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Transcription factor SOX-9

 SOX9_CHICK              Reviewed;         494 AA.
P48434; F1P307; O73668;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
09-JUL-2014, sequence version 3.
25-OCT-2017, entry version 110.
RecName: Full=Transcription factor SOX-9;
Name=SOX9;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN CARTILAGE DEVELOPMENT,
DEVELOPMENTAL STAGE, AND INDUCTION.
PubMed=10340758;
DOI=10.1002/(SICI)1097-0177(199905)215:1<69::AID-DVDY8>3.0.CO;2-N;
Healy C., Uwanogho D., Sharpe P.T.;
"Regulation and role of Sox9 in cartilage formation.";
Dev. Dyn. 215:69-78(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION IN TRANSCRIPTION REGULATION.
PubMed=9858536; DOI=10.1128/MCB.19.1.107;
Kamachi Y., Cheah K.S., Kondoh H.;
"Mechanism of regulatory target selection by the SOX high-mobility-
group domain proteins as revealed by comparison of SOX1/2/3 and
SOX9.";
Mol. Cell. Biol. 19:107-120(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Red jungle fowl;
PubMed=15592404; DOI=10.1038/nature03154;
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
Mardis E.R., Wilson R.K.;
"Sequence and comparative analysis of the chicken genome provide
unique perspectives on vertebrate evolution.";
Nature 432:695-716(2004).
[4]
FUNCTION IN NEURAL CREST DELAMINATION, INTERACTION WITH SNAI2 AND
UBE2I, SUBCELLULAR LOCATION, SUMOYLATIOON AT LYS-376, PHOSPHORYLATION
AT SER-64 AND SER-181, AND MUTAGENESIS OF LYS-61; SER-64; SER-181;
LYS-254 AND LYS-376.
PubMed=23382206; DOI=10.1073/pnas.1211747110;
Liu J.A., Wu M.H., Yan C.H., Chau B.K., So H., Ng A., Chan A.,
Cheah K.S., Briscoe J., Cheung M.;
"Phosphorylation of Sox9 is required for neural crest delamination and
is regulated downstream of BMP and canonical Wnt signaling.";
Proc. Natl. Acad. Sci. U.S.A. 110:2882-2887(2013).
-!- FUNCTION: Transcription factor that selectively activates enhancer
through its interaction with a DNA-binding partner factor.
Activates enhancer of COL2A1 through its binding with DNA sequence
5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus,
phosphorylation is induced and then sumoylation, allowing
cooperation with SNAI2 to trigger neural crest delamination.
Functions at the level of mesenchymal cell condensation by
inducing cartilage development in limbs and by changing the
aggregation properties of limb mesenchymal cells. Regulates the
cell fate decision to follow the cartilage differentiation
pathway. {ECO:0000269|PubMed:10340758,
ECO:0000269|PubMed:23382206, ECO:0000269|PubMed:9858536}.
-!- SUBUNIT: Interacts with SNAI2; triggers neural crest delamination
in a phosphorylation dependent manner. Interacts with UBE2I.
{ECO:0000269|PubMed:23382206}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00267}.
-!- DEVELOPMENTAL STAGE: Found in chondrogenic regions in the
branchial arches, somites and limb buds at E22. At E28 detected in
the limbs, developing scapula, prevertebrae and ribs. Found in
condensing mesenchyme of the forelimb at E25. Expressed in the
condensing mesenchyme at the distal tips of the developing
hindlimbs at E26. {ECO:0000269|PubMed:10340758}.
-!- INDUCTION: By BMP2 during chondrogenesis.
{ECO:0000269|PubMed:10340758}.
-!- PTM: Phosphorylated at Ser-181 in the developing neural tube.
Phosphorylation at either Ser-64 or Ser-181 is required for
sumoylation, but phosphorylation is not dependent on sumoylation.
Sumoylation is enhanced by PKA. Phosphorylation is required for
interaction with SNAI2 to trigger neural crest delamination and
for an efficient trunk neural crest delamination, whereas
sumoylation plays a less significant role. Phosphorylation and
sumoylation are induced by BMP signaling pathway.
{ECO:0000269|PubMed:23382206}.
-!- PTM: Sumoylated at Lys-376; phosphorylation at either Ser-64 or
Ser-181 is required for sumoylation. Sumoylation is induced by BMP
signaling pathway. {ECO:0000269|PubMed:23382206}.
-!- SEQUENCE CAUTION:
Sequence=AAB09663.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; U12533; AAB09663.1; ALT_FRAME; mRNA.
EMBL; AB012236; BAA25296.1; -; mRNA.
EMBL; AADN03007462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; NP_989612.1; NM_204281.1.
UniGene; Gga.890; -.
ProteinModelPortal; P48434; -.
SMR; P48434; -.
STRING; 9031.ENSGALP00000037718; -.
iPTMnet; P48434; -.
PaxDb; P48434; -.
PRIDE; P48434; -.
Ensembl; ENSGALT00000038513; ENSGALP00000037718; ENSGALG00000004386.
GeneID; 374148; -.
KEGG; gga:374148; -.
CTD; 6662; -.
eggNOG; KOG0527; Eukaryota.
eggNOG; ENOG410XT0K; LUCA.
GeneTree; ENSGT00760000118988; -.
HOGENOM; HOG000108876; -.
HOVERGEN; HBG002061; -.
InParanoid; P48434; -.
KO; K18435; -.
OMA; GTEQTHI; -.
OrthoDB; EOG091G0EKD; -.
PhylomeDB; P48434; -.
Reactome; R-GGA-3769402; Deactivation of the beta-catenin transactivating complex.
PRO; PR:P48434; -.
Proteomes; UP000000539; Chromosome 18.
Bgee; ENSGALG00000004386; -.
GO; GO:0044798; C:nuclear transcription factor complex; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IDA:AgBase.
GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0001046; F:core promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001158; F:enhancer sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0097157; F:pre-mRNA intronic binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0044390; F:ubiquitin-like protein conjugating enzyme binding; IPI:AgBase.
GO; GO:0060018; P:astrocyte fate commitment; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEP:UniProtKB.
GO; GO:0060532; P:bronchus cartilage development; IEA:Ensembl.
GO; GO:0019933; P:cAMP-mediated signaling; IEA:Ensembl.
GO; GO:0001502; P:cartilage condensation; IDA:UniProtKB.
GO; GO:0098609; P:cell-cell adhesion; IEA:Ensembl.
GO; GO:0071773; P:cellular response to BMP stimulus; IDA:UniProtKB.
GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; IEA:Ensembl.
GO; GO:0071504; P:cellular response to heparin; IEA:Ensembl.
GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0071300; P:cellular response to retinoic acid; IEP:UniProtKB.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0002062; P:chondrocyte differentiation; IDA:UniProtKB.
GO; GO:0003413; P:chondrocyte differentiation involved in endochondral bone morphogenesis; IEA:Ensembl.
GO; GO:0003415; P:chondrocyte hypertrophy; IEA:Ensembl.
GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
GO; GO:0090103; P:cochlea morphogenesis; IEA:Ensembl.
GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
GO; GO:0048566; P:embryonic digestive tract development; IMP:AgBase.
GO; GO:0003203; P:endocardial cushion morphogenesis; IEA:Ensembl.
GO; GO:0031018; P:endocrine pancreas development; IEA:Ensembl.
GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0060517; P:epithelial cell proliferation involved in prostatic bud elongation; IEA:Ensembl.
GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEA:Ensembl.
GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
GO; GO:0070384; P:Harderian gland development; IEA:Ensembl.
GO; GO:0003170; P:heart valve development; IEP:UniProtKB.
GO; GO:0003188; P:heart valve formation; IEA:Ensembl.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; IMP:AgBase.
GO; GO:0060729; P:intestinal epithelial structure maintenance; IEA:Ensembl.
GO; GO:0035622; P:intrahepatic bile duct development; IEA:Ensembl.
GO; GO:0032808; P:lacrimal gland development; IEA:Ensembl.
GO; GO:0060174; P:limb bud formation; IEA:Ensembl.
GO; GO:0060487; P:lung epithelial cell differentiation; IEA:Ensembl.
GO; GO:0061145; P:lung smooth muscle development; IEA:Ensembl.
GO; GO:0019100; P:male germ-line sex determination; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEP:UniProtKB.
GO; GO:0072289; P:metanephric nephron tubule formation; IEA:Ensembl.
GO; GO:0002009; P:morphogenesis of an epithelium; IMP:AgBase.
GO; GO:1903011; P:negative regulation of bone development; IMP:AgBase.
GO; GO:0030502; P:negative regulation of bone mineralization; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IEA:Ensembl.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:0002683; P:negative regulation of immune system process; IEA:Ensembl.
GO; GO:2001054; P:negative regulation of mesenchymal cell apoptotic process; IEA:Ensembl.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; IEA:Ensembl.
GO; GO:1902894; P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0036032; P:neural crest cell delamination; IMP:UniProtKB.
GO; GO:0014036; P:neural crest cell fate specification; IDA:UniProtKB.
GO; GO:0001755; P:neural crest cell migration; IMP:AgBase.
GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
GO; GO:0030903; P:notochord development; IEA:Ensembl.
GO; GO:0006334; P:nucleosome assembly; IEA:Ensembl.
GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
GO; GO:0001503; P:ossification; IEA:Ensembl.
GO; GO:0030916; P:otic vesicle formation; IEA:Ensembl.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:1902027; P:positive regulation of cartilage condensation; IMP:AgBase.
GO; GO:2000138; P:positive regulation of cell proliferation involved in heart morphogenesis; IEA:Ensembl.
GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IMP:AgBase.
GO; GO:0030858; P:positive regulation of epithelial cell differentiation; IEA:Ensembl.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:1901203; P:positive regulation of extracellular matrix assembly; IEA:Ensembl.
GO; GO:2000020; P:positive regulation of male gonad development; IEA:Ensembl.
GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
GO; GO:2000741; P:positive regulation of mesenchymal stem cell differentiation; IEA:Ensembl.
GO; GO:0090300; P:positive regulation of neural crest formation; IMP:AgBase.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0006461; P:protein complex assembly; IEA:Ensembl.
GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
GO; GO:0034504; P:protein localization to nucleus; IEA:Ensembl.
GO; GO:0061046; P:regulation of branching involved in lung morphogenesis; IEA:Ensembl.
GO; GO:0061035; P:regulation of cartilage development; IDA:UniProtKB.
GO; GO:0010564; P:regulation of cell cycle process; IEA:Ensembl.
GO; GO:0060784; P:regulation of cell proliferation involved in tissue homeostasis; IEA:Ensembl.
GO; GO:2000794; P:regulation of epithelial cell proliferation involved in lung morphogenesis; IEA:Ensembl.
GO; GO:0072034; P:renal vesicle induction; IEA:Ensembl.
GO; GO:0060221; P:retinal rod cell differentiation; IEA:Ensembl.
GO; GO:0060009; P:Sertoli cell development; IEA:Ensembl.
GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0060534; P:trachea cartilage development; IEA:Ensembl.
GO; GO:0006351; P:transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0060290; P:transdifferentiation; IMP:AgBase.
GO; GO:0072197; P:ureter morphogenesis; IEA:Ensembl.
GO; GO:0072193; P:ureter smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0072190; P:ureter urothelium development; IEA:Ensembl.
Gene3D; 1.10.30.10; -; 1.
InterPro; IPR009071; HMG_box_dom.
InterPro; IPR036910; HMG_box_dom_sf.
InterPro; IPR029548; SOX-9.
InterPro; IPR022151; Sox_N.
PANTHER; PTHR10270:SF212; PTHR10270:SF212; 1.
Pfam; PF00505; HMG_box; 1.
Pfam; PF12444; Sox_N; 1.
SMART; SM00398; HMG; 1.
SUPFAM; SSF47095; SSF47095; 1.
PROSITE; PS50118; HMG_BOX_2; 1.
1: Evidence at protein level;
Complete proteome; DNA-binding; Isopeptide bond; Nucleus;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 494 Transcription factor SOX-9.
/FTId=PRO_0000048745.
DNA_BIND 105 173 HMG box. {ECO:0000255|PROSITE-
ProRule:PRU00267}.
COMPBIAS 214 219 Poly-Ser.
COMPBIAS 342 360 Gln/Pro-rich.
COMPBIAS 395 402 Poly-Gln.
MOD_RES 64 64 Phosphoserine.
{ECO:0000269|PubMed:23382206}.
MOD_RES 181 181 Phosphoserine.
{ECO:0000269|PubMed:23382206}.
CROSSLNK 376 376 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
MUTAGEN 61 61 K->R: Decreases cooperating with SNAI2 to
trigger neural crest delamination; when
associated with R-254 and R-376.
{ECO:0000269|PubMed:23382206}.
MUTAGEN 64 64 S->A: Abolishes sumoylation; when
associated with A-181. Abolishes
phosphorylation; when associated with A-
181. Reduces ability to associate with
UBE2I; when associated with A-181.
Prevents trunk neural crest delamination;
when associated with A-181. Prevents
cooperating with SNAI2 to trigger neural
crest delamination; when associated with
A-181. Abolishes interaction with SNAI2;
when associated with A-181.
{ECO:0000269|PubMed:23382206}.
MUTAGEN 64 64 S->D: Sumoylation; when associated with
D-181. Initiates trunk neural crest
delamination; when associated with D-181.
Allows cooperating with SNAI2 to trigger
neural crest delamination; when
associated with D-181. Allows interaction
with SNAI2; when associated with D-181.
{ECO:0000269|PubMed:23382206}.
MUTAGEN 181 181 S->A: Abolishes sumoylation; when
associated with A-64. Abolishes
phosphorylation; when associated with A-
64. Reduces ability to associate with
UBE2I; when associated with A-64.
Prevents trunk neural crest delamination;
when associated with A-64. Prevents
cooperating with SNAI2 to trigger neural
crest delamination; when associated with
A-64. Abolishes interaction with SNAI2;
when associated with A-64.
{ECO:0000269|PubMed:23382206}.
MUTAGEN 181 181 S->D: Sumoylation; when associated with
D-64. Initiates trunk neural crest
delamination; when associated with D-64.
Allows cooperating with SNAI2 to trigger
neural crest delamination; when
associated with D-64. Allows interaction
with SNAI2; when associated with D-64.
{ECO:0000269|PubMed:23382206}.
MUTAGEN 254 254 K->R: Decreases cooperating with SNAI2 to
trigger neural crest delamination; when
associated with R-61 and R-376.
{ECO:0000269|PubMed:23382206}.
MUTAGEN 376 376 K->R: Decreases cooperating with SNAI2 to
trigger neural crest delamination; when
associated with R-61 and R-254.
{ECO:0000269|PubMed:23382206}.
MUTAGEN 376 376 K->R: Not sumoylated.
{ECO:0000269|PubMed:23382206}.
CONFLICT 17 20 CISD -> GLSG (in Ref. 1; AAB09663).
{ECO:0000305}.
CONFLICT 181 181 S -> T (in Ref. 1; AAB09663).
{ECO:0000305}.
CONFLICT 385 385 Y -> N (in Ref. 1; AAB09663).
{ECO:0000305}.
CONFLICT 415 415 S -> F (in Ref. 1; AAB09663).
{ECO:0000305}.
CONFLICT 424 424 Q -> E (in Ref. 1; AAB09663).
{ECO:0000305}.
CONFLICT 446 446 G -> S (in Ref. 1; AAB09663).
{ECO:0000305}.
CONFLICT 473 473 S -> T (in Ref. 1; AAB09663).
{ECO:0000305}.
SEQUENCE 494 AA; 54848 MW; A3926313CA954E32 CRC64;
MNLLDPFMKM TEEQDKCISD APSPTMSDDS AGSPCPSGSG SDTENTRPQE NTFPKGDPDL
KKESDEDKFP VCIREAVSQV LKGYDWTLVP MPVRVNGSSK NKPHVKRPMN AFMVWAQAAR
RKLADQYPHL HNAELSKTLG KLWRLLNESE KRPFVEEAER LRVQHKKDHP DYKYQPRRRK
SVKNGQSEQE EGSEQTHISP NAIFKALQAD SPQSSSSISE VHSPGEHSGQ SQGPPTPPTT
PKTDAQQPGK QDLKREGRPL AEGGRQPPHI DFRDVDIGEL SSDVISNIET FDVNEFDQYL
PPNGHPGVPA THGQVTTYSG TYGISSSASS PAGAGHAWMA KQQPQPPQPP AQPPAQHTLP
ALSGEQGPAQ QRPHIKTEQL SPSHYSEQQQ HSPQQQQQQQ QQLGYGSFNL QHYGSSYPPI
TRSQYDYTEH QNSGSYYSHA AGQSGGLYST FTYMNPTQRP MYTPIADTSG VPSIPQTHSP
QHWEQPVYTQ LTRP


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EIAAB42049 Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,General transcription factor IIH subunit 4,Gtf2h4,Mouse,Mus musculus,TFIIH basal transcription facto
EIAAB42048 Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,General transcription factor IIH subunit 3,Gtf2h3,Mouse,Mus musculus,TFIIH basal transcription facto
EIAAB42039 Basic transcription factor 2 62 kDa subunit,BTF2 p62,General transcription factor IIH polypeptide 1,General transcription factor IIH subunit 1,Gtf2h1,Mouse,Mus musculus,TFIIH basal transcription facto
18-003-42234 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.05 mg Aff Pur
18-003-42234 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.1 mg Protein A
EIAAB25651 Metal regulatory transcription factor 1,Mouse,MRE-binding transcription factor,Mtf1,Mtf-1,Mus musculus,Transcription factor MTF-1
18-003-42235 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.05 mg Aff Pur
18-003-43070 T-box transcription factor TBX21 - T-box protein 21; Transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet Polyclonal 0.1 mg Protein A
18-003-42235 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.1 mg Protein A
EIAAB42078 HMG box transcription factor 4,Homo sapiens,hTCF-4,Human,T-cell factor 4,T-cell-specific transcription factor 4,TCF4,TCF-4,TCF7L2,Transcription factor 7-like 2
EIAAB42042 Basic transcription factor 2 44 kDa subunit,BTF2 p44,General transcription factor IIH polypeptide 2,General transcription factor IIH subunit 2,Gtf2h2,Rat,Rattus norvegicus,TFIIH basal transcription fa
EIAAB32964 bHLH transcription factor p48,Mouse,Mus musculus,p48 DNA-binding subunit of transcription factor PTF1,Pancreas transcription factor 1 subunit alpha,Pancreas-specific transcription factor 1a,Ptf1a,Ptf1
18-003-42999 Cyclic AMP-dependent transcription factor ATF-5 - Activating transcription factor 5; Transcription factor ATFx Polyclonal 0.05 mg Aff Pur
EIAAB42079 HMG box transcription factor 4,Mouse,mTCF-4,Mus musculus,T-cell factor 4,T-cell-specific transcription factor 4,Tcf4,TCF-4,Tcf7l2,Transcription factor 7-like 2
EIAAB47163 CREB_ATF bZIP transcription factor,Crebzf,HCF-binding transcription factor Zhangfei,Host cell factor-binding transcription factor Zhangfei,Mouse,Mus musculus,Tyrosine kinase-associated leucine zipper


 

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