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Transcription factor SOX-3

 SOX3_MOUSE              Reviewed;         375 AA.
P53784; Q80XF1;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
25-OCT-2017, entry version 122.
RecName: Full=Transcription factor SOX-3;
Name=Sox3; Synonyms=Sox-3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129;
PubMed=8625802;
Collignon J., Sockanathan S., Hacker A., Cohen-Tannoudji M.,
Norris D., Rastan S., Stevanovic M., Goodfellow P.N., Lovell-Badge R.;
"A comparison of the properties of Sox-3 with Sry and two related
genes, Sox-1 and Sox-2.";
Development 122:509-520(1996).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=12748963; DOI=10.1002/gene.10193;
Brunelli S., Silva Casey E., Bell D., Harland R., Lovell-Badge R.;
"Expression of Sox3 throughout the developing central nervous system
is dependent on the combined action of discrete, evolutionarily
conserved regulatory elements.";
Genesis 36:12-24(2003).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=129/Ola;
PubMed=15456859; DOI=10.1128/MCB.24.20.8834-8846.2004;
Tanaka S., Kamachi Y., Tanouchi A., Hamada H., Jing N., Kondoh H.;
"Interplay of SOX and POU factors in regulation of the nestin gene in
neural primordial cells.";
Mol. Cell. Biol. 24:8834-8846(2004).
[4]
FUNCTION.
PubMed=14981518; DOI=10.1038/ng1309;
Rizzoti K., Brunelli S., Carmignac D., Thomas P.Q., Robinson I.C.,
Lovell-Badge R.;
"SOX3 is required during the formation of the hypothalamo-pituitary
axis.";
Nat. Genet. 36:247-255(2004).
[5]
FUNCTION, AND INTERACTION WITH SOX2 AND FGFR1.
PubMed=17728342; DOI=10.1242/dev.007906;
Rizzoti K., Lovell-Badge R.;
"SOX3 activity during pharyngeal segmentation is required for
craniofacial morphogenesis.";
Development 134:3437-3448(2007).
[6]
FUNCTION.
PubMed=21183788; DOI=10.1172/JCI42580;
Sutton E., Hughes J., White S., Sekido R., Tan J., Arboleda V.,
Rogers N., Knower K., Rowley L., Eyre H., Rizzoti K., McAninch D.,
Goncalves J., Slee J., Turbitt E., Bruno D., Bengtsson H., Harley V.,
Vilain E., Sinclair A., Lovell-Badge R., Thomas P.;
"Identification of SOX3 as an XX male sex reversal gene in mice and
humans.";
J. Clin. Invest. 121:328-341(2011).
-!- FUNCTION: Transcription factor required during the formation of
the hypothalamo-pituitary axis. May function as a switch in
neuronal development. Keeps neural cells undifferentiated by
counteracting the activity of proneural proteins and suppresses
neuronal differentiation. Required also within the pharyngeal
epithelia for craniofacial morphogenesis. Controls a genetic
switch in male development. Is necessary for initiating male sex
determination by directing the development of supporting cell
precursors (pre-Sertoli cells) as Sertoli rather than granulosa
cells. {ECO:0000269|PubMed:14981518, ECO:0000269|PubMed:17728342,
ECO:0000269|PubMed:21183788}.
-!- SUBUNIT: Interacts with SOX2 and FGFR1.
{ECO:0000269|PubMed:17728342}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Mainly in the developing central nervous
system. Expressed in developing urogenital ridge.
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EMBL; X94125; CAA63845.1; -; Genomic_DNA.
EMBL; AF434675; AAL40744.1; -; Genomic_DNA.
EMBL; AB108674; BAC75669.1; -; mRNA.
PIR; S10948; S10948.
UniGene; Mm.35784; -.
ProteinModelPortal; P53784; -.
SMR; P53784; -.
STRING; 10090.ENSMUSP00000115237; -.
iPTMnet; P53784; -.
PhosphoSitePlus; P53784; -.
MaxQB; P53784; -.
PaxDb; P53784; -.
PRIDE; P53784; -.
MGI; MGI:98365; Sox3.
eggNOG; KOG0527; Eukaryota.
eggNOG; ENOG4111FVF; LUCA.
HOGENOM; HOG000231647; -.
HOVERGEN; HBG105663; -.
InParanoid; P53784; -.
ChiTaRS; Sox3; mouse.
PRO; PR:P53784; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_SOX3; -.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0001106; F:RNA polymerase II transcription corepressor activity; IDA:UniProtKB.
GO; GO:0009887; P:animal organ morphogenesis; IMP:MGI.
GO; GO:0060324; P:face development; IMP:UniProtKB.
GO; GO:0030900; P:forebrain development; IMP:MGI.
GO; GO:0021854; P:hypothalamus development; IMP:UniProtKB.
GO; GO:0045665; P:negative regulation of neuron differentiation; ISS:UniProtKB.
GO; GO:0021983; P:pituitary gland development; IMP:UniProtKB.
GO; GO:0007423; P:sensory organ development; IMP:UniProtKB.
GO; GO:0060009; P:Sertoli cell development; IEP:UniProtKB.
GO; GO:0007530; P:sex determination; IMP:UniProtKB.
GO; GO:0048515; P:spermatid differentiation; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.30.10; -; 1.
InterPro; IPR009071; HMG_box_dom.
InterPro; IPR036910; HMG_box_dom_sf.
InterPro; IPR022097; SOX_fam.
Pfam; PF00505; HMG_box; 1.
Pfam; PF12336; SOXp; 1.
SMART; SM00398; HMG; 1.
SUPFAM; SSF47095; SSF47095; 1.
PROSITE; PS50118; HMG_BOX_2; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; DNA-binding; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 375 Transcription factor SOX-3.
/FTId=PRO_0000048721.
DNA_BIND 69 137 HMG box. {ECO:0000255|PROSITE-
ProRule:PRU00267}.
COMPBIAS 54 63 Poly-Gly.
COMPBIAS 164 177 Poly-Ala.
COMPBIAS 219 223 Poly-Pro.
COMPBIAS 252 259 Poly-Ala.
COMPBIAS 269 276 Poly-Ala.
COMPBIAS 282 293 Poly-Ala.
CONFLICT 160 160 L -> P (in Ref. 1; CAA63845 and 2;
AAL40744). {ECO:0000305}.
CONFLICT 315 315 A -> R (in Ref. 1; CAA63845 and 2;
AAL40744). {ECO:0000305}.
SEQUENCE 375 AA; 37789 MW; 3E117E20D40BFE34 CRC64;
MYSLLETELK NPVGPPTPAA GTGVPAAPGA AGKSGANPAG GANAGNGGSG GANGGGGGGG
GGGSDQDRVK RPMNAFMVWS RGQRRKMALE NPKMHNSEIS KRLGADWKLL TDAEKRPFID
EAKRLRAVHM KEYPDYKYRP RRKTKTLLKK DKYSLPGGLL PPGAAAAAAA AAAAAAASSP
VGVGQRLDTY THVNGWANGA YSLVQEQLGY AQPPSMSSPP PPPALPQMHR YDMAGLQYSP
MMPPGAQSYM NAAAAAAAAS GYGGMAPSAA AAAAAAYGQQ PATAAAAAAA AAAMSLGPMG
SVVKSEPSSP PPAIASHSQR ACLGDLRDMI SMYLPPGGDA ADAASPLPGG RLHGVHQHYQ
GAGTAVNGTV PLTHI


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