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Transcription factor CPH2 (Candida pseudohyphal regulator 2)

 CPH2_CANAL              Reviewed;         853 AA.
Q59RL7; A0A1D8PPB5; Q59S18;
19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
26-APR-2005, sequence version 1.
25-OCT-2017, entry version 87.
RecName: Full=Transcription factor CPH2;
AltName: Full=Candida pseudohyphal regulator 2;
Name=CPH2; OrderedLocusNames=CAALFM_C600280WA;
ORFNames=CaO19.1187, CaO19.8778;
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
Candida/Lodderomyces clade; Candida.
NCBI_TaxID=237561;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=15123810; DOI=10.1073/pnas.0401648101;
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
Davis R.W., Scherer S.;
"The diploid genome sequence of Candida albicans.";
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
[2]
GENOME REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
Chibana H., Nantel A., Magee P.T.;
"Assembly of the Candida albicans genome into sixteen supercontigs
aligned on the eight chromosomes.";
Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME
REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
"Assembly of a phased diploid Candida albicans genome facilitates
allele-specific measurements and provides a simple model for repeat
and indel structure.";
Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
[4]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=11595734; DOI=10.1074/jbc.M104484200;
Lane S., Birse C., Zhou S., Matson R., Liu H.;
"DNA array studies demonstrate convergent regulation of virulence
factors by Cph1, Cph2, and Efg1 in Candida albicans.";
J. Biol. Chem. 276:48988-48996(2001).
[5]
FUNCTION, DISRUPTION PHENOTYPE, AND DNA-BINDING.
PubMed=11533231; DOI=10.1128/MCB.21.19.6418-6428.2001;
Lane S., Zhou S., Pan T., Dai Q., Liu H.;
"The basic helix-loop-helix transcription factor Cph2 regulates hyphal
development in Candida albicans partly via TEC1.";
Mol. Cell. Biol. 21:6418-6428(2001).
[6]
FUNCTION.
PubMed=12581351; DOI=10.1046/j.1365-2958.2003.03358.x;
Rottmann M., Dieter S., Brunner H., Rupp S.;
"A screen in Saccharomyces cerevisiae identified CaMCM1, an essential
gene in Candida albicans crucial for morphogenesis.";
Mol. Microbiol. 47:943-959(2003).
[7]
FUNCTION, AND INDUCTION.
PubMed=15999207; DOI=10.1111/j.1745-7270.2005.00063.x;
Xu Z., Cao Y.B., Zhang J.D., Cao Y.Y., Gao P.H., Wang D.J., Fu X.P.,
Ying K., Chen W.S., Jiang Y.Y.;
"cDNA array analysis of the differential expression change in
virulence-related genes during the development of resistance in
Candida albicans.";
Acta Biochim. Biophys. Sin. 37:463-472(2005).
[8]
INDUCTION.
PubMed=15820985; DOI=10.1093/jac/dki088;
Copping V.M.S., Barelle C.J., Hube B., Gow N.A.R., Brown A.J.P.,
Odds F.C.;
"Exposure of Candida albicans to antifungal agents affects expression
of SAP2 and SAP9 secreted proteinase genes.";
J. Antimicrob. Chemother. 55:645-654(2005).
[9]
FUNCTION, AND INDUCTION.
PubMed=20435697; DOI=10.1128/EC.00034-10;
Rosenbach A., Dignard D., Pierce J.V., Whiteway M., Kumamoto C.A.;
"Adaptations of Candida albicans for growth in the mammalian
intestinal tract.";
Eukaryot. Cell 9:1075-1086(2010).
[10]
INDUCTION.
PubMed=21357478; DOI=10.1128/EC.00305-10;
Shareck J., Nantel A., Belhumeur P.;
"Conjugated linoleic acid inhibits hyphal growth in Candida albicans
by modulating Ras1p cellular levels and downregulating TEC1
expression.";
Eukaryot. Cell 10:565-577(2011).
[11]
FUNCTION.
PubMed=21407800; DOI=10.1371/journal.pone.0017046;
Wachtler B., Wilson D., Haedicke K., Dalle F., Hube B.;
"From attachment to damage: defined genes of Candida albicans mediate
adhesion, invasion and damage during interaction with oral epithelial
cells.";
PLoS ONE 6:E17046-E17046(2011).
[12]
DISRUPTION PHENOTYPE.
PubMed=22365851; DOI=10.1016/j.cub.2012.01.062;
Shapiro R.S., Sellam A., Tebbji F., Whiteway M., Nantel A.,
Cowen L.E.;
"Pho85, Pcl1, and Hms1 signaling governs Candida albicans
morphogenesis induced by high temperature or Hsp90 compromise.";
Curr. Biol. 22:461-470(2012).
[13]
INDUCTION.
PubMed=23766273; DOI=10.1111/jicd.12048;
Bandara H.M., Cheung B.P., Watt R.M., Jin L.J., Samaranayake L.P.;
"Secretory products of Escherichia coli biofilm modulate Candida
biofilm formation and hyphal development.";
J. Investig. Clin. Dent. 4:186-199(2013).
[14]
INDUCTION.
PubMed=24260276; DOI=10.1371/journal.pone.0079671;
Zhao L.X., Li D.D., Hu D.D., Hu G.H., Yan L., Wang Y., Jiang Y.Y.;
"Effect of tetrandrine against Candida albicans biofilms.";
PLoS ONE 8:E79671-E79671(2013).
-!- FUNCTION: Transcription factor that positively controls
filamentous growth, virulence, and invasiveness. Binds directly to
the two SRE-1-like elements upstream of TEC1 and thus regulates
positively expression of this important hyphal growth regulator.
Functions independently of known signaling cascades involving
EFG1. Regulates also gene expression during intestinal
colonization but is not involved in host cell adhesion.
{ECO:0000269|PubMed:11533231, ECO:0000269|PubMed:11595734,
ECO:0000269|PubMed:12581351, ECO:0000269|PubMed:15999207,
ECO:0000269|PubMed:20435697, ECO:0000269|PubMed:21407800}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- INDUCTION: Up-regulated during the yeast-to-hypha transition and
in virulent strains during intestinal colonization. Also induced
upon exposure to fluconazole. Expression is down-regulated by
tetrandrine and by Escherichia coli biofilm secretory products.
{ECO:0000269|PubMed:15820985, ECO:0000269|PubMed:15999207,
ECO:0000269|PubMed:20435697, ECO:0000269|PubMed:21357478,
ECO:0000269|PubMed:23766273, ECO:0000269|PubMed:24260276}.
-!- DISRUPTION PHENOTYPE: Impairs expression of hypha-specific
transcripts and leads to a medium-specific impairment in hyphal
development. {ECO:0000269|PubMed:11533231,
ECO:0000269|PubMed:11595734, ECO:0000269|PubMed:22365851}.
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EMBL; CP017628; AOW29977.1; -; Genomic_DNA.
RefSeq; XP_712305.1; XM_707212.2.
ProteinModelPortal; Q59RL7; -.
SMR; Q59RL7; -.
PRIDE; Q59RL7; -.
GeneID; 3646067; -.
KEGG; cal:CAALFM_C600280WA; -.
CGD; CAL0000181382; CPH2.
InParanoid; Q59RL7; -.
OrthoDB; EOG092C0J07; -.
PRO; PR:Q59RL7; -.
Proteomes; UP000000559; Chromosome 6.
GO; GO:0016020; C:membrane; IDA:CGD.
GO; GO:0005634; C:nucleus; IDA:CGD.
GO; GO:0003690; F:double-stranded DNA binding; IDA:CGD.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IMP:CGD.
GO; GO:0071280; P:cellular response to copper ion; IMP:CGD.
GO; GO:0035690; P:cellular response to drug; IMP:CGD.
GO; GO:0034605; P:cellular response to heat; IMP:CGD.
GO; GO:0036244; P:cellular response to neutral pH; IMP:CGD.
GO; GO:0030447; P:filamentous growth; IMP:CGD.
GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
GO; GO:0036171; P:filamentous growth of a population of unicellular organisms in response to chemical stimulus; IMP:CGD.
GO; GO:0036178; P:filamentous growth of a population of unicellular organisms in response to neutral pH; IMP:CGD.
GO; GO:1900430; P:positive regulation of filamentous growth of a population of unicellular organisms; IMP:CGD.
GO; GO:1900445; P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
GO; GO:1900439; P:positive regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus; IMP:CGD.
GO; GO:1900442; P:positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH; IMP:CGD.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:CGD.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:CGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:CGD.
GO; GO:0044403; P:symbiosis, encompassing mutualism through parasitism; IMP:CGD.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
1: Evidence at protein level;
Complete proteome; DNA-binding; Nucleus; Reference proteome;
Transcription; Transcription regulation.
CHAIN 1 853 Transcription factor CPH2.
/FTId=PRO_0000425613.
DOMAIN 205 274 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
COMPBIAS 303 306 Poly-Pro.
SEQUENCE 853 AA; 96046 MW; DE562E008F50362C CRC64;
MLSQYDEQLA AGDNNGFNKQ GNATLYSFDF VDADDFLDSI SGALPNNGHN NVNPNTNDIS
FEDMNIMNPN IYSPVSAASG DDFTQSSGQP MISEGSNYTG QNFTDYLSDN SLEGYDKNTS
RPLHEVDIGF SNKRSNSTST GSLSHNEEIT PISHYSVDSI VTSPEPPINK QGDFPPIKRT
TTVSSTNSIT NTTKKPAKVT KPKSKDKNSH NMIEKKYRTN INTKILALRD AVPALRIAAG
CDDVSIADLE GLTPASKLNK ASVLTKATEY IKHLESKNFI LKQQNIELHR LIQHANMNPK
SLPPPPQQMQ APPQPGFGFY PPQNQSFNVT PASQYPSPQQ QVSPTQQQTV HHPPQPNRYL
LGGMAAVMGT SLFGGSGEND FRSLSALPFS YLFPNAILNP SPLTIQLWTL TKVLLVVGSL
ASIFIPMYKQ AQLKKEDKPN TIPETSLLDW ILISIGFKTP AKLSVSKRDA IISNLQGGND
WSQLVSDYFY LAGCEINFEN CFLSLVLGTI IRHRFPVVAT ILNHYLSMKE ALLLNLDYKG
FSKSLIRLNQ LISKVDGVSI FESTNLTTRL TNVFTNNRIN ANIVDGQNHV KYIEFYQRNI
NDYYAIVFNW RLLEFIHELN VTYLEQLNDD QSQVLTDLKI IEAFFGEQDN KLFGYYQLFT
SILNANYAPY LFESLKDKVE SSLEKFRIAY EGIDLTDHEI HNTSSEDEYE QESPVVYKYE
PTLKSQKSLI SSLNLVNEEE FIILTCSLTI YYYKNKEYDR ALKLLNYLRL DNDSKTLSLL
TFTSLITLIN ELIPGKIEDN VNLDSAIRIC RDWLENPDLT QYMDEDIKLE LKKIVVTKGM
IVNGIDVNES DEE


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