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Trans-acting T-cell-specific transcription factor GATA-3

 G3GR59_CRIGR            Unreviewed;       443 AA.
G3GR59;
16-NOV-2011, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 1.
25-OCT-2017, entry version 27.
SubName: Full=Trans-acting T-cell-specific transcription factor GATA-3 {ECO:0000313|EMBL:EGV95071.1};
ORFNames=I79_000002 {ECO:0000313|EMBL:EGV95071.1};
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV95071.1, ECO:0000313|Proteomes:UP000001075};
[1] {ECO:0000313|Proteomes:UP000001075}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
PubMed=21804562; DOI=10.1038/nbt.1932;
Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
Quake S.R., Famili I., Palsson B.O., Wang J.;
"The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
line.";
Nat. Biotechnol. 29:735-741(2011).
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EMBL; JH000001; EGV95071.1; -; Genomic_DNA.
RefSeq; XP_003494969.1; XM_003494921.3.
RefSeq; XP_016831531.1; XM_016976042.1.
Ensembl; ENSCGRT00000013700; ENSCGRP00000013491; ENSCGRG00000009790.
Ensembl; ENSCGRT00001013972; ENSCGRP00001009753; ENSCGRG00001011803.
GeneID; 100760238; -.
KEGG; cge:100760238; -.
CTD; 2625; -.
InParanoid; G3GR59; -.
KO; K17895; -.
Proteomes; UP000001075; Unassembled WGS sequence.
GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0000987; F:core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0070888; F:E-box binding; IEA:Ensembl.
GO; GO:0001158; F:enhancer sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0071837; F:HMG box domain binding; IEA:Ensembl.
GO; GO:0005134; F:interleukin-2 receptor binding; IEA:Ensembl.
GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
GO; GO:0007411; P:axon guidance; IEA:Ensembl.
GO; GO:0061290; P:canonical Wnt signaling pathway involved in metanephric kidney development; IEA:Ensembl.
GO; GO:0003215; P:cardiac right ventricle morphogenesis; IEA:Ensembl.
GO; GO:0001709; P:cell fate determination; IEA:Ensembl.
GO; GO:0048469; P:cell maturation; IEA:Ensembl.
GO; GO:0071773; P:cellular response to BMP stimulus; IEA:Ensembl.
GO; GO:0035457; P:cellular response to interferon-alpha; IEA:Ensembl.
GO; GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
GO; GO:0048589; P:developmental growth; IEA:Ensembl.
GO; GO:0035162; P:embryonic hemopoiesis; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
GO; GO:0072643; P:interferon-gamma secretion; IEA:Ensembl.
GO; GO:0072602; P:interleukin-4 secretion; IEA:Ensembl.
GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
GO; GO:0072676; P:lymphocyte migration; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0060374; P:mast cell differentiation; IEA:Ensembl.
GO; GO:0060231; P:mesenchymal to epithelial transition; IEA:Ensembl.
GO; GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl.
GO; GO:2000146; P:negative regulation of cell motility; IEA:Ensembl.
GO; GO:2000607; P:negative regulation of cell proliferation involved in mesonephros development; IEA:Ensembl.
GO; GO:1901536; P:negative regulation of DNA demethylation; IEA:Ensembl.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:2000703; P:negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation; IEA:Ensembl.
GO; GO:2000734; P:negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl.
GO; GO:0032703; P:negative regulation of interleukin-2 production; IEA:Ensembl.
GO; GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
GO; GO:0072179; P:nephric duct formation; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0042421; P:norepinephrine biosynthetic process; IEA:Ensembl.
GO; GO:0071599; P:otic vesicle development; IEA:Ensembl.
GO; GO:0060017; P:parathyroid gland development; IEA:Ensembl.
GO; GO:0035898; P:parathyroid hormone secretion; IEA:Ensembl.
GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl.
GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
GO; GO:0071442; P:positive regulation of histone H3-K14 acetylation; IEA:Ensembl.
GO; GO:2000617; P:positive regulation of histone H3-K9 acetylation; IEA:Ensembl.
GO; GO:2000667; P:positive regulation of interleukin-13 secretion; IEA:Ensembl.
GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl.
GO; GO:2000664; P:positive regulation of interleukin-5 secretion; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
GO; GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; IEA:Ensembl.
GO; GO:2000611; P:positive regulation of thyroid hormone generation; IEA:Ensembl.
GO; GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IEA:Ensembl.
GO; GO:0072107; P:positive regulation of ureteric bud formation; IEA:Ensembl.
GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO; GO:0002572; P:pro-T cell differentiation; IEA:Ensembl.
GO; GO:0043370; P:regulation of CD4-positive, alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:2000683; P:regulation of cellular response to X-ray; IEA:Ensembl.
GO; GO:0042035; P:regulation of cytokine biosynthetic process; IEA:Ensembl.
GO; GO:2000114; P:regulation of establishment of cell polarity; IEA:Ensembl.
GO; GO:0061085; P:regulation of histone H3-K27 methylation; IEA:Ensembl.
GO; GO:0051569; P:regulation of histone H3-K4 methylation; IEA:Ensembl.
GO; GO:0072182; P:regulation of nephron tubule epithelial cell differentiation; IEA:Ensembl.
GO; GO:0043523; P:regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0010975; P:regulation of neuron projection development; IEA:Ensembl.
GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
GO; GO:0009615; P:response to virus; IEA:Ensembl.
GO; GO:0048485; P:sympathetic nervous system development; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0045064; P:T-helper 2 cell differentiation; IEA:Ensembl.
GO; GO:0045061; P:thymic T cell selection; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0031929; P:TOR signaling; IEA:Ensembl.
GO; GO:0035799; P:ureter maturation; IEA:Ensembl.
GO; GO:0060676; P:ureteric bud formation; IEA:Ensembl.
GO; GO:0060065; P:uterus development; IEA:Ensembl.
GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
Gene3D; 3.30.50.10; -; 2.
InterPro; IPR029521; GATA-3.
InterPro; IPR016374; TF_GATA-2/3.
InterPro; IPR000679; Znf_GATA.
InterPro; IPR013088; Znf_NHR/GATA.
PANTHER; PTHR10071:SF106; PTHR10071:SF106; 1.
Pfam; PF00320; GATA; 2.
PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
PRINTS; PR00619; GATAZNFINGER.
SMART; SM00401; ZnF_GATA; 2.
PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000001075};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00094};
Reference proteome {ECO:0000313|Proteomes:UP000001075};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00094};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00094}.
DOMAIN 257 311 GATA-type. {ECO:0000259|PROSITE:PS50114}.
DOMAIN 311 364 GATA-type. {ECO:0000259|PROSITE:PS50114}.
SEQUENCE 443 AA; 47951 MW; F38B58FB6D37E560 CRC64;
MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LGHSYMEAQY PLTEEVDVLF NIDGQGNHVP
SYYGNSVRAT VQRYPPTHHG SQVCRPPLLH GSLPWLDGGK ALSSHHTASP WNLSPFSKTS
IHHGSPGPLS VYPPASSSSL AAGHSSPHLF TFPPTPPKDV SPDPSLSTPG SAGSARQDEK
ECLKYQVPLP ESMKLETSHS RGSMTTLGGA SSSAHHPITT YPPYVPEYSS GLFPPSSLLG
GSPTGFGCKS RPKARSSTEG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL
IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI NRPLTMKKEG
IQTRNRKMSS KSKKCKKVHD ALEDFPKSSS FNPAALSRHM SSLSHISPFS HSSHMLTTPT
PMHPPSGLSF GPHHPSSMVT AMG


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