFTNLGNLT WLDLSSNNLR HIPNEAFLNL
PQSLTKLYIR DNVLNSFNWT LLQLFPHLQL LDLSGNRLSS LTNSLSKFTP SLRTLLLRRN
RISHLPSNFL SEASSLIHLD LSSNLLKMIN KSTLQTKTAT NLTILELGRN PFDCTCDIGD
FRRWMDENLD VTIPRLADVI CSSPGDQRGK SIVSLELTTC VSDTIAAILC FFTFFITITV
MLAALGHHWF YWDVWFIYHV CLAKIKGYRS LSTSQTFYDA YVSYDTKDAS VTDWVINELR
FHLEESEEKN VLLCLEERDW DPGLAIIDNL IQSINQSKKT IFVLTKKYAK NWNFKTAFYL
ALQRLMDENM DVIIFILLEP VLQNSQYLRL RQRICKSSIL QWPDNPKAEG LFWQSLKNVV
LTENDSRYNN LYVDSIKQY


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