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Transcription factor E2F6 (E2F-6) (E2F-binding site-modulating activity protein) (EMA)

 E2F6_MOUSE              Reviewed;         272 AA.
O54917; Q8K456;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
03-OCT-2012, sequence version 2.
22-NOV-2017, entry version 123.
RecName: Full=Transcription factor E2F6;
Short=E2F-6;
AltName: Full=E2F-binding site-modulating activity protein;
Short=EMA;
Name=E2f6;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=9403682; DOI=10.1038/37507;
Morkel M., Wenkel J., Bannister A.J., Kouzarides T., Hagemeier C.;
"An E2F-like repressor of transcription.";
Nature 390:567-568(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/SvJ; TISSUE=Liver;
Salih M., Tuana B.S.;
"Characterization of the complete mouse E2F6 gene.";
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
-!- FUNCTION: Inhibitor of E2F-dependent transcription. Binds DNA
cooperatively with DP proteins through the E2 recognition site,
5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F
recognition site. E2F6 lacks the transcriptional activation and
pocket protein binding domains. Appears to regulate a subset of
E2F-dependent genes whose products are required for entry into the
cell cycle but not for normal cell cycle progression. May silence
expression via the recruitment of a chromatin remodeling complex
containing histone H3-K9 methyltransferase activity.
Overexpression delays the exit of cells from the S-phase (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Component of the DRTF1/E2F transcription factor complex.
Forms heterodimers with DP family members. Part of the E2F6.com-1
complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8,
EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some
MLL1/MLL complex, at least composed of the core components
KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the
facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1,
LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2,
RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9
and TEX10 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- SIMILARITY: Belongs to the E2F/DP family. {ECO:0000305}.
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EMBL; AF032131; AAC53521.1; -; mRNA.
EMBL; AF487711; AAM45941.1; -; Genomic_DNA.
EMBL; AC157352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS36409.1; -.
RefSeq; NP_150373.2; NM_033270.2.
UniGene; Mm.23296; -.
ProteinModelPortal; O54917; -.
SMR; O54917; -.
BioGrid; 206042; 4.
DIP; DIP-59331N; -.
IntAct; O54917; 1.
STRING; 10090.ENSMUSP00000020908; -.
iPTMnet; O54917; -.
PhosphoSitePlus; O54917; -.
PaxDb; O54917; -.
PeptideAtlas; O54917; -.
PRIDE; O54917; -.
Ensembl; ENSMUST00000020908; ENSMUSP00000020908; ENSMUSG00000057469.
GeneID; 50496; -.
KEGG; mmu:50496; -.
UCSC; uc007nce.2; mouse.
CTD; 1876; -.
MGI; MGI:1354159; E2f6.
eggNOG; KOG2577; Eukaryota.
eggNOG; ENOG410XNYI; LUCA.
GeneTree; ENSGT00550000074403; -.
HOGENOM; HOG000112309; -.
HOVERGEN; HBG002227; -.
InParanoid; O54917; -.
KO; K09390; -.
OMA; SKNLIQW; -.
OrthoDB; EOG091G087U; -.
TreeFam; TF105566; -.
Reactome; R-MMU-8953750; Transcriptional Regulation by E2F6.
ChiTaRS; E2f6; mouse.
PRO; PR:O54917; -.
Proteomes; UP000000589; Chromosome 12.
Bgee; ENSMUSG00000057469; -.
CleanEx; MM_E2F6; -.
ExpressionAtlas; O54917; baseline and differential.
Genevisible; O54917; MM.
GO; GO:0005662; C:DNA replication factor A complex; IC:MGI.
GO; GO:0071339; C:MLL1 complex; ISS:UniProtKB.
GO; GO:0005730; C:nucleolus; ISO:MGI.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0090575; C:RNA polymerase II transcription factor complex; ISO:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:MGI.
GO; GO:0001227; F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISO:MGI.
GO; GO:0000083; P:regulation of transcription involved in G1/S transition of mitotic cell cycle; IGI:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd14660; E2F_DD; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR015633; E2F.
InterPro; IPR037241; E2F-DP_heterodim.
InterPro; IPR032198; E2F_CC-MB.
InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
InterPro; IPR015635; Transcription_factor_E2F6.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
PANTHER; PTHR12081; PTHR12081; 1.
PANTHER; PTHR12081:SF19; PTHR12081:SF19; 1.
Pfam; PF16421; E2F_CC-MB; 1.
Pfam; PF02319; E2F_TDP; 1.
SMART; SM01372; E2F_TDP; 1.
SUPFAM; SSF144074; SSF144074; 1.
SUPFAM; SSF46785; SSF46785; 1.
2: Evidence at transcript level;
Cell cycle; Complete proteome; DNA-binding; Nucleus;
Reference proteome; Repressor; Transcription;
Transcription regulation.
CHAIN 1 272 Transcription factor E2F6.
/FTId=PRO_0000219473.
DNA_BIND 50 129 {ECO:0000255}.
REGION 1 62 Binding to corepressors. {ECO:0000305}.
REGION 130 222 Dimerization. {ECO:0000255}.
REGION 143 164 Leucine-zipper.
REGION 173 272 Transcription repression. {ECO:0000250}.
MOTIF 95 129 DEF box.
CONFLICT 97 97 G -> S (in Ref. 1; AAC53521).
{ECO:0000305}.
SEQUENCE 272 AA; 30852 MW; B99641329C00CD08 CRC64;
MSQQRTARRQ PSLLVDPAQE TVRRRCRDPI NVENLLPSKI RINLEENVQY VSMRKALKVK
RPRFDVSLVY LTRKFMDLVR SAPGGILDLN KVATKLGVRK RRVYDITNVL DGIELVEKKS
KNHIRWIGSD LNNFGAAPQQ KKLQAELSDL SAMEDALDEL IKDCAQQLLE LTDDKENERL
AYVTYQDIHG IQAFHEQIVI AVKAPEETRL DVPAPREDSI TVHIRSTKGP IDVYLCEVEQ
NHSNGKTNDG IGASPSKSSH PQCPEKEDEP PQ


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