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Toxin TbTx5 (T-alpha* NaTx3.4)

 SCX5_TITBA              Reviewed;          86 AA.
P0C5K8;
13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
13-NOV-2007, sequence version 1.
22-NOV-2017, entry version 34.
RecName: Full=Toxin TbTx5;
AltName: Full=T-alpha* NaTx3.4;
Flags: Precursor;
Tityus bahiensis (Brazilian scorpion).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
NCBI_TaxID=50343;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Venom gland;
PubMed=11072047; DOI=10.1016/S0041-0101(00)00194-X;
Kalapothakis E., Jardim S., Magalhaes A.C., Mendes T.M., De Marco L.,
Afonso L.C.C., Chavez-Olortegui C.;
"Screening of expression libraries using ELISA: identification of
immunogenic proteins from Tityus bahiensis and Tityus serrulatus
venom.";
Toxicon 39:679-685(2001).
[2]
NOMENCLATURE.
PubMed=22355312; DOI=10.1371/journal.pone.0030478;
Guerrero-Vargas J.A., Mourao C.B., Quintero-Hernandez V.,
Possani L.D., Schwartz E.F.;
"Identification and phylogenetic analysis of Tityus pachyurus and
Tityus obscurus novel putative Na+-channel scorpion toxins.";
PLoS ONE 7:E30478-E30478(2012).
-!- FUNCTION: Alpha toxins bind voltage-independently at site-3 of
sodium channels (Nav) and inhibit the inactivation of the
activated channels, thereby blocking neuronal transmission.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- SIMILARITY: Belongs to the long (4 C-C) scorpion toxin
superfamily. Sodium channel inhibitor family. Alpha subfamily.
{ECO:0000305}.
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ProteinModelPortal; P0C5K8; -.
SMR; P0C5K8; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
GO; GO:0006952; P:defense response; IEA:InterPro.
Gene3D; 3.30.30.10; -; 1.
InterPro; IPR003614; Scorpion_toxin-like.
InterPro; IPR036574; Scorpion_toxin-like_sf.
InterPro; IPR018218; Scorpion_toxinL.
InterPro; IPR002061; Scorpion_toxinL/defensin.
Pfam; PF00537; Toxin_3; 1.
PRINTS; PR00285; SCORPNTOXIN.
SMART; SM00505; Knot1; 1.
SUPFAM; SSF57095; SSF57095; 1.
2: Evidence at transcript level;
Amidation; Disulfide bond; Ion channel impairing toxin; Neurotoxin;
Secreted; Signal; Toxin; Voltage-gated sodium channel impairing toxin.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 83 Toxin TbTx5.
/FTId=PRO_0000309006.
MOD_RES 83 83 Proline amide. {ECO:0000255}.
DISULFID 31 81 {ECO:0000250}.
DISULFID 35 57 {ECO:0000250}.
DISULFID 43 64 {ECO:0000250}.
DISULFID 47 66 {ECO:0000250}.
SEQUENCE 86 AA; 9598 MW; FCDAF902D7F612F0 CRC64;
MNDFVFLVVA CLLTAGTEGK KDGYPVEGDN CAFVCFGYDN AYCDKLCKDK KADSGYCYWV
HILCYCYGLP DKEPTKTNGR CKPGKK


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