Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Transcription factor E2F3 (E2F-3)

 E2F3_HUMAN              Reviewed;         465 AA.
O00716; Q15000; Q68DT0; Q9BZ44;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
22-NOV-2017, entry version 169.
RecName: Full=Transcription factor E2F3;
Short=E2F-3;
Name=E2F3; Synonyms=KIAA0075;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Pre-B cell;
PubMed=8246996; DOI=10.1128/MCB.13.12.7813;
Lees J.A., Saito M., Vidal M., Valentine M., Look T., Harlow E.,
Dyson N., Helin K.;
"The retinoblastoma protein binds to a family of E2F transcription
factors.";
Mol. Cell. Biol. 13:7813-7825(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-344 AND ASN-389.
NIEHS SNPs program;
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Rectum tumor;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=14574404; DOI=10.1038/nature02055;
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-465 (ISOFORM 1/2).
TISSUE=Bone marrow;
PubMed=7584044; DOI=10.1093/dnares/1.5.223;
Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S.,
Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.;
"Prediction of the coding sequences of unidentified human genes. II.
The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by
analysis of cDNA clones from human cell line KG-1.";
DNA Res. 1:223-229(1994).
[6]
INTERACTION WITH EAPP.
PubMed=15716352; DOI=10.1091/mbc.E04-11-0975;
Novy M., Pohn R., Andorfer P., Novy-Weiland T., Galos B.,
Schwarzmayr L., Rotheneder H.;
"EAPP, a novel E2F binding protein that modulates E2F-dependent
transcription.";
Mol. Biol. Cell 16:2181-2190(2005).
-!- FUNCTION: Transcription activator that binds DNA cooperatively
with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-
3' found in the promoter region of a number of genes whose
products are involved in cell cycle regulation or in DNA
replication. The DRTF1/E2F complex functions in the control of
cell-cycle progression from G1 to S phase. E2F3 binds specifically
to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis,
probably through the repression of CEBPA binding to its target
gene promoters (By similarity). {ECO:0000250|UniProtKB:O35261}.
-!- SUBUNIT: Component of the DRTF1/E2F transcription factor complex.
Binds cooperatively with TFDP1/Dp-1 to E2F sites. Interacts with
retinoblastoma protein RB1 and related proteins (such as RBL1)
that inhibit the E2F transactivation domain. Binds EAPP.
{ECO:0000269|PubMed:15716352}.
-!- INTERACTION:
Q9NRZ9:HELLS; NbExp=2; IntAct=EBI-765551, EBI-1056215;
Q96JM7:L3MBTL3; NbExp=3; IntAct=EBI-765551, EBI-2686809;
P43246:MSH2; NbExp=2; IntAct=EBI-765551, EBI-355888;
P06400:RB1; NbExp=4; IntAct=EBI-765551, EBI-491274;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=O00716-1; Sequence=Displayed;
Name=2;
IsoId=O00716-2; Sequence=VSP_045066, VSP_045067, VSP_045068;
Note=No experimental confirmation available.;
-!- SIMILARITY: Belongs to the E2F/DP family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
and Haematology;
URL="http://atlasgeneticsoncology.org/Genes/E2F3ID40384ch6p22.html";
-!- WEB RESOURCE: Name=NIEHS-SNPs;
URL="http://egp.gs.washington.edu/data/e2f3/";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; Y10479; CAA71504.1; -; mRNA.
EMBL; AF547386; AAN17846.1; -; Genomic_DNA.
EMBL; CR749285; CAH18140.1; -; mRNA.
EMBL; AL132775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AL136303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; D38550; BAA07553.1; -; mRNA.
CCDS; CCDS4545.1; -. [O00716-1]
CCDS; CCDS58999.1; -. [O00716-2]
RefSeq; NP_001230005.1; NM_001243076.2. [O00716-2]
RefSeq; NP_001940.1; NM_001949.4. [O00716-1]
UniGene; Hs.269408; -.
UniGene; Hs.703174; -.
ProteinModelPortal; O00716; -.
SMR; O00716; -.
BioGrid; 108203; 34.
DIP; DIP-24230N; -.
ELM; O00716; -.
IntAct; O00716; 131.
MINT; MINT-249699; -.
STRING; 9606.ENSP00000262904; -.
iPTMnet; O00716; -.
PhosphoSitePlus; O00716; -.
BioMuta; E2F3; -.
EPD; O00716; -.
MaxQB; O00716; -.
PaxDb; O00716; -.
PeptideAtlas; O00716; -.
PRIDE; O00716; -.
DNASU; 1871; -.
Ensembl; ENST00000346618; ENSP00000262904; ENSG00000112242. [O00716-1]
Ensembl; ENST00000535432; ENSP00000443418; ENSG00000112242. [O00716-2]
GeneID; 1871; -.
KEGG; hsa:1871; -.
UCSC; uc003nda.3; human. [O00716-1]
CTD; 1871; -.
DisGeNET; 1871; -.
EuPathDB; HostDB:ENSG00000112242.14; -.
GeneCards; E2F3; -.
HGNC; HGNC:3115; E2F3.
HPA; HPA065012; -.
MIM; 600427; gene.
neXtProt; NX_O00716; -.
OpenTargets; ENSG00000112242; -.
PharmGKB; PA27573; -.
eggNOG; KOG2577; Eukaryota.
eggNOG; ENOG410XNYI; LUCA.
GeneTree; ENSGT00550000074403; -.
HOGENOM; HOG000232045; -.
HOVERGEN; HBG002227; -.
InParanoid; O00716; -.
KO; K06620; -.
OMA; DSENQRY; -.
OrthoDB; EOG091G087U; -.
PhylomeDB; O00716; -.
TreeFam; TF105566; -.
Reactome; R-HSA-1912408; Pre-NOTCH Transcription and Translation.
Reactome; R-HSA-2559580; Oxidative Stress Induced Senescence.
Reactome; R-HSA-2559585; Oncogene Induced Senescence.
Reactome; R-HSA-68689; CDC6 association with the ORC:origin complex.
Reactome; R-HSA-68911; G2 Phase.
Reactome; R-HSA-69231; Cyclin D associated events in G1.
Reactome; R-HSA-69298; Association of licensing factors with the pre-replicative complex.
SignaLink; O00716; -.
SIGNOR; O00716; -.
GeneWiki; E2F3; -.
GenomeRNAi; 1871; -.
PRO; PR:O00716; -.
Proteomes; UP000005640; Chromosome 6.
Bgee; ENSG00000112242; -.
CleanEx; HS_E2F3; -.
ExpressionAtlas; O00716; baseline and differential.
Genevisible; O00716; HS.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0090575; C:RNA polymerase II transcription factor complex; IDA:NTNU_SB.
GO; GO:0001047; F:core promoter binding; IDA:UniProtKB.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; TAS:ProtInc.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; IC:NTNU_SB.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0070345; P:negative regulation of fat cell proliferation; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:NTNU_SB.
GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:ProtInc.
CDD; cd14660; E2F_DD; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR015633; E2F.
InterPro; IPR037241; E2F-DP_heterodim.
InterPro; IPR032198; E2F_CC-MB.
InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
PANTHER; PTHR12081; PTHR12081; 1.
Pfam; PF16421; E2F_CC-MB; 1.
Pfam; PF02319; E2F_TDP; 1.
SMART; SM01372; E2F_TDP; 1.
SUPFAM; SSF144074; SSF144074; 1.
SUPFAM; SSF46785; SSF46785; 1.
1: Evidence at protein level;
Activator; Alternative splicing; Cell cycle; Complete proteome;
DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 465 Transcription factor E2F3.
/FTId=PRO_0000219466.
DNA_BIND 155 245 {ECO:0000255}.
REGION 101 153 Cyclin A/CDK2 binding. {ECO:0000255}.
REGION 204 225 Leucine-zipper.
REGION 246 337 Dimerization. {ECO:0000255}.
REGION 391 465 Transactivation. {ECO:0000255}.
REGION 432 449 Retinoblastoma protein binding.
{ECO:0000255}.
MOTIF 209 245 DEF box.
COMPBIAS 26 31 Poly-Ala.
COMPBIAS 45 53 Poly-Ala.
COMPBIAS 120 129 Poly-Gly.
VAR_SEQ 1 6 MRKGIQ -> MPLQQQ (in isoform 2).
{ECO:0000303|PubMed:17974005}.
/FTId=VSP_045066.
VAR_SEQ 7 131 Missing (in isoform 2).
{ECO:0000303|PubMed:17974005}.
/FTId=VSP_045067.
VAR_SEQ 169 175 TPKSPSE -> K (in isoform 2).
{ECO:0000303|PubMed:17974005}.
/FTId=VSP_045068.
VARIANT 344 344 G -> R (in dbSNP:rs4134973).
{ECO:0000269|Ref.2}.
/FTId=VAR_014341.
VARIANT 389 389 D -> N (in dbSNP:rs4134982).
{ECO:0000269|Ref.2}.
/FTId=VAR_014342.
SEQUENCE 465 AA; 49162 MW; 4641565842CA99EC CRC64;
MRKGIQPALE QYLVTAGGGE GAAVVAAAAA ASMDKRALLA SPGFAAAAAA AAAPGAYIQI
LTTNTSTTSC SSSLQSGAVA AGPLLPSAPG AEQTAGSLLY TTPHGPSSRA GLLQQPPALG
RGGSGGGGGP PAKRRLELGE SGHQYLSDGL KTPKGKGRAA LRSPDSPKTP KSPSEKTRYD
TSLGLLTKKF IQLLSQSPDG VLDLNKAAEV LKVQKRRIYD ITNVLEGIHL IKKKSKNNVQ
WMGCSLSEDG GMLAQCQGLS KEVTELSQEE KKLDELIQSC TLDLKLLTED SENQRLAYVT
YQDIRKISGL KDQTVIVVKA PPETRLEVPD SIESLQIHLA STQGPIEVYL CPEETETHSP
MKTNNQDHNG NIPKPASKDL ASTNSGHSDC SVSMGNLSPL ASPANLLQQT EDQIPSNLEG
PFVNLLPPLL QEDYLLSLGE EEGISDLFDA YDLEKLPLVE DFMCS


Related products :

Catalog number Product name Quantity
E2F3_MOUSE ELISA Kit FOR Transcription factor E2F3; organism: Mouse; gene name: E2f3 96T
EIAAB12258 E2F3,E2F-3,Homo sapiens,Human,KIAA0075,Transcription factor E2F3
CSB-EL007342MO Mouse Transcription factor E2F3(E2F3) ELISA kit SpeciesMouse 96T
CSB-EL007342HU Human Transcription factor E2F3(E2F3) ELISA kit SpeciesHuman 96T
E2F3-301AP E2F transcription factor 3 WB control: PC-E2F3 Host: Rabbit Affinity purifed 100-150ul
E2F3-301AP PC-E2F3 (WB control) E2F transcription factor 3 Immunogen: peptide (13mer0 Host: Rabbit 100-150ul
E2F3-301AP E2F transcription factor 3 Antigenic peptide: P-E2F3 Host: Rabbit Affinity purifed 100ul
H7225 Transcription factor E2F3 (E2F3), Mouse, ELISA Kit 96T
EIAAB12257 E2f3,E2F-3,Mouse,Mus musculus,Transcription factor E2F3
H7224 Transcription factor E2F3 (E2F3), Human, ELISA Kit 96T
CSB-EL007342HU Human Transcription factor E2F3(E2F3) ELISA kit 96T
CSB-EL007342MO Mouse Transcription factor E2F3(E2F3) ELISA kit 96T
DL-E2F3-Hu Human E2F Transcription Factor 3 (E2F3) ELISA Kit 96T
E2F3-301AP E2F3-FITC (FITC-conjugates) E2F transcription factor 3 Immunogen: peptide (13mer0 Host: Rabbit 200ul
E2F3-301AP E2F3-Biotin (Biotin Conjugates) E2F transcription factor 3 Immunogen: peptide (13mer0 Host: Rabbit 200ul
E2F3-301AP P-E2F3 (Antigenic peptide) E2F transcription factor 3 Immunogen: peptide (13mer0 Host: Rabbit 100ul
E2F3-301AP E2F transcription factor 3 FITC-conjugates: E2F3-FITC Host: Rabbit Affinity purifed 200ul
E2F3-301AP E2F transcription factor 3 Biotin Conjugates: E2F3-Biotin Host: Rabbit Affinity purifed 200ul
PC-E2F3 E2F transcription factor 3, WB control 100-150ul
E2F3 E2F1 Gene E2F transcription factor 1
E2F5 E2F3 Gene E2F transcription factor 3
E2F3_HUMAN Human ELISA Kit FOR Transcription factor E2F3 96T
P-E2F3 E2F transcription factor 3, Antigen blocking peptide 100ul
GWB-8DC4A0 Anti- E2F3 (E2F transcription factor 3) Antibody
SEJ183Hu ELISA Kit for E2F Transcription Factor 3 (E2F3) Homo sapiens (Human) 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur