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Transcription elongation factor SPT6 (Chromatin elongation factor SPT6)

 SPT6_KLULA              Reviewed;        1460 AA.
Q6CVK3;
30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
16-AUG-2004, sequence version 1.
23-MAY-2018, entry version 93.
RecName: Full=Transcription elongation factor SPT6;
AltName: Full=Chromatin elongation factor SPT6;
Name=SPT6; OrderedLocusNames=KLLA0B11385g;
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC
1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
NCBI_TaxID=284590;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
WM37;
PubMed=15229592; DOI=10.1038/nature02579;
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
-!- FUNCTION: Plays a role in maintenance of chromatin structure
during RNA polymerase II transcription elongation thereby
repressing transcription initiation from cryptic promoters.
Mediates the reassembly of nucleosomes onto the promoters of at
least a selected set of genes during repression; the nucleosome
reassembly is essential for transcriptional repression (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000305}.
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EMBL; CR382122; CAH02429.1; -; Genomic_DNA.
RefSeq; XP_452036.1; XM_452036.1.
ProteinModelPortal; Q6CVK3; -.
SMR; Q6CVK3; -.
STRING; 284590.XP_452036.1; -.
EnsemblFungi; CAH02429; CAH02429; KLLA0_B11385g.
GeneID; 2897509; -.
KEGG; kla:KLLA0B11385g; -.
eggNOG; KOG1856; Eukaryota.
eggNOG; COG2183; LUCA.
HOGENOM; HOG000193710; -.
InParanoid; Q6CVK3; -.
KO; K11292; -.
OMA; EADWIYR; -.
OrthoDB; EOG092C04AI; -.
Proteomes; UP000000598; Chromosome B.
GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
GO; GO:0031618; C:nuclear pericentric heterochromatin; IEA:EnsemblFungi.
GO; GO:0035327; C:transcriptionally active chromatin; IEA:EnsemblFungi.
GO; GO:0003677; F:DNA binding; IEA:InterPro.
GO; GO:0042393; F:histone binding; IEA:EnsemblFungi.
GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
GO; GO:0001073; F:transcription antitermination factor activity, DNA binding; IEA:EnsemblFungi.
GO; GO:0000991; F:transcription factor activity, core RNA polymerase II binding; IEA:EnsemblFungi.
GO; GO:0000433; P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose; IEA:EnsemblFungi.
GO; GO:0070827; P:chromatin maintenance; IEA:EnsemblFungi.
GO; GO:0006338; P:chromatin remodeling; IEA:EnsemblFungi.
GO; GO:0030702; P:chromatin silencing at centromere; IEA:EnsemblFungi.
GO; GO:0000183; P:chromatin silencing at rDNA; IEA:EnsemblFungi.
GO; GO:0030466; P:chromatin silencing at silent mating-type cassette; IEA:EnsemblFungi.
GO; GO:0006348; P:chromatin silencing at telomere; IEA:EnsemblFungi.
GO; GO:0044382; P:CLRC ubiquitin ligase complex localization to heterochromatin; IEA:EnsemblFungi.
GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:EnsemblFungi.
GO; GO:1900050; P:negative regulation of histone exchange; IEA:EnsemblFungi.
GO; GO:0071441; P:negative regulation of histone H3-K14 acetylation; IEA:EnsemblFungi.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
GO; GO:0016584; P:nucleosome positioning; IEA:EnsemblFungi.
GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:EnsemblFungi.
GO; GO:1900111; P:positive regulation of histone H3-K9 dimethylation; IEA:EnsemblFungi.
GO; GO:1900114; P:positive regulation of histone H3-K9 trimethylation; IEA:EnsemblFungi.
GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
GO; GO:0071931; P:positive regulation of transcription involved in G1/S transition of mitotic cell cycle; IEA:EnsemblFungi.
GO; GO:0031454; P:regulation of extent of heterochromatin assembly; IEA:EnsemblFungi.
GO; GO:0000414; P:regulation of histone H3-K36 methylation; IEA:EnsemblFungi.
GO; GO:0051569; P:regulation of histone H3-K4 methylation; IEA:EnsemblFungi.
GO; GO:0031440; P:regulation of mRNA 3'-end processing; IEA:EnsemblFungi.
GO; GO:0060303; P:regulation of nucleosome density; IEA:EnsemblFungi.
GO; GO:0043618; P:regulation of transcription from RNA polymerase II promoter in response to stress; IEA:EnsemblFungi.
GO; GO:0001178; P:regulation of transcriptional start site selection at RNA polymerase II promoter; IEA:EnsemblFungi.
CDD; cd09928; SH2_Cterm_SPT6_like; 1.
CDD; cd09918; SH2_Nterm_SPT6_like; 1.
Gene3D; 1.10.10.650; -; 1.
Gene3D; 1.10.3500.10; -; 2.
Gene3D; 3.30.420.140; -; 2.
Gene3D; 3.30.505.10; -; 2.
InterPro; IPR012337; RNaseH-like_sf.
InterPro; IPR010994; RuvA_2-like.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR028083; Spt6_acidic_N_dom.
InterPro; IPR027999; Spt6_dom.
InterPro; IPR032706; Spt6_HHH.
InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
InterPro; IPR035420; Spt6_SH2.
InterPro; IPR035018; Spt6_SH2_C.
InterPro; IPR035019; Spt6_SH2_N.
InterPro; IPR028231; Spt6_YqgF.
InterPro; IPR023323; Tex-like_dom_sf.
InterPro; IPR023319; Tex-like_HTH_dom_sf.
InterPro; IPR017072; TF_Spt6.
InterPro; IPR006641; YqgF/RNaseH-like_dom.
InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
PANTHER; PTHR10145; PTHR10145; 1.
Pfam; PF14878; DLD; 1.
Pfam; PF14635; HHH_7; 1.
Pfam; PF14641; HTH_44; 1.
Pfam; PF14633; SH2_2; 1.
Pfam; PF14632; SPT6_acidic; 1.
Pfam; PF14639; YqgF; 1.
PIRSF; PIRSF036947; Spt6; 1.
SMART; SM00252; SH2; 1.
SMART; SM00732; YqgFc; 1.
SUPFAM; SSF47781; SSF47781; 1.
SUPFAM; SSF53098; SSF53098; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
3: Inferred from homology;
Complete proteome; Nucleus; Reference proteome; SH2 domain;
Transcription; Transcription regulation.
CHAIN 1 1460 Transcription elongation factor SPT6.
/FTId=PRO_0000238577.
DOMAIN 1257 1354 SH2. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
COMPBIAS 35 284 Glu-rich.
COMPBIAS 1449 1453 Poly-Asn.
SEQUENCE 1460 AA; 169610 MW; 188534D121A1B8DE CRC64;
MSDKEDEKQS QPVLKDDKQD QTEEPAIDDN VNGDEGPSDE EEGDDVFDSS EEDEDLDNDE
EEAQKVREGF IVDDDEEGGE EDEVVKKKSR RKRRAREEEN EALDEDDLDL LMENAGFKRP
SASEAAKQRS GKLKRLKRVG DDEEESASAE PESEVARTNK LDDFFSEEEE EEELEDDGTG
RAPSRKGVEK TVTLADDMDD FIEEDEFSDE DEEARKFRIA EKKRIKEQRL AQPTQITGLS
PDKVDEMFEV FGDGHDYDWA LELENEEELD RLEESSENEQ DENELGIDSK RKKKLTLQDI
YDLQDLKKNL LTEEDMNIRK ADIPERYQEL RTGLKNYGKL SPEDLELEKN WISDKIAVDK
NFDADYDTTE FKEAIGNAIN FIQQENLEVS FIYAYRRNYI SSRSKDGFVL IEDDLWDIVF
YDTEFHSIIY KRDYVKTFYE KLDIHDPIVD EYFSNQSMTE LNSLQDIYDY VEFKYAQEIN
DVLLSTQQDA TSKKHLKNSS YEKFKASALY QAINDTGITA EQVGENISAE HQLHPVVDHP
SLKPTDSVAN ILEGPEAKDL QIFSQNPKLA LETIEKYYAL ELSKNPKVRQ KIRDDFYKYY
IVDVALTSKG RKEIQRGSPY EDIKYALGRT PAHFRSEPDV FLRMLEAESL HLMNIQIHVS
SQDQYTNHLF QTSLETSNTS EIASEWNSFR RDAFDSALNK VFSDVSQEIK DELKKTCLRL
VTKSVRHQFM FKLDQAPFIP NPKDPKIPRV LTITCGQGKF GSDAIIAVYL NRKTEFVRDY
KIVENPFDRK EPELFENALD DIIQHCQPNV IGINGPNPST QRLYKKIQEI VQKKQIVDNR
GSHVPVIYVE DEVAVRYQSS ERAAQEFPSK PTLVKYCIAL GRYIHSPLLE YANLTNEELL
SLSIHSHQSL LTRELFLQAL ETSFVDIVNL VGIEVNKATD NHYYAKALRY IAGFGRRKSA
DFLESLQRLN EPLLARQQLI THDILTKTIF MNSAAFLYIS WNEKNQRYED LEHDQLDGTR
IHPEDYHLAT KVAADALEFD PDAIAEKEEQ GTMSEFIELL REDPDRRTKL ESLNLEAYAE
ELEKNTGQRK LNNLNTIVLE LLEGFEELRN DFHPLHGDEV FKSLTGESEK TFFKGCIIPV
RVERFRHNDI YGVTNSGVEC VINAQRHIGA QLKRPAEEVY EIGKTYPAKV IYIDYDNISC
EVSLLEHDIR RQYVPIHYSK DPSIWNVEQE MKDQEIEKKL ALEEARAKRT HRVINHPYYG
NFTGPQAEDY LRSRERGDFV IRQSSRGDDH LAITWKLDKD LFQHVDILEK DKENPLALGK
TLIVEDQKYH DLDQIIVEYL QNKVRLLNEI TSNEKFKKGT KKEVIKFIED YSKVNPNRSV
YYFSFNYEHP GWFYLMFKIN AQSQLYVWNV KLTHTGFFLV NYNYPTVIQL CNGFKTLLKS
SSRNKTQDNN NNNSGGYYGY


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