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Transcription factor MafB (Maf-B) (Kreisler) (Segmentation protein Kr) (Transcription factor Maf-1) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B)

 MAFB_MOUSE              Reviewed;         323 AA.
P54841; Q3U3C8; Q3UPT9;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
22-NOV-2017, entry version 148.
RecName: Full=Transcription factor MafB;
Short=Maf-B;
AltName: Full=Kreisler;
AltName: Full=Segmentation protein Kr;
AltName: Full=Transcription factor Maf-1;
AltName: Full=V-maf musculoaponeurotic fibrosarcoma oncogene homolog B;
Name=Mafb; Synonyms=Krml, Maf1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8001130; DOI=10.1016/0092-8674(94)90033-7;
Cordes S.P., Barsh G.S.;
"The mouse segmentation gene kr encodes a novel basic domain-leucine
zipper transcription factor.";
Cell 79:1025-1034(1994).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/SvJ;
PubMed=10721736; DOI=10.1016/S0378-1119(99)00500-4;
Huang K., Serria M.S., Nakabayashi H., Nishi S., Sakai M.;
"Molecular cloning and functional characterization of the mouse mafB
gene.";
Gene 242:419-426(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and NOD; TISSUE=Eye, and Skin;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Liver, and Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
DEVELOPMENTAL STAGE.
PubMed=10383433; DOI=10.1074/jbc.274.27.19254;
Kawauchi S., Takahashi S., Nakajima O., Ogino H., Morita M.,
Nishizawa M., Yasuda K., Yamamoto M.;
"Regulation of lens fiber cell differentiation by transcription factor
c-Maf.";
J. Biol. Chem. 274:19254-19260(1999).
[8]
FUNCTION, AND INTERACTION WITH ETS1.
PubMed=10790365; DOI=10.1093/emboj/19.9.1987;
Kelly L.M., Englmeier U., Lafon I., Sieweke M.H., Graf T.;
"MafB is an inducer of monocytic differentiation.";
EMBO J. 19:1987-1997(2000).
[9]
DISRUPTION PHENOTYPE.
PubMed=14513037; DOI=10.1038/nn1129;
Blanchi B., Kelly L.M., Viemari J.-C., Lafon I., Burnet H.,
Bevengut M., Tillmanns S., Daniel L., Graf T., Hilaire G.,
Sieweke M.H.;
"MafB deficiency causes defective respiratory rhythmogenesis and fatal
central apnea at birth.";
Nat. Neurosci. 6:1091-1100(2003).
[10]
INTERACTION WITH LRP1, AND SUBCELLULAR LOCATION.
PubMed=15135046; DOI=10.1016/j.febslet.2004.03.069;
Petersen H.H., Hilpert J., Jacobsen C., Lauwers A., Roebroek A.J.M.,
Willnow T.E.;
"Low-density lipoprotein receptor-related protein interacts with MafB,
a regulator of hindbrain development.";
FEBS Lett. 565:23-27(2004).
[11]
FUNCTION, DNA-BINDING, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
PubMed=16443760; DOI=10.2337/diabetes.55.02.06.db05-0946;
Artner I., Le Lay J., Hang Y., Elghazi L., Schisler J.C.,
Henderson E., Sosa-Pineda B., Stein R.;
"MafB: an activator of the glucagon gene expressed in developing islet
alpha- and beta-cells.";
Diabetes 55:297-304(2006).
[12]
FUNCTION, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
PubMed=16847325; DOI=10.1128/MCB.00001-06;
Moriguchi T., Hamada M., Morito N., Terunuma T., Hasegawa K.,
Zhang C., Yokomizo T., Esaki R., Kuroda E., Yoh K., Kudo T.,
Nagata M., Greaves D.R., Engel J.D., Yamamoto M., Takahashi S.;
"MafB is essential for renal development and F4/80 expression in
macrophages.";
Mol. Cell. Biol. 26:5715-5727(2006).
[13]
DISRUPTION PHENOTYPE.
PubMed=16943423; DOI=10.1128/MCB.00245-06;
Aziz A., Vanhille L., Mohideen P., Kelly L.M., Otto C., Bakri Y.,
Mossadegh N., Sarrazin S., Sieweke M.H.;
"Development of macrophages with altered actin organization in the
absence of MafB.";
Mol. Cell. Biol. 26:6808-6818(2006).
[14]
FUNCTION, SUBUNIT, INTERACTION WITH PAX6, DNA-BINDING, TISSUE
SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=17901057; DOI=10.1074/jbc.M702795200;
Gosmain Y., Avril I., Mamin A., Philippe J.;
"Pax-6 and c-Maf functionally interact with the alpha-cell-specific
DNA element G1 in vivo to promote glucagon gene expression.";
J. Biol. Chem. 282:35024-35034(2007).
[15]
FUNCTION, SUMOYLATION AT LYS-32 AND LYS-297, AND MUTAGENESIS OF LYS-32
AND LYS-297.
PubMed=17548468; DOI=10.1128/MCB.01811-06;
Tillmanns S., Otto C., Jaffray E., Du Roure C., Bakri Y., Vanhille L.,
Sarrazin S., Hay R.T., Sieweke M.H.;
"SUMO modification regulates MafB-driven macrophage differentiation by
enabling Myb-dependent transcriptional repression.";
Mol. Cell. Biol. 27:5554-5564(2007).
[16]
DISRUPTION PHENOTYPE.
PubMed=17360442; DOI=10.1073/pnas.0700013104;
Artner I., Blanchi B., Raum J.C., Guo M., Kaneko T., Cordes S.,
Sieweke M., Stein R.;
"MafB is required for islet beta cell maturation.";
Proc. Natl. Acad. Sci. U.S.A. 104:3853-3858(2007).
[17]
FUNCTION, MUTAGENESIS OF ASN-248, AND DISRUPTION PHENOTYPE.
PubMed=18199433; DOI=10.1016/j.ydbio.2007.12.009;
Nishimura W., Rowan S., Salameh T., Maas R.L., Bonner-Weir S.,
Sell S.M., Sharma A.;
"Preferential reduction of beta cells derived from Pax6-MafB pathway
in MafB deficient mice.";
Dev. Biol. 314:443-456(2008).
[18]
REVIEW, AND FUNCTION.
PubMed=19143053; DOI=10.1038/nrc2460;
Eychene A., Rocques N., Pouponnot C.;
"A new MAFia in cancer.";
Nat. Rev. Cancer 8:683-693(2008).
[19]
FUNCTION.
PubMed=19440205; DOI=10.1038/emboj.2009.127;
Smink J.J., Begay V., Schoenmaker T., Sterneck E., de Vries T.J.,
Leutz A.;
"Transcription factor C/EBPbeta isoform ratio regulates
osteoclastogenesis through MafB.";
EMBO J. 28:1769-1781(2009).
[20]
DISRUPTION PHENOTYPE.
PubMed=27181683; DOI=10.1016/j.ajhg.2016.03.023;
Park J.G., Tischfield M.A., Nugent A.A., Cheng L., Di Gioia S.A.,
Chan W.M., Maconachie G., Bosley T.M., Summers C.G., Hunter D.G.,
Robson C.D., Gottlob I., Engle E.C.;
"Loss of MAFB function in humans and mice causes Duane syndrome,
aberrant extraocular muscle innervation, and inner-ear defects.";
Am. J. Hum. Genet. 98:1220-1227(2016).
-!- FUNCTION: Acts as a transcriptional activator or repressor. Plays
a pivotal role in regulating lineage-specific hematopoiesis by
repressing ETS1-mediated transcription of erythroid-specific genes
in myeloid cells. Required for monocytic, macrophage, osteoclast,
podocyte and islet beta cell differentiation. Involved in renal
tubule survival and F4/80 maturation. Activates the insulin and
glucagon promoters. Together with PAX6, transactivates weakly the
glucagon gene promoter through the G1 element. SUMO modification
controls its transcriptional activity and ability to specify
macrophage fate. Binds element G1 on the glucagon promoter.
Involved either as an oncogene or as a tumor suppressor, depending
on the cell context. {ECO:0000250|UniProtKB:Q9Y5Q3,
ECO:0000269|PubMed:10790365, ECO:0000269|PubMed:16443760,
ECO:0000269|PubMed:16847325, ECO:0000269|PubMed:17548468,
ECO:0000269|PubMed:17901057, ECO:0000269|PubMed:18199433,
ECO:0000269|PubMed:19143053, ECO:0000269|PubMed:19440205}.
-!- SUBUNIT: Homodimer or heterodimer with other bHLH-Zip
transcription factors. Forms homodimers and heterodimers with FOS,
FOSB and FOSL2, but not with JUN proteins (JUN, JUNB and JUND).
Interacts with the intracellular cytoplasmic domain of LRP1
(LRPICD); the interaction results in a moderate reduction of MAFB
transcriptional potential (By similarity). Binds DNA as a
homodimer or a heterodimer. Interacts with PAX6; the interaction
is direct. Interacts with ETS1 and LRP1. {ECO:0000250,
ECO:0000269|PubMed:10790365, ECO:0000269|PubMed:15135046,
ECO:0000269|PubMed:17901057}.
-!- INTERACTION:
P01101:Fos; NbExp=4; IntAct=EBI-16093217, EBI-4288185;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00978, ECO:0000269|PubMed:15135046}.
-!- TISSUE SPECIFICITY: Expressed in pancreatic alpha-cells (glucagon-
positive cells), in podocytes of the kidney and macrophages (at
protein level). Most abundant in kidney, gut, lung and brain.
{ECO:0000269|PubMed:16443760, ECO:0000269|PubMed:16847325,
ECO:0000269|PubMed:17901057}.
-!- DEVELOPMENTAL STAGE: Expressed in pancreatic alpha-cells at 10.5
dpc. Expressed in insulin and glucagon islet progenitor cells at
12 dpc onwards (at protein level). Detectable at 8.0 dpc (one
somite) as a band in the caudal hindbrain and by 8.5 dpc (six to
eight somites) as a sharp rostral edge coincident with the
rhombomeres (r) 4 and 5 boundary and a diffuse caudal edge located
midway through r6. Expressed in the lens epithelial cells at 10.5
to 14.5 dpc. {ECO:0000269|PubMed:10383433,
ECO:0000269|PubMed:16443760, ECO:0000269|PubMed:17901057}.
-!- DOMAIN: The leucine-zipper domain is involved in the interaction
with LRPICD.
-!- PTM: Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its
transcriptional repression activity and promotes macrophage
differentiation from myeloid progenitors.
{ECO:0000269|PubMed:17548468}.
-!- DISRUPTION PHENOTYPE: Mice show a defect in frequency of
respiratory rhythm with a fatal apnea at birth due to lack of
neurons from the preBoetC region. They displayed renal dysgenesis
with abnormal podocyte differentiation as well as tubular
apoptosis. They show altered actin-dependent macrophage
morphology. They show a reduced number of cells expressing insulin
and glucagon. Embryos also lack the abducens nerve which normaly
innervates the lateral rectus muscle that is involved in eye
movement (PubMed:27181683). {ECO:0000269|PubMed:14513037,
ECO:0000269|PubMed:16847325, ECO:0000269|PubMed:16943423,
ECO:0000269|PubMed:17360442, ECO:0000269|PubMed:18199433,
ECO:0000269|PubMed:27181683}.
-!- SIMILARITY: Belongs to the bZIP family. Maf subfamily.
{ECO:0000305}.
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EMBL; L36435; AAA65689.1; -; mRNA.
EMBL; AF180338; AAD56221.1; -; Genomic_DNA.
EMBL; AK132425; BAE21161.1; -; mRNA.
EMBL; AK143209; BAE25306.1; -; mRNA.
EMBL; AK154830; BAE32860.1; -; mRNA.
EMBL; AL591665; CAM21248.1; -; Genomic_DNA.
EMBL; CH466551; EDL06288.1; -; Genomic_DNA.
EMBL; BC016434; AAH16434.1; -; mRNA.
EMBL; BC038256; AAH38256.1; -; mRNA.
CCDS; CCDS16994.1; -.
PIR; I49529; I49529.
RefSeq; NP_034788.1; NM_010658.3.
UniGene; Mm.330745; -.
PDB; 2WT7; X-ray; 2.30 A; B=214-303.
PDB; 2WTY; X-ray; 2.90 A; A/B=211-306.
PDB; 4AUW; X-ray; 2.90 A; A/B/E/F=211-305.
PDBsum; 2WT7; -.
PDBsum; 2WTY; -.
PDBsum; 4AUW; -.
ProteinModelPortal; P54841; -.
SMR; P54841; -.
BioGrid; 201014; 5.
DIP; DIP-60663N; -.
IntAct; P54841; 1.
STRING; 10090.ENSMUSP00000096728; -.
iPTMnet; P54841; -.
PhosphoSitePlus; P54841; -.
MaxQB; P54841; -.
PaxDb; P54841; -.
PeptideAtlas; P54841; -.
PRIDE; P54841; -.
Ensembl; ENSMUST00000099126; ENSMUSP00000096728; ENSMUSG00000074622.
GeneID; 16658; -.
KEGG; mmu:16658; -.
UCSC; uc008nqw.2; mouse.
CTD; 9935; -.
MGI; MGI:104555; Mafb.
eggNOG; KOG4196; Eukaryota.
eggNOG; ENOG41102C7; LUCA.
GeneTree; ENSGT00550000074549; -.
HOGENOM; HOG000261683; -.
HOVERGEN; HBG000313; -.
InParanoid; P54841; -.
KO; K09036; -.
OMA; CNRLQPQ; -.
OrthoDB; EOG091G0H46; -.
PhylomeDB; P54841; -.
TreeFam; TF325689; -.
ChiTaRS; Mafb; mouse.
PRO; PR:P54841; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000074622; -.
CleanEx; MM_MAF1; -.
Genevisible; P54841; MM.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0005667; C:transcription factor complex; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IMP:NTNU_SB.
GO; GO:0008134; F:transcription factor binding; ISO:MGI.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IMP:NTNU_SB.
GO; GO:0021599; P:abducens nerve formation; IMP:UniProtKB.
GO; GO:0035284; P:brain segmentation; IMP:MGI.
GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
GO; GO:0045647; P:negative regulation of erythrocyte differentiation; ISO:MGI.
GO; GO:0045671; P:negative regulation of osteoclast differentiation; IDA:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0007585; P:respiratory gaseous exchange; IMP:MGI.
GO; GO:0021571; P:rhombomere 5 development; IMP:MGI.
GO; GO:0021572; P:rhombomere 6 development; IMP:MGI.
GO; GO:0007379; P:segment specification; IMP:MGI.
GO; GO:0033077; P:T cell differentiation in thymus; IMP:MGI.
GO; GO:0048538; P:thymus development; IMP:MGI.
Gene3D; 1.10.880.10; -; 1.
InterPro; IPR004827; bZIP.
InterPro; IPR004826; bZIP_Maf.
InterPro; IPR013592; Maf_TF_N.
InterPro; IPR028571; MafB.
InterPro; IPR008917; TF_DNA-bd_sf.
InterPro; IPR024874; Transciption_factor_Maf_fam.
PANTHER; PTHR10129; PTHR10129; 1.
PANTHER; PTHR10129:SF10; PTHR10129:SF10; 1.
Pfam; PF03131; bZIP_Maf; 1.
Pfam; PF08383; Maf_N; 1.
SMART; SM00338; BRLZ; 1.
SUPFAM; SSF47454; SSF47454; 1.
PROSITE; PS50217; BZIP; 1.
1: Evidence at protein level;
3D-structure; Activator; Complete proteome; DNA-binding;
Isopeptide bond; Nucleus; Proto-oncogene; Reference proteome;
Repressor; Transcription; Transcription regulation; Tumor suppressor;
Ubl conjugation.
CHAIN 1 323 Transcription factor MafB.
/FTId=PRO_0000076495.
DOMAIN 238 301 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 238 263 Basic motif. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 266 287 Leucine-zipper. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
COMPBIAS 131 143 Poly-His.
COMPBIAS 158 167 Poly-His.
CROSSLNK 32 32 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000269|PubMed:17548468}.
CROSSLNK 297 297 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000269|PubMed:17548468}.
MUTAGEN 32 32 K->R: Loss of SUMO modification,
increases transactivation activity,
increases macrophage differentiation and
inhibits myeloid progenitor growth; when
associated with R-297.
{ECO:0000269|PubMed:17548468}.
MUTAGEN 248 248 N->A: Reduces ability to activate insulin
and glucagon gene expression.
{ECO:0000269|PubMed:18199433}.
MUTAGEN 248 248 N->S: Loss of transcriptional activity.
{ECO:0000269|PubMed:18199433}.
MUTAGEN 297 297 K->R: Loss of SUMO modification,
increases transactivation activity,
increases macrophage differentiation and
inhibits myeloid progenitor growth; when
associated with R-32.
{ECO:0000269|PubMed:17548468}.
CONFLICT 275 275 Q -> K (in Ref. 3; BAE32860).
{ECO:0000305}.
HELIX 215 218 {ECO:0000244|PDB:2WT7}.
HELIX 221 225 {ECO:0000244|PDB:2WT7}.
TURN 228 230 {ECO:0000244|PDB:2WTY}.
HELIX 233 299 {ECO:0000244|PDB:2WT7}.
SEQUENCE 323 AA; 35809 MW; D77AE07ABD9C2AD2 CRC64;
MAAELSMGQE LPTSPLAMEY VNDFDLLKFD VKKEPLGRAE RPGRPCTRLQ PAGSVSSTPL
STPCSSVPSS PSFSPTEPKT HLEDLYWMAS NYQQMNPEAL NLTPEDAVEA LIGSHPVPQP
LQSFDGFRSA HHHHHHHHPH PHHGYPGAGV THDDLGQHAH PHHHHHHQAS PPPSSAASPA
QQLPTSHPGP GPHATAAATA AGGNGSVEDR FSDDQLVSMS VRELNRHLRG FTKDEVIRLK
QKRRTLKNRG YAQSCRYKRV QQKHHLENEK TQLIQQVEQL KQEVSRLARE RDAYKVKCEK
LANSGFREAG STSDSPSSPE FFL


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CSB-EL013315CH Chicken v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) (MAFB) ELISA kit, Species Chicken, Sample Type serum, plasma 96T
CSB-EL013315MO Mouse v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) (MAFB) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL013315HU Human v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) (MAFB) ELISA kit, Species Human, Sample Type serum, plasma 96T
18-003-42098 Ets domain transcription factor - ESE3 transcription factor; EHF protein; DJ875K15.1.2 (Ets homologous factor (Ets-domain transcription factor. ESE-3B (Isoform 2))); ETS-family transcription factor EH 0.1 mg Protein A
27-921 MAFB is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The nuclear protein represses ETS1-mediated transcription o 0.1 mg
27-922 MAFB is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The nuclear protein represses ETS1-mediated transcription o 0.05 mg
MAFG-4731H Protein: Recombinant Human V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog G (Avian), His-tagged 50ug
MAFG-4731H Protein Recombinant Human V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog G (Avian), His-tagged 50ug
10-782-55042 Transcription factor AP-1 - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 N_A 0.05 mg
10-782-55042 Transcription factor AP-1 - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 N_A 0.2 mg
MAFB_MOUSE ELISA Kit FOR Transcription factor MafB; organism: Mouse; gene name: Mafb 96T
CSB-EL013315MO Mouse Transcription factor MafB(MAFB) ELISA kit SpeciesMouse 96T
CSB-EL013315CH Chicken Transcription factor MafB(MAFB) ELISA kit SpeciesChicken 96T
CSB-EL013315HU Human Transcription factor MafB(MAFB) ELISA kit SpeciesHuman 96T
MAFB_RAT ELISA Kit FOR Transcription factor MafB; organism: Rat; gene name: Mafb 96T
15-288-21143 Transcription factor AP-1 - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 Polyclonal 0.1 mg
18-003-43188 Transcription factor AP-1 - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 Polyclonal 0.1 mg Protein A
15-288-21143 Transcription factor AP-1 - Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 Polyclonal 0.05 mg


 

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