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Transcription factor SOX-2

 SOX2_MOUSE              Reviewed;         319 AA.
P48432;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
15-JUL-1999, sequence version 2.
23-MAY-2018, entry version 141.
RecName: Full=Transcription factor SOX-2;
Name=Sox2; Synonyms=Sox-2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7590241; DOI=10.1101/gad.9.21.2635;
Yuan H., Corbi N., Basilico C., Dailey L.;
"Developmental-specific activity of the FGF-4 enhancer requires the
synergistic action of Sox2 and Oct-3.";
Genes Dev. 9:2635-2645(1995).
[2]
SEQUENCE REVISION.
Yuan H., Corbi N., Basilico C., Dailey L.;
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129;
PubMed=8625802;
Collignon J., Sockanathan S., Hacker A., Cohen-Tannoudji M.,
Norris D., Rastan S., Stevanovic M., Goodfellow P.N., Lovell-Badge R.;
"A comparison of the properties of Sox-3 with Sry and two related
genes, Sox-1 and Sox-2.";
Development 122:509-520(1996).
[4]
SUMOYLATION AT LYS-247, MUTAGENESIS OF LYS-247, SUBCELLULAR LOCATION,
AND FUNCTION.
PubMed=17097055; DOI=10.1016/j.bbrc.2006.10.130;
Tsuruzoe S., Ishihara K., Uchimura Y., Watanabe S., Sekita Y.,
Aoto T., Saitoh H., Yuasa Y., Niwa H., Kawasuji M., Baba H., Nakao M.;
"Inhibition of DNA binding of Sox2 by the SUMO conjugation.";
Biochem. Biophys. Res. Commun. 351:920-926(2006).
[5]
BIOTECHNOLOGY.
PubMed=16904174; DOI=10.1016/j.cell.2006.07.024;
Takahashi K., Yamanaka S.;
"Induction of pluripotent stem cells from mouse embryonic and adult
fibroblast cultures by defined factors.";
Cell 126:663-676(2006).
[6]
INTERACTION WITH SOX3 AND FGFR1.
PubMed=17728342; DOI=10.1242/dev.007906;
Rizzoti K., Lovell-Badge R.;
"SOX3 activity during pharyngeal segmentation is required for
craniofacial morphogenesis.";
Development 134:3437-3448(2007).
[7]
INTERACTION WITH ZSCAN10.
PubMed=19740739; DOI=10.1074/jbc.M109.016162;
Yu H.B., Kunarso G., Hong F.H., Stanton L.W.;
"Zfp206, Oct4, and Sox2 are integrated components of a transcriptional
regulatory network in embryonic stem cells.";
J. Biol. Chem. 284:31327-31335(2009).
[8]
FUNCTION, AND INDUCTION.
PubMed=22198669; DOI=10.1038/nature10712;
Andreu-Agullo C., Maurin T., Thompson C.B., Lai E.C.;
"Ars2 maintains neural stem-cell identity through direct
transcriptional activation of Sox2.";
Nature 481:195-198(2012).
-!- FUNCTION: Transcription factor that forms a trimeric complex with
OCT4 on DNA and controls the expression of a number of genes
involved in embryonic development such as YES1, FGF4, UTF1 and
ZFP206. Critical for early embryogenesis and for embryonic stem
cell pluripotency. May function as a switch in neuronal
development. Downstream SRRT target that mediates the promotion of
neural stem cell self-renewal. Keeps neural cells undifferentiated
by counteracting the activity of proneural proteins and suppresses
neuronal differentiation (By similarity). {ECO:0000250,
ECO:0000269|PubMed:17097055, ECO:0000269|PubMed:22198669}.
-!- SUBUNIT: Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.
{ECO:0000269|PubMed:17728342, ECO:0000269|PubMed:19740739}.
-!- INTERACTION:
Q80Z64:Nanog; NbExp=10; IntAct=EBI-2313612, EBI-2312517;
P20263:Pou5f1; NbExp=4; IntAct=EBI-2313612, EBI-1606219;
Q60520:Sin3a; NbExp=3; IntAct=EBI-2313612, EBI-349034;
Q00899:Yy1; NbExp=2; IntAct=EBI-2313612, EBI-6921536;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00267, ECO:0000269|PubMed:17097055}.
-!- TISSUE SPECIFICITY: Expressed in the brain and retina. A very low
level expression is seen in the stomach and lung. Expressed in
developing urogenital ridge.
-!- INDUCTION: By SRRT. {ECO:0000269|PubMed:22198669}.
-!- PTM: Sumoylation inhibits binding on DNA and negatively regulates
the FGF4 transactivation. {ECO:0000269|PubMed:17097055}.
-!- BIOTECHNOLOGY: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four
Yamanaka factors. When combined, these factors are sufficient to
reprogram differentiated cells to an embryonic-like state
designated iPS (induced pluripotent stem) cells. iPS cells exhibit
the morphology and growth properties of ES cells and express ES
cell marker genes. {ECO:0000269|PubMed:16904174}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U31967; AAC31791.1; -; mRNA.
EMBL; X94127; CAA63847.1; -; Genomic_DNA.
CCDS; CCDS38413.1; -.
PIR; S10949; S10949.
RefSeq; NP_035573.3; NM_011443.4.
UniGene; Mm.65396; -.
PDB; 1GT0; X-ray; 2.60 A; D=41-120.
PDBsum; 1GT0; -.
ProteinModelPortal; P48432; -.
SMR; P48432; -.
BioGrid; 203406; 23.
DIP; DIP-54522N; -.
IntAct; P48432; 8.
MINT; P48432; -.
STRING; 10090.ENSMUSP00000096755; -.
iPTMnet; P48432; -.
PhosphoSitePlus; P48432; -.
MaxQB; P48432; -.
PaxDb; P48432; -.
PeptideAtlas; P48432; -.
PRIDE; P48432; -.
GeneID; 20674; -.
KEGG; mmu:20674; -.
CTD; 6657; -.
MGI; MGI:98364; Sox2.
eggNOG; ENOG410IPZI; Eukaryota.
eggNOG; ENOG411009V; LUCA.
HOGENOM; HOG000231647; -.
HOVERGEN; HBG105663; -.
InParanoid; P48432; -.
KO; K16796; -.
PhylomeDB; P48432; -.
EvolutionaryTrace; P48432; -.
PRO; PR:P48432; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_SOX2; -.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0044798; C:nuclear transcription factor complex; IDA:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0005667; C:transcription factor complex; IDA:MGI.
GO; GO:0003682; F:chromatin binding; IDA:MGI.
GO; GO:0031490; F:chromatin DNA binding; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0003700; F:DNA binding transcription factor activity; IDA:UniProtKB.
GO; GO:0035198; F:miRNA binding; ISO:MGI.
GO; GO:0046982; F:protein heterodimerization activity; IDA:MGI.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IDA:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO; GO:0021984; P:adenohypophysis development; IMP:MGI.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IMP:MGI.
GO; GO:0007050; P:cell cycle arrest; ISO:MGI.
GO; GO:0045165; P:cell fate commitment; IDA:MGI.
GO; GO:0001708; P:cell fate specification; IMP:MGI.
GO; GO:0021987; P:cerebral cortex development; IMP:MGI.
GO; GO:0050973; P:detection of mechanical stimulus involved in equilibrioception; IMP:MGI.
GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IMP:MGI.
GO; GO:0048852; P:diencephalon morphogenesis; IMP:MGI.
GO; GO:0048568; P:embryonic organ development; IMP:MGI.
GO; GO:0001714; P:endodermal cell fate specification; ISO:MGI.
GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IDA:MGI.
GO; GO:0021879; P:forebrain neuron differentiation; IMP:MGI.
GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
GO; GO:0060235; P:lens induction in camera-type eye; IGI:MGI.
GO; GO:0048286; P:lung alveolus development; IDA:MGI.
GO; GO:0030539; P:male genitalia development; IMP:MGI.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
GO; GO:0045596; P:negative regulation of cell differentiation; IMP:MGI.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:MGI.
GO; GO:0045665; P:negative regulation of neuron differentiation; IDA:MGI.
GO; GO:0045668; P:negative regulation of osteoblast differentiation; IDA:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:MGI.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IGI:MGI.
GO; GO:0048663; P:neuron fate commitment; IMP:MGI.
GO; GO:0097150; P:neuronal stem cell population maintenance; IGI:UniProtKB.
GO; GO:0030910; P:olfactory placode formation; IGI:MGI.
GO; GO:0001649; P:osteoblast differentiation; ISO:MGI.
GO; GO:0046148; P:pigment biosynthetic process; IMP:MGI.
GO; GO:0030858; P:positive regulation of epithelial cell differentiation; IDA:MGI.
GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:MGI.
GO; GO:0002052; P:positive regulation of neuroblast proliferation; IMP:MGI.
GO; GO:0045666; P:positive regulation of neuron differentiation; IMP:MGI.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; IDA:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0043281; P:regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
GO; GO:0010468; P:regulation of gene expression; ISO:MGI.
GO; GO:0050767; P:regulation of neurogenesis; IGI:MGI.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:MGI.
GO; GO:0070848; P:response to growth factor; ISO:MGI.
GO; GO:0010033; P:response to organic substance; IDA:MGI.
GO; GO:0032526; P:response to retinoic acid; IDA:MGI.
GO; GO:0060042; P:retina morphogenesis in camera-type eye; IMP:MGI.
GO; GO:0007605; P:sensory perception of sound; IMP:MGI.
GO; GO:0035019; P:somatic stem cell population maintenance; ISO:MGI.
GO; GO:0048863; P:stem cell differentiation; IDA:MGI.
GO; GO:0019827; P:stem cell population maintenance; IMP:UniProtKB.
GO; GO:0043586; P:tongue development; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.30.10; -; 1.
InterPro; IPR009071; HMG_box_dom.
InterPro; IPR036910; HMG_box_dom_sf.
InterPro; IPR032643; SOX-2.
InterPro; IPR022097; SOX_fam.
PANTHER; PTHR10270:SF231; PTHR10270:SF231; 1.
Pfam; PF00505; HMG_box; 1.
Pfam; PF12336; SOXp; 1.
SMART; SM00398; HMG; 1.
SUPFAM; SSF47095; SSF47095; 1.
PROSITE; PS50118; HMG_BOX_2; 1.
1: Evidence at protein level;
3D-structure; Activator; Complete proteome; Developmental protein;
DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein;
Reference proteome; Transcription; Transcription regulation;
Ubl conjugation.
CHAIN 1 319 Transcription factor SOX-2.
/FTId=PRO_0000048716.
DNA_BIND 43 111 HMG box. {ECO:0000255|PROSITE-
ProRule:PRU00267}.
COMPBIAS 19 25 Poly-Gly.
MOD_RES 253 253 Phosphoserine.
{ECO:0000250|UniProtKB:P48431}.
CROSSLNK 247 247 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
MUTAGEN 247 247 K->R: Absence of sumoylation. Increased
FGF4 activation. No effect on nuclear
localization.
{ECO:0000269|PubMed:17097055}.
CONFLICT 153 155 GGL -> AGV (in Ref. 3; CAA63847).
{ECO:0000305}.
CONFLICT 203 203 V -> D (in Ref. 3; CAA63847).
{ECO:0000305}.
CONFLICT 310 311 KY -> IN (in Ref. 3; CAA63847).
{ECO:0000305}.
HELIX 49 62 {ECO:0000244|PDB:1GT0}.
HELIX 70 81 {ECO:0000244|PDB:1GT0}.
HELIX 86 106 {ECO:0000244|PDB:1GT0}.
SEQUENCE 319 AA; 34454 MW; C40DE49E524C49F1 CRC64;
MYNMMETELK PPGPQQASGG GGGGGNATAA ATGGNQKNSP DRVKRPMNAF MVWSRGQRRK
MAQENPKMHN SEISKRLGAE WKLLSETEKR PFIDEAKRLR ALHMKEHPDY KYRPRRKTKT
LMKKDKYTLP GGLLAPGGNS MASGVGVGAG LGGGLNQRMD SYAHMNGWSN GSYSMMQEQL
GYPQHPGLNA HGAAQMQPMH RYVVSALQYN SMTSSQTYMN GSPTYSMSYS QQGTPGMALG
SMGSVVKSEA SSSPPVVTSS SHSRAPCQAG DLRDMISMYL PGAEVPEPAA PSRLHMAQHY
QSGPVPGTAK YGTLPLSHM


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