Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Transcription factor Sox-3-A (xSox3) (xSox-B1)

 SOX3A_XENLA             Reviewed;         309 AA.
P55863; A7VJ96; P40648; Q6INQ2;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 1.
23-MAY-2018, entry version 93.
RecName: Full=Transcription factor Sox-3-A;
Short=xSox3;
AltName: Full=xSox-B1;
Name=sox3-a; Synonyms=sox3;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
TISSUE=Ovary;
PubMed=9328277; DOI=10.1006/abbi.1997.0283;
Sakai Y., Hiraoka Y., Konishi M., Ogawa M., Aiso S.;
"Isolation and Characterization of Xenopus laevis xSox-B1 cDNA.";
Arch. Biochem. Biophys. 346:1-6(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE
SPECIFICITY, AND DEVELOPMENTAL STAGE.
TISSUE=Ovary;
PubMed=9099866; DOI=10.1016/S0378-1119(96)00790-1;
Koyano S., Ito M., Takamatsu N., Takiguchi S., Shiba T.;
"The Xenopus Sox3 gene expressed in oocytes of early stages.";
Gene 188:101-107(1997).
[3]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
STAGE.
PubMed=9415486;
Penzel R., Oschwald R., Chen Y., Tacke L., Grunz H.;
"Characterization and early embryonic expression of a neural specific
transcription factor xSOX3 in Xenopus laevis.";
Int. J. Dev. Biol. 41:667-677(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Gastrula;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[5]
INTERACTION WITH CTNNB1.
PubMed=10549281; DOI=10.1016/S1097-2765(00)80200-2;
Zorn A.M., Barish G.D., Williams B.O., Lavender P., Klymkowsky M.W.,
Varmus H.E.;
"Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and
XSox3 physically interact with beta-catenin.";
Mol. Cell 4:487-498(1999).
[6]
FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, TISSUE
SPECIFICITY, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF MET-44; ASN-45;
ARG-55; TRP-78; ALA-93 AND PRO-105.
PubMed=14522872; DOI=10.1242/dev.00798;
Zhang C., Basta T., Jensen E.D., Klymkowsky M.W.;
"The beta-catenin/VegT-regulated early zygotic gene Xnr5 is a direct
target of SOX3 regulation.";
Development 130:5609-5624(2003).
[7]
FUNCTION.
PubMed=15302595; DOI=10.1016/j.ydbio.2004.05.019;
Zhang C., Basta T., Hernandez-Lagunas L., Simpson P., Stemple D.L.,
Artinger K.B., Klymkowsky M.W.;
"Repression of nodal expression by maternal B1-type SOXs regulates
germ layer formation in Xenopus and zebrafish.";
Dev. Biol. 273:23-37(2004).
[8]
TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
PubMed=17056008; DOI=10.1016/j.bbrc.2006.10.040;
Nitta K.R., Takahashi S., Haramoto Y., Fukuda M., Onuma Y.,
Asashima M.;
"Expression of Sox1 during Xenopus early embryogenesis.";
Biochem. Biophys. Res. Commun. 351:287-293(2006).
[9]
TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
Ma L., Zhao S.-H., Kong Q.-H., Mao B.-Y.;
"Temporal and spatial expression patterns of Sox1 gene in Xenopus
laevis embryo.";
Dong Wu Xue Yan Jiu 28:403-408(2007).
[10]
TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
PubMed=18031719; DOI=10.1016/j.ydbio.2007.10.023;
Rogers C.D., Archer T.C., Cunningham D.D., Grammer T.C.,
Silva Casey E.M.;
"Sox3 expression is maintained by FGF signaling and restricted to the
neural plate by Vent proteins in the Xenopus embryo.";
Dev. Biol. 313:307-319(2008).
[11]
FUNCTION.
PubMed=17608734; DOI=10.1111/j.1432-0436.2007.00190.x;
Zhang C., Klymkowsky M.W.;
"The Sox axis, Nodal signaling, and germ layer specification.";
Differentiation 75:536-545(2007).
-!- FUNCTION: Transcription factor with sequence-specific DNA binding
activity. Binds to the consensus sequence 5'-[AT][AT]CAA[AT]G-3',
showing a preference for 5'-AACAAT-3' and 5'-AACAAAG-3'. Inhibits
beta-catenin-mediated dorsal axis specification by binding to
sites within the promoter of the beta-catenin-regulated gene
nodal5. Acts maternally as a transcriptional repressor of nodal5
and nodal6 to restrict their expression to the vegetal hemisphere
of early embryos and thus establish germ layer formation. Acts at
multiple points to inhibit nodal signaling, repressing the
expression of the other mesoderm-inducing nodal genes nodal,
nodal2 and nodal4, and also acting downstream to induce expression
of genes including trim33/ectodermin, ema and coco, whose products
repress nodal signaling. {ECO:0000269|PubMed:14522872,
ECO:0000269|PubMed:15302595, ECO:0000269|PubMed:17608734,
ECO:0000269|PubMed:9099866, ECO:0000269|PubMed:9328277}.
-!- SUBUNIT: Interacts with ctnnb1. {ECO:0000269|PubMed:10549281,
ECO:0000269|PubMed:14522872}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00267, ECO:0000269|PubMed:14522872}. Cytoplasm
{ECO:0000269|PubMed:14522872}. Note=Primarily cytoplasmic in early
embryos. Nuclear localization becomes more pronounced as
development proceeds.
-!- TISSUE SPECIFICITY: Expression is restricted to the animal
hemisphere of the uncleaved egg and early cleavage embryos. In
late blastula and gastrula stages, expressed in the dorsal animal
and marginal zone. In neurula stages, expressed in the developing
central nervous system including the otic vesicles, branchial
arches and the lens epithelium of the developing eye. At stage 23
(early tail bud), expressed in the neural tube and around the
anterior neural plate. Throughout tail bud stages, expressed in
the brain, and in the otic vesicle and branchial arches. Weakly
expressed in the eye lens at stage 30 (late tailbud). In adults,
mainly expressed in the ovary, with faint expression in the brain,
testis, muscle and skin. {ECO:0000269|PubMed:14522872,
ECO:0000269|PubMed:17056008, ECO:0000269|PubMed:18031719,
ECO:0000269|PubMed:9099866, ECO:0000269|PubMed:9328277,
ECO:0000269|PubMed:9415486, ECO:0000269|Ref.9}.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
Most abundant in stage I oocytes. Expression fades away at stage 7
and then is elevated at the late blastula stage (stage 9), which
continues during neurulation. From stage 25 onwards, expression
levels decrease. {ECO:0000269|PubMed:14522872,
ECO:0000269|PubMed:17056008, ECO:0000269|PubMed:18031719,
ECO:0000269|PubMed:9099866, ECO:0000269|PubMed:9328277,
ECO:0000269|PubMed:9415486, ECO:0000269|Ref.9}.
-!- INDUCTION: By bmp-antagonism. Fgf is required for maintenance of
expression, but not for induction. {ECO:0000269|PubMed:17056008,
ECO:0000269|PubMed:18031719}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB000825; BAF76379.1; -; mRNA.
EMBL; Y07542; CAA68828.1; -; mRNA.
EMBL; BC072222; AAH72222.1; -; mRNA.
PIR; S22946; S22946.
RefSeq; NP_001084148.1; NM_001090679.1.
UniGene; Xl.22; -.
ProteinModelPortal; P55863; -.
SMR; P55863; -.
BioGrid; 100660; 1.
PRIDE; P55863; -.
GeneID; 399335; -.
KEGG; xla:399335; -.
CTD; 399335; -.
Xenbase; XB-GENE-484819; sox3.
HOVERGEN; HBG105663; -.
KO; K09267; -.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0008013; F:beta-catenin binding; IDA:UniProtKB.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0001704; P:formation of primary germ layer; IMP:UniProtKB.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IMP:UniProtKB.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.30.10; -; 1.
InterPro; IPR009071; HMG_box_dom.
InterPro; IPR036910; HMG_box_dom_sf.
InterPro; IPR022097; SOX_fam.
Pfam; PF00505; HMG_box; 1.
Pfam; PF12336; SOXp; 1.
SMART; SM00398; HMG; 1.
SUPFAM; SSF47095; SSF47095; 1.
PROSITE; PS50118; HMG_BOX_2; 1.
1: Evidence at protein level;
Cytoplasm; Developmental protein; DNA-binding; Gastrulation; Nucleus;
Repressor; Transcription; Transcription regulation.
CHAIN 1 309 Transcription factor Sox-3-A.
/FTId=PRO_0000048723.
DNA_BIND 40 108 HMG box. {ECO:0000255|PROSITE-
ProRule:PRU00267}.
MUTAGEN 44 44 M->L: Abolishes binding to 5'-ATTGTT-3'
DNA sequence. Does not affect ctnnb1-
binding. {ECO:0000269|PubMed:14522872}.
MUTAGEN 45 45 N->I: Abolishes binding to 5'-ATTGTT-3'
DNA sequence. Reduces binding to the
nodal5 promoter. Does not affect ctnnb1-
binding. {ECO:0000269|PubMed:14522872}.
MUTAGEN 55 55 R->G: Abolishes binding to 5'-ATTGTT-3'
DNA sequence.
{ECO:0000269|PubMed:14522872}.
MUTAGEN 78 78 W->R: Abolishes binding to 5'-ATTGTT-3'
DNA sequence.
{ECO:0000269|PubMed:14522872}.
MUTAGEN 93 93 A->S: Does not abolish binding to 5'-
ATTGTT-3' DNA sequence.
{ECO:0000269|PubMed:14522872}.
MUTAGEN 105 105 P->A: Abolishes binding to 5'-ATTGTT-3'
DNA sequence.
{ECO:0000269|PubMed:14522872}.
CONFLICT 96 96 L -> K (in Ref. 2). {ECO:0000305}.
SEQUENCE 309 AA; 34035 MW; 89E401E6BB9EAE03 CRC64;
MYSMLDTDIK SPVQQSNAPI GGPATPGGKG NASTLDQDRV KRPMNAFMVW SRGQRRKMAQ
ENPKMHNSEI SKRLGADWKL LSDSDKRPFI DEAKRLRAVH MKDYPDYKYR PRRKTKTLLK
KDKYSLPGNL LAPGVSPVAS SVGVGQRIDT YAHMNGWTNG AYSLMQDQLG YSQHPAMNSP
QMQQIQHRYD MSGLQYNPMM TSAQNAYMNA AASTYSMSPA YNQQSSTVMS LASMGSVVKS
EPSSPPPAIT SHTQRACLGD LRDMISMYLP PGGDASDPSL QNSRLHSVHQ HYQSAAGPGV
NGTVPLTHI


Related products :

Catalog number Product name Quantity
EIAAB42084 Homo sapiens,Human,Mitochondrial transcription factor 1,MtTF1,mtTFA,TCF6,TCF-6,TCF6L2,TFAM,Transcription factor 6,Transcription factor 6-like 2,Transcription factor A, mitochondrial
18-003-42098 Ets domain transcription factor - ESE3 transcription factor; EHF protein; DJ875K15.1.2 (Ets homologous factor (Ets-domain transcription factor. ESE-3B (Isoform 2))); ETS-family transcription factor EH 0.1 mg Protein A
EIAAB42103 Immunoglobulin enhancer-binding factor E12_E47,Pan,Pancreas specific transcription factor 1c,Ptf1c,Rat,Rattus norvegicus,Tcf3,TCF-3,Tcfe2a,Transcription factor 3,Transcription factor E2-alpha,Transcri
EIAAB42104 Alf2,Immunoglobulin enhancer-binding factor E12_E47,Me2,Mouse,Mus musculus,Tcf3,TCF-3,Tcfe2a,Transcription factor 3,Transcription factor A1,Transcription factor E2-alpha
31-248 Transcription initiation factor IIA . and . chains (GTranscription Factor Antibodies2A1, Transcription Factor AntibodiesIIA p35 and p19 subunits, Transcription Factor AntibodiesIIAL) binding ability o 0.05 mg
EIAAB12290 E4F transcription factor 1,E4f1,Mouse,Mus musculus,p120E4F,Putative E3 ubiquitin-protein ligase E4F1,Transcription factor E4F,Transcription factor E4F1,Transcription factor phi AP3
18-003-44075 Transcription factor E2-alpha - Immunoglobulin enhancer-binding factor E12_E47; Transcription factor 3; TCF-3; Immunoglobulin transcription factor 1; Transcription factor ITF-1; Kappa-E2-binding facto 0.1 mg Protein A
EIAAB25650 Homo sapiens,Human,Metal regulatory transcription factor 1,MRE-binding transcription factor,MTF1,Transcription factor MTF-1
EIAAB42045 Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,General transcription factor IIH subunit 3,GTF2H3,Homo sapiens,Human,TFIIH basal transcription facto
EIAAB42050 Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,General transcription factor IIH subunit 4,GTF2H4,Homo sapiens,Human,TFIIH basal transcription facto
EIAAB42049 Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,General transcription factor IIH subunit 4,Gtf2h4,Mouse,Mus musculus,TFIIH basal transcription facto
EIAAB42048 Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,General transcription factor IIH subunit 3,Gtf2h3,Mouse,Mus musculus,TFIIH basal transcription facto
EIAAB42039 Basic transcription factor 2 62 kDa subunit,BTF2 p62,General transcription factor IIH polypeptide 1,General transcription factor IIH subunit 1,Gtf2h1,Mouse,Mus musculus,TFIIH basal transcription facto
18-003-42234 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.05 mg Aff Pur
18-003-42234 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.1 mg Protein A
EIAAB25651 Metal regulatory transcription factor 1,Mouse,MRE-binding transcription factor,Mtf1,Mtf-1,Mus musculus,Transcription factor MTF-1
18-003-42235 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.05 mg Aff Pur
18-003-43070 T-box transcription factor TBX21 - T-box protein 21; Transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet Polyclonal 0.1 mg Protein A
18-003-42235 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.1 mg Protein A
EIAAB42078 HMG box transcription factor 4,Homo sapiens,hTCF-4,Human,T-cell factor 4,T-cell-specific transcription factor 4,TCF4,TCF-4,TCF7L2,Transcription factor 7-like 2
EIAAB42042 Basic transcription factor 2 44 kDa subunit,BTF2 p44,General transcription factor IIH polypeptide 2,General transcription factor IIH subunit 2,Gtf2h2,Rat,Rattus norvegicus,TFIIH basal transcription fa
EIAAB32964 bHLH transcription factor p48,Mouse,Mus musculus,p48 DNA-binding subunit of transcription factor PTF1,Pancreas transcription factor 1 subunit alpha,Pancreas-specific transcription factor 1a,Ptf1a,Ptf1
18-003-42999 Cyclic AMP-dependent transcription factor ATF-5 - Activating transcription factor 5; Transcription factor ATFx Polyclonal 0.05 mg Aff Pur
EIAAB42079 HMG box transcription factor 4,Mouse,mTCF-4,Mus musculus,T-cell factor 4,T-cell-specific transcription factor 4,Tcf4,TCF-4,Tcf7l2,Transcription factor 7-like 2
EIAAB47163 CREB_ATF bZIP transcription factor,Crebzf,HCF-binding transcription factor Zhangfei,Host cell factor-binding transcription factor Zhangfei,Mouse,Mus musculus,Tyrosine kinase-associated leucine zipper


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur