Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog)

 JUN_PIG                 Reviewed;         331 AA.
P56432;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
15-JUL-1998, sequence version 1.
25-OCT-2017, entry version 120.
RecName: Full=Transcription factor AP-1;
AltName: Full=Activator protein 1;
Short=AP1;
AltName: Full=Proto-oncogene c-Jun;
AltName: Full=V-jun avian sarcoma virus 17 oncogene homolog;
Name=JUN;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pituitary anterior lobe;
PubMed=8793856; DOI=10.1016/0303-7207(96)03798-7;
Chung H.-O., Kato T., Kato Y.;
"Molecular cloning of c-jun and c-fos cDNAs from porcine anterior
pituitary and their involvement in gonadotropin-releasing hormone
stimulation.";
Mol. Cell. Endocrinol. 119:75-82(1996).
[2]
ERRATUM.
PubMed=8898353; DOI=10.1016/0303-7207(96)03902-0;
Chung H.-O., Kato T., Kato Y.;
Mol. Cell. Endocrinol. 122:113-114(1996).
-!- FUNCTION: Transcription factor that recognizes and binds to the
enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of
NR5A1 when phosphorylated by HIPK3 leading to increased
steroidogenic gene expression upon cAMP signaling pathway
stimulation. Involved in activated KRAS-mediated transcriptional
activation of USP28 in colorectal cancer (CRC) cells. Binds to the
USP28 promoter in colorectal cancer (CRC) cells.
{ECO:0000250|UniProtKB:P05412}.
-!- SUBUNIT: Heterodimer with either FOS or BATF3 or ATF7. The
ATF7/JUN heterodimer is essential for ATF7 transactivation
activity. Interacts with DSIPI; the interaction inhibits the
binding of active AP1 to its target DNA. Interacts with HIVEP3 and
MYBBP1A. Interacts with SP1, SPIB and TCF20. Interacts with COPS5;
the interaction leads indirectly to its phosphorylation. Component
of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter
site. The SMAD3/SMAD4 heterodimer acts synergistically with the
JUN/FOS heterodimer to activate transcription in response to TGF-
beta. Interacts (via its basic DNA binding and leucine zipper
domains) with SMAD3 (via an N-terminal domain); the interaction is
required for TGF-beta-mediated transactivation of the
SMAD3/SMAD4/JUN/FOS/complex. Interacts with methylated RNF187.
Binds to HIPK3. Interacts (when phosphorylated) with FBXW7. Found
in a complex with PRR7 and FBXW7. Interacts with PRR7 and FBXW7;
the interaction inhibits ubiquitination-mediated JUN degradation
promoting its phosphorylation and transcriptional activity.
{ECO:0000250|UniProtKB:P05412, ECO:0000250|UniProtKB:P17325}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P05412}.
-!- PTM: Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances
the transcriptional activity. Phosphorylated by HIPK3.
Phosphorylated by DYRK2 at Ser-243; this primes the protein for
subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at
Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its
ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-
89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell
proliferation and transformation. Phosphorylated by PLK3 following
hypoxia or UV irradiation, leading to increase DNA-binding
activity (By similarity). {ECO:0000250|UniProtKB:P05412}.
-!- PTM: Ubiquitinated by the SCF(FBXW7), leading to its degradation.
Ubiquitination takes place following phosphorylation, that
promotes interaction with FBXW7. {ECO:0000250|UniProtKB:P05412}.
-!- PTM: Acetylated at Lys-271 by EP300.
{ECO:0000250|UniProtKB:P05412}.
-!- SIMILARITY: Belongs to the bZIP family. Jun subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; S83515; AAB50808.1; -; mRNA.
RefSeq; NP_999045.1; NM_213880.1.
UniGene; Ssc.94492; -.
UniGene; Ssc.97579; -.
ProteinModelPortal; P56432; -.
SMR; P56432; -.
iPTMnet; P56432; -.
PRIDE; P56432; -.
GeneID; 396913; -.
KEGG; ssc:396913; -.
CTD; 3725; -.
HOGENOM; HOG000006648; -.
HOVERGEN; HBG001722; -.
InParanoid; P56432; -.
KO; K04448; -.
Proteomes; UP000008227; Unplaced.
GO; GO:0000790; C:nuclear chromatin; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IDA:AgBase.
GO; GO:0005667; C:transcription factor complex; IBA:GO_Central.
GO; GO:0003677; F:DNA binding; IMP:AgBase.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
GO; GO:0008134; F:transcription factor binding; IBA:GO_Central.
GO; GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IDA:AgBase.
GO; GO:0006955; P:immune response; IDA:AgBase.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO; GO:0045597; P:positive regulation of cell differentiation; IBA:GO_Central.
GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:AgBase.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:AgBase.
GO; GO:0007265; P:Ras protein signal transduction; ISS:UniProtKB.
GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
GO; GO:0010941; P:regulation of cell death; IBA:GO_Central.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:0051591; P:response to cAMP; IBA:GO_Central.
GO; GO:0034097; P:response to cytokine; IBA:GO_Central.
GO; GO:0042493; P:response to drug; IBA:GO_Central.
GO; GO:0009612; P:response to mechanical stimulus; IBA:GO_Central.
GO; GO:0009314; P:response to radiation; IBA:GO_Central.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.880.10; -; 1.
InterPro; IPR004827; bZIP.
InterPro; IPR015558; C_Jun/v-Jun.
InterPro; IPR005643; JNK.
InterPro; IPR002112; Leuzip_Jun.
InterPro; IPR008917; TF_DNA-bd.
PANTHER; PTHR11462:SF8; PTHR11462:SF8; 1.
Pfam; PF00170; bZIP_1; 1.
Pfam; PF03957; Jun; 1.
PRINTS; PR00043; LEUZIPPRJUN.
SMART; SM00338; BRLZ; 1.
SUPFAM; SSF47454; SSF47454; 1.
PROSITE; PS50217; BZIP; 1.
PROSITE; PS00036; BZIP_BASIC; 1.
2: Evidence at transcript level;
Acetylation; Activator; Complete proteome; DNA-binding;
Isopeptide bond; Nucleus; Phosphoprotein; Proto-oncogene;
Reference proteome; Transcription; Transcription regulation;
Ubl conjugation.
CHAIN 1 331 Transcription factor AP-1.
/FTId=PRO_0000076431.
DOMAIN 252 315 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 252 279 Basic motif. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 280 308 Leucine-zipper. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
SITE 272 272 Necessary for synergistic transcriptional
activity with SMAD3. {ECO:0000250}.
MOD_RES 2 2 Phosphothreonine; by PAK2.
{ECO:0000250|UniProtKB:P05412}.
MOD_RES 8 8 Phosphothreonine; by PAK2.
{ECO:0000250|UniProtKB:P05412}.
MOD_RES 58 58 Phosphoserine.
{ECO:0000250|UniProtKB:P05412}.
MOD_RES 63 63 Phosphoserine; by MAPK8 and PLK3.
{ECO:0000250|UniProtKB:P05412}.
MOD_RES 73 73 Phosphoserine; by MAPK8 and PLK3.
{ECO:0000250|UniProtKB:P05412}.
MOD_RES 89 89 Phosphothreonine; by PAK2.
{ECO:0000250|UniProtKB:P05412}.
MOD_RES 91 91 Phosphothreonine.
{ECO:0000250|UniProtKB:P05412}.
MOD_RES 93 93 Phosphothreonine; by PAK2.
{ECO:0000250|UniProtKB:P05412}.
MOD_RES 239 239 Phosphothreonine; by GSK3-beta.
{ECO:0000250|UniProtKB:P05412}.
MOD_RES 243 243 Phosphoserine; by DYRK2 and GSK3-beta.
{ECO:0000250|UniProtKB:P05412}.
MOD_RES 249 249 Phosphoserine; by GSK3-beta.
{ECO:0000250|UniProtKB:P05412}.
MOD_RES 271 271 N6-acetyllysine.
{ECO:0000250|UniProtKB:P05412}.
MOD_RES 286 286 Phosphothreonine; by PAK2.
{ECO:0000250|UniProtKB:P05412}.
CROSSLNK 35 35 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P05412}.
CROSSLNK 50 50 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P05412}.
CROSSLNK 70 70 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P05412}.
CROSSLNK 226 226 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P05412}.
SEQUENCE 331 AA; 35629 MW; 0B45EAD5911340EB CRC64;
MTAKMETTFY DDALNASFLQ SESGAYGYSN PKILKQSMTL NLADPVGNLK PHLRAQDSDL
LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE
LHSQNTLPSV TSAAQPVSGA GLVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA
LSSGGGAPSY GAAGLAFPAQ PQQQQQQPPQ PPHHLPVQHP RLQALKEEPQ TVPEMPGETP
PLSPIDMESQ ERIKAERKRM RNRIAASKCR KRKLERIARL EEKVKTLKAQ NSELASTANM
LREQVAQLKQ KVMNHVNSGC QLMLTQQLQT F


Related products :

Catalog number Product name Quantity
10-782-55042 Transcription factor AP-1 - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 N_A 0.05 mg
10-782-55042 Transcription factor AP-1 - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 N_A 0.2 mg
18-003-43188 Transcription factor AP-1 - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 Polyclonal 0.1 mg Protein A
15-288-21143 Transcription factor AP-1 - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 Polyclonal 0.1 mg
15-288-21143 Transcription factor AP-1 - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 Polyclonal 0.05 mg
E1292p ELISA kit Activator protein 1,AP1,JUN,Pig,Proto-oncogene c-Jun,Sus scrofa,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
U1292p CLIA Activator protein 1,AP1,JUN,Pig,Proto-oncogene c-Jun,Sus scrofa,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
E1292p ELISA Activator protein 1,AP1,JUN,Pig,Proto-oncogene c-Jun,Sus scrofa,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
E1292b ELISA Activator protein 1,AP1,Bos taurus,Bovine,JUN,Proto-oncogene c-Jun,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
E1292r ELISA Activator protein 1,AP1,Jun,Proto-oncogene c-Jun,Rat,Rattus norvegicus,Rjg-9,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
U1292b CLIA Activator protein 1,AP1,Bos taurus,Bovine,JUN,Proto-oncogene c-Jun,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
U1292r CLIA Activator protein 1,AP1,Jun,Proto-oncogene c-Jun,Rat,Rattus norvegicus,Rjg-9,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
E1292b ELISA kit Activator protein 1,AP1,Bos taurus,Bovine,JUN,Proto-oncogene c-Jun,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
E1292r ELISA kit Activator protein 1,AP1,Jun,Proto-oncogene c-Jun,Rat,Rattus norvegicus,Rjg-9,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
U1292h CLIA Activator protein 1,AP1,Homo sapiens,Human,JUN,p39,Proto-oncogene c-Jun,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
E1292h ELISA Activator protein 1,AP1,Homo sapiens,Human,JUN,p39,Proto-oncogene c-Jun,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
U1292m CLIA Activator protein 1,AH119,AP1,Jun,Jun A,Mouse,Mus musculus,Proto-oncogene c-Jun,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
E1292h ELISA kit Activator protein 1,AP1,Homo sapiens,Human,JUN,p39,Proto-oncogene c-Jun,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
E1292m ELISA kit Activator protein 1,AH119,AP1,Jun,Jun A,Mouse,Mus musculus,Proto-oncogene c-Jun,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
E1292m ELISA Activator protein 1,AH119,AP1,Jun,Jun A,Mouse,Mus musculus,Proto-oncogene c-Jun,Transcription factor AP-1,V-jun avian sarcoma virus 17 oncogene homolog 96T
18-785-210088 c-Jun (Ab-91) - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 Polyclonal 0.1 mg
18-785-210087 c-Jun (Ab-73) - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 Polyclonal 0.05 mg
18-785-210090 c-Jun (Ab-170) - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 Polyclonal 0.05 mg
18-785-210088 c-Jun (Ab-91) - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 Polyclonal 0.05 mg
18-785-210087 c-Jun (Ab-73) - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 Polyclonal 0.1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur