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Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta)

 AP2B_CANLF              Reviewed;         460 AA.
Q76HI7;
26-APR-2005, integrated into UniProtKB/Swiss-Prot.
10-JUL-2007, sequence version 2.
25-OCT-2017, entry version 87.
RecName: Full=Transcription factor AP-2-beta;
Short=AP2-beta;
AltName: Full=Activating enhancer-binding protein 2-beta;
Name=TFAP2B;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Beagle; TISSUE=Brain;
Hashizume C., Takeuchi Y., Mori Y.;
"Canis familiaris transcription factor AP-2 beta mRNA, complete cds.";
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Sequence-specific DNA-binding protein that interacts
with inducible viral and cellular enhancer elements to regulate
transcription of selected genes. AP-2 factors bind to the
consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in
a large spectrum of important biological functions including
proper eye, face, body wall, limb and neural tube development.
They also suppress a number of genes including MCAM/MUC18, C/EBP
alpha and MYC. AP-2-beta appears to be required for normal face
and limb development and for proper terminal differentiation and
function of renal tubular epithelia (By similarity).
{ECO:0000250|UniProtKB:Q92481}.
-!- SUBUNIT: Binds DNA as a dimer. Can form homodimers or heterodimers
with other AP-2 family members. Interacts with CITED4. Interacts
with UBE2I. Interacts with KCTD1; this interaction represses
transcription activation. Interacts with CITED2 (via C-terminus);
the interaction stimulates TFAP2B-transcriptional activity (By
similarity). {ECO:0000250|UniProtKB:Q92481}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- PTM: Sumoylated on Lys-21; which inhibits transcriptional
activity. {ECO:0000250}.
-!- SIMILARITY: Belongs to the AP-2 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAC80223.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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EMBL; AB101212; BAC80223.1; ALT_INIT; mRNA.
RefSeq; NP_001002977.1; NM_001002977.1.
UniGene; Cfa.174; -.
ProteinModelPortal; Q76HI7; -.
STRING; 9615.ENSCAFP00000003144; -.
PaxDb; Q76HI7; -.
Ensembl; ENSCAFT00000003387; ENSCAFP00000003144; ENSCAFG00000002156.
GeneID; 403463; -.
KEGG; cfa:403463; -.
CTD; 7021; -.
eggNOG; KOG3811; Eukaryota.
eggNOG; ENOG410XR9E; LUCA.
GeneTree; ENSGT00550000074577; -.
HOGENOM; HOG000231737; -.
HOVERGEN; HBG002455; -.
InParanoid; Q76HI7; -.
KO; K09176; -.
OMA; IGHPGME; -.
OrthoDB; EOG091G0PR6; -.
TreeFam; TF313718; -.
Reactome; R-CFA-8866904; Negative regulation of activity of TFAP2 (AP-2) family transcription factors.
Reactome; R-CFA-8866907; Activation of the TFAP2 (AP-2) family of transcription factors.
Proteomes; UP000002254; Chromosome 12.
Bgee; ENSCAFG00000002156; -.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0001158; F:enhancer sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0046983; F:protein dimerization activity; ISS:UniProtKB.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0001105; F:RNA polymerase II transcription coactivator activity; ISS:UniProtKB.
GO; GO:0001106; F:RNA polymerase II transcription corepressor activity; ISS:UniProtKB.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
GO; GO:0000983; F:transcription factor activity, RNA polymerase II core promoter sequence-specific; ISS:UniProtKB.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
GO; GO:0035909; P:aorta morphogenesis; ISS:UniProtKB.
GO; GO:0055074; P:calcium ion homeostasis; ISS:UniProtKB.
GO; GO:0097275; P:cellular ammonia homeostasis; ISS:UniProtKB.
GO; GO:0097276; P:cellular creatinine homeostasis; ISS:UniProtKB.
GO; GO:0097277; P:cellular urea homeostasis; ISS:UniProtKB.
GO; GO:0072044; P:collecting duct development; ISS:UniProtKB.
GO; GO:0072017; P:distal tubule development; ISS:UniProtKB.
GO; GO:0097070; P:ductus arteriosus closure; ISS:UniProtKB.
GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO; GO:0035136; P:forelimb morphogenesis; ISS:UniProtKB.
GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
GO; GO:0006006; P:glucose metabolic process; ISS:UniProtKB.
GO; GO:0035137; P:hindlimb morphogenesis; ISS:UniProtKB.
GO; GO:0001822; P:kidney development; ISS:UniProtKB.
GO; GO:0010960; P:magnesium ion homeostasis; ISS:UniProtKB.
GO; GO:0072210; P:metanephric nephron development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0055062; P:phosphate ion homeostasis; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0035810; P:positive regulation of urine volume; ISS:UniProtKB.
GO; GO:0055075; P:potassium ion homeostasis; ISS:UniProtKB.
GO; GO:0030510; P:regulation of BMP signaling pathway; ISS:UniProtKB.
GO; GO:0045595; P:regulation of cell differentiation; ISS:UniProtKB.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0003091; P:renal water homeostasis; ISS:UniProtKB.
GO; GO:0010842; P:retina layer formation; IEA:Ensembl.
GO; GO:0043588; P:skin development; IEA:Ensembl.
GO; GO:0055078; P:sodium ion homeostasis; ISS:UniProtKB.
GO; GO:0048485; P:sympathetic nervous system development; ISS:UniProtKB.
GO; GO:0006366; P:transcription from RNA polymerase II promoter; ISS:UniProtKB.
InterPro; IPR004979; TF_AP2.
InterPro; IPR008122; TF_AP2_beta.
InterPro; IPR013854; TF_AP2_C.
PANTHER; PTHR10812; PTHR10812; 1.
PANTHER; PTHR10812:SF14; PTHR10812:SF14; 1.
Pfam; PF03299; TF_AP-2; 1.
PRINTS; PR01750; AP2BTNSCPFCT.
PRINTS; PR01748; AP2TNSCPFCT.
2: Evidence at transcript level;
Activator; Complete proteome; DNA-binding; Isopeptide bond; Nucleus;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 460 Transcription factor AP-2-beta.
/FTId=PRO_0000184800.
COMPBIAS 41 131 Gln/Pro-rich (transactivation domain).
MOD_RES 258 258 Phosphoserine; by PKA. {ECO:0000250}.
CROSSLNK 21 21 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
SEQUENCE 460 AA; 50474 MW; A6420EA0C265DDA2 CRC64;
MHSPPRDQAA IMLWKLVENV KYEDIYEDRH DGVPSHSSRL SQLGSVSQGP YSSAPPLSHT
PSSDFQPPYF PPPYQPLPYH QSQDPYSHVN DPYSLNPLHQ PQQHPWGQRQ RQEVGSEAGS
LLPQPRAALP QLSGLDPRRD YHSVRRPDVL LHSAHHGLDA GMGDSLSLHG LGHPGMEDVQ
SVEDANNSGM NLLDQSVIKK VPVPPKSVTS LMMNKDGFLG GMSVNTGEVF CSVPGRLSLL
SSTSKYKVTV GEVQRRLSPP ECLNASLLGG VLRRAKSKNG GRSLRERLEK IGLNLPAGRR
KAANVTLLTS LVEGEAVHLA RDFGYICETE FPAKAVSEYL NRQHTDPSDL HSRKNMLLAT
KQLCKEFTDL LAQDRTPIGN SRPSPILEPG IQSCLTHFSL ITHGFGAPAI CAALTALQNY
LTEALKGMDK MFLNNTTTNR HTSGEGPGSK TGDKEEKHRK


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