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Transcription factor MYB124 (Myb-related protein 124) (AtMYB124) (Protein FOUR LIPS)

 MY124_ARATH             Reviewed;         436 AA.
Q94FL6; Q9M9S7;
18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
05-JUL-2017, entry version 135.
RecName: Full=Transcription factor MYB124 {ECO:0000303|PubMed:11597504};
AltName: Full=Myb-related protein 124 {ECO:0000303|PubMed:11597504};
Short=AtMYB124 {ECO:0000303|PubMed:11597504};
AltName: Full=Protein FOUR LIPS {ECO:0000303|PubMed:11536724};
Name=MYB124 {ECO:0000303|PubMed:11597504};
Synonyms=FLP {ECO:0000303|PubMed:11536724};
OrderedLocusNames=At1g14350 {ECO:0000312|Araport:AT1G14350};
ORFNames=F14L17.12 {ECO:0000312|EMBL:AAF43935.1};
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
STRAIN=cv. Columbia;
PubMed=11597504; DOI=10.1016/S1369-5266(00)00199-0;
Stracke R., Werber M., Weisshaar B.;
"The R2R3-MYB gene family in Arabidopsis thaliana.";
Curr. Opin. Plant Biol. 4:447-456(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130712; DOI=10.1038/35048500;
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis
thaliana.";
Nature 408:816-820(2000).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.;
"Arabidopsis ORF clones.";
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
[5]
FUNCTION, AND DISRUPTION PHENOTYPE.
STRAIN=cv. Columbia;
PubMed=11536724; DOI=10.1105/tpc.7.12.2227;
Yang M., Sack F.D.;
"The too many mouths and four lips mutations affect stomatal
production in Arabidopsis.";
Plant Cell 7:2227-2239(1995).
[6]
FUNCTION, AND DISRUPTION PHENOTYPE.
STRAIN=cv. C24, and cv. Columbia;
PubMed=9684356; DOI=10.1007/s004250050351;
Geisler M., Yang M., Sack F.D.;
"Divergent regulation of stomatal initiation and patterning in organ
and suborgan regions of the Arabidopsis mutants too many mouths and
four lips.";
Planta 205:522-530(1998).
[7]
REVIEW ON STOMATAL DEVELOPMENT.
PubMed=11641073; DOI=10.1016/S1369-5266(00)00215-6;
von Groll U., Altmann T.;
"Stomatal cell biology.";
Curr. Opin. Plant Biol. 4:555-560(2001).
[8]
REVIEW ON STOMATAL DEVELOPMENT.
PubMed=22303215; DOI=10.1199/tab.0066;
Nadeau J.A., Sack F.D.;
"Stomatal development in Arabidopsis.";
Arabidopsis Book 1:E0066-E0066(2002).
[9]
FUNCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF GLU-84, AND TISSUE
SPECIFICITY.
STRAIN=cv. C24, cv. Columbia, and cv. Landsberg erecta;
PubMed=16155180; DOI=10.1105/tpc.105.034116;
Lai L.B., Nadeau J.A., Lucas J., Lee E.-K., Nakagawa T., Zhao L.,
Geisler M., Sack F.D.;
"The Arabidopsis R2R3 MYB proteins FOUR LIPS and MYB88 restrict
divisions late in the stomatal cell lineage.";
Plant Cell 17:2754-2767(2005).
[10]
FUNCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF GLU-84, AND SUBCELLULAR
LOCATION.
STRAIN=cv. Columbia;
PubMed=20675570; DOI=10.1105/tpc.110.074609;
Xie Z., Lee E., Lucas J.R., Morohashi K., Li D., Murray J.A.,
Sack F.D., Grotewold E.;
"Regulation of cell proliferation in the stomatal lineage by the
Arabidopsis MYB FOUR LIPS via direct targeting of core cell cycle
genes.";
Plant Cell 22:2306-2321(2010).
[11]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=21105921; DOI=10.1111/j.1365-313X.2010.04364.x;
Xie Z., Li D., Wang L., Sack F.D., Grotewold E.;
"Role of the stomatal development regulators FLP/MYB88 in abiotic
stress responses.";
Plant J. 64:731-739(2010).
[12]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=21772250; DOI=10.1038/emboj.2011.240;
Vanneste S., Coppens F., Lee E., Donner T.J., Xie Z.,
Van Isterdael G., Dhondt S., De Winter F., De Rybel B., Vuylsteke M.,
De Veylder L., Friml J., Inze D., Grotewold E., Scarpella E., Sack F.,
Beemster G.T., Beeckman T.;
"Developmental regulation of CYCA2s contributes to tissue-specific
proliferation in Arabidopsis.";
EMBO J. 30:3430-3441(2011).
[13]
FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
STRAIN=cv. Columbia, and cv. Landsberg erecta;
PubMed=22915737; DOI=10.1093/jxb/ers209;
Makkena S., Lee E., Sack F.D., Lamb R.S.;
"The R2R3 MYB transcription factors FOUR LIPS and MYB88 regulate
female reproductive development.";
J. Exp. Bot. 63:5545-5558(2012).
[14]
FUNCTION, AND DISRUPTION PHENOTYPE.
STRAIN=cv. Columbia;
PubMed=24123248; DOI=10.1093/jxb/ert313;
Lee E., Liu X., Eglit Y., Sack F.;
"FOUR LIPS and MYB88 conditionally restrict the G1/S transition during
stomatal formation.";
J. Exp. Bot. 64:5207-5219(2013).
[15]
FUNCTION, AND DISRUPTION PHENOTYPE.
STRAIN=cv. Columbia;
PubMed=24687979; DOI=10.1093/jxb/eru139;
Yang K., Wang H., Xue S., Qu X., Zou J., Le J.;
"Requirement for A-type cyclin-dependent kinase and cyclins for the
terminal division in the stomatal lineage of Arabidopsis.";
J. Exp. Bot. 65:2449-2461(2014).
[16]
FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, AND INTERACTION
WITH RBR1.
STRAIN=cv. Columbia;
PubMed=24571519; DOI=10.1111/tpj.12489;
Lee E., Lucas J.R., Sack F.D.;
"Deep functional redundancy between FAMA and FOUR LIPS in stomatal
development.";
Plant J. 78:555-565(2014).
[17]
FUNCTION.
STRAIN=cv. Columbia;
PubMed=24654956; DOI=10.1111/tpj.12516;
Lee E., Lucas J.R., Goodrich J., Sack F.D.;
"Arabidopsis guard cell integrity involves the epigenetic
stabilization of the FLP and FAMA transcription factor genes.";
Plant J. 78:566-577(2014).
[18]
TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
STRAIN=cv. Columbia GL1;
PubMed=26391711; DOI=10.3732/ajb.1500056;
Lei Q., Lee E., Keerthisinghe S., Lai L., Li M., Lucas J.R., Wen X.,
Ren X., Sack F.D.;
"The FOUR LIPS and MYB88 transcription factor genes are widely
expressed in Arabidopsis thaliana during development.";
Am. J. Bot. 102:1521-1528(2015).
[19]
FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION BY AUXIN.
PubMed=26578065; DOI=10.1038/ncomms9821;
Chen Q., Liu Y., Maere S., Lee E., Van Isterdael G., Xie Z., Xuan W.,
Lucas J., Vassileva V., Kitakura S., Marhavy P., Wabnik K.,
Geldner N., Benkova E., Le J., Fukaki H., Grotewold E., Li C.,
Friml J., Sack F., Beeckman T., Vanneste S.;
"A coherent transcriptional feed-forward motif model for mediating
auxin-sensitive PIN3 expression during lateral root development.";
Nat. Commun. 6:8821-8821(2015).
[20]
FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
STRAIN=cv. Columbia, and cv. Landsberg erecta;
PubMed=26578169; DOI=10.1038/ncomms9822;
Wang H.-Z., Yang K.-Z., Zou J.-J., Zhu L.-L., Xie Z.D., Morita M.T.,
Tasaka M., Friml J., Grotewold E., Beeckman T., Vanneste S., Sack F.,
Le J.;
"Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during
Arabidopsis root gravitropism.";
Nat. Commun. 6:8822-8822(2015).
-!- FUNCTION: Transcription factor that binds to DNA in promoters cis-
regulatory element 5'-GGCGCGC-3' of cell cycle genes, including
cyclins, cyclin-dependent kinases (CDKs), and components of the
pre-replication complex (PubMed:20675570, PubMed:24687979). Binds
to DNA in promoters cis-regulatory element 5'-AGCCG-3' of auxin
regulated genes (e.g. PIN3 and PIN7) (PubMed:26578169). Together
with FAMA and MYB88, ensures that stomata contain just two guard
cells (GCs) by enforcing a single symmetric precursor cell
division before stomatal maturity (PubMed:24571519). Represses the
expression of the mitosis-inducing factors CDKB1-1 and CDKA-1,
specifically required for the last guard mother cells (GMC)
symmetric divisions in the stomatal pathway (PubMed:20675570,
PubMed:24687979). Represses CYCA2-3 in newly formed guard cells
(PubMed:21772250). Together with MYB88, regulates stomata spacing
by restricting divisions late in the stomatal cell lineage thus
limiting the number of GMC divisions (PubMed:11536724,
PubMed:9684356, PubMed:16155180, PubMed:24123248). In
collaboration with CDKB1-1 and CDKB1-2, restrict the G1/S
transition and chloroplast and nuclear number during stomatal
formation, and normally maintain fate and developmental
progression throughout the stomatal cell lineage
(PubMed:24123248). Also involved in the shape regulation of
pavement cells (PubMed:9684356). Involved in sensing and/or
transducing abiotic stress (e.g. drought and salt), probably via
the positive regulation of NAC019 (PubMed:21105921). Regulates
female reproduction being required for entry into
megasporogenesis, probably via the regulation of cell cycle genes
(PubMed:22915737). Promotes histone H3K27me3 marks and represses
stem cell gene expression (PubMed:24654956). Required for lateral
roots (LRs) initiation via the regulation of PIN3 expression in an
auxin-dependent manner (PubMed:26578065). Involved in responses to
gravity stimulation in primary roots by regulating the
transcription of PIN3 and PIN7 in gravity-sensing cells, thus
modulating auxin asymmetric redistribution (PubMed:26578169).
{ECO:0000269|PubMed:11536724, ECO:0000269|PubMed:16155180,
ECO:0000269|PubMed:20675570, ECO:0000269|PubMed:21105921,
ECO:0000269|PubMed:21772250, ECO:0000269|PubMed:22915737,
ECO:0000269|PubMed:24123248, ECO:0000269|PubMed:24571519,
ECO:0000269|PubMed:24654956, ECO:0000269|PubMed:24687979,
ECO:0000269|PubMed:26578065, ECO:0000269|PubMed:26578169,
ECO:0000269|PubMed:9684356}.
-!- SUBUNIT: Interacts with RBR1. {ECO:0000269|PubMed:24571519}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00625, ECO:0000269|PubMed:20675570}.
-!- TISSUE SPECIFICITY: Expressed in all shoot organs with higher
levels in leaves, stems, flowers, siliques and floral buds. Also
detected in roots tips. {ECO:0000269|PubMed:16155180,
ECO:0000269|PubMed:26391711}.
-!- DEVELOPMENTAL STAGE: Expressed at the transition to terminal
stomatal differentiation, just before and after the symmetric
division of stomatal differentiation, being confined to late-stage
guard mother cells (GMC) and to young, still differentiating guard
cells (PubMed:16155180, PubMed:24571519). Detected in unopened
flower buds, at the bases of sepals, petals, and stamens and in
the receptacle of carpels, as well as both in style and stigma.
Present at strong levels in the placenta within the ovary.
Accumulates during ovule development in a dynamic pattern; first
observed at high levels in the funiculus once integument outgrowth
has begun and persists into later stages. Also expressed in the
nucellus of younger ovules, especially in the megaspore mother
cell (MMC) and in epidermal cells. Present in integuments, in the
endothelial layer and the outer layer of the outer integument,
which will form the mucilage-containing seed coat cells
(PubMed:22915737). In developing embryos, first detected in cells
in the ground tissue meristem at the early heart stage accumulates
in the torpedo stage. In mature embryos, expressed in the
embryonic hypocotyl and root tip. In seedlings, present first in
the lower part of the hypocotyl and in the root tip, and later in
petioles of cotyledons, young leaves, and lateral root primordia,
near the pericycle. In young plants, strongly expressed in
petioles of young leaves and cotyledons, especially in veins, in
the basal part of young first leaves and cotyledons, and in root
tips of lateral roots. Detected in the phloem, as well as in the
cortex of inflorescence stems (PubMed:26391711). In roots, present
in the root tip in columella cells, specifically in the lower tier
of columella cells, as well as in developing metaxylem
(PubMed:26391711, PubMed:26578169). Widely expressed in freshly
emerged lateral roots. In elongating lateral roots, confined at
high levels transiently in columella cells until differentiation
(PubMed:26578169). Expressed at the base of developing flowers,
including ovaries. In flowers, detected in ovaries, receptacles,
and transiently, in anthers, and, later, in filaments. Also
detected in the valve margins and receptacles of siliques and at
the joint between the stigma and the style, as well as in the
tapetum around pollen grains in maturing anthers
(PubMed:26391711). {ECO:0000269|PubMed:16155180,
ECO:0000269|PubMed:22915737, ECO:0000269|PubMed:24571519,
ECO:0000269|PubMed:26391711, ECO:0000269|PubMed:26578169}.
-!- INDUCTION: Strongly induced by auxin in a IAA14/SLR1 and ARF7
dependent manner, especially in xylem pole pericycle cells,
lateral roots initiating cells. {ECO:0000269|PubMed:26578065}.
-!- DISRUPTION PHENOTYPE: Abnormal stomatal clusters formation
composed by two to four adjacent stomata and some unpaired guard
cells originating of extra symmetric divisions in cells with an
abnormally persistent guard mother cell (GMC) identity
(PubMed:11536724, PubMed:9684356, PubMed:16155180,
PubMed:20675570). Abnormal stomatal cluster formation is
complemented by FAMA (PubMed:24571519). Increased accumulation of
CDKB1-1 in single flp-1 and double flp-1 myb88 mutants
(PubMed:20675570). Induction of ectopic precursor cell division
and delayed stomatal differentiation. End wall thickenings in all
first generation GMCs (PubMed:16155180). Stronger accumulation of
stomatal clusters separated by jigsaw-shaped pavement cells with
wavy anticlinal walls in dorsiventral (e.g. cotyledons, sepals,
and anthers) than in cylindrical organs (e.g. stems, flower
stalks, and siliques), where pavement cells are rectangular
(PubMed:9684356). Double mutants flp-7 myb88 and flp-1 myb88 have
strong defects in stomata repartition with large stomatal clusters
formation (PubMed:16155180). Double mutants flp-1 myb88 have
increased susceptibility to drought and high salt (NaCl), as well
as increased rates of water loss; these phenotypes are associated
with reduced accumulation of many typical abiotic stress gene
transcripts. Lower stomatal closure in response to abscisic acid
(ABA) treatment (PubMed:21105921). Accumulation of CYCA2-3 in
newly formed guard cells in flp-1 myb88 double mutant
(PubMed:21772250). The double mutants flp-1 myb88 and flp-7 myb88
treated with oryzalin, a microtubule depolymerizing drug, exhibit
round-to-oval-shaped single guard cells (sGCs) associated with
increased DNA content due to endoreplication leading to 10C DNA
levels. The quadruple mutant flp-1 myb88 cdkb1;1 cdkb1;2 has a
reduced number of large single guard cells blocked at mitosis,
with strongly altered shape and size and characterized by enlarged
nucleus due to endomitosis and endocycling, as well as extensive
chloroplast replication (PubMed:24123248). The double mutant flp-1
myb88 displays an enhanced stomatal phenotype with more and larger
stomatal clusters. Triple mutants cdka;1 flp-1 myb88 don't have
guard cells stacks but accumulates sGCs. Accumulation of CDKA-1 in
the double mutant flp-1 myb88 (PubMed:24687979). Increased number
of ovules produced by the placenta but reduced female fertility
due to defective meiotic entry and progression, and subsequent
altered embryo sac development, thus leading to reduced seed set
(PubMed:22915737). Reduced numbers of lateral roots (LRs). The
double mutants flp-1 myb88 and flp-7 myb88 lack lateral roots with
reduced PIN3 levels (PubMed:26578065). Gravitropic defects in
primary roots associated with a delayed auxin asymmetric
redistribution due to reduced PIN3 and PIN7 levels
(PubMed:26578169). {ECO:0000269|PubMed:11536724,
ECO:0000269|PubMed:16155180, ECO:0000269|PubMed:20675570,
ECO:0000269|PubMed:21105921, ECO:0000269|PubMed:21772250,
ECO:0000269|PubMed:22915737, ECO:0000269|PubMed:24123248,
ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24687979,
ECO:0000269|PubMed:26578065, ECO:0000269|PubMed:26578169,
ECO:0000269|PubMed:9684356}.
-!- SEQUENCE CAUTION:
Sequence=AAF43935.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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EMBL; AF371982; AAK54745.2; -; mRNA.
EMBL; AC012188; AAF43935.1; ALT_SEQ; Genomic_DNA.
EMBL; CP002684; AEE29150.1; -; Genomic_DNA.
EMBL; CP002684; AEE29151.1; -; Genomic_DNA.
EMBL; BT026126; ABG48482.1; -; mRNA.
PIR; H86277; H86277.
RefSeq; NP_001077534.1; NM_001084065.3.
RefSeq; NP_563948.1; NM_101302.3.
UniGene; At.12041; -.
UniGene; At.56083; -.
ProteinModelPortal; Q94FL6; -.
SMR; Q94FL6; -.
STRING; 3702.AT1G14350.1; -.
PaxDb; Q94FL6; -.
EnsemblPlants; AT1G14350.1; AT1G14350.1; AT1G14350.
EnsemblPlants; AT1G14350.2; AT1G14350.2; AT1G14350.
GeneID; 837997; -.
Gramene; AT1G14350.1; AT1G14350.1; AT1G14350.
Gramene; AT1G14350.2; AT1G14350.2; AT1G14350.
KEGG; ath:AT1G14350; -.
Araport; AT1G14350; -.
TAIR; locus:2012587; AT1G14350.
eggNOG; KOG0048; Eukaryota.
eggNOG; COG5147; LUCA.
HOGENOM; HOG000084300; -.
KO; K09422; -.
OMA; SSYEDND; -.
OrthoDB; EOG093606LS; -.
PhylomeDB; Q94FL6; -.
PRO; PR:Q94FL6; -.
Proteomes; UP000006548; Chromosome 1.
ExpressionAtlas; Q94FL6; baseline and differential.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0001135; F:transcription factor activity, RNA polymerase II transcription factor recruiting; IBA:GO_Central.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0044212; F:transcription regulatory region DNA binding; IBA:GO_Central.
GO; GO:0009926; P:auxin polar transport; IMP:UniProtKB.
GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
GO; GO:0009553; P:embryo sac development; IMP:TAIR.
GO; GO:0010052; P:guard cell differentiation; IGI:UniProtKB.
GO; GO:0010235; P:guard mother cell cytokinesis; IMP:UniProtKB.
GO; GO:0010444; P:guard mother cell differentiation; IMP:UniProtKB.
GO; GO:0090436; P:leaf pavement cell development; IMP:UniProtKB.
GO; GO:0009554; P:megasporogenesis; IMP:UniProtKB.
GO; GO:0050891; P:multicellular organismal water homeostasis; IMP:UniProtKB.
GO; GO:0061087; P:positive regulation of histone H3-K27 methylation; IMP:UniProtKB.
GO; GO:1901333; P:positive regulation of lateral root development; IMP:UniProtKB.
GO; GO:1901002; P:positive regulation of response to salt stress; IMP:UniProtKB.
GO; GO:1902584; P:positive regulation of response to water deprivation; IMP:UniProtKB.
GO; GO:0080022; P:primary root development; IMP:UniProtKB.
GO; GO:1902806; P:regulation of cell cycle G1/S phase transition; IMP:UniProtKB.
GO; GO:0032875; P:regulation of DNA endoreduplication; IMP:UniProtKB.
GO; GO:2000037; P:regulation of stomatal complex patterning; IMP:UniProtKB.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0009737; P:response to abscisic acid; IMP:UniProtKB.
GO; GO:0009733; P:response to auxin; IEP:UniProtKB.
GO; GO:0009629; P:response to gravity; IMP:UniProtKB.
GO; GO:0010376; P:stomatal complex formation; IMP:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR009057; Homeobox-like.
InterPro; IPR017930; Myb_dom.
InterPro; IPR001005; SANT/Myb.
SMART; SM00717; SANT; 2.
SUPFAM; SSF46689; SSF46689; 2.
PROSITE; PS51294; HTH_MYB; 2.
1: Evidence at protein level;
Auxin signaling pathway; Cell cycle; Complete proteome;
Developmental protein; DNA-binding; Nucleus; Reference proteome;
Repeat; Repressor; Stress response; Transcription;
Transcription regulation.
CHAIN 1 436 Transcription factor MYB124.
/FTId=PRO_0000438722.
DOMAIN 20 71 HTH myb-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00625}.
DOMAIN 72 126 HTH myb-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00625}.
DNA_BIND 48 71 H-T-H motif. {ECO:0000255|PROSITE-
ProRule:PRU00625}.
DNA_BIND 99 122 H-T-H motif. {ECO:0000255|PROSITE-
ProRule:PRU00625}.
MOTIF 8 15 Nuclear localization signal 1.
{ECO:0000255|PROSITE-ProRule:PRU00768}.
MOTIF 151 158 Nuclear localization signal 2.
{ECO:0000255|PROSITE-ProRule:PRU00768}.
MUTAGEN 84 84 E->K: In flp-8; abnormal stomatal
clusters formation. Impaired DNA-binding.
{ECO:0000269|PubMed:16155180,
ECO:0000269|PubMed:20675570}.
SEQUENCE 436 AA; 49600 MW; 3122911BF8545CFD CRC64;
MEDTKKKKKK NINNNQDSKK KERHIVTWSQ EEDVILREQI TLHGTENWAI IASKFKDKST
RQCRRRWYTY LNSDFKRGGW SPEEDMLLCE AQRVFGNRWT EIAKVVSGRT DNAVKNRFTT
LCKKRAKHEA MTKDSNSNTK RMLFLDGIST PRKSENETPI AKKLKRSHIL DLTEISNYGR
AEACVNQQIR SPFSVLARNA TGIDSLEEQN QTSNVNESDG EGMFLKKDDP KVTALMQQAE
LLSSLAQKVN ADNTEQSMEN AWKVLQDFLN KGKENDLFRY GIPDIDFKIE EFKDLIEDLR
SGYEDNQLSW RQPDLHDSPA SSEYSSGSTI MVDQSGDKTQ PFSADTQTEH KQVGEELLVP
KNPDENMPIS GEEKFSSPIQ VTPLFRSLAD GIPSPQFSES ERSFLLKTLG IESSSPCPSA
NPSKPPPCKR VLLHSL


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