Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Transcription factor 7-like 1 (HMG box transcription factor 3) (TCF-3) (mTCF-3)

 TF7L1_MOUSE             Reviewed;         584 AA.
Q9Z1J1; O70450; O70573;
25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
25-MAR-2003, sequence version 2.
25-OCT-2017, entry version 137.
RecName: Full=Transcription factor 7-like 1;
AltName: Full=HMG box transcription factor 3;
Short=TCF-3;
Short=mTCF-3;
Name=Tcf7l1; Synonyms=Tcf3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH CTNNB1.
STRAIN=C57BL/6J; TISSUE=Embryo;
PubMed=9488439; DOI=10.1128/MCB.18.3.1248;
Korinek V., Barker N., Willert K., Molenaar M., Roose J., Wagenaar G.,
Markman M., Lamers W., Destree O., Clevers H.;
"Two members of the Tcf family implicated in Wnt/b-catenin signaling
during embryogenesis in the mouse.";
Mol. Cell. Biol. 18:1248-1256(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 28-584.
STRAIN=CD-1; TISSUE=Limb;
Melchionna R., Murphy P., La Valle R., Borello U., Cossu G.;
"Cloning of murine Tcf-3: a possible role in muscle development.";
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 173-584.
Sussman D.J.;
"Partial mRNA sequence of mouse transcription factor mTCF-3.";
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
[4]
TISSUE SPECIFICITY.
PubMed=10498690;
DasGupta R., Fuchs E.;
"Multiple roles for activated LEF/TCF transcription complexes during
hair follicle development and differentiation.";
Development 126:4557-4568(1999).
[5]
FUNCTION, AND MUTAGENESIS OF LEU-383 AND PRO-407.
PubMed=11445543; DOI=10.1101/gad.891401;
Merrill B.J., Gat U., DasGupta R., Fuchs E.;
"Tcf3 and Lef1 regulate lineage differentiation of multipotent stem
cells in skin.";
Genes Dev. 15:1688-1705(2001).
-!- FUNCTION: Participates in the Wnt signaling pathway. Binds to DNA
and acts as a repressor in the absence of CTNNB1, and as an
activator in its presence. Necessary for the terminal
differentiation of epidermal cells, the formation of keratohyalin
granules and the development of the barrier function of the
epidermis. {ECO:0000269|PubMed:11445543}.
-!- SUBUNIT: Binds the armadillo repeat of CTNNB1 and forms a stable
complex.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Detected in the basal layer of epidermis and
in outer root sheath and bulge of hair follicles.
{ECO:0000269|PubMed:10498690}.
-!- DOMAIN: The putative Groucho interaction domain between the N-
terminal CTNNB1 binding domain and the HMG-box is necessary for
repression of the transactivation mediated by TCF7L1 and CTNNB1.
-!- SIMILARITY: Belongs to the TCF/LEF family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AJ223069; CAA11070.1; -; mRNA.
EMBL; AJ223233; CAA11201.1; -; mRNA.
EMBL; AF057691; AAC13696.1; -; mRNA.
RefSeq; NP_033358.2; NM_009332.3.
UniGene; Mm.440067; -.
ProteinModelPortal; Q9Z1J1; -.
SMR; Q9Z1J1; -.
BioGrid; 204008; 3.
DIP; DIP-49605N; -.
IntAct; Q9Z1J1; 5.
STRING; 10090.ENSMUSP00000109687; -.
iPTMnet; Q9Z1J1; -.
PhosphoSitePlus; Q9Z1J1; -.
MaxQB; Q9Z1J1; -.
PaxDb; Q9Z1J1; -.
PRIDE; Q9Z1J1; -.
GeneID; 21415; -.
KEGG; mmu:21415; -.
CTD; 83439; -.
MGI; MGI:1202876; Tcf7l1.
eggNOG; KOG3248; Eukaryota.
eggNOG; ENOG41109RU; LUCA.
HOVERGEN; HBG000419; -.
InParanoid; Q9Z1J1; -.
KO; K04490; -.
ChiTaRS; Tcf7l1; mouse.
PRO; PR:Q9Z1J1; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_TCF3; -.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0005667; C:transcription factor complex; IBA:GO_Central.
GO; GO:0008013; F:beta-catenin binding; IPI:MGI.
GO; GO:0003682; F:chromatin binding; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:MGI.
GO; GO:0044212; F:transcription regulatory region DNA binding; IBA:GO_Central.
GO; GO:0008595; P:anterior/posterior axis specification, embryo; IMP:MGI.
GO; GO:0048319; P:axial mesoderm morphogenesis; IMP:MGI.
GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI.
GO; GO:0046022; P:positive regulation of transcription from RNA polymerase II promoter during mitotic cell cycle; IDA:MGI.
GO; GO:2000036; P:regulation of stem cell population maintenance; IMP:MGI.
GO; GO:0043588; P:skin development; IGI:MGI.
GO; GO:0035019; P:somatic stem cell population maintenance; IGI:MGI.
GO; GO:0048863; P:stem cell differentiation; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.30.10; -; 1.
Gene3D; 4.10.900.10; -; 1.
InterPro; IPR027397; Catenin_binding_dom.
InterPro; IPR013558; CTNNB1-bd_N.
InterPro; IPR009071; HMG_box_dom.
InterPro; IPR036910; HMG_box_dom_sf.
InterPro; IPR024940; TCF/LEF.
InterPro; IPR028773; TCF7L.
PANTHER; PTHR10373; PTHR10373; 1.
PANTHER; PTHR10373:SF25; PTHR10373:SF25; 1.
Pfam; PF08347; CTNNB1_binding; 1.
Pfam; PF00505; HMG_box; 1.
SMART; SM00398; HMG; 1.
SUPFAM; SSF47095; SSF47095; 1.
PROSITE; PS50118; HMG_BOX_2; 1.
1: Evidence at protein level;
Activator; Complete proteome; DNA-binding; Nucleus;
Reference proteome; Repressor; Transcription;
Transcription regulation; Wnt signaling pathway.
CHAIN 1 584 Transcription factor 7-like 1.
/FTId=PRO_0000048615.
DNA_BIND 342 410 HMG box. {ECO:0000255|PROSITE-
ProRule:PRU00267}.
REGION 1 71 CTNNB1-binding. {ECO:0000250}.
MOTIF 417 423 Nuclear localization signal.
{ECO:0000255}.
COMPBIAS 5 26 Gly-rich.
COMPBIAS 167 322 Pro-rich.
MUTAGEN 383 383 L->P: Abolishes DNA-binding and
transactivator/repressor activity; when
associated with I-407.
{ECO:0000269|PubMed:11445543}.
MUTAGEN 407 407 P->I: Abolishes DNA-binding and
transactivator/repressor activity; when
associated with P-383.
{ECO:0000269|PubMed:11445543}.
CONFLICT 114 114 G -> P (in Ref. 2; CAA11201).
{ECO:0000305}.
CONFLICT 301 301 I -> M (in Ref. 2; CAA11201).
{ECO:0000305}.
CONFLICT 404 405 QL -> HV (in Ref. 2; CAA11201).
{ECO:0000305}.
CONFLICT 463 463 S -> I (in Ref. 2; CAA11201).
{ECO:0000305}.
CONFLICT 471 471 A -> T (in Ref. 2 and 3). {ECO:0000305}.
SEQUENCE 584 AA; 62298 MW; BA8B4F570AFC72CB CRC64;
MPQLGGGRGG AGGGGGGSGA GATSGGDDLG ANDELIPFQD EGGEEQEPSS DTASAQRDLD
EVKSSLVNES ENQSSSSDSE AERRPQPARD AFQKPRDYFA EVRRPQDGAF FKGGAYPGYP
FLMIPDLSSP YLSNGPLSPG GARTYLQMKW PLLDVPSSAT VKDTRSPSPA HLSNKVPVVQ
HPHHMHPLTP LITYSNDHFS PASPPTHLSP EIDPKTGIPR PPHPSELSPY YPLSPGAVGQ
IPHPLGWLVP QQGQPMYSLP PGGFRHPYPA LAMNASMSSL VSSRFPHMVA PAHPGLPTSG
IPHPAIVSPI VKQEPAAPSL SPAVSAKSPV TVKKEEEKKP HVKKPLNAFM LYMKEMRAKV
VAECTLKESA AINQILGRKW HNLSREEQAK YYELARKERQ LHAQLYPTWS ARDNYGKKKK
RKREKQLSQT QSQQQIQEAE GALASKSKKP CIQYLPPEKP CDSPASSHGS ALDSPATPSA
ALASPAAPAA THSEQAQPLS LTTKPEARAQ LALHSAAFLS AKAAASNSSQ MGSQPPLLSR
PLPLGSMPAA LLTSPPTFPA TLHAHQALPV LQAQPLSLVT KSAH


Related products :

Catalog number Product name Quantity
EIAAB42079 HMG box transcription factor 4,Mouse,mTCF-4,Mus musculus,T-cell factor 4,T-cell-specific transcription factor 4,Tcf4,TCF-4,Tcf7l2,Transcription factor 7-like 2
EIAAB42076 HMG box transcription factor 3,Mouse,mTCF-3,Mus musculus,Tcf3,TCF-3,Tcf7l1,Transcription factor 7-like 1
EIAAB42084 Homo sapiens,Human,Mitochondrial transcription factor 1,MtTF1,mtTFA,TCF6,TCF-6,TCF6L2,TFAM,Transcription factor 6,Transcription factor 6-like 2,Transcription factor A, mitochondrial
18-003-42098 Ets domain transcription factor - ESE3 transcription factor; EHF protein; DJ875K15.1.2 (Ets homologous factor (Ets-domain transcription factor. ESE-3B (Isoform 2))); ETS-family transcription factor EH 0.1 mg Protein A
EIAAB42103 Immunoglobulin enhancer-binding factor E12_E47,Pan,Pancreas specific transcription factor 1c,Ptf1c,Rat,Rattus norvegicus,Tcf3,TCF-3,Tcfe2a,Transcription factor 3,Transcription factor E2-alpha,Transcri
EIAAB42104 Alf2,Immunoglobulin enhancer-binding factor E12_E47,Me2,Mouse,Mus musculus,Tcf3,TCF-3,Tcfe2a,Transcription factor 3,Transcription factor A1,Transcription factor E2-alpha
31-248 Transcription initiation factor IIA . and . chains (GTranscription Factor Antibodies2A1, Transcription Factor AntibodiesIIA p35 and p19 subunits, Transcription Factor AntibodiesIIAL) binding ability o 0.05 mg
EIAAB12290 E4F transcription factor 1,E4f1,Mouse,Mus musculus,p120E4F,Putative E3 ubiquitin-protein ligase E4F1,Transcription factor E4F,Transcription factor E4F1,Transcription factor phi AP3
18-003-44075 Transcription factor E2-alpha - Immunoglobulin enhancer-binding factor E12_E47; Transcription factor 3; TCF-3; Immunoglobulin transcription factor 1; Transcription factor ITF-1; Kappa-E2-binding facto 0.1 mg Protein A
EIAAB25650 Homo sapiens,Human,Metal regulatory transcription factor 1,MRE-binding transcription factor,MTF1,Transcription factor MTF-1
EIAAB42050 Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,General transcription factor IIH subunit 4,GTF2H4,Homo sapiens,Human,TFIIH basal transcription facto
EIAAB42045 Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,General transcription factor IIH subunit 3,GTF2H3,Homo sapiens,Human,TFIIH basal transcription facto
EIAAB42049 Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,General transcription factor IIH subunit 4,Gtf2h4,Mouse,Mus musculus,TFIIH basal transcription facto
EIAAB42039 Basic transcription factor 2 62 kDa subunit,BTF2 p62,General transcription factor IIH polypeptide 1,General transcription factor IIH subunit 1,Gtf2h1,Mouse,Mus musculus,TFIIH basal transcription facto
EIAAB42048 Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,General transcription factor IIH subunit 3,Gtf2h3,Mouse,Mus musculus,TFIIH basal transcription facto
EIAAB25651 Metal regulatory transcription factor 1,Mouse,MRE-binding transcription factor,Mtf1,Mtf-1,Mus musculus,Transcription factor MTF-1
18-003-42235 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.1 mg Protein A
18-003-42234 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.05 mg Aff Pur
18-003-42234 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.1 mg Protein A
18-003-43070 T-box transcription factor TBX21 - T-box protein 21; Transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet Polyclonal 0.1 mg Protein A
18-003-42235 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.05 mg Aff Pur
EIAAB42078 HMG box transcription factor 4,Homo sapiens,hTCF-4,Human,T-cell factor 4,T-cell-specific transcription factor 4,TCF4,TCF-4,TCF7L2,Transcription factor 7-like 2
EIAAB42042 Basic transcription factor 2 44 kDa subunit,BTF2 p44,General transcription factor IIH polypeptide 2,General transcription factor IIH subunit 2,Gtf2h2,Rat,Rattus norvegicus,TFIIH basal transcription fa
EIAAB32964 bHLH transcription factor p48,Mouse,Mus musculus,p48 DNA-binding subunit of transcription factor PTF1,Pancreas transcription factor 1 subunit alpha,Pancreas-specific transcription factor 1a,Ptf1a,Ptf1
18-003-42999 Cyclic AMP-dependent transcription factor ATF-5 - Activating transcription factor 5; Transcription factor ATFx Polyclonal 0.05 mg Aff Pur


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur