Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Transcription factor SOX-2

 SOX2_MOUSE              Reviewed;         319 AA.
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
15-JUL-1999, sequence version 2.
16-JAN-2019, entry version 145.
RecName: Full=Transcription factor SOX-2;
Name=Sox2; Synonyms=Sox-2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
PubMed=7590241; DOI=10.1101/gad.9.21.2635;
Yuan H., Corbi N., Basilico C., Dailey L.;
"Developmental-specific activity of the FGF-4 enhancer requires the
synergistic action of Sox2 and Oct-3.";
Genes Dev. 9:2635-2645(1995).
Yuan H., Corbi N., Basilico C., Dailey L.;
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Collignon J., Sockanathan S., Hacker A., Cohen-Tannoudji M.,
Norris D., Rastan S., Stevanovic M., Goodfellow P.N., Lovell-Badge R.;
"A comparison of the properties of Sox-3 with Sry and two related
genes, Sox-1 and Sox-2.";
Development 122:509-520(1996).
PubMed=17097055; DOI=10.1016/j.bbrc.2006.10.130;
Tsuruzoe S., Ishihara K., Uchimura Y., Watanabe S., Sekita Y.,
Aoto T., Saitoh H., Yuasa Y., Niwa H., Kawasuji M., Baba H., Nakao M.;
"Inhibition of DNA binding of Sox2 by the SUMO conjugation.";
Biochem. Biophys. Res. Commun. 351:920-926(2006).
PubMed=16904174; DOI=10.1016/j.cell.2006.07.024;
Takahashi K., Yamanaka S.;
"Induction of pluripotent stem cells from mouse embryonic and adult
fibroblast cultures by defined factors.";
Cell 126:663-676(2006).
PubMed=17728342; DOI=10.1242/dev.007906;
Rizzoti K., Lovell-Badge R.;
"SOX3 activity during pharyngeal segmentation is required for
craniofacial morphogenesis.";
Development 134:3437-3448(2007).
PubMed=19740739; DOI=10.1074/jbc.M109.016162;
Yu H.B., Kunarso G., Hong F.H., Stanton L.W.;
"Zfp206, Oct4, and Sox2 are integrated components of a transcriptional
regulatory network in embryonic stem cells.";
J. Biol. Chem. 284:31327-31335(2009).
PubMed=22198669; DOI=10.1038/nature10712;
Andreu-Agullo C., Maurin T., Thompson C.B., Lai E.C.;
"Ars2 maintains neural stem-cell identity through direct
transcriptional activation of Sox2.";
Nature 481:195-198(2012).
-!- FUNCTION: Transcription factor that forms a trimeric complex with
OCT4 on DNA and controls the expression of a number of genes
involved in embryonic development such as YES1, FGF4, UTF1 and
ZFP206. Critical for early embryogenesis and for embryonic stem
cell pluripotency. May function as a switch in neuronal
development. Downstream SRRT target that mediates the promotion of
neural stem cell self-renewal. Keeps neural cells undifferentiated
by counteracting the activity of proneural proteins and suppresses
neuronal differentiation (By similarity). {ECO:0000250,
ECO:0000269|PubMed:17097055, ECO:0000269|PubMed:22198669}.
-!- SUBUNIT: Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.
{ECO:0000269|PubMed:17728342, ECO:0000269|PubMed:19740739}.
Q80Z64:Nanog; NbExp=10; IntAct=EBI-2313612, EBI-2312517;
P20263:Pou5f1; NbExp=4; IntAct=EBI-2313612, EBI-1606219;
Q60520:Sin3a; NbExp=3; IntAct=EBI-2313612, EBI-349034;
Q00899:Yy1; NbExp=2; IntAct=EBI-2313612, EBI-6921536;
ProRule:PRU00267, ECO:0000269|PubMed:17097055}.
-!- TISSUE SPECIFICITY: Expressed in the brain and retina. A very low
level expression is seen in the stomach and lung. Expressed in
developing urogenital ridge.
-!- INDUCTION: By SRRT. {ECO:0000269|PubMed:22198669}.
-!- PTM: Sumoylation inhibits binding on DNA and negatively regulates
the FGF4 transactivation. {ECO:0000269|PubMed:17097055}.
-!- BIOTECHNOLOGY: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four
Yamanaka factors. When combined, these factors are sufficient to
reprogram differentiated cells to an embryonic-like state
designated iPS (induced pluripotent stem) cells. iPS cells exhibit
the morphology and growth properties of ES cells and express ES
cell marker genes. {ECO:0000269|PubMed:16904174}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; U31967; AAC31791.1; -; mRNA.
EMBL; X94127; CAA63847.1; -; Genomic_DNA.
CCDS; CCDS38413.1; -.
PIR; S10949; S10949.
RefSeq; NP_035573.3; NM_011443.4.
UniGene; Mm.65396; -.
PDB; 1GT0; X-ray; 2.60 A; D=41-120.
PDBsum; 1GT0; -.
ProteinModelPortal; P48432; -.
SMR; P48432; -.
BioGrid; 203406; 23.
DIP; DIP-54522N; -.
IntAct; P48432; 8.
MINT; P48432; -.
STRING; 10090.ENSMUSP00000096755; -.
iPTMnet; P48432; -.
PhosphoSitePlus; P48432; -.
MaxQB; P48432; -.
PaxDb; P48432; -.
PeptideAtlas; P48432; -.
PRIDE; P48432; -.
GeneID; 20674; -.
KEGG; mmu:20674; -.
CTD; 6657; -.
MGI; MGI:98364; Sox2.
eggNOG; ENOG410IPZI; Eukaryota.
eggNOG; ENOG411009V; LUCA.
HOGENOM; HOG000231647; -.
HOVERGEN; HBG105663; -.
InParanoid; P48432; -.
KO; K16796; -.
OrthoDB; 1161594at2759; -.
PhylomeDB; P48432; -.
EvolutionaryTrace; P48432; -.
PRO; PR:P48432; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_SOX2; -.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0044798; C:nuclear transcription factor complex; IDA:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0005667; C:transcription factor complex; IDA:MGI.
GO; GO:0003682; F:chromatin binding; IDA:MGI.
GO; GO:0031490; F:chromatin DNA binding; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:MGI.
GO; GO:0035198; F:miRNA binding; ISO:MGI.
GO; GO:0046982; F:protein heterodimerization activity; IDA:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; ISO:MGI.
GO; GO:0021984; P:adenohypophysis development; IMP:MGI.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IMP:MGI.
GO; GO:0007050; P:cell cycle arrest; ISO:MGI.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0045165; P:cell fate commitment; IDA:MGI.
GO; GO:0001708; P:cell fate specification; IMP:MGI.
GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
GO; GO:0021987; P:cerebral cortex development; IMP:MGI.
GO; GO:0050973; P:detection of mechanical stimulus involved in equilibrioception; IMP:MGI.
GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IMP:MGI.
GO; GO:0048852; P:diencephalon morphogenesis; IMP:MGI.
GO; GO:0048568; P:embryonic organ development; IMP:MGI.
GO; GO:0001714; P:endodermal cell fate specification; ISO:MGI.
GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IDA:MGI.
GO; GO:0030900; P:forebrain development; IBA:GO_Central.
GO; GO:0021879; P:forebrain neuron differentiation; IMP:MGI.
GO; GO:0048839; P:inner ear development; IBA:GO_Central.
GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
GO; GO:0060235; P:lens induction in camera-type eye; IGI:MGI.
GO; GO:0048286; P:lung alveolus development; IDA:MGI.
GO; GO:0030539; P:male genitalia development; IMP:MGI.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
GO; GO:0045596; P:negative regulation of cell differentiation; IMP:MGI.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:MGI.
GO; GO:0045665; P:negative regulation of neuron differentiation; IDA:MGI.
GO; GO:0045668; P:negative regulation of osteoblast differentiation; IDA:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:MGI.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IGI:MGI.
GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
GO; GO:0048663; P:neuron fate commitment; IMP:MGI.
GO; GO:0097150; P:neuronal stem cell population maintenance; IGI:UniProtKB.
GO; GO:0030910; P:olfactory placode formation; IGI:MGI.
GO; GO:0001649; P:osteoblast differentiation; ISO:MGI.
GO; GO:0046148; P:pigment biosynthetic process; IMP:MGI.
GO; GO:0045597; P:positive regulation of cell differentiation; ISO:MGI.
GO; GO:0022409; P:positive regulation of cell-cell adhesion; ISO:MGI.
GO; GO:0030858; P:positive regulation of epithelial cell differentiation; IDA:MGI.
GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:MGI.
GO; GO:0002052; P:positive regulation of neuroblast proliferation; IMP:MGI.
GO; GO:0045666; P:positive regulation of neuron differentiation; IMP:MGI.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; IDA:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0043281; P:regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
GO; GO:0010468; P:regulation of gene expression; ISO:MGI.
GO; GO:0050767; P:regulation of neurogenesis; IGI:MGI.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:MGI.
GO; GO:0070848; P:response to growth factor; ISO:MGI.
GO; GO:0010033; P:response to organic substance; IDA:MGI.
GO; GO:0032526; P:response to retinoic acid; IDA:MGI.
GO; GO:0060042; P:retina morphogenesis in camera-type eye; IMP:MGI.
GO; GO:0007605; P:sensory perception of sound; IMP:MGI.
GO; GO:0035019; P:somatic stem cell population maintenance; ISO:MGI.
GO; GO:0048863; P:stem cell differentiation; IDA:MGI.
GO; GO:0019827; P:stem cell population maintenance; IMP:UniProtKB.
GO; GO:0043586; P:tongue development; IMP:MGI.
Gene3D;; -; 1.
InterPro; IPR009071; HMG_box_dom.
InterPro; IPR036910; HMG_box_dom_sf.
InterPro; IPR032643; SOX-2.
InterPro; IPR022097; SOX_fam.
PANTHER; PTHR10270:SF231; PTHR10270:SF231; 1.
Pfam; PF00505; HMG_box; 1.
Pfam; PF12336; SOXp; 1.
SMART; SM00398; HMG; 1.
SUPFAM; SSF47095; SSF47095; 1.
PROSITE; PS50118; HMG_BOX_2; 1.
1: Evidence at protein level;
3D-structure; Activator; Complete proteome; Developmental protein;
DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein;
Reference proteome; Transcription; Transcription regulation;
Ubl conjugation.
CHAIN 1 319 Transcription factor SOX-2.
DNA_BIND 43 111 HMG box. {ECO:0000255|PROSITE-
COMPBIAS 19 25 Poly-Gly.
MOD_RES 253 253 Phosphoserine.
CROSSLNK 247 247 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
MUTAGEN 247 247 K->R: Absence of sumoylation. Increased
FGF4 activation. No effect on nuclear
CONFLICT 153 155 GGL -> AGV (in Ref. 3; CAA63847).
CONFLICT 203 203 V -> D (in Ref. 3; CAA63847).
CONFLICT 310 311 KY -> IN (in Ref. 3; CAA63847).
HELIX 49 62 {ECO:0000244|PDB:1GT0}.
HELIX 70 81 {ECO:0000244|PDB:1GT0}.
HELIX 86 106 {ECO:0000244|PDB:1GT0}.
SEQUENCE 319 AA; 34454 MW; C40DE49E524C49F1 CRC64;

Related products :

Catalog number Product name Quantity
EIAAB42084 Homo sapiens,Human,Mitochondrial transcription factor 1,MtTF1,mtTFA,TCF6,TCF-6,TCF6L2,TFAM,Transcription factor 6,Transcription factor 6-like 2,Transcription factor A, mitochondrial
18-003-42098 Ets domain transcription factor - ESE3 transcription factor; EHF protein; DJ875K15.1.2 (Ets homologous factor (Ets-domain transcription factor. ESE-3B (Isoform 2))); ETS-family transcription factor EH 0.1 mg Protein A
EIAAB42103 Immunoglobulin enhancer-binding factor E12_E47,Pan,Pancreas specific transcription factor 1c,Ptf1c,Rat,Rattus norvegicus,Tcf3,TCF-3,Tcfe2a,Transcription factor 3,Transcription factor E2-alpha,Transcri
EIAAB42104 Alf2,Immunoglobulin enhancer-binding factor E12_E47,Me2,Mouse,Mus musculus,Tcf3,TCF-3,Tcfe2a,Transcription factor 3,Transcription factor A1,Transcription factor E2-alpha
31-248 Transcription initiation factor IIA . and . chains (GTranscription Factor Antibodies2A1, Transcription Factor AntibodiesIIA p35 and p19 subunits, Transcription Factor AntibodiesIIAL) binding ability o 0.05 mg
EIAAB12290 E4F transcription factor 1,E4f1,Mouse,Mus musculus,p120E4F,Putative E3 ubiquitin-protein ligase E4F1,Transcription factor E4F,Transcription factor E4F1,Transcription factor phi AP3
18-003-44075 Transcription factor E2-alpha - Immunoglobulin enhancer-binding factor E12_E47; Transcription factor 3; TCF-3; Immunoglobulin transcription factor 1; Transcription factor ITF-1; Kappa-E2-binding facto 0.1 mg Protein A
EIAAB25650 Homo sapiens,Human,Metal regulatory transcription factor 1,MRE-binding transcription factor,MTF1,Transcription factor MTF-1
EIAAB42045 Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,General transcription factor IIH subunit 3,GTF2H3,Homo sapiens,Human,TFIIH basal transcription facto
EIAAB42050 Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,General transcription factor IIH subunit 4,GTF2H4,Homo sapiens,Human,TFIIH basal transcription facto
EIAAB42049 Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,General transcription factor IIH subunit 4,Gtf2h4,Mouse,Mus musculus,TFIIH basal transcription facto
EIAAB42048 Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,General transcription factor IIH subunit 3,Gtf2h3,Mouse,Mus musculus,TFIIH basal transcription facto
EIAAB42039 Basic transcription factor 2 62 kDa subunit,BTF2 p62,General transcription factor IIH polypeptide 1,General transcription factor IIH subunit 1,Gtf2h1,Mouse,Mus musculus,TFIIH basal transcription facto
18-003-42234 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.05 mg Aff Pur
18-003-42234 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.1 mg Protein A
EIAAB25651 Metal regulatory transcription factor 1,Mouse,MRE-binding transcription factor,Mtf1,Mtf-1,Mus musculus,Transcription factor MTF-1
18-003-42235 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.05 mg Aff Pur
18-003-43070 T-box transcription factor TBX21 - T-box protein 21; Transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet Polyclonal 0.1 mg Protein A
18-003-42235 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.1 mg Protein A
EIAAB42078 HMG box transcription factor 4,Homo sapiens,hTCF-4,Human,T-cell factor 4,T-cell-specific transcription factor 4,TCF4,TCF-4,TCF7L2,Transcription factor 7-like 2
EIAAB42042 Basic transcription factor 2 44 kDa subunit,BTF2 p44,General transcription factor IIH polypeptide 2,General transcription factor IIH subunit 2,Gtf2h2,Rat,Rattus norvegicus,TFIIH basal transcription fa
EIAAB32964 bHLH transcription factor p48,Mouse,Mus musculus,p48 DNA-binding subunit of transcription factor PTF1,Pancreas transcription factor 1 subunit alpha,Pancreas-specific transcription factor 1a,Ptf1a,Ptf1
18-003-42999 Cyclic AMP-dependent transcription factor ATF-5 - Activating transcription factor 5; Transcription factor ATFx Polyclonal 0.05 mg Aff Pur
EIAAB42079 HMG box transcription factor 4,Mouse,mTCF-4,Mus musculus,T-cell factor 4,T-cell-specific transcription factor 4,Tcf4,TCF-4,Tcf7l2,Transcription factor 7-like 2
EIAAB47163 CREB_ATF bZIP transcription factor,Crebzf,HCF-binding transcription factor Zhangfei,Host cell factor-binding transcription factor Zhangfei,Mouse,Mus musculus,Tyrosine kinase-associated leucine zipper

https://antibody-antibodies.com/ | https://gentaur.com/ | https://gen-script.com/ | https://diagenox.com/ | https://clonagen.com/ | http://gentaursearch.com/ | http://gentaurpub.com/ | https://gentaur-online.com/ | http://anti-anti-pdf.com/ | http://gentaur-worldwide.com/


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur

Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur