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Toxin Ts4 (Non-toxic protein TsNTxP) (NTxP) (P-Allerg-alpha* NaTx4.1) (PT-Immun-alpha* NaTx4.2) (Tityustoxin VI) (Ts VI) (TsTX-VI) (TsTXVI) (TsVI) (Tityustoxin-6) (Ts-6)

 SCX4_TITSE              Reviewed;          84 AA.
O77463; P45669;
22-FEB-2003, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
25-OCT-2017, entry version 58.
RecName: Full=Toxin Ts4;
AltName: Full=Non-toxic protein TsNTxP;
Short=NTxP;
AltName: Full=P-Allerg-alpha* NaTx4.1;
AltName: Full=PT-Immun-alpha* NaTx4.2;
AltName: Full=Tityustoxin VI;
Short=Ts VI;
Short=TsTX-VI;
Short=TsTXVI;
Short=TsVI;
AltName: Full=Tityustoxin-6;
Short=Ts-6;
Flags: Precursor;
Tityus serrulatus (Brazilian scorpion).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
NCBI_TaxID=6887;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=10080354; DOI=10.1016/S0041-0101(98)00187-1;
Guatimosim S.C., Prado V.F., Diniz C.R., Chavez-Olortegui C.,
Kalapothakis E.;
"Molecular cloning and genomic analysis of TsNTxp: an immunogenic
protein from Tityus serrulatus scorpion venom.";
Toxicon 37:507-517(1999).
[2]
PROTEIN SEQUENCE OF 20-81, SUBCELLULAR LOCATION, AND LETHAL DOSE.
TISSUE=Venom;
PubMed=2085384; DOI=10.1007/BF01025013;
Marangoni S., Ghiso J., Sampaio S.V., Arantes E.C., Giglio J.R.,
Oliveira B., Frangione B.;
"The complete amino acid sequence of toxin TsTX-VI isolated from the
venom of the scorpion Tityus serrulatus.";
J. Protein Chem. 9:595-601(1990).
[3]
PROTEIN SEQUENCE OF 20-34, AND SUBCELLULAR LOCATION.
TISSUE=Venom {ECO:0000303|PubMed:25199494};
PubMed=25199494; DOI=10.1016/j.toxicon.2014.08.064;
Pucca M.B., Amorim F.G., Cerni F.A., Bordon K.C.F., Cardoso I.A.,
Anjolette F.A., Arantes E.C.;
"Influence of post-starvation extraction time and prey-specific diet
in Tityus serrulatus scorpion venom composition and hyaluronidase
activity.";
Toxicon 90:326-336(2014).
[4]
FUNCTION.
PubMed=8843341;
Sampaio S.V., Coutinho-Netto J., Arantes E.C., Marangoni S.,
Oliveira B., Giglio J.R.;
"Isolation of toxin TsTX-VI from Tityus serrulatus scorpion venom.
Effects on the release of neurotransmitters from synaptosomes.";
Biochem. Mol. Biol. Int. 39:729-740(1996).
[5]
FUNCTION.
TISSUE=Venom;
PubMed=9080578; DOI=10.1016/S0041-0101(96)00133-X;
Chavez-Olortegui C., Kalapothakis E., Ferreira A.M.B.M.,
Ferreira A.P., Diniz C.R.;
"Neutralizing capacity of antibodies elicited by a non-toxic protein
purified from the venom of the scorpion Tityus serrulatus.";
Toxicon 35:213-221(1997).
[6]
NOMENCLATURE.
PubMed=19689419; DOI=10.2174/092986609788923329;
Cologna C.T., Marcussi S., Giglio J.R., Soares A.M., Arantes E.C.;
"Tityus serrulatus scorpion venom and toxins: an overview.";
Protein Pept. Lett. 16:920-932(2009).
[7]
NOMENCLATURE.
PubMed=22355312; DOI=10.1371/journal.pone.0030478;
Guerrero-Vargas J.A., Mourao C.B., Quintero-Hernandez V.,
Possani L.D., Schwartz E.F.;
"Identification and phylogenetic analysis of Tityus pachyurus and
Tityus obscurus novel putative Na+-channel scorpion toxins.";
PLoS ONE 7:E30478-E30478(2012).
-!- FUNCTION: Not toxic. Induces an immune response similar to that
induced by whole venom. Induces a dose dependent release of the
neurotransmitters glutamic acid and gamma aminobutyric acid from
rat brain synaptosomes. Thus, polyclonal antibodies raised against
this protein can neutralize the effects of the venom.
{ECO:0000269|PubMed:8843341, ECO:0000269|PubMed:9080578}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2085384,
ECO:0000269|PubMed:25199494}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
{ECO:0000305|PubMed:25199494}.
-!- TOXIC DOSE: LD(50) is 15 mg/kg by intravenous injection into mice.
{ECO:0000269|PubMed:2085384}.
-!- SIMILARITY: Belongs to the long (4 C-C) scorpion toxin
superfamily. Sodium channel inhibitor family. Alpha subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF039600; AAC25689.1; -; Genomic_DNA.
EMBL; AF039599; AAC25688.1; -; mRNA.
PIR; A61484; A61484.
ProteinModelPortal; O77463; -.
SMR; O77463; -.
TCDB; 8.B.1.1.3; the long (4c-c) scorpion toxin (l-st) superfamily.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
GO; GO:0006952; P:defense response; IEA:InterPro.
Gene3D; 3.30.30.10; -; 1.
InterPro; IPR003614; Scorpion_toxin-like.
InterPro; IPR036574; Scorpion_toxin-like_sf.
InterPro; IPR018218; Scorpion_toxinL.
InterPro; IPR002061; Scorpion_toxinL/defensin.
Pfam; PF00537; Toxin_3; 1.
PRINTS; PR00285; SCORPNTOXIN.
SMART; SM00505; Knot1; 1.
SUPFAM; SSF57095; SSF57095; 1.
1: Evidence at protein level;
Allergen; Amidation; Direct protein sequencing; Disulfide bond;
Secreted; Signal.
SIGNAL 1 19 {ECO:0000269|PubMed:2085384,
ECO:0000269|PubMed:25199494}.
CHAIN 20 81 Toxin Ts4.
/FTId=PRO_0000035303.
PROPEP 82 84
/FTId=PRO_0000035304.
MOD_RES 81 81 Cysteine amide.
{ECO:0000250|UniProtKB:P56612}.
DISULFID 31 81 {ECO:0000250}.
DISULFID 35 57 {ECO:0000250}.
DISULFID 43 62 {ECO:0000250}.
DISULFID 47 64 {ECO:0000250}.
CONFLICT 69 69 D -> E (in Ref. 2; AA sequence).
{ECO:0000305}.
SEQUENCE 84 AA; 9176 MW; DDEDE77B5B18C8EA CRC64;
MKRMILFISC LLLIDIVVGG REGYPADSKG CKITCFLTAA GYCNTECTLK KGSSGYCAWP
ACYCYGLPDS VKIWTSETNK CGKK


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