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Transcription factor E2F7 (E2F-7)

 E2F7_DANRE              Reviewed;         723 AA.
Q5RIX9;
09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
08-APR-2008, sequence version 2.
25-OCT-2017, entry version 106.
RecName: Full=Transcription factor E2F7;
Short=E2F-7;
Name=e2f7; ORFNames=si:dkey-217k21.2;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen;
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
[2]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=22903062; DOI=10.1038/emboj.2012.231;
Weijts B.G., Bakker W.J., Cornelissen P.W., Liang K.H.,
Schaftenaar F.H., Westendorp B., de Wolf C.A., Paciejewska M.,
Scheele C.L., Kent L., Leone G., Schulte-Merker S., de Bruin A.;
"E2F7 and E2F8 promote angiogenesis through transcriptional activation
of VEGFA in cooperation with HIF1.";
EMBO J. 31:3871-3884(2012).
-!- FUNCTION: Atypical E2F transcription factor that participates in
various processes such as angiogenesis and polyploidization of
specialized cells. Mainly acts as a transcription repressor that
binds DNA independently of DP proteins and specifically recognizes
the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses
transcription of classical E2F transcription factors such as e2f1.
Acts as a regulator of S-phase by recognizing and binding the E2-
related site 5'-TTCCCGCC-3' and mediating repression of G1/S-
regulated genes (By similarity). Acts as a promoter of sprouting
angiogenesis, possibly by acting as a transcription activator and
promoting expression of vegfa. {ECO:0000250,
ECO:0000269|PubMed:22903062}.
-!- SUBUNIT: Homodimer and heterodimer: mainly forms homodimers and,
to a lesser extent, heterodimers with e2f8. {ECO:0000250}.
-!- INTERACTION:
Q16665:HIF1A (xeno); NbExp=2; IntAct=EBI-8030618, EBI-447269;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- DOMAIN: In contrast to classical members of the E2F transcription
factor, atypical members contain 2 DNA-binding domains and
regulate transcription in a DP-independent manner. Both DNA-
binding domains are required for DNA-binding and are proposed to
form an intramolecular structure that is similar to the winged
helix structure of the E2F-DP heterodimer (By similarity).
{ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Embryos lacking both e2f7 and e2f8 contain
multiple intersegmental arteries that completely fail to migrate
from the dorsal aorta. Gross morphology of these embryos and
initial formation of main axial vessels are unaltered.
{ECO:0000269|PubMed:22903062}.
-!- SIMILARITY: Belongs to the E2F/DP family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; BX072538; CAI20917.2; -; Genomic_DNA.
RefSeq; NP_001038612.2; NM_001045147.2.
UniGene; Dr.78654; -.
ProteinModelPortal; Q5RIX9; -.
SMR; Q5RIX9; -.
IntAct; Q5RIX9; 1.
MINT; MINT-8409442; -.
STRING; 7955.ENSDARP00000117568; -.
PaxDb; Q5RIX9; -.
PRIDE; Q5RIX9; -.
Ensembl; ENSDART00000140760; ENSDARP00000117568; ENSDARG00000008986.
GeneID; 567941; -.
KEGG; dre:567941; -.
CTD; 144455; -.
ZFIN; ZDB-GENE-030131-3527; e2f7.
eggNOG; KOG2578; Eukaryota.
eggNOG; ENOG4111IGY; LUCA.
GeneTree; ENSGT00530000063616; -.
HOGENOM; HOG000013193; -.
HOVERGEN; HBG063270; -.
InParanoid; Q5RIX9; -.
KO; K09391; -.
OMA; HYLYVPN; -.
OrthoDB; EOG091G0F9Z; -.
PhylomeDB; Q5RIX9; -.
TreeFam; TF105567; -.
Reactome; R-DRE-6804116; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.
PRO; PR:Q5RIX9; -.
Proteomes; UP000000437; Chromosome 4.
Bgee; ENSDARG00000008986; -.
ExpressionAtlas; Q5RIX9; baseline and differential.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005667; C:transcription factor complex; IEA:InterPro.
GO; GO:0001047; F:core promoter binding; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; IDA:ZFIN.
GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IMP:UniProtKB.
GO; GO:0060718; P:chorionic trophoblast cell differentiation; ISS:UniProtKB.
GO; GO:0030330; P:DNA damage response, signal transduction by p53 class mediator; ISS:UniProtKB.
GO; GO:0070365; P:hepatocyte differentiation; ISS:UniProtKB.
GO; GO:0001946; P:lymphangiogenesis; IGI:ZFIN.
GO; GO:0008045; P:motor neuron axon guidance; IGI:ZFIN.
GO; GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0032466; P:negative regulation of cytokinesis; ISS:UniProtKB.
GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0071930; P:negative regulation of transcription involved in G1/S transition of mitotic cell cycle; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IGI:ZFIN.
GO; GO:0032877; P:positive regulation of DNA endoreduplication; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
GO; GO:0002040; P:sprouting angiogenesis; IMP:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.10.10; -; 2.
InterPro; IPR015633; E2F.
InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
PANTHER; PTHR12081; PTHR12081; 3.
Pfam; PF02319; E2F_TDP; 2.
SMART; SM01372; E2F_TDP; 2.
SUPFAM; SSF46785; SSF46785; 2.
1: Evidence at protein level;
Activator; Cell cycle; Complete proteome; DNA-binding; Nucleus;
Reference proteome; Repressor; Transcription;
Transcription regulation.
CHAIN 1 723 Transcription factor E2F7.
/FTId=PRO_0000420706.
DNA_BIND 147 216 {ECO:0000255}.
DNA_BIND 264 349 {ECO:0000255}.
SEQUENCE 723 AA; 79326 MW; 679462218849C317 CRC64;
MQEVKCLTLK DLLGVRTLVN KTGSDDAASM NDHKENICMD RRKMTPLKSE SLTAALNGHG
KISSPEITHI TPIKLTEKAH PDPWTPTANL KMLINAASPD IRDREMKKTL FKPIENKGKI
AEEEEEEELD DSCQYEALDE SERRPSRKQK SLGLLCQKFL ALYPDYPESS ESINISLDEV
ATCLGVERRR IYDIVNVLES LMLVSRKAKN MYVWHGRSRL PQTLQGLLQA GRDQHYDLLM
DQREGNGLHA VQHVQNAHAA SSRRKDKSLR IMSQKFVMLF LVSKTQTVTL DMAAKILIEE
GQEESYDSKY KTKVRRLYDI ANVLTSLNLI KKIHMREEKT RKPVFKWIGP GNFQSSSNSD
DLRGQISNSG TERREKMARH SSFQVITAPP VNQRLISSAP STPHRYSTDE PVDYSRKSGN
NSAVCRLQFG DGVHPSVSPA VPSALASLAM PLQADLMPVP ASFSHPLAIL PQTPLLMLYS
GNISDGASSL RKRERSEEDD HQTTKCRRRS ASIESDTVES ESLSSSTRRS PVCSPEGSPW
DEASFGGLHE DDVAASSSKD ALLSPHYLYV PNTAGLNSFN FLLPAGHAQG GVPAVAMPYF
VVQSPLIAGA MPTSSTEGAA GFSVPTVLSP AQFVMAGGAY GVTEILQSPE HHGNVPATTS
SPRAEESPKP AQTQTPVTPK EASLGSKSFF ETPGAFGSLV NQSAARKRGS AQRRLDIGHT
AAN


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