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Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)

 SMCA4_RAT               Reviewed;        1613 AA.
Q8K1P7;
09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
31-JAN-2018, entry version 111.
RecName: Full=Transcription activator BRG1;
EC=3.6.4.-;
AltName: Full=ATP-dependent helicase SMARCA4;
AltName: Full=BRG1-associated factor 190A;
Short=BAF190A;
AltName: Full=Protein brahma homolog 1;
AltName: Full=SNF2-beta;
AltName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4;
Name=Smarca4; Synonyms=Baf190a, Brg1, Snf2b, Snf2l4;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Hippocampus;
Hirsch O., Almeida O.F.X.;
"Isolation and characterization of the rat brahma related gene-1 (BRG-
1).";
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
[2]
FUNCTION, AND INTERACTION WITH SS18L1; HDAC1; RB1 AND SP1.
PubMed=19081374; DOI=10.1016/j.neuron.2008.09.040;
Qiu Z., Ghosh A.;
"A calcium-dependent switch in a CREST-BRG1 complex regulates
activity-dependent gene expression.";
Neuron 60:775-787(2008).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613; SER-695; SER-699;
SER-1419; SER-1536; SER-1541; SER-1552; SER-1593 AND SER-1597, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Involved in transcriptional activation and repression of
select genes by chromatin remodeling (alteration of DNA-nucleosome
topology). Component of SWI/SNF chromatin remodeling complexes
that carry out key enzymatic activities, changing chromatin
structure by altering DNA-histone contacts within a nucleosome in
an ATP-dependent manner. Component of the CREST-BRG1 complex, a
multiprotein complex that regulates promoter activation by
orchestrating a calcium-dependent release of a repressor complex
and a recruitment of an activator complex. In resting neurons,
transcription of the c-FOS promoter is inhibited by BRG1-dependent
recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium
influx, RB1 is dephosphorylated by calcineurin, which leads to
release of the repressor complex. At the same time, there is
increased recruitment of CREBBP to the promoter by a CREST-
dependent mechanism, which leads to transcriptional activation.
The CREST-BRG1 complex also binds to the NR2B promoter, and
activity-dependent induction of NR2B expression involves a release
of HDAC1 and recruitment of CREBBP. Belongs to the neural
progenitors-specific chromatin remodeling complex (npBAF complex)
and the neuron-specific chromatin remodeling complex (nBAF
complex). During neural development a switch from a
stem/progenitor to a postmitotic chromatin remodeling mechanism
occurs as neurons exit the cell cycle and become committed to
their adult state. The transition from proliferating neural
stem/progenitor cells to postmitotic neurons requires a switch in
subunit composition of the npBAF and nBAF complexes. As neural
progenitors exit mitosis and differentiate into neurons, npBAF
complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are
exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B
or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The
npBAF complex is essential for the self-renewal/proliferative
capacity of the multipotent neural stem cells. The nBAF complex
along with CREST plays a role regulating the activity of genes
essential for dendrite growth. SMARCA4/BAF190A may promote neural
stem cell self-renewal/proliferation by enhancing Notch-dependent
proliferative signals, while concurrently making the neural stem
cell insensitive to SHH-dependent differentiating cues. Acts as a
corepressor of ZEB1 to regulate E-cadherin transcription and is
required for induction of epithelial-mesenchymal transition (EMT)
by ZEB1 (By similarity). {ECO:0000250|UniProtKB:P51532,
ECO:0000269|PubMed:19081374}.
-!- SUBUNIT: Component of the multiprotein chromatin-remodeling
complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related
complexes. The canonical complex contains a catalytic subunit
(either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least
SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and
SMARCB1/SNF5/BAF47. Other subunits specific to each of the
complexes may also be present permitting several possible
combinations developmentally and tissue specific (By similarity).
Component of the BAF complex, which includes at least actin
(ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM,
SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57,
SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more
SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle
cells, the BAF complex also contains DPF3. Component of neural
progenitors-specific chromatin remodeling complex (npBAF complex)
composed of at least, ARID1A/BAF250A or ARID1B/BAF250B,
SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B,
SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155,
SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and
actin. Component of neuron-specific chromatin remodeling complex
(nBAF complex) composed of at least, ARID1A/BAF250A or
ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C,
SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47,
SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B,
DPF3/BAF45C, ACTL6B/BAF53B and actin. Component of the SWI/SNF-B
(PBAF) chromatin remodeling complex, at least composed of
SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B,
SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps
SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180,
ARID2/BAF200 and actin. Component of the BAF53 complex, at least
composed of BAF53A, RUVBL1, SMARCA4/BRG1/BAF190A, and TRRAP, which
preferentially acetylates histone H4 (and H2A) within nucleosomes
(By similarity). Component of the CREST-BRG1 complex, at least
composed of SMARCA4/BRG1/BAF190A, SS18L1/CREST, HDAC1, RB1 and SP1
(By similarity). Interacts with PHF10/BAF45A (By similarity).
Interacts with MYOG (By similarity). Interacts directly with
IKFZ1; the interaction associates IKFZ1 with the BAF complex.
Interacts with ZEB1 (via N-terminus). Interacts with NR3C1, PGR,
SMARD1, TOPBP1 and ZMIM2/ZIMP7. Interacts with (via the
bromodomain) with TERT; the interaction regulates Wnt-mediated
signaling (By similarity). Interacts with TBX21 in a KDM6B-
dependent manner (By similarity). Interacts with KDM6A and KDM6B
(By similarity). Interacts with HNRNPU; this interaction occurs in
embryonic stem cells and stimulates global Pol II-mediated
transcription (By similarity). Interacts with ACTL6A (By
similarity). {ECO:0000250|UniProtKB:P51532,
ECO:0000250|UniProtKB:Q3TKT4}.
-!- INTERACTION:
G3V612:Olig2; NbExp=2; IntAct=EBI-689301, EBI-6676662;
Q12824:SMARCB1 (xeno); NbExp=2; IntAct=EBI-689301, EBI-358419;
Q4KLI0:Smarcb1; NbExp=2; IntAct=EBI-689301, EBI-689316;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3TKT4}.
-!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
{ECO:0000305}.
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EMBL; AJ504723; CAD43278.1; -; mRNA.
UniGene; Rn.23417; -.
ProteinModelPortal; Q8K1P7; -.
SMR; Q8K1P7; -.
IntAct; Q8K1P7; 4.
STRING; 10116.ENSRNOP00000013166; -.
iPTMnet; Q8K1P7; -.
PhosphoSitePlus; Q8K1P7; -.
PaxDb; Q8K1P7; -.
PRIDE; Q8K1P7; -.
UCSC; RGD:621728; rat.
RGD; 621728; Smarca4.
eggNOG; KOG0386; Eukaryota.
eggNOG; COG0553; LUCA.
eggNOG; COG5076; LUCA.
HOGENOM; HOG000172363; -.
HOVERGEN; HBG056636; -.
InParanoid; Q8K1P7; -.
PhylomeDB; Q8K1P7; -.
PRO; PR:Q8K1P7; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005615; C:extracellular space; ISO:RGD.
GO; GO:0000792; C:heterochromatin; ISO:RGD.
GO; GO:0016020; C:membrane; ISO:RGD.
GO; GO:0071565; C:nBAF complex; ISS:UniProtKB.
GO; GO:0071564; C:npBAF complex; ISS:UniProtKB.
GO; GO:0000790; C:nuclear chromatin; ISO:RGD.
GO; GO:0005719; C:nuclear euchromatin; ISO:RGD.
GO; GO:0005730; C:nucleolus; ISO:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0005726; C:perichromatin fibrils; ISO:RGD.
GO; GO:0043234; C:protein complex; ISO:RGD.
GO; GO:0016514; C:SWI/SNF complex; IDA:RGD.
GO; GO:0050681; F:androgen receptor binding; ISO:RGD.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0016887; F:ATPase activity; ISO:RGD.
GO; GO:0003682; F:chromatin binding; IDA:RGD.
GO; GO:0070182; F:DNA polymerase binding; ISO:RGD.
GO; GO:0008094; F:DNA-dependent ATPase activity; ISO:RGD.
GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO; GO:0070577; F:lysine-acetylated histone binding; ISO:RGD.
GO; GO:0002039; F:p53 binding; ISO:RGD.
GO; GO:0032403; F:protein complex binding; IDA:RGD.
GO; GO:0047485; F:protein N-terminus binding; ISO:RGD.
GO; GO:0001164; F:RNA polymerase I CORE element sequence-specific DNA binding; ISO:RGD.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:RGD.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISO:RGD.
GO; GO:0001105; F:RNA polymerase II transcription coactivator activity; ISO:RGD.
GO; GO:0030957; F:Tat protein binding; ISO:RGD.
GO; GO:0003713; F:transcription coactivator activity; ISO:RGD.
GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
GO; GO:0008134; F:transcription factor binding; ISO:RGD.
GO; GO:0035904; P:aorta development; ISO:RGD.
GO; GO:0035887; P:aortic smooth muscle cell differentiation; ISO:RGD.
GO; GO:0043044; P:ATP-dependent chromatin remodeling; IDA:RGD.
GO; GO:0001832; P:blastocyst growth; ISO:RGD.
GO; GO:0001835; P:blastocyst hatching; ISO:RGD.
GO; GO:0001568; P:blood vessel development; ISO:RGD.
GO; GO:0000902; P:cell morphogenesis; ISO:RGD.
GO; GO:0006338; P:chromatin remodeling; ISO:RGD.
GO; GO:0060976; P:coronary vasculature development; ISO:RGD.
GO; GO:0060318; P:definitive erythrocyte differentiation; ISO:RGD.
GO; GO:0010424; P:DNA methylation on cytosine within a CG sequence; ISO:RGD.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; ISO:RGD.
GO; GO:0048562; P:embryonic organ morphogenesis; ISO:RGD.
GO; GO:0048730; P:epidermis morphogenesis; ISO:RGD.
GO; GO:0030198; P:extracellular matrix organization; ISO:RGD.
GO; GO:0030900; P:forebrain development; ISO:RGD.
GO; GO:0007403; P:glial cell fate determination; ISO:RGD.
GO; GO:0007507; P:heart development; ISO:RGD.
GO; GO:0060347; P:heart trabecula formation; ISO:RGD.
GO; GO:0030902; P:hindbrain development; ISO:RGD.
GO; GO:0043966; P:histone H3 acetylation; ISO:RGD.
GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
GO; GO:0030216; P:keratinocyte differentiation; ISO:RGD.
GO; GO:0070307; P:lens fiber cell development; ISO:RGD.
GO; GO:0001889; P:liver development; ISO:RGD.
GO; GO:0006346; P:methylation-dependent chromatin silencing; ISO:RGD.
GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; ISO:RGD.
GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
GO; GO:0030308; P:negative regulation of cell growth; ISO:RGD.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISO:RGD.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:RGD.
GO; GO:0007399; P:nervous system development; ISO:RGD.
GO; GO:0003407; P:neural retina development; ISO:RGD.
GO; GO:0022008; P:neurogenesis; ISO:RGD.
GO; GO:0006337; P:nucleosome disassembly; IDA:RGD.
GO; GO:0003151; P:outflow tract morphogenesis; ISO:RGD.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; ISO:RGD.
GO; GO:0043923; P:positive regulation by host of viral transcription; ISO:RGD.
GO; GO:0045597; P:positive regulation of cell differentiation; ISO:RGD.
GO; GO:0008284; P:positive regulation of cell proliferation; ISO:RGD.
GO; GO:0043388; P:positive regulation of DNA binding; ISO:RGD.
GO; GO:0051091; P:positive regulation of DNA binding transcription factor activity; ISO:RGD.
GO; GO:1902661; P:positive regulation of glucose mediated signaling pathway; ISO:RGD.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription from RNA polymerase II promoter; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:1901838; P:positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter; ISO:RGD.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0030177; P:positive regulation of Wnt signaling pathway; ISO:RGD.
GO; GO:0030334; P:regulation of cell migration; ISO:RGD.
GO; GO:0007286; P:spermatid development; IEP:RGD.
GO; GO:0019827; P:stem cell population maintenance; ISO:RGD.
GO; GO:0001570; P:vasculogenesis; ISO:RGD.
GO; GO:0003281; P:ventricular septum development; ISO:RGD.
CDD; cd00079; HELICc; 1.
Gene3D; 1.20.920.10; -; 2.
InterPro; IPR030100; BRG1.
InterPro; IPR006576; BRK_domain.
InterPro; IPR037259; BRK_sf.
InterPro; IPR001487; Bromodomain.
InterPro; IPR036427; Bromodomain-like_sf.
InterPro; IPR018359; Bromodomain_CS.
InterPro; IPR014978; Gln-Leu-Gln_QLQ.
InterPro; IPR014001; Helicase_ATP-bd.
InterPro; IPR001650; Helicase_C.
InterPro; IPR014012; HSA_dom.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR029295; SnAC.
InterPro; IPR000330; SNF2_N.
PANTHER; PTHR10799:SF76; PTHR10799:SF76; 1.
Pfam; PF07533; BRK; 1.
Pfam; PF00439; Bromodomain; 1.
Pfam; PF00271; Helicase_C; 1.
Pfam; PF07529; HSA; 1.
Pfam; PF08880; QLQ; 1.
Pfam; PF14619; SnAC; 1.
Pfam; PF00176; SNF2_N; 1.
PRINTS; PR00503; BROMODOMAIN.
SMART; SM00592; BRK; 1.
SMART; SM00297; BROMO; 1.
SMART; SM00487; DEXDc; 1.
SMART; SM00490; HELICc; 1.
SMART; SM00573; HSA; 1.
SMART; SM00951; QLQ; 1.
SMART; SM01314; SnAC; 1.
SUPFAM; SSF160481; SSF160481; 1.
SUPFAM; SSF47370; SSF47370; 1.
SUPFAM; SSF52540; SSF52540; 2.
PROSITE; PS00633; BROMODOMAIN_1; 1.
PROSITE; PS50014; BROMODOMAIN_2; 1.
PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PROSITE; PS51194; HELICASE_CTER; 1.
PROSITE; PS51204; HSA; 1.
PROSITE; PS51666; QLQ; 1.
1: Evidence at protein level;
Acetylation; Activator; ATP-binding; Bromodomain; Chromatin regulator;
Complete proteome; Helicase; Hydrolase; Isopeptide bond; Neurogenesis;
Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome;
Repressor; Transcription; Transcription regulation; Ubl conjugation.
CHAIN 1 1613 Transcription activator BRG1.
/FTId=PRO_0000391344.
DOMAIN 171 206 QLQ. {ECO:0000255|PROSITE-
ProRule:PRU01001}.
DOMAIN 460 532 HSA. {ECO:0000255|PROSITE-
ProRule:PRU00549}.
DOMAIN 766 931 Helicase ATP-binding.
{ECO:0000255|PROSITE-ProRule:PRU00541}.
DOMAIN 1084 1246 Helicase C-terminal.
{ECO:0000255|PROSITE-ProRule:PRU00542}.
DOMAIN 1443 1513 Bromo. {ECO:0000255|PROSITE-
ProRule:PRU00035}.
NP_BIND 779 786 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00541}.
REGION 1 282 Necessary for interaction with
SS18L1/CREST.
{ECO:0000269|PubMed:19081374}.
MOTIF 881 884 DEGH box. {ECO:0000250}.
COMPBIAS 663 672 Poly-Glu.
COMPBIAS 1252 1370 Glu-rich.
COMPBIAS 1531 1555 Glu-rich.
SITE 1505 1506 Required for binding to 'Lys-15'-
acetylated histone 3. {ECO:0000250}.
MOD_RES 11 11 Phosphothreonine.
{ECO:0000250|UniProtKB:P51532}.
MOD_RES 188 188 N6-acetyllysine.
{ECO:0000250|UniProtKB:P51532}.
MOD_RES 353 353 Phosphothreonine.
{ECO:0000250|UniProtKB:P51532}.
MOD_RES 609 609 Phosphothreonine.
{ECO:0000250|UniProtKB:P51532}.
MOD_RES 610 610 Phosphoserine.
{ECO:0000250|UniProtKB:P51532}.
MOD_RES 613 613 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 695 695 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 699 699 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 1349 1349 Phosphoserine.
{ECO:0000250|UniProtKB:P51532}.
MOD_RES 1390 1390 Phosphothreonine.
{ECO:0000250|UniProtKB:Q3TKT4}.
MOD_RES 1419 1419 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 1536 1536 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 1541 1541 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 1552 1552 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 1593 1593 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 1597 1597 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
CROSSLNK 1332 1332 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P51532}.
SEQUENCE 1613 AA; 181427 MW; 7E5F1B04D4C26C87 CRC64;
MSTPDPPLGG TPRPGPSPGP GPSPGAMLGP SPGPSPGSAH SMMGPSPGPP SAGHPMPTQG
PGGYPQDNMH QMHKPMESMH EKGMPDDPRY NQMKGMGMRS GAHTGMGPPP SPMDQHSQGY
PSPLGGSEHA SSPVPASGPS SGPQMSSGPG GAPLDGSDPQ ALGQQNRGPT PFNQNQLHQL
RAQIMAYKML ARGQPLPDHL QMAVQGKRPM PGMQQQMPTL PPPSVSATGP GPGPGPGPGP
GPGPAPPNYS RPHGMGGPNM PPPGPSGVPP GMPGQPPGGP PKPWPEGPMA NAAAPTSTPQ
KLIPPQPTGR PSPAPPAVPP AASPVMPPQT QSPGQPAQPA PLVPLHQKQS RITPIQKPRG
LDPVEILQER EYRLQARIVH RIQELENLPG SLAGDLRTKA TIELKALRLL NFQRQLRQEV
VVCMRRDTAL ETALNAKAYK RSKRQSLREA RITEKLEKQQ KIEQERKRRQ KHQEYLNSIL
QHAKDFREYH RSVTGKLQKL TKAVATYHAN TEREQKKENE RIEKERMRRL MAEDEEGYRK
LIDQKKDKRL AYLLQQTDEY VANLTELVRQ HKAAQVAKEK KKKKKKKKAE NAEGQTPAIG
PDGEPLDETS QMSDLPVKVI HVESGKILTG TDAPKAGQLE AWLEMNPGYE VAPRSDSEES
GSEEEEEEEE EEQPQPAQPP TLPVEEKKKI PDPDSDDVSE VDARHIIENA KQDVDDEYGV
SQALARGLQS YYAVAHAVTE RVDKQSALMV NGVLKQYQIK GLEWLVSLYN NNLNGILADE
MGLGKTIQTI ALITYLMEHK RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA
RRAFVPQLRS GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH
YVAPRRLLLT GTPLQNKLPE LWALLNFLLP TIFKSCSTFE QWFNAPFAMT GEKVDLNEEE
TILIIRRLHK VLRPFLLRRL KKEVEAQLPE KVEYVIKCDM SALQRVLYRH MQAKGVLLTD
GSEKDKKGKG GTKTLMNTIM QLRKICNHPY MFQHIEESFS EHLGFTGGIV QGLDLYRASG
KFELLDRILP KLRATNHKVL LFCQMTSLMT IMEDYFAYRG FKYLRLDGTT KAEDRGMLLK
TFNEPGSEYF IFLLSTRAGG LGLNLQSADT VIIFDSDWNP HQDLQAQDRA HRIGQQNEVR
VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ AGMFDQKSSS HERRAFLQAI LEHEEQDEEE
DEVPDDETVN QMIARHEEEF DLFMRMDLDR RREEARNPKR KPRLMEEDEL PSWIIKDDAE
VERLTCEEEE EKMFGRGSRH RKEVDYSDSL TEKQWLKAIE EGTLEEIEEE VRQKKSSRKR
KRDSEAGSST PTTSTRSRDK DEESKKQKKR GRPPAEKLSP NPPNLTKKMK KIVDAVIKYK
DSSGRQLSEV FIQLPSRKEL PEYYELIRKP VDFKKIKERI RNHKYRSLND LEKDVMLLCQ
NAQTFNLEGS LIYEDSIVLQ SVFTSVRQKI EKEDDSEGEE SEEEEEGEEE GSESESRSVK
VKIKLGRKEK AQDRLKGGRR RPSRGSRAKP VVSDDDSDEE QEEDRSGSGS EED


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EIAAB38778 ATP-dependent helicase SMARCA4,BAF190A,BAF190A,Bos taurus,Bovine,BRG1,BRG1-associated factor 190A,Protein brahma homolog 1,SMARCA4,SNF2B,SNF2-beta,SNF2L4,SWI_SNF-related matrix-associated actin-depend
EIAAB38779 ATP-dependent helicase SMARCA4,BAF190A,Baf190a,Brg1,BRG1-associated factor 190A,Mouse,Mus musculus,Protein brahma homolog 1,Smarca4,Snf2b,SNF2-beta,Snf2l4,SWI_SNF-related matrix-associated actin-depen
EIAAB38780 ATP-dependent helicase SMARCA4,BAF190A,BAF190A,BRG1,BRG1-associated factor 190A,Homo sapiens,Human,Mitotic growth and transcription activator,Protein brahma homolog 1,Protein BRG-1,SMARCA4,SNF2B,SNF2-
20-372-60078 SWI_SNF related. matrix associated. actin dependent regulator of chromatin. subfamily a. member 4 (SMARCA4) - Mouse monoclonal anti-human SMARCA4 antibody; EC 3.6.1.-; ATP-dependent helicase SMARCA4; 0.1 mg
18-003-43477 SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 - BRG1-associated factor 57 Polyclonal 0.05 mg Aff Pur
18-003-43138 SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 - 60 kDa BRG-1_Brm-associated factor subunit C; BRG1-associated factor 60C Polyclonal 0.05 mg Aff Pur
18-003-43476 SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 - 60 kDa BRG-1_Brm-associated factor subunit B; BRG1-associated factor 60B Polyclonal 0.05 mg Aff Pur
EIAAB38867 60 kDa BRG-1_Brm-associated factor subunit B,BAF60B,Bos taurus,Bovine,BRG1-associated factor 60B,SMARCD2,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
EIAAB38776 ATP-dependent helicase SMARCA2,BAF190B,BAF190B,BRG1-associated factor 190B,BRM,hBRM,Homo sapiens,Human,Probable global transcription activator SNF2L2,Protein brahma homolog,SMARCA2,SNF2A,SNF2-alpha,SN
EIAAB38784 BAF57,Baf57,BRG1-associated factor 57,Mouse,Mus musculus,Smarce1,SWI_SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1
EIAAB38951 BAF47,BAF47,Bos taurus,Bovine,BRG1-associated factor 47,SMARCB1,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
EIAAB38785 BAF57,BAF57,BRG1-associated factor 57,Homo sapiens,Human,SMARCE1,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
18-272-195641 SMARCA2 - Rabbit polyclonal to SMARCA2; EC 3.6.1.-; ATP-dependent helicase SMARCA2; SNF2-alpha; SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; hBRM Poly 0.1 ml
18-272-195642 SMARCA2 - Rabbit polyclonal to SMARCA2; EC 3.6.1.-; ATP-dependent helicase SMARCA2; SNF2-alpha; SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; hBRM Poly 0.1 ml
EIAAB38777 ATP-dependent helicase SMARCA2,BAF190B,Baf190b,BRG1-associated factor 190B,Brm,Mouse,Mus musculus,Probable global transcription activator SNF2L2,Protein brahma homolog,Smarca2,Snf2a,SNF2-alpha,Snf2l2,
SMARCA4 SMARCA4 Gene SWI_SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
EIAAB38868 60 kDa BRG-1_Brm-associated factor subunit B,BAF60B,Baf60b,BRG1-associated factor 60B,Mouse,Mus musculus,Smarcd2,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D me
EIAAB38865 60 kDa BRG-1_Brm-associated factor subunit B,BAF60B,Baf60b,BRG1-associated factor 60B,Rat,Rattus norvegicus,Smarcd2,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D
EIAAB38870 60 kDa BRG-1_Brm-associated factor subunit C,BAF60C,BAF60C,BRG1-associated factor 60C,Homo sapiens,Human,SMARCD3,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D me
60078 IgG,SWI_SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4) 0.1 mg
GWB-C76DD5 SWI SNF related matrix associated actin dependent regulator of chromatin subfamily a member 4 (SMARCA4), Antibody
201-20-5439 SMARCA4{SWI_SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4}rabbit.pAb 0.2ml
GWB-C76DD5 SWI_SNF related matrix associated actin dependent regulator of chromatin subfamily a member 4 (SMARCA4), Antibody
EIAAB38948 BAF47,Baf47,BRG1-associated factor 47,Ini1,Integrase interactor 1 protein,Mouse,mSNF5,Mus musculus,Smarcb1,SNF5 homolog,Snf5l1,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin


 

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